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SI9500350B - Oralni multipli emulzijski predkoncentrat - Google Patents

Oralni multipli emulzijski predkoncentrat Download PDF

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Publication number
SI9500350B
SI9500350B SI9500350A SI9500350A SI9500350B SI 9500350 B SI9500350 B SI 9500350B SI 9500350 A SI9500350 A SI 9500350A SI 9500350 A SI9500350 A SI 9500350A SI 9500350 B SI9500350 B SI 9500350B
Authority
SI
Slovenia
Prior art keywords
weight
composition
ester
solvent
polyethylene glycol
Prior art date
Application number
SI9500350A
Other languages
English (en)
Other versions
SI9500350A (en
Inventor
Istvan Kovacs
Marta Jusztin
Erzsebet Takacs
Zoltan Balazs
Ildiko Kiss
Zsolt Varga
Sandor Jancso
Csaba Heim
Nee Korcsmaros Ildiko Kanya
Erzsebet Erdoehati
Marta Jarabin
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of SI9500350A publication Critical patent/SI9500350A/sl
Publication of SI9500350B publication Critical patent/SI9500350B/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Claims (6)

  1. PATENTNI ZAHTEVKI 1. Oralni sestavek multiplo-emulzijskega predkoncentrata, ki vsebuje, i) 5-30 % (masni delež) ciklosporina, ii) 5-30 % (masni delež) tokoferol polietilenglikolnega estra karboksilne kisline, iii) 5-20 % (masni delež) etanola, iv) 20-55 % (masni delež) lipofilnega topila v) 10-20 % (masni delež) kosurfaktanta z vrednostjo HLB 4-10, in vi) opcijsko 10 do 55 % (masni delež) amfitilnega topila.
  2. 2. Sestavek po zahtevku 1, pri čemer je lipofilno topilo gliceridni ester maščobne kisline.
  3. 3. Sestavek po zahtevku 1, pri čemer je amfifilno topilo farmacevtsko sprejemljiv alkil ester C2.8-polikarboksilne kisline.
  4. 4. Sestavek po zahtevku 3, pri čemer je farmacevtsko sprejemljiv alkil ester C2_8-polikarboksilne kisline trietil citrat ali acetil trietil citrat.
  5. 5. Sestavek po zahtevku 1, pri čemer je kotenzid izbran iz sorbitanovega estra maščobnih kislin ali alkil poliglikoletrovega estra ortofosforjeve kisline.
  6. 6. Sestavek po zahtevku 1, ki obsega d-a-tokoferil polietilenglikol 1000 sukcinat kot adjuvant in surfaktant.
SI9500350A 1994-11-21 1995-11-13 Oralni multipli emulzijski predkoncentrat SI9500350B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9403328A HU215966B (hu) 1994-11-21 1994-11-21 Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum

Publications (2)

Publication Number Publication Date
SI9500350A SI9500350A (en) 1996-06-30
SI9500350B true SI9500350B (sl) 2005-02-28

Family

ID=10985774

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9500350A SI9500350B (sl) 1994-11-21 1995-11-13 Oralni multipli emulzijski predkoncentrat

Country Status (17)

Country Link
US (1) US5583105A (sl)
EP (1) EP0712631B1 (sl)
KR (1) KR100377058B1 (sl)
AT (2) ATE245994T1 (sl)
CA (1) CA2145242C (sl)
CZ (1) CZ286686B6 (sl)
DE (2) DE69531389T2 (sl)
DK (1) DK0712631T3 (sl)
ES (1) ES2202330T3 (sl)
GB (1) GB2295546B (sl)
HK (1) HK1016814A1 (sl)
HU (1) HU215966B (sl)
IT (1) IT1281337B1 (sl)
PL (1) PL182716B1 (sl)
PT (1) PT712631E (sl)
SI (1) SI9500350B (sl)
SK (1) SK283045B6 (sl)

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Also Published As

Publication number Publication date
PT712631E (pt) 2003-11-28
ES2202330T3 (es) 2004-04-01
PL182716B1 (pl) 2002-02-28
SI9500350A (en) 1996-06-30
CZ286686B6 (en) 2000-06-14
DE69531389D1 (de) 2003-09-04
DK0712631T3 (da) 2003-10-27
CZ105495A3 (en) 1996-07-17
DE19543271B4 (de) 2006-05-24
DE19543271A1 (de) 1996-06-05
ATE245994T1 (de) 2003-08-15
EP0712631B1 (en) 2003-07-30
GB9523295D0 (en) 1996-01-17
CA2145242C (en) 2001-08-07
GB2295546B (en) 1998-07-22
KR100377058B1 (ko) 2003-06-11
AT408945B (de) 2002-04-25
DE69531389T2 (de) 2004-04-15
KR960016903A (ko) 1996-06-17
SK54495A3 (en) 1997-02-05
HU9403328D0 (en) 1995-02-28
US5583105A (en) 1996-12-10
PL311430A1 (en) 1996-05-27
SK283045B6 (sk) 2003-02-04
ATA189395A (de) 2001-09-15
HK1016814A1 (en) 1999-11-05
CA2145242A1 (en) 1996-05-22
ITMI952411A1 (it) 1997-05-21
GB2295546A (en) 1996-06-05
ITMI952411A0 (sl) 1995-11-21
EP0712631A3 (en) 1996-12-04
EP0712631A2 (en) 1996-05-22
IT1281337B1 (it) 1998-02-18
HU215966B (hu) 1999-07-28

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Legal Events

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OU02 Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims

Effective date: 20041118

SP73 Change of data on owner

Owner name: TEVA GYOGYSZERGYAR RESZVENYTARSASAG; HU

Effective date: 20050517

SP73 Change of data on owner

Owner name: TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYT; HU

Effective date: 20070124

KO00 Lapse of patent

Effective date: 20110728