SI9300244A - Novi kinazolini kot inhibitorji HIV reverzne transkriptaze - Google Patents

Novi kinazolini kot inhibitorji HIV reverzne transkriptaze Download PDF

Info

Publication number: SI9300244A
Authority: SI; Slovenia
Prior art keywords: chloro; cyclopropyl; dihydro; quinazolin; pyridyl
Prior art date: 1992-05-07

Application number

SI9300244A

Other languages

English (en)

Slovenian (sl)

Inventor

Terry A Lyle

Thomas J Tucker

Catherine M Wiscount

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-07

Filing date

1993-05-07

Publication date

1993-12-31

1993-05-07 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1993-12-31 Publication of SI9300244A publication Critical patent/SI9300244A/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SI9300244A 1992-05-07 1993-05-07 Novi kinazolini kot inhibitorji HIV reverzne transkriptaze SI9300244A (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US88011992A	1992-05-07	1992-05-07
US99116492A	1992-12-16	1992-12-16

Publications (1)

Publication Number	Publication Date
SI9300244A true SI9300244A (sl)	1993-12-31

Family

ID=27128564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9300244A SI9300244A (sl)	1992-05-07	1993-05-07	Novi kinazolini kot inhibitorji HIV reverzne transkriptaze

Country Status (15)

Country	Link
EP (2)	EP0639184A1 (fr)
JP (1)	JPH0813805B2 (fr)
KR (1)	KR950701322A (fr)
CN (1)	CN1085550A (fr)
AU (2)	AU4220493A (fr)
BG (1)	BG99149A (fr)
CA (1)	CA2095194A1 (fr)
CZ (1)	CZ272494A3 (fr)
FI (1)	FI945199A (fr)
HR (1)	HRP930857A2 (fr)
HU (1)	HUT71401A (fr)
IL (1)	IL105551A0 (fr)
MX (1)	MX9302681A (fr)
SI (1)	SI9300244A (fr)
WO (1)	WO1993022292A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2281297A (en) *	1993-08-27	1995-03-01	Merck & Co Inc	Quinazoline compounds
US5434152A (en) *	1993-11-08	1995-07-18	Merck & Co., Inc.	Asymmetric synthesis of (S)-(-)-6-chloro-4- cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-quinazolinone
US6124302A (en) *	1997-04-09	2000-09-26	Dupont Pharmaceuticals	4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors
HRP980143A2 (en) *	1997-04-09	1999-02-28	Soo Sung Ko	4,4-disubstituted-3,4-dihydro-2 (1h)-quinazolinones useful as hiv reverse transcriptase inhibitors
EP1091939A1 (fr) *	1998-06-30	2001-04-18	Du Pont Pharmaceuticals Company	Quinoline-2(1h)-ones substituees utiles comme inhibiteurs de la transcriptase inverse du vih
CA2370141A1 (fr)	1999-05-26	2000-12-07	James D. Rodgers	Inhibiteurs de transcriptase inverse du vih a base de 1,4-benzodiazepin-2-ones
EP1189882A1 (fr) *	2000-04-25	2002-03-27	SAMSUNG ELECTRONICS Co. Ltd.	Derives d'acide diphenylbutyrique inhibiteurs de metalloproteinase matricielle
US7119111B2 (en) *	2002-05-29	2006-10-10	Amgen, Inc.	2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use
JP5470043B2 (ja) *	2007-10-05	2014-04-16	Ｍｓｄ株式会社	ベンゾオキサジノン誘導体
CN101544630B (zh) *	2009-05-13	2013-03-13	中国科学院广州生物医药与健康研究院	羟基化茚地那韦的制备方法
WO2017003724A1 (fr)	2015-07-01	2017-01-05	Crinetics Pharmaceuticals, Inc.	Modulateurs de somatostatine et leurs utilisations
JOP20180009A1 (ar)	2017-02-06	2019-01-30	Gilead Sciences Inc	مركبات مثبط فيروس hiv
WO2019023278A1 (fr)	2017-07-25	2019-01-31	Crinetics Pharmaceuticals, Inc.	Modulateurs de la somatostatine et utilisations de ces derniers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL147140B (nl) *	1968-11-26	1975-09-15	Farmaceutici Italia	Werkwijze voor het bereiden van geneesmiddelen met een remmende werking op het centrale zenuwstelsel.
IL102764A0 (en) *	1991-08-16	1993-01-31	Merck & Co Inc	Quinazoline derivatives,and pharmaceutical compositions containing them

1993
- 1993-04-28 HU HU9403187A patent/HUT71401A/hu unknown
- 1993-04-28 CZ CZ942724A patent/CZ272494A3/cs unknown
- 1993-04-28 WO PCT/US1993/003975 patent/WO1993022292A1/fr not_active Application Discontinuation
- 1993-04-28 EP EP93910860A patent/EP0639184A1/fr not_active Withdrawn
- 1993-04-28 AU AU42204/93A patent/AU4220493A/en not_active Abandoned
- 1993-04-28 KR KR1019940703948A patent/KR950701322A/ko not_active Application Discontinuation
- 1993-04-29 EP EP93201232A patent/EP0569083A1/fr not_active Withdrawn
- 1993-04-29 IL IL105551A patent/IL105551A0/xx unknown
- 1993-04-29 CA CA002095194A patent/CA2095194A1/fr not_active Abandoned
- 1993-05-05 HR HR930857A patent/HRP930857A2/hr not_active Application Discontinuation
- 1993-05-06 MX MX9302681A patent/MX9302681A/es unknown
- 1993-05-06 CN CN93107074A patent/CN1085550A/zh active Pending
- 1993-05-06 AU AU38413/93A patent/AU3841393A/en not_active Abandoned
- 1993-05-07 SI SI9300244A patent/SI9300244A/sl unknown
- 1993-05-07 JP JP5107015A patent/JPH0813805B2/ja not_active Expired - Lifetime
1994
- 1994-10-31 BG BG99149A patent/BG99149A/xx unknown
- 1994-11-04 FI FI945199A patent/FI945199A/fi unknown

Also Published As

Publication number	Publication date
WO1993022292A1 (fr)	1993-11-11
JPH0813805B2 (ja)	1996-02-14
JPH069578A (ja)	1994-01-18
HRP930857A2 (en)	1995-06-30
CN1085550A (zh)	1994-04-20
FI945199A0 (fi)	1994-11-04
IL105551A0 (en)	1993-08-18
CA2095194A1 (fr)	1993-11-08
MX9302681A (es)	1994-05-31
AU3841393A (en)	1993-11-11
BG99149A (en)	1995-06-30
CZ272494A3 (en)	1995-10-18
KR950701322A (ko)	1995-03-23
HUT71401A (en)	1995-11-28
EP0569083A1 (fr)	1993-11-10
AU4220493A (en)	1993-11-29
EP0639184A1 (fr)	1995-02-22
FI945199A (fi)	1994-11-04

Publication	Publication Date	Title
WO1995012583A1 (fr)	1995-05-11	Nouvelles quinazolines utilisees comme inhibtiteurs de la transcriptase inverse du vih
AU676563B2 (en)	1997-03-13	HIV protease inhibitors useful for the treatment of AIDS
EP0766674B1 (fr)	2003-10-15	Nouveaux inhibiteurs de protease de vih
JP4625838B2 (ja)	2011-02-02	Ｈｉｖインテグラーゼ阻害薬
EP0617968B1 (fr)	2003-01-08	Inhibiteurs de protease de l'HIV en mélanges pharmaceutiques pour le traitement du SIDA
US5807841A (en)	1998-09-15	HIV protease inhibitors useful for the treatment of AIDS
JP2008537741A (ja)	2008-09-25	Ｐ２ｘ７調節因子としてのビシクロヘテロアリール化合物およびそれらの使用
SI9300244A (sl)	1993-12-31	Novi kinazolini kot inhibitorji HIV reverzne transkriptaze
KR20010075268A (ko)	2001-08-09	시아노페닐 유도체
PL175615B1 (pl)	1999-01-29	Benzoksazynony będące inhibitorami odwrotnej transkryptazy HIV, zawierające je środki farmaceutyczne oraz sposób wytwarzania (-)-6-chloro-4-cyklopropyloetynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu
WO1998042666A1 (fr)	1998-10-01	Derives 3,4-dialcoxyphenyle et leur utilisation
US5846978A (en)	1998-12-08	HIV protease inhibitors useful for the treatment of AIDS
GB2271566A (en)	1994-04-20	HIV integrase inhibitors
US5650412A (en)	1997-07-22	HIV protease inhibitors useful for the treatment of AIDS
CA2269135A1 (fr)	1998-05-07	Derives de benzodiazepine hydrazide utilises comme inhibiteurs de l'integrase du vih
US5939414A (en)	1999-08-17	Benzodiazepine hydrazide derivatives as inhibitors of HIV integrase
DE68906617T2 (de)	1993-09-23	Substituierte 5,6,7,8-tetrahydroimidazo(1,5-a)pyridine und verfahren zu ihrer herstellung.
US5747540A (en)	1998-05-05	HIV protease inhibitors useful for the treatment of AIDS
DE102005034264A1 (de)	2007-02-01	4-Chromenonyl-1,4-dihydropyridincarbonitrile und ihre Verwendung
CA2252915A1 (fr)	1997-11-06	Inhibiteurs de la protease du vih utilises dans le traitement du sida