SI9010633B - Postopki za pridobivanje pteridin-4(3H)-onov in zdravilni pripravki, ki jih vsebujejo - Google Patents

Postopki za pridobivanje pteridin-4(3H)-onov in zdravilni pripravki, ki jih vsebujejo Download PDF

Info

Publication number: SI9010633B
Authority: SI; Slovenia
Prior art keywords: pteridin; formula; process according; pharmaceutically acceptable; radical
Prior art date: 1989-03-30

Application number

SI9010633A

Other languages

English (en)

Slovenian (sl)

Other versions

SI9010633A (en

Inventor

Gerard Ferrand

Herve Dumas

Jean-Claude Depin

Yvette Quentin

Original Assignee

Lipha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-30

Filing date

1990-03-29

Publication date

1999-06-30

1990-03-29 Application filed by Lipha filed Critical Lipha

1997-02-28 Publication of SI9010633A publication Critical patent/SI9010633A/sl

1999-06-30 Publication of SI9010633B publication Critical patent/SI9010633B/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SI9010633A 1989-03-30 1990-03-29 Postopki za pridobivanje pteridin-4(3H)-onov in zdravilni pripravki, ki jih vsebujejo SI9010633B (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8904193A FR2645152B1 (fr)	1989-03-30	1989-03-30	3h-pteridinones-4, procedes de preparation et medicaments les contenant
YU63390A YU47346B (sh)	1989-03-30	1990-03-29	Postupak za dobivanje pteridin-4(3h)-ona

Publications (2)

Publication Number	Publication Date
SI9010633A SI9010633A (en)	1997-02-28
SI9010633B true SI9010633B (sl)	1999-06-30

Family

ID=9380213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9010633A SI9010633B (sl)	1989-03-30	1990-03-29	Postopki za pridobivanje pteridin-4(3H)-onov in zdravilni pripravki, ki jih vsebujejo

Country Status (30)

Country	Link
US (1)	US5167949A (de)
EP (1)	EP0399856B1 (de)
JP (1)	JPH0725761B2 (de)
AR (1)	AR248278A1 (de)
AT (1)	ATE126229T1 (de)
AU (1)	AU630178B2 (de)
CA (1)	CA2013324C (de)
CZ (1)	CZ284679B6 (de)
DD (1)	DD296927A5 (de)
DE (1)	DE69021444T2 (de)
DK (1)	DK0399856T3 (de)
ES (1)	ES2078324T3 (de)
FR (1)	FR2645152B1 (de)
GE (1)	GEP19971023B (de)
GR (1)	GR3017245T3 (de)
HR (1)	HRP920759B1 (de)
HU (1)	HU208826B (de)
IE (1)	IE68689B1 (de)
IL (1)	IL93914A (de)
LV (1)	LV5821B4 (de)
MA (1)	MA21786A1 (de)
NO (1)	NO175100C (de)
NZ (1)	NZ233130A (de)
OA (1)	OA09441A (de)
PT (1)	PT93600B (de)
RU (1)	RU1836344C (de)
SI (1)	SI9010633B (de)
TN (1)	TNSN90040A1 (de)
YU (1)	YU47346B (de)
ZA (1)	ZA902397B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5270465A (en) *	1989-03-30	1993-12-14	Lipha, Lyonnaise Industrille Pharmaceutique	4(3H)-pteridinone compounds
FR2772615B1 (fr) *	1997-12-23	2002-06-14	Lipha	Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
US6806272B2 (en)	2001-09-04	2004-10-19	Boehringer Ingelheim Pharma Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
UA76512C2 (en) *	2001-09-04	2006-08-15	Boehringer Ingelheim Pharma	Dihydropteridinones, a method for producing thereof and use thereof as medicament
FR2831789B1 (fr) *	2001-11-07	2004-01-23	Oreal	Procede et dispositif pour l'evaluation de la secheresse cutanee notamment
US6861422B2 (en)	2003-02-26	2005-03-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
DE102004029784A1 (de)	2004-06-21	2006-01-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de)	2004-07-09	2006-02-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US7759485B2 (en)	2004-08-14	2010-07-20	Boehringer Ingelheim International Gmbh	Process for the manufacture of dihydropteridinones
US20060058311A1 (en)	2004-08-14	2006-03-16	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation
US7728134B2 (en)	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060035903A1 (en) *	2004-08-14	2006-02-16	Boehringer Ingelheim International Gmbh	Storage stable perfusion solution for dihydropteridinones
US20060074088A1 (en)	2004-08-14	2006-04-06	Boehringer Ingelheim International Gmbh	Dihydropteridinones for the treatment of cancer diseases
EP1632493A1 (de) *	2004-08-25	2006-03-08	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1630163A1 (de)	2004-08-25	2006-03-01	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) *	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en)	2006-02-08	2008-10-21	Boehringer Ingelheim International Gmbh	Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
WO2008116742A1 (en) *	2007-03-23	2008-10-02	F. Hoffmann-La Roche Ag	Aza-pyridopyrimidinone derivatives
EP2185559A1 (de)	2007-08-03	2010-05-19	Boehringer Ingelheim International GmbH	Kristalline form eines dihydropteridionderivats
US8546566B2 (en)	2010-10-12	2013-10-01	Boehringer Ingelheim International Gmbh	Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en)	2010-11-29	2016-06-07	Boehringer Ingelheim International Gmbh	Method for treating acute myeloid leukemia
US9370535B2 (en)	2011-05-17	2016-06-21	Boehringer Ingelheim International Gmbh	Method for treatment of advanced solid tumors
US20150031699A1 (en)	2013-07-26	2015-01-29	Boehringer Ingelheim International Gmbh	Treatment of myelodysplastic syndrome
US9867831B2 (en)	2014-10-01	2018-01-16	Boehringer Ingelheim International Gmbh	Combination treatment of acute myeloid leukemia and myelodysplastic syndrome

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3159628A (en) *	1962-05-28	1964-12-01	Smith Kline French Lab	Pteridine-5-oxide derivatives
US3426019A (en) *	1962-06-29	1969-02-04	Smithkline Corp	Derivatives of pteridine and a method for their preparation
SE307365B (de) *	1966-05-28	1969-01-07	Yoshitomi Pharmaceutical
US3732224A (en) *	1969-10-20	1973-05-08	Sherwin Williams Co	Method of controlling plant growth and 3-substituted lumazines used in such method
US3819631A (en) *	1970-12-15	1974-06-25	May & Baker Ltd	Azapurinones
US3859287A (en) *	1971-05-05	1975-01-07	Walter Wesley Parish	Thiopteridines and process for producing same
DE2232098A1 (de) *	1972-06-30	1974-01-17	Boehringer Mannheim Gmbh	2-alkyl-4(3h)-pteridinone und verfahren zu ihrer herstellung
US4183934A (en) *	1978-10-16	1980-01-15	Abbott Laboratories	4-Hydroxy-7-(substituted)phenylpteridines
US4361700A (en) *	1980-05-20	1982-11-30	James S. Waldron	Pyridopyrimidinone derivatives

1989
- 1989-03-30 FR FR8904193A patent/FR2645152B1/fr not_active Expired - Lifetime
1990
- 1990-03-26 AU AU52218/90A patent/AU630178B2/en not_active Ceased
- 1990-03-27 AT AT90400827T patent/ATE126229T1/de not_active IP Right Cessation
- 1990-03-27 IL IL9391490A patent/IL93914A/en not_active IP Right Cessation
- 1990-03-27 ES ES90400827T patent/ES2078324T3/es not_active Expired - Lifetime
- 1990-03-27 DK DK90400827.3T patent/DK0399856T3/da active
- 1990-03-27 DE DE69021444T patent/DE69021444T2/de not_active Expired - Fee Related
- 1990-03-27 MA MA22052A patent/MA21786A1/fr unknown
- 1990-03-27 OA OA59755A patent/OA09441A/xx unknown
- 1990-03-27 EP EP90400827A patent/EP0399856B1/de not_active Expired - Lifetime
- 1990-03-28 ZA ZA902397A patent/ZA902397B/xx unknown
- 1990-03-28 CZ CS901520A patent/CZ284679B6/cs not_active IP Right Cessation
- 1990-03-28 CA CA002013324A patent/CA2013324C/fr not_active Expired - Fee Related
- 1990-03-29 US US07/501,104 patent/US5167949A/en not_active Expired - Fee Related
- 1990-03-29 HU HU901898A patent/HU208826B/hu not_active IP Right Cessation
- 1990-03-29 PT PT93600A patent/PT93600B/pt not_active IP Right Cessation
- 1990-03-29 NZ NZ233130A patent/NZ233130A/en unknown
- 1990-03-29 DD DD90339197A patent/DD296927A5/de unknown
- 1990-03-29 IE IE115790A patent/IE68689B1/en not_active IP Right Cessation
- 1990-03-29 NO NO901430A patent/NO175100C/no not_active IP Right Cessation
- 1990-03-29 SI SI9010633A patent/SI9010633B/sl not_active IP Right Cessation
- 1990-03-29 YU YU63390A patent/YU47346B/sh unknown
- 1990-03-29 AR AR90316504A patent/AR248278A1/es active
- 1990-03-29 RU SU904743545A patent/RU1836344C/ru active
- 1990-03-30 TN TNTNSN90040A patent/TNSN90040A1/fr unknown
- 1990-03-30 JP JP2081429A patent/JPH0725761B2/ja not_active Expired - Fee Related
1992
- 1992-10-01 HR HRP-633/90A patent/HRP920759B1/xx not_active IP Right Cessation
1993
- 1993-03-11 GE GEAP1993603A patent/GEP19971023B/en unknown
1995
- 1995-08-30 GR GR950402356T patent/GR3017245T3/el unknown
1996
- 1996-07-18 LV LV960271A patent/LV5821B4/xx unknown

Also Published As

Publication number	Publication date
FR2645152A1 (fr)	1990-10-05
NO175100B (no)	1994-05-24
MA21786A1 (fr)	1990-10-01
US5167949A (en)	1992-12-01
LV5821B4 (lv)	1997-10-20
PT93600A (pt)	1990-11-20
NO901430L (no)	1990-10-01
AU5221890A (en)	1990-10-04
CA2013324C (fr)	2001-08-21
PT93600B (pt)	1996-03-29
CZ152090A3 (cs)	1998-11-11
EP0399856A1 (de)	1990-11-28
CA2013324A1 (fr)	1990-09-30
NO901430D0 (no)	1990-03-29
JPH0725761B2 (ja)	1995-03-22
RU1836344C (ru)	1993-08-23
DE69021444T2 (de)	1996-03-14
ES2078324T3 (es)	1995-12-16
DE69021444D1 (de)	1995-09-14
LV5821A4 (lv)	1997-04-20
AR248278A1 (es)	1995-07-12
IE901157L (en)	1990-09-30
DK0399856T3 (da)	1995-09-18
JPH02304089A (ja)	1990-12-17
DD296927A5 (de)	1991-12-19
HU901898D0 (en)	1990-08-28
NO175100C (no)	1994-08-31
HRP920759B1 (en)	1998-08-31
IE68689B1 (en)	1996-07-10
NZ233130A (en)	1992-01-29
YU63390A (en)	1991-10-31
CZ284679B6 (cs)	1999-02-17
HU208826B (en)	1994-01-28
HRP920759A2 (en)	1995-06-30
ZA902397B (en)	1991-01-30
OA09441A (fr)	1992-10-15
TNSN90040A1 (fr)	1991-03-05
FR2645152B1 (fr)	1991-05-31
YU47346B (sh)	1995-01-31
IL93914A0 (en)	1990-12-23
SI9010633A (en)	1997-02-28
GR3017245T3 (en)	1995-11-30
AU630178B2 (en)	1992-10-22
HUT53646A (en)	1990-11-28
EP0399856B1 (de)	1995-08-09
GEP19971023B (en)	1997-06-13
IL93914A (en)	1994-02-27
ATE126229T1 (de)	1995-08-15

Publication	Publication Date	Title
SI9010633B (sl)	1999-06-30	Postopki za pridobivanje pteridin-4(3H)-onov in zdravilni pripravki, ki jih vsebujejo
AU655798B2 (en)	1995-01-12	2,4-diaminoquinazolines derivatives for enhancing antitumor activity
KR900014358A (ko)	1990-10-23	2-(1-피페라진일)-4-페닐시클로알카노피리딘 유도체, 그들의 제조방법 및 그들을 함유하는 약학적 조성물
JPH0517457A (ja)	1993-01-26	ベンズイソチアゾールおよびベンズイソキサゾールピペラジン誘導体
BR0110240A (pt)	2003-01-07	Composto, processo para a preparação de um composto, processo para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto, e, composição farmacêutica
BR9914379A (pt)	2001-08-07	Composto, processo para a preparação de um composto, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, e, composição farmacêutica
JP2007511527A5 (de)	2007-12-27
HK1071136A1 (en)	2005-07-08	Quinoline derivative and quinazoline derivative and medicinal composition containing the same
KR880002234B1 (ko)	1988-10-20	4-아닐리노피리미딘 유도체의 제조방법
CA3090330A1 (en)	2019-08-15	Atr inhibitor and application thereof
IE34765L (en)	1971-05-26	Nitrofuryl-thienopyrimidines
JPH02270821A (ja)	1990-11-05	チアゾリジニルアルキレンピペラジン誘導体含有医薬組成物
KR920019746A (ko)	1992-11-19	신규한 시클로헥실벤즈아미드 유도체, 그의 제조방법 및 약제로서의 용도
IL82541A (en)	1992-06-21	4(5)-substituted imidazole derivatives,intermediates thereof,processes for their preparation and pharmaceutical compositions containing them
KR890017244A (ko)	1989-12-15	6-페닐-3-(피페라지닐알킬)-2,4-(1h,3h)-피리미딘디온 유도체, 그의 제법 및 치료에의 이용
AU653601B2 (en)	1994-10-06	Pyrimidine derivatives for enhancing antitumor activity
CN111518104A (zh)	2020-08-11	一种含硫脲嘧啶的1,2,4-三氮唑并[1,5-a]嘧啶类化合物及其制备方法和应用
CA2959980A1 (en)	2016-06-16	7-(morpholinyl)-2-(n-piperazinyl) methyl thieno [2, 3-c] pyridine derivatives as anticancer drugs
PT708093E (pt)	2001-06-29	Quinoxalina processo para a sua preparacao e sua utilizacao
FI86637B (fi)	1992-06-15	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tiazolo/3,2a/ pyrimidinderivat.
Othman et al.	2018	Cyanoacetyl urea in heterocyclic synthesis part V: Facile synthesis of poly-functionalized pyrimdines via different behaviors of its free urea amino group
ES279017A1 (es)	1962-11-16	Un metodo de producir una 2,4-diaminopirido (2,3-d) pirimidina
CA2021556A1 (en)	1991-01-20	Dihydropyrimidothiazine derivatives
Jeon et al.	2023	Synthesis and Reactions of Trifluoromethyl‐Substituted 1, 3, 5‐Triazines
CN117624139A (zh)	2024-03-01	二芳基类化合物及其制备方法和用途

Legal Events

Date	Code	Title	Description
2005-02-28	KO00	Lapse of patent	Effective date: 20050103