SI3107559T1 - Režim odmerjanja spojine FGF-18 - Google Patents

Režim odmerjanja spojine FGF-18

Info

Publication number: SI3107559T1
Authority: SI; Slovenia
Prior art keywords: fgf; dosing regimen; compound dosing; compound; regimen
Prior art date: 2014-02-20

Application number

SI201530428T

Other languages

English (en)

Inventor

Christoph H. Ladel

Hans Guehring

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-02-20

Filing date

2015-02-20

Publication date

2018-11-30

2015-02-20 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2018-11-30 Publication of SI3107559T1 publication Critical patent/SI3107559T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2006—IL-1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SI201530428T 2014-02-20 2015-02-20 Režim odmerjanja spojine FGF-18 SI3107559T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP14000600		2014-02-20
PCT/EP2015/053624 WO2015124727A1 (en)	2014-02-20	2015-02-20	Fgf-18 compound dosing regimen
EP15706006.2A EP3107559B1 (en)	2014-02-20	2015-02-20	Fgf-18 compound dosing regimen

Publications (1)

Publication Number	Publication Date
SI3107559T1 true SI3107559T1 (sl)	2018-11-30

Family

ID=50151088

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI201530428T SI3107559T1 (sl)	2014-02-20	2015-02-20	Režim odmerjanja spojine FGF-18
SI201530410T SI3119417T1 (sl)	2014-02-20	2015-02-20	Režim odmerjanja spojine FGF-18

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SI201530410T SI3119417T1 (sl)	2014-02-20	2015-02-20	Režim odmerjanja spojine FGF-18

Country Status (25)

Country	Link
US (2)	US9889179B2 (sl)
EP (2)	EP3119417B1 (sl)
JP (2)	JP6431082B2 (sl)
KR (2)	KR102410988B1 (sl)
CN (2)	CN106456713A (sl)
AR (2)	AR099558A1 (sl)
AU (2)	AU2015220777B2 (sl)
BR (2)	BR112016018696A2 (sl)
CA (2)	CA2938793A1 (sl)
DK (2)	DK3119417T3 (sl)
ES (2)	ES2688551T3 (sl)
HR (2)	HRP20181570T1 (sl)
HU (1)	HUE040350T2 (sl)
IL (2)	IL247084B (sl)
LT (2)	LT3107559T (sl)
MX (2)	MX2016010872A (sl)
NZ (2)	NZ723148A (sl)
PL (2)	PL3119417T3 (sl)
PT (2)	PT3119417T (sl)
RS (2)	RS57853B1 (sl)
RU (2)	RU2691946C2 (sl)
SG (2)	SG11201606505UA (sl)
SI (2)	SI3107559T1 (sl)
WO (2)	WO2015124731A1 (sl)
ZA (2)	ZA201605548B (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10086112B2 (en)	2014-02-20	2018-10-02	Merck Patent Gmbh	Implant comprising FGF-18
RS57853B1 (sr)	2014-02-20	2018-12-31	Merck Patent Gmbh	Dozni režim fgf-18 jedinjenja
HUE054819T2 (hu)	2016-02-22	2021-10-28	Novartis Ag	Eljárások FXR agonista alkalmazására
IL273574B1 (en) *	2017-09-29	2024-09-01	Merck Patent Gmbh	Inflammatory biomarkers for predicting response to FGF-18 compound
AU2020218844A1 (en) *	2019-02-08	2021-08-19	Merck Patent Gmbh	Treatment of patients at risk of rapid progression of osteoarthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1551426B1 (en) *	2002-10-07	2014-06-25	ZymoGenetics, Inc.	Methods of administering fgf18
ES2706848T3 (es) *	2004-07-06	2019-04-01	Zymogenetics Inc	Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso
WO2007070983A1 (en) *	2005-12-22	2007-06-28	Apollo Life Sciences Limited	Transdermal delivery of pharmaceutical agents
CN101505787B (zh) *	2006-08-25	2013-09-04	阿雷斯贸易股份有限公司	软骨障碍的治疗
AR062522A1 (es)	2006-08-25	2008-11-12	Ares Trading Sa	Tratamiento de desordenes en cartilagos
DE102006043260A1 (de) *	2006-09-11	2008-03-27	Krones Ag	Etikettieranlage
CA2830882C (en) *	2011-03-22	2021-03-16	Dinesh Barawkar	Substituted fused tricyclic compounds, compositions and medicinal applications thereof
US10086112B2 (en)	2014-02-20	2018-10-02	Merck Patent Gmbh	Implant comprising FGF-18
RS57853B1 (sr)	2014-02-20	2018-12-31	Merck Patent Gmbh	Dozni režim fgf-18 jedinjenja
RU2682159C2 (ru)	2014-02-20	2019-03-15	Мерк Патент Гмбх	Fgf-18 в процедурах пересадки трансплантата и тканевой инженерии

2015
- 2015-02-20 RS RS20181167A patent/RS57853B1/sr unknown
- 2015-02-20 SG SG11201606505UA patent/SG11201606505UA/en unknown
- 2015-02-20 PL PL15707076T patent/PL3119417T3/pl unknown
- 2015-02-20 RU RU2016137289A patent/RU2691946C2/ru active
- 2015-02-20 US US15/120,131 patent/US9889179B2/en active Active
- 2015-02-20 LT LTEP15706006.2T patent/LT3107559T/lt unknown
- 2015-02-20 CA CA2938793A patent/CA2938793A1/en active Pending
- 2015-02-20 MX MX2016010872A patent/MX2016010872A/es active IP Right Grant
- 2015-02-20 AR ARP150100507A patent/AR099558A1/es unknown
- 2015-02-20 DK DK15707076.4T patent/DK3119417T3/en active
- 2015-02-20 BR BR112016018696A patent/BR112016018696A2/pt not_active Application Discontinuation
- 2015-02-20 KR KR1020167025245A patent/KR102410988B1/ko active IP Right Grant
- 2015-02-20 WO PCT/EP2015/053631 patent/WO2015124731A1/en active Application Filing
- 2015-02-20 ES ES15707076.4T patent/ES2688551T3/es active Active
- 2015-02-20 PT PT15707076T patent/PT3119417T/pt unknown
- 2015-02-20 CA CA2938791A patent/CA2938791A1/en not_active Abandoned
- 2015-02-20 PT PT15706006T patent/PT3107559T/pt unknown
- 2015-02-20 SI SI201530428T patent/SI3107559T1/sl unknown
- 2015-02-20 WO PCT/EP2015/053624 patent/WO2015124727A1/en active Application Filing
- 2015-02-20 KR KR1020167025246A patent/KR102410986B1/ko active IP Right Grant
- 2015-02-20 MX MX2016010871A patent/MX2016010871A/es active IP Right Grant
- 2015-02-20 NZ NZ723148A patent/NZ723148A/en unknown
- 2015-02-20 JP JP2016553284A patent/JP6431082B2/ja active Active
- 2015-02-20 CN CN201580020532.4A patent/CN106456713A/zh active Pending
- 2015-02-20 NZ NZ723139A patent/NZ723139A/en unknown
- 2015-02-20 CN CN201580020536.2A patent/CN106232622A/zh active Pending
- 2015-02-20 RU RU2016137292A patent/RU2700582C2/ru active
- 2015-02-20 BR BR112016018685A patent/BR112016018685A2/pt not_active Application Discontinuation
- 2015-02-20 US US15/120,134 patent/US9724388B2/en active Active
- 2015-02-20 EP EP15707076.4A patent/EP3119417B1/en active Active
- 2015-02-20 AU AU2015220777A patent/AU2015220777B2/en active Active
- 2015-02-20 AU AU2015220773A patent/AU2015220773B2/en active Active
- 2015-02-20 AR ARP150100508A patent/AR099510A1/es unknown
- 2015-02-20 PL PL15706006T patent/PL3107559T3/pl unknown
- 2015-02-20 RS RS20181168A patent/RS57709B1/sr unknown
- 2015-02-20 EP EP15706006.2A patent/EP3107559B1/en active Active
- 2015-02-20 JP JP2016553329A patent/JP6431083B2/ja active Active
- 2015-02-20 DK DK15706006.2T patent/DK3107559T3/en active
- 2015-02-20 ES ES15706006.2T patent/ES2689071T3/es active Active
- 2015-02-20 HU HUE15706006A patent/HUE040350T2/hu unknown
- 2015-02-20 SI SI201530410T patent/SI3119417T1/sl unknown
- 2015-02-20 LT LTEP15707076.4T patent/LT3119417T/lt unknown
- 2015-02-20 SG SG11201606502YA patent/SG11201606502YA/en unknown
2016
- 2016-08-03 IL IL247084A patent/IL247084B/en active IP Right Grant
- 2016-08-03 IL IL247083A patent/IL247083B/en active IP Right Grant
- 2016-08-10 ZA ZA2016/05548A patent/ZA201605548B/en unknown
- 2016-08-10 ZA ZA2016/05547A patent/ZA201605547B/en unknown
2018
- 2018-10-02 HR HRP20181570TT patent/HRP20181570T1/hr unknown
- 2018-10-02 HR HRP20181572TT patent/HRP20181572T1/hr unknown

Also Published As

Publication number	Publication date
ES2688551T3 (es)	2018-11-05
EP3107559B1 (en)	2018-07-11
CA2938793A1 (en)	2015-08-27
IL247084A0 (en)	2016-09-29
IL247083B (en)	2019-09-26
LT3119417T (lt)	2018-10-25
EP3119417A1 (en)	2017-01-25
MX2016010871A (es)	2016-11-17
CA2938791A1 (en)	2015-08-27
US20170072017A1 (en)	2017-03-16
AR099558A1 (es)	2016-08-03
RS57853B1 (sr)	2018-12-31
KR102410986B1 (ko)	2022-06-17
NZ723148A (en)	2022-08-26
AU2015220777B2 (en)	2020-10-22
RU2016137292A3 (sl)	2018-09-17
RU2016137289A3 (sl)	2018-10-19
AU2015220773A1 (en)	2016-09-01
EP3107559A1 (en)	2016-12-28
SI3119417T1 (sl)	2018-11-30
HRP20181572T1 (hr)	2018-11-30
AU2015220777A1 (en)	2016-09-01
IL247083A0 (en)	2016-09-29
SG11201606502YA (en)	2016-09-29
JP2017512194A (ja)	2017-05-18
DK3107559T3 (en)	2018-10-15
AU2015220773B2 (en)	2020-10-08
US9889179B2 (en)	2018-02-13
WO2015124727A1 (en)	2015-08-27
NZ723139A (en)	2022-12-23
IL247084B (en)	2019-09-26
PL3119417T3 (pl)	2019-01-31
KR102410988B1 (ko)	2022-06-17
PL3107559T3 (pl)	2019-01-31
RS57709B1 (sr)	2018-12-31
PT3107559T (pt)	2018-10-31
RU2016137289A (ru)	2018-03-21
KR20160116001A (ko)	2016-10-06
HRP20181570T1 (hr)	2018-11-30
EP3119417B1 (en)	2018-07-11
AR099510A1 (es)	2016-07-27
RU2016137292A (ru)	2018-03-21
RU2691946C2 (ru)	2019-06-19
JP2017507142A (ja)	2017-03-16
BR112016018685A2 (pt)	2017-10-17
HUE040350T2 (hu)	2019-03-28
US9724388B2 (en)	2017-08-08
ZA201605548B (en)	2018-12-19
RU2700582C2 (ru)	2019-09-18
JP6431082B2 (ja)	2018-11-28
KR20160116000A (ko)	2016-10-06
BR112016018696A2 (pt)	2017-10-17
WO2015124731A1 (en)	2015-08-27
SG11201606505UA (en)	2016-09-29
LT3107559T (lt)	2018-10-25
ES2689071T3 (es)	2018-11-08
MX2016010872A (es)	2016-11-17
ZA201605547B (en)	2019-09-25
JP6431083B2 (ja)	2018-11-28
CN106232622A (zh)	2016-12-14
US20170056474A1 (en)	2017-03-02
PT3119417T (pt)	2018-10-31
DK3119417T3 (en)	2018-10-22
CN106456713A (zh)	2017-02-22

Publication	Publication Date	Title
GB2544029B (en)	2017-10-25	Packages
SI3347054T1 (sl)	2021-08-31	Režimi doziranja konjugatov zdravil proti TF protitelesu
HK1259491A1 (zh)	2019-11-29	給藥方案
HRP20181572T1 (hr)	2018-11-30	Režim doziranja spoja fgf-18
GB2545674B (en)	2021-03-31	Dosing module
GB201510451D0 (en)	2015-07-29	Actuated-valve metering
GB201418710D0 (en)	2014-12-03	Dosage regimen
GB201516836D0 (en)	2015-11-04	Dosing regimen of combination
HRP20181756T1 (hr)	2018-12-28	Režim liječenja sa spojem tiakumicina
ZA201800217B (en)	2019-06-26	Novel dosage regimen tiacumicin compound
GB201720519D0 (en)	2018-01-24	Dosing regimen
GB201718106D0 (en)	2017-12-13	Dosing regimen
GB201718000D0 (en)	2017-12-13	Dosing regimen
GB201717694D0 (en)	2017-12-13	Dosing regimen
GB201609758D0 (en)	2016-07-20	Dosing Regimen
GB201521216D0 (en)	2016-01-13	Dosage regimen
GB201418708D0 (en)	2014-12-03	Dosage regimen
GB201713609D0 (en)	2017-10-11	Packages
GB201400171D0 (en)	2014-02-19	Dosage regimen