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SI2459167T2 - Subkutana formulacija protitelesa proti HER2 - Google Patents

Subkutana formulacija protitelesa proti HER2

Info

Publication number
SI2459167T2
SI2459167T2 SI201030218T SI201030218T SI2459167T2 SI 2459167 T2 SI2459167 T2 SI 2459167T2 SI 201030218 T SI201030218 T SI 201030218T SI 201030218 T SI201030218 T SI 201030218T SI 2459167 T2 SI2459167 T2 SI 2459167T2
Authority
SI
Slovenia
Prior art keywords
her2 antibody
antibody formulation
subcutaneous anti
subcutaneous
formulation
Prior art date
Application number
SI201030218T
Other languages
English (en)
Other versions
SI2459167T1 (sl
Inventor
Michael Adler
Ulla Grauschopf
Hanns-Christian Mahler
Oliver Boris Stauch
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43500473&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2459167(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of SI2459167T1 publication Critical patent/SI2459167T1/sl
Publication of SI2459167T2 publication Critical patent/SI2459167T2/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201030218T 2009-07-31 2010-07-28 Subkutana formulacija protitelesa proti HER2 SI2459167T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09167025 2009-07-31
EP10737891.1A EP2459167B2 (en) 2009-07-31 2010-07-28 Subcutaneous anti-her2 antibody formulation
PCT/EP2010/060930 WO2011012637A2 (en) 2009-07-31 2010-07-28 Subcutaneous anti-her2 antibody formulation

Publications (2)

Publication Number Publication Date
SI2459167T1 SI2459167T1 (sl) 2013-07-31
SI2459167T2 true SI2459167T2 (sl) 2022-05-31

Family

ID=43500473

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201032130T SI2687202T1 (sl) 2009-07-31 2010-07-28 Subkutana formulacija protitelesa proti her2
SI201030218T SI2459167T2 (sl) 2009-07-31 2010-07-28 Subkutana formulacija protitelesa proti HER2

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI201032130T SI2687202T1 (sl) 2009-07-31 2010-07-28 Subkutana formulacija protitelesa proti her2

Country Status (41)

Country Link
US (7) US9345661B2 (sl)
EP (4) EP4257150A3 (sl)
JP (2) JP5462944B2 (sl)
KR (2) KR101413947B1 (sl)
CN (3) CN102573789B (sl)
AR (2) AR077605A1 (sl)
AU (1) AU2010277657B2 (sl)
BR (1) BR112012002080A2 (sl)
CA (1) CA2768458C (sl)
CL (2) CL2012000269A1 (sl)
CO (1) CO6430421A2 (sl)
CR (1) CR20110679A (sl)
CY (1) CY1114185T1 (sl)
DK (2) DK2687202T3 (sl)
DO (1) DOP2015000255A (sl)
EA (2) EA031013B1 (sl)
EC (2) ECSP12011643A (sl)
ES (2) ES2413090T5 (sl)
FI (1) FI2687202T3 (sl)
GT (1) GT201200024A (sl)
HK (2) HK1215157A1 (sl)
HR (2) HRP20130697T4 (sl)
HU (1) HUE062122T2 (sl)
IL (2) IL217382A (sl)
IN (1) IN2012CN00961A (sl)
LT (1) LT2687202T (sl)
MA (1) MA33471B1 (sl)
MX (2) MX2012001124A (sl)
MY (2) MY163001A (sl)
NZ (2) NZ597190A (sl)
PE (2) PE20131324A1 (sl)
PL (2) PL2459167T5 (sl)
PT (2) PT2459167E (sl)
RS (2) RS64314B1 (sl)
SG (2) SG178185A1 (sl)
SI (2) SI2687202T1 (sl)
TN (1) TN2012000023A1 (sl)
TW (2) TWI474834B (sl)
UA (2) UA102166C2 (sl)
WO (1) WO2011012637A2 (sl)
ZA (2) ZA201109459B (sl)

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CL2012000269A1 (es) 2012-10-12
TWI474834B (zh) 2015-03-01
MY172245A (en) 2019-11-19
BR112012002080A2 (pt) 2016-04-12
EA201200204A1 (ru) 2012-08-30
ZA201109459B (en) 2013-05-29
CN102573789B (zh) 2015-09-30
KR101769652B1 (ko) 2017-08-18
HK1172236A1 (en) 2013-04-19
CN102573789A (zh) 2012-07-11
KR20120038540A (ko) 2012-04-23
IL253941B (en) 2021-10-31
US9968676B2 (en) 2018-05-15
WO2011012637A2 (en) 2011-02-03
ES2413090T3 (es) 2013-07-15
RS52913B2 (sr) 2022-05-31
EA031013B1 (ru) 2018-11-30
WO2011012637A3 (en) 2011-08-25
CN105168125A (zh) 2015-12-23
EP4339212A2 (en) 2024-03-20
HRP20130697T4 (hr) 2022-04-29
DK2459167T3 (da) 2013-06-03
TW201106973A (en) 2011-03-01
CA2768458C (en) 2013-12-03
HRP20130697T1 (en) 2013-09-30
SG178185A1 (en) 2012-03-29
US20210353753A1 (en) 2021-11-18
NZ597190A (en) 2012-12-21
CL2013002550A1 (es) 2013-12-13
TW201328708A (zh) 2013-07-16
JP2013500947A (ja) 2013-01-10
CY1114185T1 (el) 2016-08-31
PE20120665A1 (es) 2012-06-01
PT2459167E (pt) 2013-06-24
KR101413947B1 (ko) 2014-06-30
EP2459167B1 (en) 2013-05-15
RS64314B1 (sr) 2023-08-31
PL2687202T3 (pl) 2023-07-24
EA027553B1 (ru) 2017-08-31
ES2948033T3 (es) 2023-08-30
CR20110679A (es) 2012-03-06
UA102166C2 (ru) 2013-06-10
MY163001A (en) 2017-07-31
CA2768458A1 (en) 2011-02-03
ECSP12011643A (es) 2012-02-29
FI2687202T3 (fi) 2023-06-21
WO2011012637A4 (en) 2011-11-03
TWI401089B (zh) 2013-07-11
US20160166689A1 (en) 2016-06-16
CO6430421A2 (es) 2012-04-30
DOP2015000255A (es) 2016-01-31
IL217382A (en) 2017-09-28
JP2013224305A (ja) 2013-10-31
EP2687202A1 (en) 2014-01-22
US20130216532A1 (en) 2013-08-22
EP2687202B1 (en) 2023-05-10
US20110044977A1 (en) 2011-02-24
LT2687202T (lt) 2023-07-10
UA104254C2 (ru) 2014-01-10
EP2459167B2 (en) 2022-03-02
HUE062122T2 (hu) 2023-09-28
US9345661B2 (en) 2016-05-24
KR20130041374A (ko) 2013-04-24
EP2459167A2 (en) 2012-06-06
HRP20230462T1 (hr) 2023-07-21

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