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SI2285808T1 - Spiro-indolni derivati za zdravljenje parazitskih bolezni - Google Patents

Spiro-indolni derivati za zdravljenje parazitskih bolezni

Info

Publication number
SI2285808T1
SI2285808T1 SI200930847T SI200930847T SI2285808T1 SI 2285808 T1 SI2285808 T1 SI 2285808T1 SI 200930847 T SI200930847 T SI 200930847T SI 200930847 T SI200930847 T SI 200930847T SI 2285808 T1 SI2285808 T1 SI 2285808T1
Authority
SI
Slovenia
Prior art keywords
spiro
treatment
indole derivatives
parasitic diseases
parasitic
Prior art date
Application number
SI200930847T
Other languages
English (en)
Inventor
Shi Hua Ang
Philipp Krastel
Seh Yong Leong
Liying Jocelyn Tan
Wei Lin Josephine Wong
Bryan Ks Yeung
Bin Zou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2285808(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI2285808T1 publication Critical patent/SI2285808T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI200930847T 2008-04-29 2009-04-01 Spiro-indolni derivati za zdravljenje parazitskih bolezni SI2285808T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP08155342 2008-04-29
EP09151117 2009-01-22
PCT/EP2009/053902 WO2009132921A1 (en) 2008-04-29 2009-04-01 Spiro-indole derivatives for the treatment of parasitic diseases
EP09737965.5A EP2285808B1 (en) 2008-04-29 2009-04-01 Spiro-indole derivatives for the treatment of parasitic diseases

Publications (1)

Publication Number Publication Date
SI2285808T1 true SI2285808T1 (sl) 2014-03-31

Family

ID=40613087

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930847T SI2285808T1 (sl) 2008-04-29 2009-04-01 Spiro-indolni derivati za zdravljenje parazitskih bolezni

Country Status (31)

Country Link
US (2) US8053442B2 (sl)
EP (2) EP2722333A1 (sl)
JP (2) JP5438098B2 (sl)
KR (1) KR101390081B1 (sl)
CN (1) CN102015711B (sl)
AR (1) AR071222A1 (sl)
AU (1) AU2009242279B2 (sl)
BR (1) BRPI0911577B8 (sl)
CA (1) CA2719365C (sl)
CL (1) CL2009001007A1 (sl)
CO (1) CO6300940A2 (sl)
CY (1) CY1114874T1 (sl)
DK (1) DK2285808T3 (sl)
EA (1) EA019601B1 (sl)
EC (2) ECSP10010646A (sl)
ES (1) ES2447590T3 (sl)
HK (1) HK1149935A1 (sl)
HR (1) HRP20140151T1 (sl)
IL (1) IL208357A (sl)
JO (1) JO2904B1 (sl)
MA (1) MA32316B1 (sl)
MX (1) MX2010011868A (sl)
MY (2) MY156601A (sl)
NZ (1) NZ588217A (sl)
PE (1) PE20091787A1 (sl)
PL (1) PL2285808T3 (sl)
PT (1) PT2285808E (sl)
SI (1) SI2285808T1 (sl)
TW (1) TWI442921B (sl)
WO (1) WO2009132921A1 (sl)
ZA (1) ZA201006752B (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2722333A1 (en) * 2008-04-29 2014-04-23 Novartis AG Spiro-indole derivatives for the treatment of parasitic diseases.
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
WO2013142770A1 (en) 2012-03-23 2013-09-26 Codexis, Inc. Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
PT2828256T (pt) * 2012-03-23 2019-10-18 Novartis Ag Processo químico para a preparação de espiroindolonas e dos seus intermediários
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
SG10202012428PA (en) 2014-11-25 2021-01-28 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP3233852B1 (en) 2014-12-18 2020-07-15 F. Hoffmann-La Roche AG Tetrahydro-pyrido[3,4-b]indoles as estrogen receptor modulators and uses thereof
MY190895A (en) * 2015-01-23 2022-05-18 Glaxosmithkline Ip Dev Ltd Pyrazolo [3,4-d] pyrimidin derivative and its use for the treatment of leishmaniasis
WO2016147205A1 (en) * 2015-03-13 2016-09-22 Council Of Scientific & Industrial Research Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
US11174267B2 (en) 2015-06-12 2021-11-16 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
UA128114C2 (uk) 2018-06-21 2024-04-10 Ф. Хоффманн-Ля Рош Аг Тверді форми 3-((1r,3r)-1-(2,6-дифтор-4-((1-(3-фторпропіл)азетидин-3-іл)аміно)феніл)-3-метил-1,3,4,9-тетрагідро-2h-піридo[3,4-b]індол-2-іл)-2,2-дифторпропан-1-олу і способи одержання конденсованих трициклічних сполук, що містять заміщене фенільне або піридинільне угруповання, в тому числі способи їх застосування
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
WO2021186348A1 (en) * 2020-03-17 2021-09-23 The University Of Buea Dihydro-spiro[indoline-3:1'-isoquinolin]-2-ones as antimalarial agents
CN116273188B (zh) * 2023-03-01 2024-06-25 岭南师范学院 一种负载金属的多孔有机框架材料在催化Pictet-Spengler反应中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
HUP0102851A3 (en) * 1998-07-14 2003-03-28 Bayer Ag Antiparasitic artemisinin derivatives (endoperoxides), process for their preparation and pharmaceutical compositions containing them
EP1144411B1 (en) 1998-12-19 2005-04-27 Janssen Pharmaceutica N.V. Antihistaminic spiro compounds
US20050101623A1 (en) * 2003-07-23 2005-05-12 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
RU2009119394A (ru) 2006-12-07 2011-01-20 Ф. Хоффманн-Ля Рош Аг (Ch) Производные спиро-пиперидина в качестве антагонистов рецептора v1a
US8642660B2 (en) * 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
CA2714888C (en) 2008-01-09 2017-03-14 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
EP2722333A1 (en) * 2008-04-29 2014-04-23 Novartis AG Spiro-indole derivatives for the treatment of parasitic diseases.

Also Published As

Publication number Publication date
AU2009242279B2 (en) 2012-08-30
ES2447590T3 (es) 2014-03-12
CA2719365A1 (en) 2009-11-05
BRPI0911577A2 (pt) 2016-01-05
US20110275613A1 (en) 2011-11-10
IL208357A (en) 2014-11-30
DK2285808T3 (da) 2014-02-03
AU2009242279A1 (en) 2009-11-05
PT2285808E (pt) 2014-02-24
NZ588217A (en) 2012-10-26
MA32316B1 (fr) 2011-05-02
CN102015711A (zh) 2011-04-13
TWI442921B (zh) 2014-07-01
CO6300940A2 (es) 2011-07-21
BRPI0911577B1 (pt) 2021-02-23
ECSP17068127A (es) 2017-10-31
JP5438098B2 (ja) 2014-03-12
JO2904B1 (en) 2015-09-15
EA019601B1 (ru) 2014-04-30
HRP20140151T1 (hr) 2014-03-28
HK1149935A1 (en) 2011-10-21
WO2009132921A1 (en) 2009-11-05
CL2009001007A1 (es) 2010-06-11
IL208357A0 (en) 2010-12-30
MY152021A (en) 2014-08-15
ECSP10010646A (es) 2010-12-30
BRPI0911577A8 (pt) 2018-03-06
US20090275560A1 (en) 2009-11-05
US8399453B2 (en) 2013-03-19
EP2285808A1 (en) 2011-02-23
CN102015711B (zh) 2013-05-01
MX2010011868A (es) 2010-11-26
CA2719365C (en) 2017-03-07
ZA201006752B (en) 2011-05-25
EP2285808B1 (en) 2013-11-20
AR071222A1 (es) 2010-06-02
PL2285808T3 (pl) 2014-04-30
BRPI0911577B8 (pt) 2021-05-25
TW200948357A (en) 2009-12-01
PE20091787A1 (es) 2009-12-14
EA201001689A1 (ru) 2011-08-30
JP2011518852A (ja) 2011-06-30
CY1114874T1 (el) 2016-12-14
MY156601A (en) 2016-03-15
US8053442B2 (en) 2011-11-08
EP2722333A1 (en) 2014-04-23
KR101390081B1 (ko) 2014-04-29
KR20100135320A (ko) 2010-12-24
JP2014065729A (ja) 2014-04-17

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