SI2121920T1 - Postopek za kloniranje sorodnih protiteles - Google Patents
Postopek za kloniranje sorodnih protitelesInfo
- Publication number
- SI2121920T1 SI2121920T1 SI200830415T SI200830415T SI2121920T1 SI 2121920 T1 SI2121920 T1 SI 2121920T1 SI 200830415 T SI200830415 T SI 200830415T SI 200830415 T SI200830415 T SI 200830415T SI 2121920 T1 SI2121920 T1 SI 2121920T1
- Authority
- SI
- Slovenia
- Prior art keywords
- linking
- procedure
- generation
- methods
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200700316 | 2007-03-01 | ||
US90477207P | 2007-03-05 | 2007-03-05 | |
PCT/DK2008/050048 WO2008104184A2 (en) | 2007-03-01 | 2008-02-27 | Method for cloning cognate antibodies |
EP08706942A EP2121920B1 (en) | 2007-03-01 | 2008-02-27 | Method for cloning cognate antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2121920T1 true SI2121920T1 (sl) | 2011-12-30 |
Family
ID=38561767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200830415T SI2121920T1 (sl) | 2007-03-01 | 2008-02-27 | Postopek za kloniranje sorodnih protiteles |
Country Status (24)
Country | Link |
---|---|
US (2) | US8283294B2 (sl) |
EP (1) | EP2121920B1 (sl) |
JP (1) | JP5669397B2 (sl) |
KR (1) | KR20090118993A (sl) |
CN (1) | CN101622346A (sl) |
AT (1) | ATE521704T1 (sl) |
AU (1) | AU2008221119B2 (sl) |
BR (1) | BRPI0808171A2 (sl) |
CA (1) | CA2677771A1 (sl) |
CY (1) | CY1112664T1 (sl) |
DK (1) | DK2121920T3 (sl) |
ES (1) | ES2369946T3 (sl) |
HK (1) | HK1133905A1 (sl) |
HR (1) | HRP20110686T1 (sl) |
IL (1) | IL199773A0 (sl) |
MX (1) | MX2009008908A (sl) |
NZ (1) | NZ578851A (sl) |
PL (1) | PL2121920T3 (sl) |
PT (1) | PT2121920E (sl) |
RU (1) | RU2459868C2 (sl) |
SI (1) | SI2121920T1 (sl) |
TW (1) | TW200911986A (sl) |
WO (1) | WO2008104184A2 (sl) |
ZA (1) | ZA200905831B (sl) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009008909A (es) * | 2007-03-01 | 2009-08-28 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
DE102007037215A1 (de) * | 2007-08-07 | 2009-02-12 | Robert Bosch Gmbh | Stellorgan |
WO2010000864A1 (en) * | 2008-07-04 | 2010-01-07 | Novo Nordisk A/S | Method for producing monoclonal antibodies |
RU2011111725A (ru) * | 2008-08-29 | 2012-10-10 | Симфоген А/С (Dk) | Способ клонирования антител птиц |
WO2010022736A2 (en) | 2008-08-29 | 2010-03-04 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US8691510B2 (en) * | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
ES2453066T3 (es) | 2008-11-07 | 2014-04-03 | Sequenta, Inc. | Métodos para supervisar las condiciones por análisis de secuencia |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
PT2387627E (pt) | 2009-01-15 | 2016-06-03 | Adaptive Biotechnologies Corp | Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais |
US9079942B2 (en) * | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
WO2010094475A1 (en) | 2009-02-20 | 2010-08-26 | F. Hoffmann-La Roche Ag | Method for obtaining immunoglobulin encoding nucleic acid |
US20100317539A1 (en) * | 2009-06-12 | 2010-12-16 | Guo-Liang Yu | Library of Engineered-Antibody Producing Cells |
AU2010263172B2 (en) | 2009-06-25 | 2016-03-31 | Fred Hutchinson Cancer Research Center | Method of measuring adaptive immunity |
US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
DE102010037622B4 (de) | 2010-09-17 | 2012-07-12 | Lophius Biosciences Gmbh | Verfahren zum Nachweis, Differenzieren und Quantifizieren von T-Zellpopulationen mittels der Reverse Transkription quantitativen Real-Time PCR (RT-qPCR) Technologie |
EP3561073A1 (en) | 2010-10-08 | 2019-10-30 | President and Fellows of Harvard College | High-throughput immune sequencing |
US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
JP5920835B2 (ja) * | 2010-12-01 | 2016-05-18 | 田辺三菱製薬株式会社 | 無細胞翻訳系でFabを提示しうるポリヌクレオチド構築物ならびにそれを用いたFabの製造方法およびスクリーニング方法 |
US20130316358A1 (en) * | 2011-01-31 | 2013-11-28 | Yeda Research And Development Co. Ltd. | Methods of diagnosing disease using overlap extension pcr |
BR112013027540A2 (pt) | 2011-04-28 | 2016-09-20 | Us Dept Veterans Affairs | banco de composição de polinucleotídeo, método para produzir um ou mais polinucletídeos de interesse e método para analisar e utilizar dados de sequenciamento |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
RU2014113678A (ru) * | 2011-09-21 | 2015-10-27 | Ф. Хоффманн-Ля Рош Аг | Способ получения fab фрагментов из единичных клеток, продуцирующих антитела, путем мультиплексной пцр в комбинации с taqman зондами |
US9279159B2 (en) | 2011-10-21 | 2016-03-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
EP3904536A1 (en) | 2011-12-09 | 2021-11-03 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
EP2626433B1 (en) | 2012-02-09 | 2017-04-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for linking nucleic acids in a microsome from endoplasmatic reticuli |
ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
KR101933990B1 (ko) | 2012-05-02 | 2018-12-31 | 심포젠 에이/에스 | 인간화 panher 항체 조성물 |
MX354329B (es) | 2012-05-08 | 2018-02-27 | Adaptive Biotechnologies Corp | Composiciones y metodos para medir y calibrar el error de amplificacion en reacciones de pcr multiple. |
DK2861760T3 (da) * | 2012-06-15 | 2020-03-09 | Univ Texas | Sekventering med høj kapacitet af flere udskrifter af en enkelt celle |
CA2886647A1 (en) | 2012-10-01 | 2014-04-10 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
CN103074349B (zh) * | 2012-11-07 | 2014-10-15 | 杭州鸿运华宁生物医药工程有限公司 | 巢式一步法rt-pcr从单个b细胞扩增鼠源抗体重链和轻链可变区基因全序列的方法 |
CA2903025A1 (en) * | 2013-03-11 | 2014-10-09 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
US20160033504A1 (en) * | 2013-03-15 | 2016-02-04 | Alder Biopharmaceuticals, Inc. | Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens |
EP3381939A1 (en) | 2013-05-31 | 2018-10-03 | Genentech, Inc. | Anti-wall teichoic antibodies and conjugates |
JP6506262B2 (ja) | 2013-05-31 | 2019-04-24 | ジェネンテック, インコーポレイテッド | 抗細胞壁タイコ酸抗体及びコンジュゲート |
US9803002B2 (en) | 2013-05-31 | 2017-10-31 | Genentench, Inc. | Anti-wall teichoic antibodies and conjugates |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
EP3715455A1 (en) | 2014-10-29 | 2020-09-30 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
EP3498866A1 (en) | 2014-11-25 | 2019-06-19 | Adaptive Biotechnologies Corp. | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
WO2016090038A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Anti-staphylococcus aureus antibody rifamycin conjugates and uses thereof |
EP3262196B1 (en) | 2015-02-24 | 2020-12-09 | Adaptive Biotechnologies Corp. | Method for determining hla status using immune repertoire sequencing |
US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
EP3995587B1 (en) * | 2015-06-09 | 2024-08-14 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
US9422547B1 (en) | 2015-06-09 | 2016-08-23 | Gigagen, Inc. | Recombinant fusion proteins and libraries from immune cell repertoires |
EP4105235A1 (en) | 2015-10-02 | 2022-12-21 | Symphogen A/S | Anti-pd-1 antibodies and compositions |
EP3423457B1 (en) | 2016-03-04 | 2021-02-17 | H. Hoffnabb-La Roche Ag | Process for the preparation of an antibody-rifamycin conjugate |
US20200123237A1 (en) | 2016-05-18 | 2020-04-23 | Genmab B.V. | Antibodies and methods of use thereof in treatment of infectious disease |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
EP3541841B1 (en) | 2016-11-18 | 2024-09-11 | Les Laboratoires Servier | Anti-pd-1 antibodies and compositions |
MX2019007356A (es) * | 2016-12-23 | 2019-09-05 | Visterra Inc | Polipeptidos de union y metodos para fabricarlos. |
US11866785B2 (en) | 2017-10-27 | 2024-01-09 | Board Of Regents, The University Of Texas System | Tumor specific antibodies and T-cell receptors and methods of identifying the same |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
CN113226470A (zh) | 2018-12-21 | 2021-08-06 | 瑞泽恩制药公司 | 利福霉素类似物及其抗体-药物缀合物 |
CN109972209B (zh) * | 2019-01-18 | 2022-05-03 | 南开大学 | 基于乳液pcr的一步法将单链抗体库重排为全长抗体库的方法 |
WO2020191365A1 (en) | 2019-03-21 | 2020-09-24 | Gigamune, Inc. | Engineered cells expressing anti-viral t cell receptors and methods of use thereof |
CN115109794A (zh) * | 2022-06-30 | 2022-09-27 | 武汉生之源生物科技股份有限公司 | 一种噬菌粒载体及其制备方法和应用 |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
US5576195A (en) * | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
US5906936A (en) * | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
AU1457992A (en) | 1991-03-01 | 1992-10-06 | Stratagene | Pcr generated dicistronic dna molecules for producing antibodies |
US6284471B1 (en) * | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
DE69228247T2 (de) | 1991-08-10 | 1999-07-08 | Medical Research Council, London | Behandlung von Zellpopulationen |
JPH07505293A (ja) | 1992-03-31 | 1995-06-15 | アボツト・ラボラトリーズ | 多重リガーゼ連鎖反応方法 |
GB9220808D0 (en) | 1992-10-02 | 1992-11-18 | Medical Res Council | Antibody genes |
US6096878A (en) * | 1993-05-10 | 2000-08-01 | Japan Tobacco Inc. | Human immunoglobulin VH gene segments and DNA fragments containing the same |
DK0744958T3 (da) | 1994-01-31 | 2003-10-20 | Univ Boston | Polyklonale antistofbiblioteker |
FR2724393A1 (fr) * | 1994-09-12 | 1996-03-15 | Inst Nat Sante Rech Med | Obtention d'un anticorps monoclonal recombinant humanise a partir d'un anticorps monoclonal murin, sa production en cellules d'insecte, et ses utilisations |
US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
US6258529B1 (en) * | 1994-12-01 | 2001-07-10 | Oravax, Inc. | PCR amplification of rearranged genomic variable regions of immunoglobulin genes |
US5882856A (en) * | 1995-06-07 | 1999-03-16 | Genzyme Corporation | Universal primer sequence for multiplex DNA amplification |
EP0985033A4 (en) * | 1997-04-04 | 2005-07-13 | Biosite Inc | POLYVALENT AND POLYCLONAL LIBRARIES |
US6610293B1 (en) * | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
WO1999016904A1 (en) | 1997-09-29 | 1999-04-08 | City Of Hope | Efficient linking of nucleic acid segments |
WO1999029888A1 (en) * | 1997-12-05 | 1999-06-17 | The Scripps Research Institute | Humanization of murine antibody |
US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
CA2382165A1 (en) * | 1999-12-08 | 2001-06-14 | Genset S.A. | Full-length human cdnas encoding potentially secreted proteins |
EP1283720B1 (en) | 2000-05-26 | 2007-04-18 | Symphogen A/S | Recombinant or purified polyclonal antibodies for treating allergy |
IL136459A0 (en) | 2000-05-30 | 2001-06-14 | Galim Galil Immunology Ltd | Antibody library |
US6849259B2 (en) * | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
US6994963B1 (en) * | 2000-07-10 | 2006-02-07 | Ambion, Inc. | Methods for recombinatorial nucleic acid synthesis |
US6867021B2 (en) * | 2001-02-20 | 2005-03-15 | Board Of Trustees Of Michigan State University | Multiplex RT-PCR/PCR for simultaneous detection of bovine coronavirus, bovine rotavirus, Cryptosporidium parvum, and Escherichia coli |
DK1517921T3 (da) * | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
US20040067532A1 (en) * | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
DK1583830T3 (da) | 2003-01-07 | 2007-01-15 | Symphogen As | Fremgangsmåde til fremstilling af rekombinante polyklonale proteiner |
US20050090453A1 (en) * | 2003-01-15 | 2005-04-28 | Solbec Pharmaceuticals Co., Ltd. | Methods of modulating IL-6 |
US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
RU2392324C2 (ru) * | 2003-09-18 | 2010-06-20 | Симфоген А/С | Способ связывания интересующих последовательностей |
TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
ATE474915T1 (de) * | 2003-11-19 | 2010-08-15 | Us Gov Health & Human Serv | Verfahren zur induktion der entwicklung und terminalen differenzierung von gedächtnis-b- zellen |
WO2006007850A1 (en) | 2004-07-20 | 2006-01-26 | Symphogen A/S | Anti-rhesus d recombinant polyclonal antibody and methods of manufacture |
WO2006007853A2 (en) | 2004-07-20 | 2006-01-26 | Symphogen A/S | A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
US20060094645A1 (en) * | 2004-10-06 | 2006-05-04 | Oliver Lawless | Method for defining and treating chemically-induced immune disorders using tumor necrosis factor (TFNalpha), interleukin-1 (lL-1), and interleulin-6R(lL-6R) antagonists |
EP1910513B1 (en) * | 2005-07-01 | 2016-08-10 | John Schrader | Methods of isolating antibody secreting cells from blood samples of immunized animals and generating monoclonal antibodies from said antibody secreting cells. |
US7850965B2 (en) * | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
CN101395182A (zh) | 2006-03-06 | 2009-03-25 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组多克隆抗体 |
MX2009008909A (es) * | 2007-03-01 | 2009-08-28 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
BRPI0808673A2 (pt) * | 2007-03-06 | 2014-08-12 | Symphogen As | Anticorpos recombinantes para tratamento de infecções com vírus sinciciais respiratórios. |
NZ581316A (en) * | 2007-05-25 | 2012-02-24 | Symphogen As | Method for manufacturing a recombinant polyclonal protein |
CN101821289A (zh) * | 2007-09-07 | 2010-09-01 | 西福根有限公司 | 重组制造抗rsv抗体的方法 |
RU2011111725A (ru) * | 2008-08-29 | 2012-10-10 | Симфоген А/С (Dk) | Способ клонирования антител птиц |
-
2008
- 2008-02-27 SI SI200830415T patent/SI2121920T1/sl unknown
- 2008-02-27 RU RU2009136342/10A patent/RU2459868C2/ru not_active IP Right Cessation
- 2008-02-27 CA CA002677771A patent/CA2677771A1/en not_active Abandoned
- 2008-02-27 CN CN200880006843A patent/CN101622346A/zh active Pending
- 2008-02-27 MX MX2009008908A patent/MX2009008908A/es active IP Right Grant
- 2008-02-27 KR KR1020097020517A patent/KR20090118993A/ko not_active Application Discontinuation
- 2008-02-27 PL PL08706942T patent/PL2121920T3/pl unknown
- 2008-02-27 NZ NZ578851A patent/NZ578851A/en not_active IP Right Cessation
- 2008-02-27 AT AT08706942T patent/ATE521704T1/de active
- 2008-02-27 AU AU2008221119A patent/AU2008221119B2/en active Active
- 2008-02-27 WO PCT/DK2008/050048 patent/WO2008104184A2/en active Application Filing
- 2008-02-27 PT PT08706942T patent/PT2121920E/pt unknown
- 2008-02-27 JP JP2009551103A patent/JP5669397B2/ja active Active
- 2008-02-27 EP EP08706942A patent/EP2121920B1/en active Active
- 2008-02-27 ES ES08706942T patent/ES2369946T3/es active Active
- 2008-02-27 BR BRPI0808171-9A2A patent/BRPI0808171A2/pt not_active IP Right Cessation
- 2008-02-27 DK DK08706942.3T patent/DK2121920T3/da active
- 2008-02-29 US US12/074,066 patent/US8283294B2/en active Active
- 2008-02-29 TW TW097107003A patent/TW200911986A/zh unknown
-
2009
- 2009-07-09 IL IL199773A patent/IL199773A0/en unknown
- 2009-08-21 ZA ZA2009/05831A patent/ZA200905831B/en unknown
-
2010
- 2010-02-19 HK HK10101773.9A patent/HK1133905A1/xx not_active IP Right Cessation
-
2011
- 2011-09-23 HR HR20110686T patent/HRP20110686T1/hr unknown
- 2011-11-16 CY CY20111101105T patent/CY1112664T1/el unknown
-
2012
- 2012-09-14 US US13/617,778 patent/US20130023447A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW200911986A (en) | 2009-03-16 |
HK1133905A1 (en) | 2010-04-09 |
CN101622346A (zh) | 2010-01-06 |
CA2677771A1 (en) | 2008-09-04 |
WO2008104184A3 (en) | 2008-10-16 |
KR20090118993A (ko) | 2009-11-18 |
ATE521704T1 (de) | 2011-09-15 |
ES2369946T3 (es) | 2011-12-09 |
JP2010535150A (ja) | 2010-11-18 |
AU2008221119B2 (en) | 2013-11-14 |
CY1112664T1 (el) | 2016-02-10 |
DK2121920T3 (da) | 2011-11-21 |
US20080227660A1 (en) | 2008-09-18 |
PL2121920T3 (pl) | 2012-01-31 |
US20130023447A1 (en) | 2013-01-24 |
PT2121920E (pt) | 2011-10-03 |
IL199773A0 (en) | 2010-04-15 |
WO2008104184A2 (en) | 2008-09-04 |
US8283294B2 (en) | 2012-10-09 |
RU2009136342A (ru) | 2011-04-10 |
MX2009008908A (es) | 2009-08-28 |
ZA200905831B (en) | 2011-02-23 |
BRPI0808171A2 (pt) | 2014-08-05 |
AU2008221119A1 (en) | 2008-09-04 |
HRP20110686T1 (hr) | 2011-10-31 |
RU2459868C2 (ru) | 2012-08-27 |
EP2121920A2 (en) | 2009-11-25 |
JP5669397B2 (ja) | 2015-02-12 |
NZ578851A (en) | 2011-09-30 |
EP2121920B1 (en) | 2011-08-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL199773A0 (en) | Method for cloning cognate antibodies | |
BRPI0917352A2 (pt) | Métodos para produção de uma biblioteca de pares cognatos que compreende sequências ligadas que codificam regiões variáveis e para gerar um vetor que codifica um anticorpo quimérico com regiões de seres humanos constantes e regiões variáveis não humanas, biblioteca de vetores, e método para produção de uma biblioteca de sequências de imunoglobulina derivadas de aves | |
WO2008069906A3 (en) | Digital expression of gene analysis | |
WO2010070145A3 (en) | Genetic immunization for producing immunoglobulins against cell-associated antigens such as p2x7, cxcr7 or cxcr4 | |
WO2007123744A3 (en) | Systems and devices for sequence by synthesis analysis | |
MX338063B (es) | Molecula de union especifica al rsv. | |
WO2007136736A3 (en) | Methods for nucleic acid sorting and synthesis | |
WO2007058527A3 (en) | Inducible expression systems | |
IN2012DN00403A (sl) | ||
WO2008052101A3 (en) | Multiplex automated genome engineering | |
WO2006081222A3 (en) | Isothermal dna amplification | |
WO2008078180A3 (en) | Materials and methods for the generation of transcripts comprising modified nucleotides | |
WO2009145820A3 (en) | Generation of modified polymerases for improved accuracy in single molecule sequencing | |
CL2011000442A1 (es) | Secuencia de acido nucleico de locus de floracion de remolacha azucarera; polipeptido codificados por dichas secuencias, vector de expresion que comprende dichos polinucleotidos, y procedimiento para prodiucir semillas hibridas con resistencia al espigado. | |
MY148907A (en) | Method for linking sequences of interest | |
MX2010002463A (es) | Plantas con rasgos relacionados con un rendimiento aumentado y un metodo para producirlas. | |
WO2008042067A3 (en) | Compositions and methods for nucleotide sequencing | |
NZ591543A (en) | Improved antibody libraries | |
WO2008061129A3 (en) | Methods and compositions related to continuous flow thermal gradient pcr | |
WO2008058282A3 (en) | Methods and compositions for large-scale analysis of nucleic acids using dna deletions | |
MX2010002753A (es) | Plantas que tienen rasgos aumentados relacionados con el rendimiento y un metodo para obtenerlas. | |
WO2007005645A3 (en) | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts | |
MX2009007246A (es) | Plantas con rasgos relacionados con el rendimiento mejorado y un metodo para producirlas. | |
MX346024B (es) | Optimización de solubilidad de inmuno-aglutinantes. | |
WO2012017329A8 (en) | Method for targeted genomic events in algae |