SI1916001T1 - Äśloveĺ ka protitelesa specifiäśna za kdr in njihova uporaba - Google Patents
Äśloveĺ ka protitelesa specifiäśna za kdr in njihova uporabaInfo
- Publication number
- SI1916001T1 SI1916001T1 SI200332035T SI200332035T SI1916001T1 SI 1916001 T1 SI1916001 T1 SI 1916001T1 SI 200332035 T SI200332035 T SI 200332035T SI 200332035 T SI200332035 T SI 200332035T SI 1916001 T1 SI1916001 T1 SI 1916001T1
- Authority
- SI
- Slovenia
- Prior art keywords
- antibodies
- kdr
- human antibodies
- antibodies specific
- single chain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36178302P | 2002-03-04 | 2002-03-04 | |
EP07023361A EP1916001B1 (en) | 2002-03-04 | 2003-03-04 | Human antibodies specific to KDR and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1916001T1 true SI1916001T1 (sl) | 2011-10-28 |
Family
ID=27805075
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332035T SI1916001T1 (sl) | 2002-03-04 | 2003-03-04 | Äśloveĺ ka protitelesa specifiäśna za kdr in njihova uporaba |
SI200331888T SI1487856T1 (sl) | 2002-03-04 | 2003-03-04 | Äśloveĺ ka protitelesa specifiäśna za kdr (receptor z domeno kinaznega vkljuäśka) in njihove uporabe |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200331888T SI1487856T1 (sl) | 2002-03-04 | 2003-03-04 | Äśloveĺ ka protitelesa specifiäśna za kdr (receptor z domeno kinaznega vkljuäśka) in njihove uporabe |
Country Status (18)
Country | Link |
---|---|
US (2) | US7498414B2 (sl) |
EP (3) | EP1916001B1 (sl) |
JP (3) | JP2005526506A (sl) |
AT (2) | ATE510561T1 (sl) |
AU (1) | AU2003213687A1 (sl) |
BE (1) | BE2015C027I2 (sl) |
CA (1) | CA2478169C (sl) |
CY (3) | CY1111141T1 (sl) |
DE (1) | DE60333554D1 (sl) |
DK (2) | DK1487856T3 (sl) |
ES (2) | ES2362931T3 (sl) |
FR (1) | FR15C0034I2 (sl) |
HK (1) | HK1118229A1 (sl) |
HU (1) | HUS1500025I1 (sl) |
LU (1) | LU92710I2 (sl) |
PT (2) | PT1916001E (sl) |
SI (2) | SI1916001T1 (sl) |
WO (1) | WO2003075840A2 (sl) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1916001T1 (sl) * | 2002-03-04 | 2011-10-28 | Imclone Llc | Äśloveĺ ka protitelesa specifiäśna za kdr in njihova uporaba |
WO2005016970A2 (en) | 2003-05-01 | 2005-02-24 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
CN1946417A (zh) | 2003-12-05 | 2007-04-11 | 阿德内克休斯治疗公司 | 2型血管内皮生长因子受体的抑制剂 |
PL2383295T3 (pl) * | 2003-12-10 | 2015-08-31 | Squibb & Sons Llc | IP-10 przeciwciała i ich zastosowanie |
RS51908B (en) * | 2004-02-06 | 2012-02-29 | University Of Massachusetts | CLOSTRIDIUM DIFFICILE TOXIN ANTIBODIES AND THEIR USES |
MXPA06010715A (es) | 2004-03-19 | 2007-05-23 | Imclone Systems Inc | Anticuerpo del receptor del factor de crecimiento humano anti-epidermico. |
EP2357201B1 (en) | 2004-04-13 | 2017-08-30 | F. Hoffmann-La Roche AG | Anti-P-selectin antibodies |
WO2006072620A1 (en) | 2005-01-05 | 2006-07-13 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
US20060234941A1 (en) | 2005-04-15 | 2006-10-19 | The Gov. Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Peptide epitopes of VEGFR-2/KDR that inhibit angiogenesis |
EP2100618B1 (en) | 2005-06-17 | 2014-02-12 | ImClone LLC | An anti-PDGFRalpha antibody for use in the treatment of metastatic bone cancer |
AU2006267097A1 (en) * | 2005-07-13 | 2007-01-18 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating an inflammatory response |
KR101371773B1 (ko) * | 2005-12-15 | 2014-03-07 | 아스트라제네카 아베 | 암 치료를 위한, 안지오포이에틴-2 길항자와 vegf-a,kdr 및/또는 flt1 길항자의 조합물 |
AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
WO2008066752A2 (en) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R & D Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir |
AU2008252854A1 (en) * | 2007-05-24 | 2008-11-27 | Ablynx N.V. | Amino acid sequences directed against growth factor receptors and polypeptides comprising the same for the treatment of diseases and disorders associated with growth factors and their receptors |
KR100883430B1 (ko) | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
JP5602625B2 (ja) | 2007-06-26 | 2014-10-08 | エフ−スター ビオテヒノロギッシェ フォルシュングス− ウント エントヴィッケルングスゲゼルシャフト ミット ベシュレンクテル ハフツング | 結合物質のディスプレイ |
AU2008270274B2 (en) * | 2007-07-03 | 2012-06-28 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating CDR and/or FR positions |
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UY31478A1 (es) | 2007-11-21 | 2009-07-17 | Inhibicion del receptor para la proteina estimulante del macrofago (ron) y métodos para el tratamiento de lo mismo | |
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- 2003-03-04 DE DE60333554T patent/DE60333554D1/de not_active Expired - Lifetime
- 2003-03-04 PT PT07023361T patent/PT1916001E/pt unknown
- 2003-03-04 AT AT07023361T patent/ATE510561T1/de active
- 2003-03-04 WO PCT/US2003/006459 patent/WO2003075840A2/en active Application Filing
- 2003-03-04 EP EP07023361A patent/EP1916001B1/en not_active Expired - Lifetime
- 2003-03-04 AT AT03711375T patent/ATE475431T1/de active
- 2003-03-04 AU AU2003213687A patent/AU2003213687A1/en not_active Abandoned
- 2003-03-04 JP JP2003574116A patent/JP2005526506A/ja active Pending
- 2003-03-04 EP EP10183791A patent/EP2298346A3/en not_active Withdrawn
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- 2003-03-04 US US10/506,997 patent/US7498414B2/en active Active
- 2003-03-04 DK DK07023361.4T patent/DK1916001T3/da active
- 2003-03-04 EP EP03711375A patent/EP1487856B1/en not_active Expired - Lifetime
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