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SI1852415T1 - Postopek za pripravo N-monosubstituiranih beta-amino alkoholov - Google Patents

Postopek za pripravo N-monosubstituiranih beta-amino alkoholov

Info

Publication number
SI1852415T1
SI1852415T1 SI200331714T SI200331714T SI1852415T1 SI 1852415 T1 SI1852415 T1 SI 1852415T1 SI 200331714 T SI200331714 T SI 200331714T SI 200331714 T SI200331714 T SI 200331714T SI 1852415 T1 SI1852415 T1 SI 1852415T1
Authority
SI
Slovenia
Prior art keywords
preparation
amino alcohols
monosubstituted beta
monosubstituted
beta
Prior art date
Application number
SI200331714T
Other languages
English (en)
Inventor
Dominique Dr Michel
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30011063&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1852415(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza Ag filed Critical Lonza Ag
Priority claimed from EP07015051A external-priority patent/EP1852415B1/en
Publication of SI1852415T1 publication Critical patent/SI1852415T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/42Singly bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/46Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200331714T 2002-07-09 2003-07-09 Postopek za pripravo N-monosubstituiranih beta-amino alkoholov SI1852415T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02015229 2002-07-09
EP07015051A EP1852415B1 (en) 2002-07-09 2003-07-09 Process for the preparation of N-monosubstituted beta-amino alcohols

Publications (1)

Publication Number Publication Date
SI1852415T1 true SI1852415T1 (sl) 2010-01-29

Family

ID=30011063

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200331714T SI1852415T1 (sl) 2002-07-09 2003-07-09 Postopek za pripravo N-monosubstituiranih beta-amino alkoholov

Country Status (20)

Country Link
US (7) US20080119661A1 (sl)
JP (1) JP4546242B2 (sl)
KR (2) KR101027358B1 (sl)
CN (4) CN100497295C (sl)
AT (2) ATE444949T1 (sl)
AU (1) AU2010201850B2 (sl)
BR (1) BR0312651B1 (sl)
CA (1) CA2491472C (sl)
CY (1) CY1109691T1 (sl)
DE (2) DE60316698T2 (sl)
DK (1) DK1539673T3 (sl)
EA (1) EA009394B1 (sl)
ES (2) ES2293029T3 (sl)
HK (2) HK1079765A1 (sl)
IL (1) IL166107A (sl)
NO (2) NO329267B1 (sl)
NZ (1) NZ537567A (sl)
PT (2) PT1852415E (sl)
SI (1) SI1852415T1 (sl)
WO (1) WO2004005239A1 (sl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166719B2 (en) 2002-06-27 2007-01-23 Health Research, Inc. Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
DE10240026A1 (de) * 2002-08-27 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von Monoalkylaminoketonen
DE10302595A1 (de) * 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
SI1720852T1 (sl) 2004-02-19 2012-11-30 Lonza Ag Postopek za pripravo enantiomerno čistih substituiranih aminoalkoholov
EP1566383A1 (en) * 2004-02-19 2005-08-24 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
DE102004021434A1 (de) 2004-04-30 2005-11-24 Basf Ag Schnelle schaumarme Netzer für hydrophobe Oberflächen
CN101124196B (zh) 2005-02-21 2011-05-11 隆萨股份公司 对映体纯的1-取代的-3-氨基醇的制备方法
CZ299270B6 (cs) 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
CN101484435A (zh) 2006-07-03 2009-07-15 兰贝克赛实验室有限公司 制备n-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺及其纯对应异构体盐的方法
CN101657438A (zh) 2006-12-22 2010-02-24 斯索恩有限公司 制备度洛西汀和相关化合物的方法
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
CZ304602B6 (cs) 2009-09-02 2014-07-30 Zentiva, K. S. Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
CN108707096B (zh) * 2018-05-07 2021-03-19 上海科技大学 一种制备氨基醇衍生物的方法
CN108947798B (zh) * 2018-05-30 2021-03-02 上海科技大学 一种降解聚合物的方法
CN109134427B (zh) * 2018-10-24 2020-06-30 浙江乐普药业股份有限公司 一种3-甲氨基-1-(2-噻吩基)-1-丙酮盐酸盐的合成方法
CN115677512A (zh) * 2022-10-27 2023-02-03 大连万福制药有限公司 一种合成乐卡地平中间体n-甲基-3,3-二苯基丙胺盐酸盐的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3031248A1 (de) * 1980-08-19 1982-04-01 Ruhrchemie Ag, 4200 Oberhausen Verfahren zur herstellung von 3-dimethylamino-2,2-dimethylpropanal
US5362866A (en) * 1983-09-02 1994-11-08 Molecular Biosystems, Inc. Oligonucleotide polymeric support system with an oxidation cleavable link
FI912280A (fi) * 1990-05-17 1991-11-18 Lilly Co Eli Kiral syntes av 1-aryl-3-aminopropan-1 -oler.
US5362886A (en) 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
DE10240026A1 (de) 2002-08-27 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von Monoalkylaminoketonen
EP1510517A1 (en) * 2003-09-01 2005-03-02 Lonza AG Process for the asymmetric hydrogenation of beta-amino ketones

Also Published As

Publication number Publication date
CY1109691T1 (el) 2014-08-13
IL166107A0 (en) 2006-01-15
ES2334397T3 (es) 2010-03-09
NO20050079L (no) 2005-03-11
WO2004005239A1 (en) 2004-01-15
US20100240911A1 (en) 2010-09-23
CN100497295C (zh) 2009-06-10
KR101021460B1 (ko) 2011-03-16
NO329267B1 (no) 2010-09-20
KR101027358B1 (ko) 2011-04-11
HK1145317A1 (en) 2011-04-15
ATE444949T1 (de) 2009-10-15
BR0312651A (pt) 2005-04-26
US20110004007A1 (en) 2011-01-06
CN101851168B (zh) 2013-07-03
PT1852415E (pt) 2009-12-18
DE60329640D1 (de) 2009-11-19
KR20100135331A (ko) 2010-12-24
US20130310574A1 (en) 2013-11-21
KR20050017092A (ko) 2005-02-21
HK1079765A1 (en) 2006-04-13
EA009394B1 (ru) 2007-12-28
BR0312651B1 (pt) 2017-10-31
CA2491472A1 (en) 2004-01-15
CN1891683A (zh) 2007-01-10
JP2005532383A (ja) 2005-10-27
AU2010201850B2 (en) 2011-08-25
DE60316698D1 (de) 2007-11-15
US20170369467A1 (en) 2017-12-28
DE60316698T2 (de) 2008-07-17
NO20100728L (no) 2005-03-11
US20080119661A1 (en) 2008-05-22
AU2003250924A1 (en) 2004-01-23
US20150361064A1 (en) 2015-12-17
CA2491472C (en) 2011-09-27
DK1539673T3 (da) 2008-01-21
CN101851168A (zh) 2010-10-06
PT1539673E (pt) 2007-11-14
US8962865B2 (en) 2015-02-24
EA200500137A1 (ru) 2005-08-25
NZ537567A (en) 2006-11-30
CN1665773A (zh) 2005-09-07
CN103058986A (zh) 2013-04-24
US20150112086A1 (en) 2015-04-23
JP4546242B2 (ja) 2010-09-15
IL166107A (en) 2012-06-28
ES2293029T3 (es) 2008-03-16
US8558014B2 (en) 2013-10-15
AU2010201850A1 (en) 2010-05-27
ATE374744T1 (de) 2007-10-15

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