SI1028961T1 - Pleuromutilin derivatives as antimicrobials - Google Patents

Pleuromutilin derivatives as antimicrobials

Info

Publication number: SI1028961T1
Authority: SI; Slovenia
Prior art keywords: antimicrobials; pleuromutilin derivatives; pleuromutilin; derivatives
Prior art date: 1997-10-29

Application number

SI9830709T

Other languages

English (en)

Slovenian (sl)

Inventor

Valerie SmithKline Beecham Pharmaceuticals BERRY

Stephen SmithKline Beecham Pharmaceuticals DABBS

Colin Henry SmithKline Beecham FRYDRYCH

Eric SmithKline Beecham Pharmaceuticals HUNT

Gary SmithKline Beecham Pharmaceuticals WOODNUTT

Francis Dominic SmithKline Beecham SANDERSON

Original Assignee

Smithkline Beecham Plc

Smithkline Beecham Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-29

Filing date

1998-10-27

Publication date

2005-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26312507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1028961(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-10-29 Priority claimed from GBGB9722817.5A external-priority patent/GB9722817D0/en

1998-06-25 Priority claimed from GBGB9813689.8A external-priority patent/GB9813689D0/en

1998-10-27 Application filed by Smithkline Beecham Plc, Smithkline Beecham Corporation filed Critical Smithkline Beecham Plc

2005-02-28 Publication of SI1028961T1 publication Critical patent/SI1028961T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C271/36—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Medicinal Preparation (AREA)

SI9830709T 1997-10-29 1998-10-27 Pleuromutilin derivatives as antimicrobials SI1028961T1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9722817.5A GB9722817D0 (en)	1997-10-29	1997-10-29	Novel compounds
GBGB9813689.8A GB9813689D0 (en)	1998-06-25	1998-06-25	Novel compounds
EP98950202A EP1028961B3 (en)	1997-10-29	1998-10-27	Pleuromutilin derivatives as antimicrobials
PCT/GB1998/003211 WO1999021855A1 (en)	1997-10-29	1998-10-27	Pleuromutilin derivatives as antimicrobials

Publications (1)

Publication Number	Publication Date
SI1028961T1 true SI1028961T1 (en)	2005-02-28

Family

ID=26312507

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI9830709T SI1028961T1 (en)	1997-10-29	1998-10-27	Pleuromutilin derivatives as antimicrobials
SI9830932T SI1930330T1 (sl)	1997-10-29	1998-10-27	Plevromutilinski derivati kot protimikrobna sredstva

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SI9830932T SI1930330T1 (sl)	1997-10-29	1998-10-27	Plevromutilinski derivati kot protimikrobna sredstva

Country Status (36)

Country	Link
US (3)	US6281226B1 (da)
EP (3)	EP1930330B1 (da)
JP (2)	JP4227729B2 (da)
KR (1)	KR100538721B1 (da)
CN (1)	CN1205211C (da)
AR (1)	AR015987A1 (da)
AT (2)	ATE277925T1 (da)
AU (1)	AU742167C (da)
BR (1)	BR9814747B1 (da)
CA (1)	CA2307551C (da)
CO (1)	CO5021129A1 (da)
CY (2)	CY2007028I2 (da)
CZ (1)	CZ298543B6 (da)
DE (2)	DE122007000076I2 (da)
DK (2)	DK1930330T3 (da)
DZ (1)	DZ2634A1 (da)
EG (1)	EG24177A (da)
ES (2)	ES2371205T3 (da)
FR (1)	FR07C0057I2 (da)
HK (1)	HK1031376A1 (da)
HU (2)	HU229792B1 (da)
IL (2)	IL135811A0 (da)
LU (1)	LU91372I2 (da)
MY (1)	MY130665A (da)
NL (1)	NL300304I2 (da)
NO (3)	NO327392B1 (da)
NZ (1)	NZ504203A (da)
PE (1)	PE123299A1 (da)
PL (2)	PL197672B1 (da)
PT (2)	PT1930330E (da)
SI (2)	SI1028961T1 (da)
TR (1)	TR200001203T2 (da)
TW (1)	TWI232861B (da)
UY (1)	UY25225A1 (da)
WO (1)	WO1999021855A1 (da)
ZA (1)	ZA989767B (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY25225A1 (es) *	1997-10-29	2000-12-29	Smithkline Beecham Plc	Derivados de pleuromutilina utiles como agentes antimicrobianos
WO2000027790A1 (en) *	1998-11-11	2000-05-18	Smithkline Beecham P.L.C.	Mutilin compounds
GB9912657D0 (en) *	1999-06-01	1999-07-28	Smithkline Beecham Plc	Novel compounds
GB9918037D0 (en) *	1999-07-30	1999-09-29	Biochemie Gmbh	Organic compounds
GB9919839D0 (en) *	1999-08-20	1999-10-27	Smithkline Beecham Plc	Novel compounds
KR100758441B1 (ko)	2000-04-04	2007-09-14	스미스클라인비이참피이엘시이	항균제용 2―히드록시―무틸린 카르바메이트 유도체
GB0017073D0 (en) *	2000-07-11	2000-08-30	Univ London	Microorganism
GB0017031D0 (en)	2000-07-11	2000-08-30	Biochemie Gmbh	Antimicrobials
PE20020676A1 (es)	2000-09-13	2002-08-27	Biochemie Gmbh	Compuestos de mutilina como antibacterianos
GB0024811D0 (en) *	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds
GB0027705D0 (en)	2000-11-11	2000-12-27	S P A	Novel compounds
FR2835186B1 (fr) *	2002-01-28	2006-10-20	Aventis Pharma Sa	Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
GB0207495D0 (en) *	2002-03-28	2002-05-08	Biochemie Gmbh	Organic compounds
EP1534678B1 (en) *	2002-07-24	2007-10-31	Nabriva Therapeutics Forschungs GmbH	Pleuromutilin derivatives as antimicrobbials
GB0218578D0 (en) *	2002-08-09	2002-09-18	Glaxo Group Ltd	Novel method
GB0308114D0 (en) *	2003-04-08	2003-05-14	Glaxo Group Ltd	Novel compounds
ATE450535T1 (de) *	2003-09-03	2009-12-15	Glaxo Group Ltd	Neues verfahren zur herstellung von pleuromutilinderivaten
JP2007537261A (ja) *	2004-05-13	2007-12-20	グラクソ　グループ　リミテッド	ムスカリン性アセチルコリン受容体アンタゴニスト
GB0504314D0 (en) *	2005-03-02	2005-04-06	Glaxo Group Ltd	Novel polymorph
US20080171766A1 (en) *	2005-03-10	2008-07-17	Smithkline Beecham Corporation	Novel Method
TW200730488A (en) *	2005-06-27	2007-08-16	Nabriva Therapeutics Forschungs Gmbh	Organic compounds
GB0513058D0 (en) *	2005-06-27	2005-08-03	Sandoz Ag	Organic compounds
WO2007037518A1 (ja) *	2005-09-29	2007-04-05	Dainippon Sumitomo Pharma Co., Ltd.	ムチリン誘導体及びそれを含有する医薬組成物
WO2007079173A2 (en) *	2005-12-30	2007-07-12	Emergent Biosolutions Inc.	Novel 2-heteroaryloxy-phenol derivatives as antibacterial agents
CA2678193A1 (en)	2007-02-09	2008-08-14	Astellas Pharma Inc.	Aza-bridged-ring compound
WO2008117796A1 (ja) *	2007-03-28	2008-10-02	Dainippon Sumitomo Pharma Co., Ltd.	新規ムチリン誘導体
JP5322927B2 (ja)	2007-05-24	2013-10-23	杏林製薬株式会社	１４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
US20090076071A1 (en) *	2007-09-13	2009-03-19	Protia, Llc	Deuterium-enriched retapamulin
US20090234125A1 (en) *	2007-11-26	2009-09-17	Eli Lancry	Amorphous retapamulin and processes for preparation thereof
US20090149655A1 (en) *	2007-12-05	2009-06-11	Lilach Hedvati	Process for the preparation of Retapamulin and its intermediates
US8278313B2 (en)	2008-03-11	2012-10-02	Abbott Laboratories	Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en)	2008-04-03	2013-05-07	Abbott Laboratories	Macrocyclic pyrimidine derivatives
US20100184987A1 (en) *	2008-11-13	2010-07-22	Teva Pharmaceutical Industries Ltd.	Preparation of Retapamulin via its Pleuromutilin-thiol precursor
JP5422821B2 (ja) *	2009-03-03	2014-02-19	独立行政法人放射線医学総合研究所	コリンエステラーゼ活性測定用試薬
CN102510862A (zh)	2009-07-14	2012-06-20	阿尔巴尼分子研究公司	5-ht3受体调节剂、其制备方法和用途
CN102344397B (zh) *	2011-08-23	2013-09-04	浙江升华拜克生物股份有限公司	一种伐奈莫林盐酸盐的提纯方法
CN103626693B (zh) *	2012-08-28	2016-09-14	中国科学院上海药物研究所	一类截短侧耳素衍生物、其药物组合物及其合成方法与用途
CN103709093B (zh) *	2012-09-28	2016-06-08	山东亨利医药科技有限责任公司	含有并环的截短侧耳素类抗生素
CN111436896A (zh)	2014-07-21	2020-07-24	恩多巧爱思股份有限公司	多焦、多相机内窥镜系统
WO2017151492A1 (en) *	2016-03-02	2017-09-08	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
EP3423065B1 (en)	2016-03-02	2021-07-21	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
US10874679B2 (en)	2016-03-02	2020-12-29	Bill & Melinda Gates Foundation	Boron-containing small molecules
CN106496085B (zh) *	2016-09-21	2018-01-26	盐城市舜宝化工有限公司	合成盐酸沃尼妙林的中间体化合物以及盐酸沃尼妙林的制备方法
TWI762573B (zh)	2017-02-10	2022-05-01	奧地利商納畢瓦治療有限責任公司	截短側耳素之純化
CN111574395B (zh) *	2020-06-18	2021-07-02	华南农业大学	一种具有酰胺侧链的截短侧耳素衍生物及制备与应用
AT523646B1 (de)	2020-07-21	2021-10-15	Gerd Dr Ascher	Pharmazeutische Verbindungen, ihre Anwendung alleine oder in Kombination, zur Prophylaxe und lokalen Initial-Therapie bei bakteriellen und viralen Infektionen, insbesondere Coronaviren
US11155514B1 (en) *	2020-12-19	2021-10-26	Shaanxi University Of Science And Technology	Pleuromulin acitretin ester with antibacterial activity and a method of preparing the same
US11332430B1 (en) *	2021-01-25	2022-05-17	Xi'an Taikomed Pharmaceutical Technology Co., Ltd.	Pleuromulin lauric acid ester with antibacterial activity and a method of preparing the same
CN112919463B (zh) *	2021-04-09	2021-10-26	南京理工大学	一种利用泰妙菌素废盐制备的活性炭及其制备方法
CN113121355B (zh) *	2021-04-13	2023-05-09	西安康诺化工有限公司	一种截短侧耳素大黄酸酯及其制备方法和应用
CN114736194A (zh) *	2022-03-29	2022-07-12	中牧实业股份有限公司	一种具有抗病原微生物活性的含吡啶季铵盐侧链的截短侧耳素衍生物及其制备方法与应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4060542A (en) *	1969-07-25	1977-11-29	Biochemie Gesellschaft M.B.H.	14-Desoxy-14 thiocyanato-acetoxy-mutilin
BE789629A (fr) *	1971-10-05	1973-04-03	Sandoz Sa	Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
CH575375A5 (da)	1972-05-25	1976-05-14	Sandoz Ag
US4032530A (en)	1971-10-05	1977-06-28	Sandoz Ltd.	Certain pleuromutilins
US3919290A (en)	1972-10-03	1975-11-11	Sandoz Ltd	Substituted 14-desoxy-mutilins
US4208326A (en)	1971-10-05	1980-06-17	Sandoz Ltd.	Pleuromutilin esters
CH593912A5 (en)	1972-07-07	1977-12-30	Sandoz Ag	Pleuromutilin derivs. - prepd. by acylating derivs. contg. a (4)-hydroxyalkyl-(1)-piperazinyl gp.
DE2404046C3 (de)	1974-01-29	1984-07-26	Henkel KGaA, 4000 Düsseldorf	Verwendung von Carboxyl- bzw. Carboxylat- und Hydroxylgruppen aufweisenden Polymeren als Hautfeuchthaltemittel
US3987194A (en)	1975-05-12	1976-10-19	E. R. Squibb & Sons, Inc.	Use of pleuromutilin derivatives for the treatment of swine dysentery
CH619450A5 (da)	1976-01-15	1980-09-30	Sandoz Ag
US4130709A (en)	1977-12-08	1978-12-19	Eli Lilly And Company	Pleuromutilin glycoside derivatives
GB2025930B (en)	1978-06-01	1983-02-09	Sandoz Ltd	Process for the production of pleuromutilin derivatives
JPS5594359A (en) *	1979-01-12	1980-07-17	Sandoz Ag	Novel pleuromutilin derivatives*their manufacture and use
EP0013768B1 (en) *	1979-01-12	1984-02-01	Sandoz Ag	New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
FR2502951B1 (fr)	1981-04-06	1985-12-06	Sandoz Sa	Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
EP0153277B1 (de) *	1984-02-17	1987-08-26	Sandoz Ag	Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3405632A1 (de) *	1984-02-17	1985-08-22	Sandoz-Patent-GmbH, 7850 Lörrach	Neue pleuromutilinderivate, verfahren zu ihrer herstellung und ihre verwendung
AT400674B (de)	1991-07-24	1996-02-26	Biochemie Gmbh	Pharmazeutische pleuromutilin-zubereitung
GB9201751D0 (en)	1992-01-28	1992-03-11	Smithkline Beecham Plc	Compounds
AT397654B (de)	1992-05-04	1994-06-27	Biochemie Gmbh	Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
PL321003A1 (en)	1994-12-23	1997-11-24	Thomae Gmbh Dr K	Derivatives of piperasine, drugs containing them, their application and methods of obtaining them
BR9612426A (pt) *	1996-01-03	1999-07-13	Smithkline Beecham Plc	Derivados carbomoilóxi e sua aplicação como antibacterianos
HUP0001741A3 (en)	1996-08-02	2000-11-28	Smithkline Beecham Plc	Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
HUP9904308A3 (en)	1996-10-01	2002-06-28	Smithkline Beecham Plc	Use of mupirocin for manufacture of a medicament for the treatment of bacterial infections associated with colonisation by pathogenic organisms at the nasopharynx
UY25225A1 (es) *	1997-10-29	2000-12-29	Smithkline Beecham Plc	Derivados de pleuromutilina utiles como agentes antimicrobianos
ATE450535T1 (de)	2003-09-03	2009-12-15	Glaxo Group Ltd	Neues verfahren zur herstellung von pleuromutilinderivaten
GB0504314D0 (en)	2005-03-02	2005-04-06	Glaxo Group Ltd	Novel polymorph

1996
- 1996-05-07 UY UY25225A patent/UY25225A1/es not_active IP Right Cessation
1998
- 1998-10-27 US US09/530,446 patent/US6281226B1/en not_active Ceased
- 1998-10-27 PL PL375435A patent/PL197672B1/pl unknown
- 1998-10-27 EP EP08152170A patent/EP1930330B1/en not_active Expired - Lifetime
- 1998-10-27 HU HU0004040A patent/HU229792B1/hu active Protection Beyond IP Right Term
- 1998-10-27 US US13/102,156 patent/USRE43390E1/en not_active Expired - Lifetime
- 1998-10-27 MY MYPI98004896A patent/MY130665A/en unknown
- 1998-10-27 PL PL340254A patent/PL191927B1/pl unknown
- 1998-10-27 SI SI9830709T patent/SI1028961T1/xx unknown
- 1998-10-27 BR BRPI9814747-1A patent/BR9814747B1/pt not_active IP Right Cessation
- 1998-10-27 US US10/631,707 patent/USRE39128E1/en not_active Ceased
- 1998-10-27 PT PT08152170T patent/PT1930330E/pt unknown
- 1998-10-27 DK DK08152170.0T patent/DK1930330T3/da active
- 1998-10-27 CN CNB988127318A patent/CN1205211C/zh not_active Expired - Lifetime
- 1998-10-27 JP JP2000517965A patent/JP4227729B2/ja not_active Expired - Lifetime
- 1998-10-27 WO PCT/GB1998/003211 patent/WO1999021855A1/en active IP Right Grant
- 1998-10-27 AU AU96361/98A patent/AU742167C/en not_active Expired
- 1998-10-27 ES ES08152170T patent/ES2371205T3/es not_active Expired - Lifetime
- 1998-10-27 SI SI9830932T patent/SI1930330T1/sl unknown
- 1998-10-27 AT AT98950202T patent/ATE277925T1/de active
- 1998-10-27 IL IL13581198A patent/IL135811A0/xx active IP Right Grant
- 1998-10-27 AR ARP980105377A patent/AR015987A1/es active IP Right Grant
- 1998-10-27 DK DK98950202T patent/DK1028961T5/da active
- 1998-10-27 TR TR2000/01203T patent/TR200001203T2/xx unknown
- 1998-10-27 EP EP04076485A patent/EP1452534A1/en not_active Withdrawn
- 1998-10-27 NZ NZ504203A patent/NZ504203A/xx not_active IP Right Cessation
- 1998-10-27 DE DE122007000076C patent/DE122007000076I2/de active Active
- 1998-10-27 CZ CZ20001551A patent/CZ298543B6/cs not_active IP Right Cessation
- 1998-10-27 DE DE69826704T patent/DE69826704T3/de not_active Expired - Lifetime
- 1998-10-27 KR KR10-2000-7004707A patent/KR100538721B1/ko not_active IP Right Cessation
- 1998-10-27 ZA ZA9809767A patent/ZA989767B/xx unknown
- 1998-10-27 EP EP98950202A patent/EP1028961B3/en not_active Expired - Lifetime
- 1998-10-27 ES ES98950202T patent/ES2229538T7/es active Active
- 1998-10-27 PT PT98950202T patent/PT1028961E/pt unknown
- 1998-10-27 CA CA002307551A patent/CA2307551C/en not_active Expired - Lifetime
- 1998-10-27 AT AT08152170T patent/ATE525373T1/de active
- 1998-10-28 DZ DZ980244A patent/DZ2634A1/xx active
- 1998-10-29 CO CO98063556A patent/CO5021129A1/es unknown
- 1998-10-29 EG EG132598A patent/EG24177A/xx active
- 1998-10-29 PE PE1998001018A patent/PE123299A1/es not_active Application Discontinuation
- 1998-11-24 TW TW087119420A patent/TWI232861B/zh not_active IP Right Cessation
2000
- 2000-04-24 IL IL135811A patent/IL135811A/en not_active IP Right Cessation
- 2000-04-27 NO NO20002173A patent/NO327392B1/no not_active IP Right Cessation
2001
- 2001-02-05 HK HK01100820A patent/HK1031376A1/xx not_active IP Right Cessation
2007
- 2007-10-24 LU LU91372C patent/LU91372I2/fr unknown
- 2007-11-06 NL NL300304C patent/NL300304I2/nl unknown
- 2007-11-09 FR FR07C0057C patent/FR07C0057I2/fr active Active
- 2007-11-12 CY CY200700028C patent/CY2007028I2/el unknown
2008
- 2008-08-25 JP JP2008215667A patent/JP2009040789A/ja active Pending
2009
- 2009-04-01 NO NO20091344A patent/NO20091344L/no not_active Application Discontinuation
- 2009-09-25 NO NO2009023C patent/NO2009023I2/no unknown
2011
- 2011-10-31 CY CY20111101037T patent/CY1112062T1/el unknown
2014
- 2014-12-18 HU HUS1400060C patent/HUS1400060I1/hu unknown

Also Published As

Publication number	Publication date
AU742167C (en)	2003-08-07
NO327392B1 (no)	2009-06-22
US6281226B1 (en)	2001-08-28
EP1930330B1 (en)	2011-09-21
DK1028961T5 (da)	2009-03-09
JP2001521033A (ja)	2001-11-06
DE69826704T2 (de)	2005-10-06
NZ504203A (en)	2002-11-26
BR9814747A (pt)	2001-11-20
ES2229538T7 (es)	2009-06-18
AU9636198A (en)	1999-05-17
PL197672B1 (pl)	2008-04-30
IL135811A0 (en)	2001-05-20
NO2009023I2 (no)	2012-12-03
DE69826704D1 (de)	2004-11-04
CY2007028I1 (el)	2009-11-04
DK1028961T3 (da)	2005-01-03
CZ298543B6 (cs)	2007-10-31
EG24177A (en)	2008-09-28
EP1028961A1 (en)	2000-08-23
TWI232861B (en)	2005-05-21
ZA989767B (en)	2000-04-28
BR9814747B1 (pt)	2010-12-14
TR200001203T2 (tr)	2000-08-21
PE123299A1 (es)	2000-02-05
HK1031376A1 (en)	2001-06-15
CN1205211C (zh)	2005-06-08
DE122007000076I2 (de)	2010-03-25
NL300304I1 (nl)	2008-01-02
CN1283197A (zh)	2001-02-07
NL300304I2 (nl)	2008-03-03
PL340254A1 (en)	2001-01-29
EP1452534A1 (en)	2004-09-01
SI1930330T1 (sl)	2011-12-30
ATE525373T1 (de)	2011-10-15
HUP0004040A3 (en)	2001-08-28
AR015987A1 (es)	2001-05-30
NO20002173L (no)	2000-06-05
CA2307551C (en)	2007-01-30
USRE39128E1 (en)	2006-06-13
DK1930330T3 (da)	2011-12-12
CZ20001551A3 (cs)	2001-01-17
FR07C0057I2 (fr)	2008-05-16
JP2009040789A (ja)	2009-02-26
LU91372I2 (fr)	2007-12-24
EP1028961B3 (en)	2008-12-03
LU91372I9 (da)	2019-01-02
EP1028961B1 (en)	2004-09-29
CY2007028I2 (el)	2009-11-04
DE69826704T3 (de)	2009-07-23
NO20091344L (no)	2000-06-05
EP1930330A1 (en)	2008-06-11
PT1028961E (pt)	2005-01-31
JP4227729B2 (ja)	2009-02-18
MY130665A (en)	2007-07-31
DE122007000076I1 (de)	2008-02-14
FR07C0057I1 (da)	2007-12-14
CO5021129A1 (es)	2001-03-27
IL135811A (en)	2006-12-31
HUS1400060I1 (hu)	2016-09-28
KR20010031654A (ko)	2001-04-16
USRE43390E1 (en)	2012-05-15
ATE277925T1 (de)	2004-10-15
AU742167B2 (en)	2001-12-20
ES2229538T3 (es)	2005-04-16
KR100538721B1 (ko)	2005-12-26
CY1112062T1 (el)	2015-11-04
PT1930330E (pt)	2011-10-31
UY25225A1 (es)	2000-12-29
ES2371205T3 (es)	2011-12-28
CA2307551A1 (en)	1999-05-06
HU229792B1 (en)	2014-07-28
DZ2634A1 (fr)	2003-03-08
HUP0004040A1 (hu)	2001-05-28
WO1999021855A1 (en)	1999-05-06
NO2009023I1 (no)	2009-10-12
NO20002173D0 (no)	2000-04-27
PL191927B1 (pl)	2006-07-31

Publication	Publication Date	Title
HUS1400060I1 (hu)	2016-09-28	Antimikrobiális hatású pleuromutilin-származékok
EG24081A (en)	2008-05-11	4-Substituted-9-deoxo-9a-aza-9a-homerythromycin derivatives
PL334847A1 (en)	2000-03-27	Substituted 3-heterocyclyl-benzoyl derivatives
GB9702194D0 (en)	1997-03-26	Sulphonide derivatives
HUP0003642A3 (en)	2001-11-28	N-alkanoylphenylalanine derivatives
ZA987602B (en)	1999-05-04	N-alkanoylphenylalanine derivatives
PL335999A1 (en)	2000-06-05	Substituted 3-cyanoquinolines
AP2000001795A0 (en)	2000-06-30	Substituted 4-aminothiazol-2-yol
HUP9801168A3 (en)	1999-11-29	Triazinylaminostilbene derivatives
HK1030371A1 (en)	2001-05-04	Antimicrobials
IL132982A0 (en)	2001-03-19	Cis-disubstituted aminocycloalkyl-pyrrolidine derivatives
IL136199A0 (en)	2001-05-20	Retraction means
GB9715821D0 (en)	1997-10-01	Amidino-camptothecin derivatives
GB2321457B (en)	2001-02-28	5-Aroylnaphthalene derivatives
GB9701628D0 (en)	1997-03-19	Imino-aza-anthracyclinone derivatives
GB9725541D0 (en)	1998-02-04	Amino-benzothiazole derivatives
PL334546A1 (en)	2000-03-13	Substituted 4-benzoylpyrazoles
ZA983116B (en)	1998-10-21	Arylsecocholadiene derivatives
HU9800889D0 (en)	1998-06-29	New naphtylpiperazine derivatives
IL131159A0 (en)	2001-01-28	4-Aminoethoxyindazole derivatives
IL133261A0 (en)	2001-04-30	Substituted naphthropyrans
ZA985761B (en)	1999-01-27	Substituted aryluracils
GB9706753D0 (en)	1997-05-21	Aralkoxy-morphinan derivatives
SI1005445T1 (en)	2004-12-31	N-alkanoylphenylalanine derivatives
PL322697A1 (en)	1999-04-26	Novel compound - furane derivatives