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SG89492G - A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride - Google Patents

A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Info

Publication number
SG89492G
SG89492G SG894/92A SG89492A SG89492G SG 89492 G SG89492 G SG 89492G SG 894/92 A SG894/92 A SG 894/92A SG 89492 A SG89492 A SG 89492A SG 89492 G SG89492 G SG 89492G
Authority
SG
Singapore
Prior art keywords
phenylmethyl
dihydrochloride
piperazinyl
chlorophenyl
ethoxy
Prior art date
Application number
SG894/92A
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of SG89492G publication Critical patent/SG89492G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG894/92A 1988-11-23 1992-09-05 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride SG89492G (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (1)

Publication Number Publication Date
SG89492G true SG89492G (en) 1992-12-04

Family

ID=10647347

Family Applications (1)

Application Number Title Priority Date Filing Date
SG894/92A SG89492G (en) 1988-11-23 1992-09-05 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Country Status (16)

Country Link
KR (1) KR970009728B1 (en)
AT (1) AT398971B (en)
CA (1) CA1317300C (en)
CY (1) CY1671A (en)
DK (1) DK174543B1 (en)
ES (1) ES2021907A6 (en)
FI (1) FI91862C (en)
GB (2) GB8827391D0 (en)
GR (1) GR1000553B (en)
HK (1) HK95892A (en)
HU (1) HU205094B (en)
NO (1) NO172342C (en)
PH (1) PH25982A (en)
PL (1) PL161379B1 (en)
PT (1) PT92364B (en)
SG (1) SG89492G (en)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
JPH08501561A (en) * 1992-09-24 1996-02-20 セプラコア，インコーポレイテッド (-) Composition for treating allergic diseases using cetirizine
WO1994006430A1 (en) * 1992-09-24 1994-03-31 Sepracor, Inc. Methods and compositions for treating allergic disorders using optically pure (+) cetirizine
AU703690B2 (en) * 1992-09-24 1999-04-01 Sepracor, Inc. Methods for treating allergic disorders using optically pure (+)cetirizine
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010095A3 (en) * 1996-04-10 1997-12-02 Ucb Sa METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS.
BE1010094A3 (en) * 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
EP1020443B1 (en) 1997-06-04 2003-09-10 Azwell Inc. Process for producing piperazinesulfonamide derivatives and salts thereof
EP0919550A1 (en) 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
GR990100135A (en) * 1999-04-22 2000-12-29 Genepharm �.�. Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt
JP2002249487A (en) 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd 4-(tert-butoxycarbonyl)piperazine derivative, optically active acid addition salt of the same, method for producing them and optically active 1-[(substituted phenyl)phenylmethylpiperazine which uses them
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
CA2514145A1 (en) 2003-01-23 2004-08-05 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
KR100503443B1 (en) 2004-02-02 2005-07-22 한림제약(주) Processes for preparing an optically active cetirizine or its salt
NZ556580A (en) * 2005-03-03 2009-08-28 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
EP2121643B1 (en) 2007-03-12 2013-10-23 Krka, tovarna zdravil, d.d., Novo mesto New process for the preparation of levocetirizine and intermediates thereof
SI22489A (en) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New procedure for preparation of levocetirizine and its intermediates
US8084606B2 (en) 2007-06-15 2011-12-27 Symed Labs Limited Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
WO2009062036A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
ATE499352T1 (en) 2007-11-21 2011-03-15 Synthon Bv METHOD FOR PRODUCING N-(DIPHENYLMETHYL)PIPERAZINES
KR20110022635A (en) 2008-06-02 2011-03-07 시플라 리미티드 Processes for the synthesis of levocetirizine and intermediates for use therein
EP2297122B1 (en) * 2008-06-11 2014-05-21 KRKA, tovarna zdravil, d.d., Novo mesto New process for the preparation of levocetirizine and intermediates thereof
KR100998067B1 (en) 2008-09-08 2010-12-03 주식회사 삼오제약 A novel Bis1-[4-chlorophenylphenylmethyl]piperazine-2,3-Dibenzoyl tartarate intermediate salt and the method for isolating optically active 1-[4-chlorophenylphenylmethyl]piperazine using thereby
WO2010046908A2 (en) 2008-09-17 2010-04-29 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010107404A1 (en) 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
TR201007652A2 (en) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Synergistic effect.
TR201009398A2 (en) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Tablet formulations with improved physical properties
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
CN103044355A (en) * 2011-10-13 2013-04-17 湖南九典制药有限公司 Key intermediate for synthesizing levocetirizine and preparation method thereof
KR101418404B1 (en) 2012-01-06 2014-07-10 한미약품 주식회사 Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof
KR102226833B1 (en) 2013-06-28 2021-03-12 한미약품 주식회사 Complex granule formulation having improved stability comprising levocetirizine and montelukast
CN104045607B (en) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 A kind of purification process of cetrizine hcl
CN105924409B (en) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 The method for splitting of one kind (R) -1- ((2- chlorphenyl)-(phenyl)-methyl)-piperazine
CN111205247B (en) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 Preparation method of levocetirizine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI75816C (en) * 1981-02-06 1988-08-08 Ucb Sa Process for the preparation of therapeutically active 2- [4- (diphenylmethyl) -1-piperazinyl] -acetic acid or its amide

Also Published As

Publication number Publication date
GB2225321A (en) 1990-05-30
DK586789A (en) 1990-05-24
ATA266589A (en) 1994-07-15
KR900007825A (en) 1990-06-02
DK174543B1 (en) 2003-05-19
NO894651D0 (en) 1989-11-22
NO172342C (en) 1993-07-07
FI895564A0 (en) 1989-11-22
PL161379B1 (en) 1993-06-30
HU205094B (en) 1992-03-30
PT92364A (en) 1990-05-31
HU896131D0 (en) 1990-02-28
AT398971B (en) 1995-02-27
DK586789D0 (en) 1989-11-22
HK95892A (en) 1992-12-11
GR1000553B (en) 1992-08-26
GB2225321B (en) 1992-04-08
GB8926243D0 (en) 1990-01-10
FI91862C (en) 1994-08-25
KR970009728B1 (en) 1997-06-17
NO894651L (en) 1990-05-25
CY1671A (en) 1993-05-14
NO172342B (en) 1993-03-29
PT92364B (en) 1995-07-18
ES2021907A6 (en) 1991-11-16
FI91862B (en) 1994-05-13
CA1317300C (en) 1993-05-04
HUT53627A (en) 1990-11-28
GB8827391D0 (en) 1988-12-29
GR890100770A (en) 1990-12-31
PH25982A (en) 1992-01-13

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