SG68556A1 - Novel method of producing 7-(substituted)-9-[(substituted glycyl)-amido]-6-demethyl-6-deoxytetracyclines - Google Patents

Novel method of producing 7-(substituted)-9-[(substituted glycyl)-amido]-6-demethyl-6-deoxytetracyclines

Info

Publication number: SG68556A1
Authority: SG; Singapore
Prior art keywords: substituted; novel method; producing; deoxytetracyclines; demethyl
Prior art date: 1992-08-13

Application number

SG1996003389A

Other languages

English (en)

Inventor

Phaik-Eng Sum

Ving J Lee

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-13

Filing date

1993-05-12

Publication date

1999-11-16

1993-05-12 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1999-11-16 Publication of SG68556A1 publication Critical patent/SG68556A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

SG1996003389A 1992-08-13 1993-05-12 Novel method of producing 7-(substituted)-9-[(substituted glycyl)-amido]-6-demethyl-6-deoxytetracyclines SG68556A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/928,588 US5284963A (en)	1992-08-13	1992-08-13	Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines

Publications (1)

Publication Number	Publication Date
SG68556A1 true SG68556A1 (en)	1999-11-16

Family

ID=25456483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996003389A SG68556A1 (en)	1992-08-13	1993-05-12	Novel method of producing 7-(substituted)-9-[(substituted glycyl)-amido]-6-demethyl-6-deoxytetracyclines

Country Status (27)

Country	Link
US (1)	US5284963A (no)
EP (1)	EP0582790B1 (no)
JP (1)	JP3590643B2 (no)
KR (1)	KR100250603B1 (no)
CN (1)	CN1037680C (no)
AT (1)	ATE174903T1 (no)
AU (1)	AU674689B2 (no)
CA (1)	CA2103837C (no)
CZ (1)	CZ286261B6 (no)
DE (1)	DE69322708T2 (no)
DK (1)	DK0582790T3 (no)
ES (1)	ES2125927T3 (no)
FI (1)	FI115722B (no)
GR (1)	GR3029764T3 (no)
HU (1)	HU222886B1 (no)
IL (3)	IL106674A (no)
LV (1)	LV12273B (no)
MX (1)	MX9304649A (no)
NO (1)	NO303574B1 (no)
NZ (1)	NZ248358A (no)
PH (1)	PH30150A (no)
PL (2)	PL173606B1 (no)
RU (1)	RU2111958C1 (no)
SG (1)	SG68556A1 (no)
SK (1)	SK281698B6 (no)
TW (1)	TW221285B (no)
ZA (1)	ZA935891B (no)

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SG47520A1 (en) *	1992-08-13	1998-04-17	American Cyanamid Co	New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5328902A (en) *	1992-08-13	1994-07-12	American Cyanamid Co.	7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) *	1992-08-13	1995-05-30	American Cyanamid Company	7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) *	1992-08-13	1995-08-15	American Cyanamid Company	9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) *	1992-08-13	1993-09-28	American Cyanamid Company	Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US6946118B1 (en)	1999-09-14	2005-09-20	Orapharma, Inc.	Formulations for treating or preventing mucositis
CN102336680A (zh) *	1999-09-14	2012-02-01	塔夫茨大学信托人	用基于过渡金属的化学制备取代四环素的方法
US8106225B2 (en) *	1999-09-14	2012-01-31	Trustees Of Tufts College	Methods of preparing substituted tetracyclines with transition metal-based chemistries
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EP1301466A2 (en) *	2000-07-07	2003-04-16	Trustees Of Tufts College	7-substituted tetracycline compounds
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CN1653037A (zh)	2002-03-21	2005-08-10	帕拉特克药品公司	取代的四环素化合物
WO2004000223A2 (en) *	2002-06-20	2003-12-31	Orapharma, Inc.	Rapidly disintegrating formulations for treating or preventing mucositis
AU2004259659B2 (en)	2003-07-09	2011-11-03	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
US20060287283A1 (en) *	2003-07-09	2006-12-21	Paratek Pharmaceuticals, Inc.	Prodrugs of 9-aminomethyl tetracycline compounds
EP2287140A3 (en)	2004-10-25	2011-09-21	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
US7534766B2 (en)	2004-11-05	2009-05-19	Wyeth	Glucuronide metabolites and epimers thereof of tigecycline
WO2006084265A1 (en)	2005-02-04	2006-08-10	Paratek Pharmaceuticals, Inc.	11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS
US20060183758A1 (en) *	2005-02-17	2006-08-17	Cb Research And Development, Inc.	Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
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DK2427425T3 (en)	2009-05-08	2017-06-12	Tetraphase Pharmaceuticals Inc	tetracycline
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1992
- 1992-08-13 US US07/928,588 patent/US5284963A/en not_active Expired - Lifetime
- 1992-11-03 TW TW081108731A patent/TW221285B/zh active
1993
- 1993-05-12 AT AT93107719T patent/ATE174903T1/de not_active IP Right Cessation
- 1993-05-12 DK DK93107719T patent/DK0582790T3/da active
- 1993-05-12 DE DE69322708T patent/DE69322708T2/de not_active Expired - Lifetime
- 1993-05-12 EP EP93107719A patent/EP0582790B1/en not_active Expired - Lifetime
- 1993-05-12 SG SG1996003389A patent/SG68556A1/en unknown
- 1993-05-12 ES ES93107719T patent/ES2125927T3/es not_active Expired - Lifetime
- 1993-06-17 CN CN93107463A patent/CN1037680C/zh not_active Expired - Fee Related
- 1993-08-02 MX MX9304649A patent/MX9304649A/es unknown
- 1993-08-04 CZ CZ19931577A patent/CZ286261B6/cs not_active IP Right Cessation
- 1993-08-06 SK SK849-93A patent/SK281698B6/sk not_active IP Right Cessation
- 1993-08-09 NZ NZ248358A patent/NZ248358A/en not_active IP Right Cessation
- 1993-08-10 JP JP21816793A patent/JP3590643B2/ja not_active Expired - Fee Related
- 1993-08-10 PH PH46662A patent/PH30150A/en unknown
- 1993-08-11 CA CA002103837A patent/CA2103837C/en not_active Expired - Fee Related
- 1993-08-12 PL PL93300064A patent/PL173606B1/pl not_active IP Right Cessation
- 1993-08-12 AU AU44603/93A patent/AU674689B2/en not_active Ceased
- 1993-08-12 NO NO932870A patent/NO303574B1/no not_active IP Right Cessation
- 1993-08-12 HU HU9302331A patent/HU222886B1/hu active IP Right Grant
- 1993-08-12 KR KR1019930015643A patent/KR100250603B1/ko not_active IP Right Cessation
- 1993-08-12 IL IL10667493A patent/IL106674A/en not_active IP Right Cessation
- 1993-08-12 FI FI933566A patent/FI115722B/fi active IP Right Grant
- 1993-08-12 RU RU93043144A patent/RU2111958C1/ru not_active IP Right Cessation
- 1993-08-12 PL PL93316522A patent/PL173923B1/pl not_active IP Right Cessation
- 1993-08-12 IL IL11955193A patent/IL119551A/xx not_active IP Right Cessation
- 1993-08-12 ZA ZA935891A patent/ZA935891B/xx unknown
1996
- 1996-11-03 IL IL11955196A patent/IL119551A0/xx unknown
1999
- 1999-02-08 LV LVP-99-19A patent/LV12273B/en unknown
- 1999-03-22 GR GR990400850T patent/GR3029764T3/el unknown

Also Published As

Publication number	Publication date
DK0582790T3 (da)	1999-08-23
NO932870L (no)	1994-02-14
JP3590643B2 (ja)	2004-11-17
FI933566A0 (fi)	1993-08-12
EP0582790B1 (en)	1998-12-23
IL106674A (en)	1998-07-15
ES2125927T3 (es)	1999-03-16
LV12273B (en)	1999-11-20
NO303574B1 (no)	1998-08-03
IL106674A0 (en)	1993-12-08
KR940003923A (ko)	1994-03-14
JPH06184075A (ja)	1994-07-05
NZ248358A (en)	1996-04-26
KR100250603B1 (ko)	2000-04-01
EP0582790A1 (en)	1994-02-16
US5284963A (en)	1994-02-08
CZ157793A3 (en)	1994-03-16
HU222886B1 (hu)	2003-12-29
RU2111958C1 (ru)	1998-05-27
CA2103837C (en)	2004-10-05
PL173606B1 (pl)	1998-03-31
CZ286261B6 (cs)	2000-02-16
NO932870D0 (no)	1993-08-12
IL119551A (en)	2003-02-12
PL300064A1 (en)	1994-02-21
DE69322708D1 (de)	1999-02-04
HUT64941A (en)	1994-03-28
LV12273A (lv)	1999-05-20
GR3029764T3 (en)	1999-06-30
SK281698B6 (sk)	2001-07-10
FI115722B (fi)	2005-06-30
MX9304649A (es)	1994-02-28
CN1083047A (zh)	1994-03-02
ATE174903T1 (de)	1999-01-15
CN1037680C (zh)	1998-03-11
FI933566A (fi)	1994-02-14
ZA935891B (en)	1994-03-09
AU4460393A (en)	1994-02-17
HU9302331D0 (en)	1993-10-28
AU674689B2 (en)	1997-01-09
PL173923B1 (pl)	1998-05-29
SK84993A3 (en)	1994-06-08
CA2103837A1 (en)	1994-02-14
DE69322708T2 (de)	1999-04-29
IL119551A0 (en)	1997-02-18
TW221285B (no)	1994-02-21
PH30150A (en)	1997-01-21

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