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SG170766A1 - Oral fast-disintegrating tablet - Google Patents

Oral fast-disintegrating tablet

Info

Publication number
SG170766A1
SG170766A1 SG201102110-2A SG2011021102A SG170766A1 SG 170766 A1 SG170766 A1 SG 170766A1 SG 2011021102 A SG2011021102 A SG 2011021102A SG 170766 A1 SG170766 A1 SG 170766A1
Authority
SG
Singapore
Prior art keywords
starch
tablet
bacterium
crystalline cellulose
anhydrous silicic
Prior art date
Application number
SG201102110-2A
Inventor
Masatsugu Nozaki
Sachio Motegi
Kana Matsumoto
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Publication of SG170766A1 publication Critical patent/SG170766A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

By compression-molding a mixed powder of a useful bacterium, crystalline cellulose/light anhydrous silicic acid (an excipient that is produced by mixing crystalline cellulose and a small amount of light anhydrous silicic acid in the slurry form and then by spray-drying it) and a starch-containing saccharide (a starch powder, a granulated starch, a granulated mixture of starch and lactose) in the dry form to obtain a tablet with a tablet hardness of about 30N-60N, a moisture content of 3.2% by weight or less, an of a useful bacterium such as a Bifidobacterium or a lactic acid bacterium having a high stability in tablet making and storage stability can be obtained. NO FIGURE.
SG201102110-2A 2006-03-24 2007-03-23 Oral fast-disintegrating tablet SG170766A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006083857 2006-03-24

Publications (1)

Publication Number Publication Date
SG170766A1 true SG170766A1 (en) 2011-05-30

Family

ID=38541289

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201102110-2A SG170766A1 (en) 2006-03-24 2007-03-23 Oral fast-disintegrating tablet

Country Status (6)

Country Link
JP (1) JP5100634B2 (en)
KR (1) KR101470483B1 (en)
CN (1) CN101410127B (en)
MY (1) MY149923A (en)
SG (1) SG170766A1 (en)
WO (1) WO2007111375A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6983407B2 (en) * 2015-07-07 2021-12-17 東亜薬品工業株式会社 Bacterial fast-disintegrating tablet containing bacteria
KR20230004619A (en) * 2020-04-17 2023-01-06 에벨로 바이오사이언시즈, 인크. Solid dosage form with improved disintegration profile

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0441434A (en) * 1990-06-07 1992-02-12 Asahi Breweries Ltd Lactobacillus tablet provided with enteric coating
JPH054926A (en) * 1991-06-27 1993-01-14 Dainippon Pharmaceut Co Ltd Enteral useful bacterium-containing sugar-coated tablet
ATE216577T1 (en) * 1992-01-29 2002-05-15 Takeda Chemical Industries Ltd QUICK DISSOLVABLE TABLET AND PRODUCTION THEREOF
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
JP3591801B2 (en) * 1997-06-19 2004-11-24 田辺製薬株式会社 Manufacturing method of oral disintegrating preparation
SI0931543T1 (en) * 1997-12-19 2002-10-31 Merck Patent Gmbh Multilayered tablet comprising probiotic microorganisms such as lactobacilli or bifidobacteria
JP4063386B2 (en) * 1998-01-29 2008-03-19 キッセイ薬品工業株式会社 Rapid-release oral pharmaceutical composition
JP2000063289A (en) * 1998-08-20 2000-02-29 Morinaga Milk Ind Co Ltd Pharmaceutical preparation containing physiologically active substance
JP2001122785A (en) * 1999-10-22 2001-05-08 Nippon Boehringer Ingelheim Co Ltd Tablet containing brotizolam
CA2461708C (en) * 2001-09-28 2012-08-07 Nutraceutix, Inc. Delivery system for biological component
JP4605977B2 (en) * 2002-06-14 2011-01-05 日本ベーリンガーインゲルハイム株式会社 Tablets containing brotizolam
US20040265375A1 (en) * 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets

Also Published As

Publication number Publication date
KR101470483B1 (en) 2014-12-08
JPWO2007111375A1 (en) 2009-08-13
JP5100634B2 (en) 2012-12-19
WO2007111375A1 (en) 2007-10-04
KR20080111014A (en) 2008-12-22
MY149923A (en) 2013-10-31
CN101410127B (en) 2011-08-31
CN101410127A (en) 2009-04-15

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