SG140591A1 - Heterocycle-substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors - Google Patents

Heterocycle-substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

Info

Publication number: SG140591A1
Authority: SG; Singapore
Prior art keywords: kinase inhibitors; heterocycle; preparation; pharmaceutical use; substituted cyclic
Prior art date: 2004-07-27

Application number

SG200801117-3A

Other languages

English (en)

Inventor

Hartmut Strobel

Sven Ruf

Dominique Lesuisse

Conception Nemecek

Stefan Guessregen

Anne Lebrun

Kurt Ritter

Jean-Luc Malleron

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-27

Filing date

2005-07-25

Publication date

2008-03-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34931290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG140591(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-07-25 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2008-03-28 Publication of SG140591A1 publication Critical patent/SG140591A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Obesity (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

SG200801117-3A 2004-07-27 2005-07-25 Heterocycle-substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors SG140591A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP04291905A EP1621539A1 (fr)	2004-07-27	2004-07-27	Dérivées d'urée cyclique substitués par un heterocycle, leur prépration et leur utilisation pharmaceutique comee inhibiteurs de kinases

Publications (1)

Publication Number	Publication Date
SG140591A1 true SG140591A1 (en)	2008-03-28

Family

ID=34931290

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200801117-3A SG140591A1 (en)	2004-07-27	2005-07-25	Heterocycle-substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

Country Status (20)

Country	Link
US (1)	US20070259891A1 (fr)
EP (2)	EP1621539A1 (fr)
JP (1)	JP2008508229A (fr)
KR (1)	KR20070044440A (fr)
CN (1)	CN1993359A (fr)
AR (1)	AR050267A1 (fr)
AU (1)	AU2005266461A1 (fr)
BR (1)	BRPI0513863A (fr)
CA (1)	CA2571324A1 (fr)
EA (1)	EA200700142A1 (fr)
IL (1)	IL180257A0 (fr)
MA (1)	MA28753B1 (fr)
MX (1)	MX2007000735A (fr)
NO (1)	NO20071073L (fr)
PE (1)	PE20060556A1 (fr)
SG (1)	SG140591A1 (fr)
TW (1)	TW200617004A (fr)
UY (1)	UY29037A1 (fr)
WO (1)	WO2006010642A1 (fr)
ZA (1)	ZA200700706B (fr)

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US7354933B2 (en) *	2003-01-31	2008-04-08	Aventis Pharma Sa	Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
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US7718684B2 (en)	2004-02-24	2010-05-18	The Regents Of The University Of California	Methods and materials for assessing prostate cancer therapies and compounds
EP1621536A1 (fr) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Dérivés d'urées cycliques aminés, leur préparation et utilisation pharmaceutique en tant qu'inhibiteurs de Kinase
US7709517B2 (en)	2005-05-13	2010-05-04	The Regents Of The University Of California	Diarylhydantoin compounds
FR2896503B1 (fr) *	2006-01-23	2012-07-13	Aventis Pharma Sa	Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896504B1 (fr)	2006-01-23	2012-07-13	Aventis Pharma Sa	Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
AU2013205325B2 (en) *	2006-03-27	2016-03-24	The Regents Of The University Of California	Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
PT2656842T (pt)	2006-03-27	2016-10-04	Univ California	Modulador do recetor de androgénios para o tratamento de cancro da próstata e doenças associadas ao recetor de androgénios
AU2012241184B2 (en) *	2006-03-27	2016-01-07	The Regents Of The University Of California	Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
AU2016201061B2 (en) *	2006-03-27	2017-03-02	The Regents Of The University Of California	Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
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EP2054408B1 (fr)	2006-08-15	2016-07-13	Novartis AG	Composés héterocycliques utiles dans le traitement de maladies liées a un taux elevé de lipides
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AR069039A1 (es)	2007-10-26	2009-12-23	Univ California	Compuestos de diarilhidantoina, composicion farmaceutica, proceso de obtencion del compuesto, utiles para desordenes hiperproliferativos
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WO2009094169A1 (fr)	2008-01-24	2009-07-30	Vitae Pharmaceuticals, Inc.	Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11β-hydroxystéroïde déshydrogénase 1
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US8598160B2 (en) *	2008-02-15	2013-12-03	Vitae Pharmaceuticals, Inc.	Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EP2245029B1 (fr) *	2008-02-20	2015-04-15	Novartis AG	Inhibiteurs hétérocycliques de la stéaroyl-coa désaturase
EP2274287B1 (fr) *	2008-03-18	2016-03-09	Vitae Pharmaceuticals, Inc.	Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase de type 1
AR071609A1 (es) *	2008-05-01	2010-06-30	Vitae Pharmaceuticals Inc	Inhibidores ciclicos de 11(beta) -hidroxiesteroide deshidrogenasa 1
EP2291370B1 (fr)	2008-05-01	2013-11-27	Vitae Pharmaceuticals, Inc.	Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
JP5451752B2 (ja) *	2008-05-01	2014-03-26	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
CA2723039A1 (fr)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Inhibiteurs cycliques de la 11-beta-hydroxysteroide dehydrogenase 1
JP5379160B2 (ja)	2008-07-25	2013-12-25	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8846668B2 (en)	2008-07-25	2014-09-30	Vitae Pharmaceuticals, Inc.	Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010089303A1 (fr)	2009-02-04	2010-08-12	Boehringer Ingelheim International Gmbh	Inhibiteurs cycliques de la 11β-hydroxystéroïde déshydrogénase de type 1
TW201039034A (en) *	2009-04-27	2010-11-01	Chunghwa Picture Tubes Ltd	Pixel structure and the method of forming the same
GEP20156309B (en) *	2009-04-30	2015-07-10	Vitae Pharmaceuticals Inc	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
UA109255C2 (ru)	2009-04-30	2015-08-10	Берінгер Інгельхайм Інтернешнл Гмбх	Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
MY161325A (en)	2009-05-12	2017-04-14	Janssen Pharmaceuticals Inc	1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
US8927539B2 (en)	2009-06-11	2015-01-06	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
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EP3357917A1 (fr)	2010-02-16	2018-08-08	Aragon Pharmaceuticals, Inc.	Modulateurs de récepteur d'androgène et utilisations associées
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EP2585444B1 (fr)	2010-06-25	2014-10-22	Boehringer Ingelheim International GmbH	Azaspirohexanones comme inhibiteurs de 11-beta -hsd1 pour le traitement de troubles métaboliques
JP2013540801A (ja)	2010-11-02	2013-11-07	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	代謝異常の治療のための組合せ医薬
UA124967C2 (uk)	2012-09-26	2021-12-22	Араґон Фармасьютікалз, Інк.	Антиандрогени для лікування неметастатичного кастраційно-резистентного раку передміхурової залози
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US5411981A (en) *	1991-01-09	1995-05-02	Roussel Uclaf	Phenylimidazolidines having antiandrogenic activity
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US7354933B2 (en) *	2003-01-31	2008-04-08	Aventis Pharma Sa	Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621536A1 (fr) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Dérivés d'urées cycliques aminés, leur préparation et utilisation pharmaceutique en tant qu'inhibiteurs de Kinase

2004
- 2004-07-27 EP EP04291905A patent/EP1621539A1/fr not_active Withdrawn
2005
- 2005-07-25 SG SG200801117-3A patent/SG140591A1/en unknown
- 2005-07-25 BR BRPI0513863-9A patent/BRPI0513863A/pt not_active IP Right Cessation
- 2005-07-25 CA CA002571324A patent/CA2571324A1/fr not_active Abandoned
- 2005-07-25 EP EP05776537A patent/EP1773828A1/fr not_active Ceased
- 2005-07-25 WO PCT/EP2005/008721 patent/WO2006010642A1/fr active Application Filing
- 2005-07-25 EA EA200700142A patent/EA200700142A1/ru unknown
- 2005-07-25 MX MX2007000735A patent/MX2007000735A/es not_active Application Discontinuation
- 2005-07-25 PE PE2005000867A patent/PE20060556A1/es not_active Application Discontinuation
- 2005-07-25 KR KR1020077002138A patent/KR20070044440A/ko not_active Application Discontinuation
- 2005-07-25 CN CNA2005800255207A patent/CN1993359A/zh active Pending
- 2005-07-25 ZA ZA200700706A patent/ZA200700706B/xx unknown
- 2005-07-25 JP JP2007523039A patent/JP2008508229A/ja active Pending
- 2005-07-25 AR ARP050103073A patent/AR050267A1/es unknown
- 2005-07-25 AU AU2005266461A patent/AU2005266461A1/en not_active Abandoned
- 2005-07-26 TW TW094125193A patent/TW200617004A/zh unknown
- 2005-07-27 UY UY29037A patent/UY29037A1/es unknown
2006
- 2006-12-21 IL IL180257A patent/IL180257A0/en unknown
2007
- 2007-01-26 US US11/627,505 patent/US20070259891A1/en not_active Abandoned
- 2007-01-29 MA MA29637A patent/MA28753B1/fr unknown
- 2007-02-26 NO NO20071073A patent/NO20071073L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2005266461A1 (en)	2006-02-02
CN1993359A (zh)	2007-07-04
IL180257A0 (en)	2007-07-04
TW200617004A (en)	2006-06-01
MA28753B1 (fr)	2007-07-02
BRPI0513863A (pt)	2008-05-20
US20070259891A1 (en)	2007-11-08
PE20060556A1 (es)	2006-07-03
ZA200700706B (en)	2008-10-29
WO2006010642A1 (fr)	2006-02-02
JP2008508229A (ja)	2008-03-21
CA2571324A1 (fr)	2006-02-02
MX2007000735A (es)	2007-03-30
UY29037A1 (es)	2006-02-24
KR20070044440A (ko)	2007-04-27
AR050267A1 (es)	2006-10-11
EP1621539A1 (fr)	2006-02-01
EP1773828A1 (fr)	2007-04-18
EA200700142A1 (ru)	2007-08-31
NO20071073L (no)	2007-04-26

Publication	Publication Date	Title
SG140591A1 (en)	2008-03-28	Heterocycle-substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EA200700168A1 (ru)	2007-06-29	Производные замещенной циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназы
NO20090628L (no)	2009-04-21	Pyridizinon derivativater
TW200621729A (en)	2006-07-01	Pyrimidine derivatives
IL180286A0 (en)	2007-07-04	Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
MX2009011964A (es)	2009-12-01	Derivados heterociclicos pirrolo-nitrogenosos, su preparacion y uso farmaceutico.
TNSN07074A1 (en)	2008-06-02	Pyrimidine derivatives
MY139302A (en)	2009-09-30	Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
TNSN06411A1 (en)	2008-02-22	Pyrimidine urea derivatives as kinase inhibitors
IL189375A (en)	2013-05-30	Derivatives 1-Heterocyclicsulfonyl-3-Aminomethyl-5- (hetero-) aryl-1-h- Pyrol
NO20071242L (no)	2007-05-07	Triazolpyridinylsulfanylderivater som P38-MAP-kinaseinhibitorer
ATE532781T1 (de)	2011-11-15	5-(acylamino)indazol-derivate als kinase- inhibitoren
WO2009132774A8 (fr)	2010-09-23	Nouveaux dérivés substitués indolin-2-one et utilisation de ces derniers en tant qu'inhibiteurs de kinase activés par le mitogène p39
MX2008001538A (es)	2008-04-04	Aril piridinas y metodos para su uso.
TW200611904A (en)	2006-04-16	Aza-bicyclononanes
EA200702375A1 (ru)	2008-06-30	Производные мочевины, способы их получения и применения
UA90285C2 (ru)	2010-04-26	Производные гидантоина, полезные как ингибиторы металлопротеиназ
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