SG149867A1 - Selective estrogen receptor modulators for the treatment of vasomotor symptoms - Google Patents
Selective estrogen receptor modulators for the treatment of vasomotor symptomsInfo
- Publication number
- SG149867A1 SG149867A1 SG200900414-4A SG2009004144A SG149867A1 SG 149867 A1 SG149867 A1 SG 149867A1 SG 2009004144 A SG2009004144 A SG 2009004144A SG 149867 A1 SG149867 A1 SG 149867A1
- Authority
- SG
- Singapore
- Prior art keywords
- treatment
- estrogen receptor
- receptor modulators
- selective estrogen
- vasomotor symptoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53834204P | 2004-01-22 | 2004-01-22 | |
| US53844204P | 2004-01-22 | 2004-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG149867A1 true SG149867A1 (en) | 2009-02-27 |
Family
ID=34830456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200900414-4A SG149867A1 (en) | 2004-01-22 | 2005-01-18 | Selective estrogen receptor modulators for the treatment of vasomotor symptoms |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20090023917A1 (es) |
| EP (1) | EP1709021B1 (es) |
| JP (1) | JP4909086B2 (es) |
| KR (2) | KR101008804B1 (es) |
| CN (1) | CN102250042A (es) |
| AT (1) | ATE476428T1 (es) |
| AU (1) | AU2005207821B2 (es) |
| BR (1) | BRPI0506721A (es) |
| CA (1) | CA2551956C (es) |
| CR (1) | CR8517A (es) |
| DE (1) | DE602005022673D1 (es) |
| EA (2) | EA016613B1 (es) |
| EC (1) | ECSP066711A (es) |
| ES (1) | ES2347973T3 (es) |
| IL (1) | IL176738A0 (es) |
| MA (1) | MA28436B1 (es) |
| NO (1) | NO20063760L (es) |
| SG (1) | SG149867A1 (es) |
| UA (1) | UA85862C2 (es) |
| WO (1) | WO2005073204A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2656067C (en) | 2006-06-23 | 2014-08-12 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
| US10144736B2 (en) * | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US20100087402A1 (en) * | 2008-09-29 | 2010-04-08 | Vivus, Inc. | Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders |
| WO2010036497A2 (en) * | 2008-09-29 | 2010-04-01 | Eli Lilly And Company | Selective estrogen receptor modulator |
| US20100317635A1 (en) * | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
| ME02474B (me) | 2010-05-12 | 2017-02-20 | Radius Health Inc | Terapijski režimi |
| US9133182B2 (en) | 2010-09-28 | 2015-09-15 | Radius Health, Inc. | Selective androgen receptor modulators |
| FR3014434B1 (fr) * | 2013-12-05 | 2015-12-25 | Servier Lab | Nouveau procede de synthese du 7-methoxy-naphtalene-1-carbaldehyde et application a la synthese de l'agomelatine |
| FR3014437B1 (fr) * | 2013-12-05 | 2016-12-23 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| ES2939940T3 (es) | 2014-03-28 | 2023-04-28 | Univ Duke | Tratamiento del cáncer de mama utilizando moduladores selectivos de los receptores de estrógenos |
| HUE050029T2 (hu) | 2015-03-04 | 2020-11-30 | Gilead Sciences Inc | 4,6-Diamino-pirido[3,2-d]pirimidin-származékok és alkalmazásuk toll-szerû receptorok modulátoraként |
| HRP20220619T1 (hr) | 2016-06-22 | 2023-02-03 | Ellipses Pharma Ltd | Postupci za liječenje ar+ raka dojke |
| EP3507288B1 (en) | 2016-09-02 | 2020-08-26 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| MA46093A (fr) | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | Composés modulateurs du recepteur de type toll |
| KR20240137130A (ko) | 2017-01-05 | 2024-09-19 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| CN108675999B (zh) * | 2018-05-09 | 2021-03-16 | 浙江农林大学暨阳学院 | 一种醋酸铜催化制备8-(9-亚砜基-10-二氢菲)喹啉类化合物的方法 |
| CA3104395A1 (en) | 2018-07-04 | 2020-01-09 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
| UA125890C2 (uk) | 2018-07-12 | 2022-06-29 | Елі Ліллі Енд Компані | Селективні супресори рецепторів естрогенів |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202115056A (zh) | 2019-06-28 | 2021-04-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| TW202300492A (zh) | 2021-03-16 | 2023-01-01 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| WO2023150056A1 (en) | 2022-02-01 | 2023-08-10 | Eli Lilly And Company | Processes for the preparation of selective estrogen receptor degraders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| US5726186A (en) * | 1995-09-08 | 1998-03-10 | Eli Lilly And Company | Pentacyclic compounds, intermediates, processes, compositions, and methods |
| ID19392A (id) * | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
| CA2213810C (en) * | 1996-08-29 | 2006-06-06 | Lewis Dale Pennington | Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods |
| US5916916A (en) * | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
| CA2217810A1 (en) * | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
| WO1999007377A1 (en) * | 1997-08-07 | 1999-02-18 | Eli Lilly And Company | 1-[4-(substituted alkoxy)benzyl]naphthalene compounds having estrogen inhibitory activity |
| ES2326593T3 (es) * | 2002-07-22 | 2009-10-15 | Eli Lilly And Company | Moduladores de receptores de estrogeno selectivos que contienen un grupo fenilsulfonilo. |
-
2005
- 2005-01-18 JP JP2006551097A patent/JP4909086B2/ja not_active Expired - Fee Related
- 2005-01-18 CN CN2011101337521A patent/CN102250042A/zh active Pending
- 2005-01-18 WO PCT/US2005/000020 patent/WO2005073204A1/en active Application Filing
- 2005-01-18 EA EA200900586A patent/EA016613B1/ru not_active IP Right Cessation
- 2005-01-18 EA EA200601353A patent/EA012262B1/ru not_active IP Right Cessation
- 2005-01-18 DE DE602005022673T patent/DE602005022673D1/de active Active
- 2005-01-18 KR KR1020087003065A patent/KR101008804B1/ko not_active IP Right Cessation
- 2005-01-18 SG SG200900414-4A patent/SG149867A1/en unknown
- 2005-01-18 CA CA2551956A patent/CA2551956C/en not_active Expired - Fee Related
- 2005-01-18 UA UAA200607867A patent/UA85862C2/uk unknown
- 2005-01-18 EP EP05704874A patent/EP1709021B1/en active Active
- 2005-01-18 AT AT05704874T patent/ATE476428T1/de not_active IP Right Cessation
- 2005-01-18 AU AU2005207821A patent/AU2005207821B2/en not_active Ceased
- 2005-01-18 ES ES05704874T patent/ES2347973T3/es active Active
- 2005-01-18 US US10/597,241 patent/US20090023917A1/en not_active Abandoned
- 2005-01-18 BR BRPI0506721-9A patent/BRPI0506721A/pt not_active IP Right Cessation
- 2005-01-18 KR KR1020067014630A patent/KR100849559B1/ko not_active IP Right Cessation
-
2006
- 2006-07-06 IL IL176738A patent/IL176738A0/en unknown
- 2006-07-19 EC EC2006006711A patent/ECSP066711A/es unknown
- 2006-07-19 CR CR8517A patent/CR8517A/es unknown
- 2006-08-18 MA MA29277A patent/MA28436B1/fr unknown
- 2006-08-22 NO NO20063760A patent/NO20063760L/no not_active Application Discontinuation
-
2011
- 2011-06-23 US US13/167,343 patent/US8217032B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20110281847A1 (en) | 2011-11-17 |
| JP2007519721A (ja) | 2007-07-19 |
| US8217032B2 (en) | 2012-07-10 |
| KR101008804B1 (ko) | 2011-01-14 |
| US20090023917A1 (en) | 2009-01-22 |
| MA28436B1 (fr) | 2007-02-01 |
| ATE476428T1 (de) | 2010-08-15 |
| BRPI0506721A (pt) | 2007-05-02 |
| JP4909086B2 (ja) | 2012-04-04 |
| DE602005022673D1 (de) | 2010-09-16 |
| KR20060129277A (ko) | 2006-12-15 |
| UA85862C2 (uk) | 2009-03-10 |
| NO20063760L (no) | 2006-10-16 |
| CA2551956A1 (en) | 2005-08-11 |
| CR8517A (es) | 2006-12-01 |
| AU2005207821B2 (en) | 2011-02-10 |
| CA2551956C (en) | 2013-05-07 |
| CN102250042A (zh) | 2011-11-23 |
| EP1709021B1 (en) | 2010-08-04 |
| AU2005207821A1 (en) | 2005-08-11 |
| WO2005073204A1 (en) | 2005-08-11 |
| EA200900586A1 (ru) | 2009-08-28 |
| EP1709021A1 (en) | 2006-10-11 |
| IL176738A0 (en) | 2006-10-31 |
| ES2347973T3 (es) | 2010-11-26 |
| KR20080016755A (ko) | 2008-02-21 |
| EA016613B1 (ru) | 2012-06-29 |
| EA012262B1 (ru) | 2009-08-28 |
| KR100849559B1 (ko) | 2008-07-31 |
| ECSP066711A (es) | 2006-10-31 |
| EA200601353A1 (ru) | 2007-02-27 |
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