[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

SG11202101454PA - Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors - Google Patents

Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors

Info

Publication number
SG11202101454PA
SG11202101454PA SG11202101454PA SG11202101454PA SG11202101454PA SG 11202101454P A SG11202101454P A SG 11202101454PA SG 11202101454P A SG11202101454P A SG 11202101454PA SG 11202101454P A SG11202101454P A SG 11202101454PA SG 11202101454P A SG11202101454P A SG 11202101454PA
Authority
SG
Singapore
Prior art keywords
ccr4
antagonists
combination therapy
immune checkpoint
chemokine receptor
Prior art date
Application number
SG11202101454PA
Inventor
Shijie Li
Venkat Reddy Mali
Rajinder Singh
Ju Yang
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of SG11202101454PA publication Critical patent/SG11202101454PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/82—Colon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/852—Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202101454PA 2018-08-29 2019-08-28 Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors SG11202101454PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862724412P 2018-08-29 2018-08-29
US201862771853P 2018-11-27 2018-11-27
PCT/US2019/048461 WO2020047030A1 (en) 2018-08-29 2019-08-28 Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors

Publications (1)

Publication Number Publication Date
SG11202101454PA true SG11202101454PA (en) 2021-03-30

Family

ID=69639506

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202101454PA SG11202101454PA (en) 2018-08-29 2019-08-28 Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors

Country Status (14)

Country Link
US (2) US11446289B2 (en)
EP (1) EP3843734A4 (en)
JP (1) JP7554180B2 (en)
KR (1) KR20210053306A (en)
CN (1) CN112601526A (en)
AU (1) AU2019327430B2 (en)
BR (1) BR112021002928A2 (en)
CA (1) CA3109498A1 (en)
IL (1) IL280831B2 (en)
MA (1) MA53503A (en)
MX (1) MX2021002302A (en)
SG (1) SG11202101454PA (en)
TW (1) TW202023555A (en)
WO (1) WO2020047030A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6141864B2 (en) 2011-12-01 2017-06-07 ケモセントリックス，インコーポレイティド Substituted anilines as CCR (4) antagonists
SG11202101454PA (en) * 2018-08-29 2021-03-30 Chemocentryx Inc Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors
KR20230149729A (en) * 2022-04-19 2023-10-27 케모센트릭스, 인크. Ccr4 antagonists

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002213467A1 (en) * 2000-10-11 2002-04-22 Chemocentryx, Inc. Modulation of ccr4 function
AU2003256923A1 (en) 2002-07-31 2004-02-16 Smithkline Beecham Corporation Substituted benzanilides as modulators of the ccr5 receptor
JP2007210887A (en) 2004-06-21 2007-08-23 Astellas Pharma Inc Ring-fused bicyclic pyrimidine derivative
US20090182140A1 (en) 2005-12-02 2009-07-16 Mitsubishi Tanabe Pharma Corporation Alicyclic Heterocyclic Compound
GB0718167D0 (en) 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
JP2009148309A (en) 2007-12-18 2009-07-09 Uni Charm Corp Absorbent article
WO2009100140A1 (en) 2008-02-04 2009-08-13 Medarex, Inc. Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof
EP2495263B1 (en) 2009-10-26 2014-04-16 China Petroleum & Chemical Corporation Supported non-metallocene catalyst, preparation method and uses thereof
US8952112B2 (en) 2009-10-26 2015-02-10 China Petroleum & Chemical Corp. Supported nonmetallocene catalyst, preparation and use thereof
WO2011056423A2 (en) 2009-10-28 2011-05-12 Exxonmobil Chemical Patents Inc. Catalyst compounds and use thereof
JP5670465B2 (en) 2009-11-13 2015-02-18 中國石油化工股▲分▼有限公司 Supported nonmetallocene catalyst, process for its production and use thereof
US8952113B2 (en) 2009-11-13 2015-02-10 China Petroleum & Chemical Corp. Supported nonmetallocene catalyst, preparation and use thereof
JP2014503528A (en) 2010-12-14 2014-02-13 エレクトロプホレトイクス リミテッド Casein kinase 1δ (CK1δ) inhibitor and its use in the treatment of neurodegenerative diseases such as tauopathy
JP6141864B2 (en) * 2011-12-01 2017-06-07 ケモセントリックス，インコーポレイティド Substituted anilines as CCR (4) antagonists
CN105073128A (en) * 2013-04-03 2015-11-18 Ibc药品公司 Combination therapy for inducing immune response to disease
WO2016073759A1 (en) * 2014-11-05 2016-05-12 The Regents Of The University Of California Combination immunotherapy
CA2929850A1 (en) * 2015-05-14 2016-11-14 Pfizer Inc. Combination therapies comprising a pyrrolidine-2,5-dione ido1 inhibitor
WO2017010106A1 (en) * 2015-07-14 2017-01-19 Kyowa Hakko Kirin Co., Ltd. A therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody
TWI724056B (en) * 2015-11-19 2021-04-11 美商卡默森屈有限公司 Inhibitors of cxcr2
SG10201603721TA (en) 2016-05-10 2017-12-28 Agency Science Tech & Res Anti-CTLA-4 Antibodies
CN109803651B (en) * 2016-06-27 2022-05-31 凯莫森特里克斯股份有限公司 Immunomodulatory compounds
PL3490565T3 (en) * 2016-07-29 2022-09-26 Rapt Therapeutics, Inc. Azetidine derivatives as chemokine receptor modulators and uses thereof
WO2018035710A1 (en) 2016-08-23 2018-03-01 Akeso Biopharma, Inc. Anti-ctla4 antibodies
WO2018101448A1 (en) * 2016-11-30 2018-06-07 Kyowa Hakko Kirin Co., Ltd. Method of treating cancer using anti-ccr4 antibody and anti-pd-1 antibody
SG11202101454PA (en) * 2018-08-29 2021-03-30 Chemocentryx Inc Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors

Also Published As

Publication number Publication date
KR20210053306A (en) 2021-05-11
US20200069673A1 (en) 2020-03-05
EP3843734A4 (en) 2022-05-25
US20230097128A1 (en) 2023-03-30
IL280831B2 (en) 2024-05-01
JP2021536442A (en) 2021-12-27
WO2020047030A1 (en) 2020-03-05
IL280831B1 (en) 2024-01-01
US12011439B2 (en) 2024-06-18
JP7554180B2 (en) 2024-09-19
CA3109498A1 (en) 2020-03-05
TW202023555A (en) 2020-07-01
EP3843734A1 (en) 2021-07-07
BR112021002928A2 (en) 2021-05-11
AU2019327430B2 (en) 2024-10-03
US11446289B2 (en) 2022-09-20
MA53503A (en) 2021-07-07
MX2021002302A (en) 2021-04-28
AU2019327430A1 (en) 2021-03-18
CN112601526A (en) 2021-04-02
IL280831A (en) 2021-04-29

Similar Documents

Publication Publication Date Title
IL280831A (en) Combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immune checkpoint inhibitors
IL286998A (en) Pyrimidinone derivatives and their use as shp2 antagonists
IL286077A (en) Carboxamide-pyrimidine derivatives and their use as shp2 antagonists
IL282487A (en) Tyk2 inhibitors and uses thereof
ZA201803367B (en) Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders
IL271751A (en) Novel t cell receptors and immune therapy using the same
IL280479A (en) Tlr7/8 antagonists and their use
IL273188A (en) Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
IL283409A (en) Tyk2 inhibitors and uses thereof
IL282090A (en) Tyk2 inhibitors and uses thereof
EP3856719C0 (en) Compounds as neuronal histamine receptor-3 antagonists and uses thereof
IL279152A (en) Melanocortin subtype-2 receptor (mc2r) antagonists and uses thereof
IL277144A (en) Adenosine receptor antagonists and uses thereof
EP3712144C0 (en) P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof
IL281769A (en) Cd40l antagonist and uses thereof
IL292219A (en) Immunomodulatory il-2 agents in combination with immune checkpoint inhibitors
IL281802A (en) Use of an inhibitor of an ent family transporter in the treatment of cancer and combination thereof with an adenosine receptor antagonist
IL292692A (en) Mrgprx2 antagonists and uses thereof
IL288010A (en) Antagonists of the complement system for use in methods of treating paraproteinemic neuropathies
IL288085A (en) Expression systems for the alpha 9/alpha 10 nicotinic acetylcholine receptor and methods of use thereof
EP3525779C0 (en) Combination containing the sgc stimulator vericuguat and the mineralcorticoid receptor antagonist finerenone
ZA201701852B (en) Combination therapy of inhibitors of c-c chemokine receptor type 9 (ccr9) and anti-alha4beta7 integrin blocking antibodies
IL281357B (en) Cd73 inhibitors and pharmaceutical uses thereof
GB201802307D0 (en) CD36 antagonists for use in melanoma treatment
IL290200A (en) Kv1.3 antagonists for use in the treatment of chronic and acute pain