SG11202012321PA - Nlrp3 inflammasome inhibitors - Google Patents
Nlrp3 inflammasome inhibitorsInfo
- Publication number
- SG11202012321PA SG11202012321PA SG11202012321PA SG11202012321PA SG11202012321PA SG 11202012321P A SG11202012321P A SG 11202012321PA SG 11202012321P A SG11202012321P A SG 11202012321PA SG 11202012321P A SG11202012321P A SG 11202012321PA SG 11202012321P A SG11202012321P A SG 11202012321PA
- Authority
- SG
- Singapore
- Prior art keywords
- nlrp3 inflammasome
- inflammasome inhibitors
- inhibitors
- nlrp3
- inflammasome
- Prior art date
Links
- 229940122390 Inflammasome inhibitor Drugs 0.000 title 1
- 108091008099 NLRP3 inflammasome Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18185580 | 2018-07-25 | ||
| EP19175246 | 2019-05-17 | ||
| PCT/IB2019/056278 WO2020021447A1 (en) | 2018-07-25 | 2019-07-23 | Nlrp3 inflammasome inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012321PA true SG11202012321PA (en) | 2021-02-25 |
Family
ID=67989037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012321PA SG11202012321PA (en) | 2018-07-25 | 2019-07-23 | Nlrp3 inflammasome inhibitors |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20210308140A1 (en) |
| EP (1) | EP3827008B1 (en) |
| JP (1) | JP7555327B2 (en) |
| KR (1) | KR20210038877A (en) |
| CN (1) | CN112424207B (en) |
| AU (1) | AU2019309727B2 (en) |
| BR (1) | BR112021000964A2 (en) |
| CA (1) | CA3103943A1 (en) |
| CL (1) | CL2021000191A1 (en) |
| CO (1) | CO2021000537A2 (en) |
| CR (1) | CR20210045A (en) |
| CU (1) | CU20210009A7 (en) |
| DO (1) | DOP2021000019A (en) |
| EC (1) | ECSP21004787A (en) |
| IL (1) | IL280336A (en) |
| JO (1) | JOP20210017A1 (en) |
| MA (1) | MA53388A (en) |
| MX (1) | MX2021000925A (en) |
| PE (1) | PE20210406A1 (en) |
| PH (1) | PH12021550166A1 (en) |
| SG (1) | SG11202012321PA (en) |
| WO (1) | WO2020021447A1 (en) |
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| EP4126015A4 (en) * | 2020-03-31 | 2024-04-24 | Olatec Therapeutics, Inc. | Method for preventing or treating lung infection and lung inflammation |
| US20230203044A1 (en) | 2020-04-15 | 2023-06-29 | Janssen Pharmaceutica Nv | Pyrazolo[1,5-d][1,2,4]triazine-5(4h)-acetamides as inhibitors of the nlrp3 inflammasome |
| EP4135842B1 (en) | 2020-04-15 | 2024-10-23 | JANSSEN Pharmaceutica NV | Pyrrolo[1,2-d][1,2,4]triazine-2-yl-acetamides as inhibitors of the nlrp3 inflammasome pathway |
| US20230203064A1 (en) | 2020-04-23 | 2023-06-29 | Janssen Pharmaceutica Nv | Tricyclic compounds as inhibitors of nlrp3 |
| BR112022021881A2 (en) | 2020-04-30 | 2022-12-20 | Janssen Pharmaceutica Nv | NEW TRIAZINOINDOL COMPOUNDS |
| AU2021279305A1 (en) | 2020-05-28 | 2023-02-09 | Janssen Pharmaceutica Nv | Compounds |
| IL299084A (en) | 2020-06-19 | 2023-02-01 | Ac Immune Sa | Dihydrooxazole and thiourea or urea derivatives modulating the nlrp3 inflammasome pathway |
| US20230357162A1 (en) * | 2020-08-14 | 2023-11-09 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| EP4217347A1 (en) | 2020-09-24 | 2023-08-02 | JANSSEN Pharmaceutica NV | New compounds |
| EP3974415A1 (en) | 2020-09-24 | 2022-03-30 | Janssen Pharmaceutica NV | Nlrp3 modulators |
| CN114478537B (en) * | 2020-11-13 | 2024-02-02 | 上海拓界生物医药科技有限公司 | Cyclic amide parallel-ring compound and medical application thereof |
| WO2022184843A1 (en) | 2021-03-04 | 2022-09-09 | Janssen Pharmaceutica Nv | 4-amino-6-oxo-pyridazine derivatives modulating nlrp3 |
| KR20230152016A (en) | 2021-03-04 | 2023-11-02 | 얀센 파마슈티카 엔브이 | 4-Alkoxy-6-oxo-pyridazine derivatives that modulate NLRP3 |
| CN113230240B (en) * | 2021-03-22 | 2022-12-27 | 广州医科大学 | 1,3-diphenylprop-2-en-1-one derivative and application thereof |
| KR20230170692A (en) | 2021-04-13 | 2023-12-19 | 유니티 바이오테크놀로지, 인크. | How to Treat Retinal Angiopathy |
| US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
| AU2022263621A1 (en) * | 2021-04-29 | 2023-12-14 | Janssen Pharmaceutica Nv | Phthalazinone derivatives as nlrp3 inflammasome inhibitors |
| IL294231A (en) | 2021-06-23 | 2023-01-01 | Yoda Pharmaceuticals Inc | Benzimidazole derivatives for treatment and/or prevention of diseases and disorders mediated by nlrp3 |
| US20240279223A1 (en) | 2021-07-01 | 2024-08-22 | Janssen Pharmaceutica Nv | 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl acetamides |
| WO2023028536A1 (en) * | 2021-08-25 | 2023-03-02 | Ptc Therapeutics, Inc. | 1,2,4-triazine derivatives useful as inhibitors of nlrp3 |
| CN118302170A (en) * | 2021-09-17 | 2024-07-05 | 尼科治疗有限公司 | Compounds, compositions, and methods |
| KR20230066899A (en) | 2021-11-08 | 2023-05-16 | 제일약품주식회사 | Novel compounds as nlrp3 inhibitor and pharmaceutical composition comprising the same |
| WO2023118521A1 (en) | 2021-12-22 | 2023-06-29 | Ac Immune Sa | Dihydro-oxazol derivative compounds |
| KR20240151767A (en) * | 2022-02-21 | 2024-10-18 | 사노피 | Thienopyrrolotriazine compounds, their preparation and their therapeutic uses |
| WO2024013395A1 (en) | 2022-07-14 | 2024-01-18 | Ac Immune Sa | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
| WO2024023266A1 (en) | 2022-07-28 | 2024-02-01 | Ac Immune Sa | Novel compounds |
| WO2024033845A1 (en) * | 2022-08-10 | 2024-02-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| KR20240022938A (en) | 2022-08-12 | 2024-02-20 | 제일약품주식회사 | Novel compounds as nlrp3 inhibitor and pharmaceutical composition comprising the same |
| WO2024064245A1 (en) | 2022-09-23 | 2024-03-28 | Merck Sharp & Dohme Llc | Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3 |
| WO2024196788A1 (en) * | 2023-03-17 | 2024-09-26 | Ventus Therapeutics U.S., Inc. | Amide derivatives for inhibiting nlrp3 and uses thereof |
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| WO2009008906A2 (en) * | 2007-02-06 | 2009-01-15 | The Trustees Of The University Of Pennsylvania | Therapeutic compounds for blocking dna synthesis of pox viruses |
| WO2010128152A1 (en) | 2009-05-07 | 2010-11-11 | Novartis Ag | Fused heterocyclic c-glycosides for the treatment of diabetes |
| US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
| WO2011048148A2 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Glycoside derivative and uses thereof |
| PL2975042T3 (en) | 2010-06-23 | 2019-07-31 | Hanmi Science Co., Ltd. | Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity |
| SG187796A1 (en) | 2010-08-10 | 2013-03-28 | Celgene Avilomics Res Inc | Besylate salt of a btk inhibitor |
| CU24152B1 (en) | 2010-12-20 | 2016-02-29 | Irm Llc | 1,2 OXAZOL-8-AZABICICLO [3,2,1] OCTANO 8 IL AS FXR MODULATORS |
| EP2718270B1 (en) | 2011-06-10 | 2022-04-27 | Merck Patent GmbH | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
| UA111756C2 (en) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | HETEROARYLPYRIDONE AND AZAPIRIDONE COMPOUNDS AS BRUTON TYROSINKINASE INHIBITORS |
| KR20180034705A (en) | 2011-11-29 | 2018-04-04 | 오노 야꾸힝 고교 가부시키가이샤 | Purinone derivative hydrochloride |
| WO2013185082A2 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Inhibitors of bruton's tyrosine kinase |
| SI2892900T1 (en) | 2012-09-10 | 2018-01-31 | Principia Biopharma Inc. | Pyrazolopyrimidine compounds as kinase inhibitors |
| CN104853758A (en) | 2012-11-28 | 2015-08-19 | 英特赛普特医药品公司 | Treatment of pulmonary disease |
| UY35368A (en) | 2013-03-08 | 2014-10-31 | Irm Llc | PEPTIDES AND COMPOSITIONS FOR THE TREATMENT OF ARTICULAR DAMAGE |
| JO3377B1 (en) | 2013-03-11 | 2019-03-13 | Takeda Pharmaceuticals Co | Pyridinyl and fused pyridinyl triazolone derivatives |
| WO2014173289A1 (en) | 2013-04-25 | 2014-10-30 | Beigene, Ltd. | Fused heterocyclic compounds as protein kinase inhibitors |
| AP2016009165A0 (en) | 2013-11-05 | 2016-04-30 | Novartis Ag | Compositions and methods for modulating farnesoid x receptors |
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| KR20160093062A (en) | 2013-12-05 | 2016-08-05 | 아세르타 파마. 비.브이. | Therapeutic combination of a pi3k inhibitor and a btk inhibitor |
| SG11201602787YA (en) | 2013-12-20 | 2016-07-28 | Novartis Ag | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
| WO2015110923A2 (en) | 2014-01-21 | 2015-07-30 | Acerta Pharma B.V. | Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia usng a btk inhibitor |
| JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
| JOP20200096A1 (en) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | Antibody molecules to tim-3 and uses thereof |
| WO2015138920A1 (en) | 2014-03-14 | 2015-09-17 | Novartis Ag | Antibody molecules to lag-3 and uses thereof |
| DK3143026T3 (en) | 2014-05-13 | 2024-09-30 | Novartis Ag | COMPOUNDS AND COMPOSITIONS FOR INDUCTION OF CHONDROGENESIS |
| TWI716362B (en) | 2014-10-14 | 2021-01-21 | 瑞士商諾華公司 | Antibody molecules to pd-l1 and uses thereof |
| UY36371A (en) | 2014-10-24 | 2016-04-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | INDOLCARBOXAMIDE COMPOUNDS KINASE INHIBITORS TYPE BTK AND TYPE TEC |
| CA2971109A1 (en) | 2014-12-24 | 2016-06-30 | Principia Biopharma Inc. | Site specific dosing of a btk inhibitor |
| CN113149983B (en) | 2015-06-03 | 2024-03-29 | 普林斯匹亚生物制药公司 | Tyrosine kinase inhibitors |
| EP3307732A1 (en) | 2015-06-10 | 2018-04-18 | Biogen MA Inc. | Forms and compositions of biaryl inhibitors of bruton's tyrosine kinase |
| CA3001744A1 (en) | 2015-10-09 | 2017-04-13 | ACEA Therapeutics, Inc. | Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same |
| EP4014977A1 (en) | 2015-11-04 | 2022-06-22 | Merck Patent GmbH | Pyrimidine compounds with btk inhibitory activity for use in treating cancer |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| JP6913274B2 (en) | 2016-01-05 | 2021-08-04 | ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． | Crystal form of BTK kinase inhibitor and its production method |
| BR112018071347A2 (en) * | 2016-04-19 | 2019-02-05 | Innate Tumor Immunity Inc | nlrp3 modulators |
| KR101865120B1 (en) | 2016-06-29 | 2018-06-08 | 숭실대학교 산학협력단 | Wireless positioning method based on test node and apparatus thereof |
| JP7129704B2 (en) | 2016-06-29 | 2022-09-02 | プリンシピア バイオファーマ インコーポレイテッド | 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-D]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4- Modified release formulations of [4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
| GB201712282D0 (en) * | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
| WO2019034693A1 (en) * | 2017-08-15 | 2019-02-21 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors |
-
2019
- 2019-07-23 PE PE2021000092A patent/PE20210406A1/en unknown
- 2019-07-23 KR KR1020217001895A patent/KR20210038877A/en unknown
- 2019-07-23 CU CU2021000009A patent/CU20210009A7/en unknown
- 2019-07-23 SG SG11202012321PA patent/SG11202012321PA/en unknown
- 2019-07-23 EP EP19769892.1A patent/EP3827008B1/en active Active
- 2019-07-23 MA MA053388A patent/MA53388A/en unknown
- 2019-07-23 US US17/259,252 patent/US20210308140A1/en active Pending
- 2019-07-23 JO JOP/2021/0017A patent/JOP20210017A1/en unknown
- 2019-07-23 CN CN201980047047.4A patent/CN112424207B/en active Active
- 2019-07-23 BR BR112021000964-7A patent/BR112021000964A2/en not_active Application Discontinuation
- 2019-07-23 MX MX2021000925A patent/MX2021000925A/en unknown
- 2019-07-23 CA CA3103943A patent/CA3103943A1/en active Pending
- 2019-07-23 AU AU2019309727A patent/AU2019309727B2/en not_active Ceased
- 2019-07-23 CR CR20210045A patent/CR20210045A/en unknown
- 2019-07-23 WO PCT/IB2019/056278 patent/WO2020021447A1/en active Application Filing
- 2019-07-23 JP JP2021503752A patent/JP7555327B2/en active Active
-
2021
- 2021-01-21 IL IL280336A patent/IL280336A/en unknown
- 2021-01-21 PH PH12021550166A patent/PH12021550166A1/en unknown
- 2021-01-22 CO CONC2021/0000537A patent/CO2021000537A2/en unknown
- 2021-01-22 DO DO2021000019A patent/DOP2021000019A/en unknown
- 2021-01-22 CL CL2021000191A patent/CL2021000191A1/en unknown
- 2021-01-22 EC ECSENADI20214787A patent/ECSP21004787A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210038877A (en) | 2021-04-08 |
| CR20210045A (en) | 2021-06-18 |
| ECSP21004787A (en) | 2021-03-31 |
| CN112424207B (en) | 2024-03-19 |
| MX2021000925A (en) | 2021-03-31 |
| CU20210009A7 (en) | 2021-08-06 |
| DOP2021000019A (en) | 2021-02-15 |
| EP3827008A1 (en) | 2021-06-02 |
| MA53388A (en) | 2021-06-02 |
| CN112424207A (en) | 2021-02-26 |
| EP3827008B1 (en) | 2024-07-31 |
| WO2020021447A1 (en) | 2020-01-30 |
| JOP20210017A1 (en) | 2021-01-21 |
| CL2021000191A1 (en) | 2021-08-20 |
| US20210308140A1 (en) | 2021-10-07 |
| AU2019309727A1 (en) | 2021-01-07 |
| JP7555327B2 (en) | 2024-09-24 |
| JP2021532124A (en) | 2021-11-25 |
| AU2019309727B2 (en) | 2021-12-23 |
| PH12021550166A1 (en) | 2021-09-13 |
| CO2021000537A2 (en) | 2021-01-29 |
| IL280336A (en) | 2021-03-01 |
| PE20210406A1 (en) | 2021-03-02 |
| BR112021000964A2 (en) | 2021-04-20 |
| CA3103943A1 (en) | 2020-01-30 |
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