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SG11202011382PA - Polycyclic carbamoylpyridone derivative - Google Patents

Polycyclic carbamoylpyridone derivative

Info

Publication number
SG11202011382PA
SG11202011382PA SG11202011382PA SG11202011382PA SG11202011382PA SG 11202011382P A SG11202011382P A SG 11202011382PA SG 11202011382P A SG11202011382P A SG 11202011382PA SG 11202011382P A SG11202011382P A SG 11202011382PA SG 11202011382P A SG11202011382P A SG 11202011382PA
Authority
SG
Singapore
Prior art keywords
polycyclic carbamoylpyridone
carbamoylpyridone derivative
derivative
polycyclic
carbamoylpyridone
Prior art date
Application number
SG11202011382PA
Inventor
Yoshiyuki Taoda
Yuto UNOH
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of SG11202011382PA publication Critical patent/SG11202011382PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11202011382PA 2018-05-31 2019-05-30 Polycyclic carbamoylpyridone derivative SG11202011382PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018104156 2018-05-31
PCT/JP2019/021446 WO2019230858A1 (en) 2018-05-31 2019-05-30 Polycyclic carbamoylpyridone derivative

Publications (1)

Publication Number Publication Date
SG11202011382PA true SG11202011382PA (en) 2020-12-30

Family

ID=68698918

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011382PA SG11202011382PA (en) 2018-05-31 2019-05-30 Polycyclic carbamoylpyridone derivative

Country Status (30)

Country Link
US (2) US11649236B2 (en)
EP (2) EP4257137A3 (en)
JP (2) JP7328962B2 (en)
KR (1) KR20210015922A (en)
CN (2) CN117327072A (en)
AR (1) AR115455A1 (en)
AU (2) AU2019277548B2 (en)
BR (1) BR112020024077A2 (en)
CA (1) CA3102063A1 (en)
CL (1) CL2020003002A1 (en)
CO (1) CO2020014294A2 (en)
CR (2) CR20230571A (en)
DK (1) DK3805220T3 (en)
DO (1) DOP2020000221A (en)
EA (1) EA202092921A1 (en)
ES (1) ES2984245T3 (en)
FI (1) FI3805220T3 (en)
IL (2) IL313474A (en)
LT (1) LT3805220T (en)
MA (1) MA52795A (en)
MD (1) MD3805220T2 (en)
MX (2) MX2020012176A (en)
PE (1) PE20210477A1 (en)
PH (1) PH12020552000A1 (en)
PT (1) PT3805220T (en)
RS (1) RS65891B1 (en)
SG (1) SG11202011382PA (en)
SI (1) SI3805220T1 (en)
WO (1) WO2019230858A1 (en)
ZA (1) ZA202007567B (en)

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JPWO2021107065A1 (en) * 2019-11-28 2021-06-03
EP4066839A4 (en) * 2019-11-28 2023-12-27 Shionogi & Co., Ltd Prophylactic and therapeutic pharmaceutical agent for hiv infectious diseases characterized by comprising combination of integrase inhibitor and anti-hiv agent
CN115151545A (en) 2020-02-24 2022-10-04 吉利德科学公司 Tetracyclic compounds for the treatment of HIV infection
JP7407976B2 (en) * 2020-05-21 2024-01-04 シーセン ファーマシューティカル カンパニー リミテッド Fused ring derivatives and their pharmaceutical uses
KR20230044252A (en) * 2020-07-27 2023-04-03 머크 샤프 앤드 돔 엘엘씨 Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza
LT4196479T (en) 2021-01-19 2023-12-11 Gilead Sciences, Inc. Substituted pyridotriazine compounds and uses thereof
WO2023006087A1 (en) * 2021-07-30 2023-02-02 南京明德新药研发有限公司 Macrocyclic pyridone compound and application thereof
TWI843506B (en) 2022-04-06 2024-05-21 美商基利科學股份有限公司 Bridged tricyclic carbamoylpyridone compounds and uses thereof
WO2024061257A1 (en) * 2022-09-20 2024-03-28 吉斯凯(苏州)制药有限公司 Polycyclic n-heterocyclic ketone compound and use thereof

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PL377354A1 (en) 2002-12-27 2006-01-23 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
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SI3938047T1 (en) 2019-03-22 2022-10-28 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use

Also Published As

Publication number Publication date
ZA202007567B (en) 2022-04-28
EP4257137A2 (en) 2023-10-11
BR112020024077A2 (en) 2021-02-09
CO2020014294A2 (en) 2020-12-21
MA52795A (en) 2021-04-14
ES2984245T3 (en) 2024-10-29
SI3805220T1 (en) 2024-10-30
MD3805220T2 (en) 2024-10-31
IL279051A (en) 2021-01-31
EP3805220A1 (en) 2021-04-14
RS65891B1 (en) 2024-09-30
DOP2020000221A (en) 2021-03-15
US11649236B2 (en) 2023-05-16
CR20200644A (en) 2021-02-05
MX2020012176A (en) 2021-01-29
IL279051B1 (en) 2024-09-01
MX2023010377A (en) 2023-09-12
CR20230571A (en) 2024-01-22
EP4257137A3 (en) 2023-11-01
AU2019277548A1 (en) 2021-01-14
LT3805220T (en) 2024-08-26
DK3805220T3 (en) 2024-08-26
AU2019277548B2 (en) 2023-12-14
PE20210477A1 (en) 2021-03-11
CL2020003002A1 (en) 2021-04-16
FI3805220T3 (en) 2024-08-30
CN112513042B (en) 2023-09-29
PT3805220T (en) 2024-08-16
KR20210015922A (en) 2021-02-10
PH12020552000A1 (en) 2021-09-27
US20230227454A1 (en) 2023-07-20
IL313474A (en) 2024-08-01
AR115455A1 (en) 2021-01-20
EP3805220A4 (en) 2022-01-05
CN117327072A (en) 2024-01-02
JP7328962B2 (en) 2023-08-17
CN112513042A (en) 2021-03-16
US20210122751A1 (en) 2021-04-29
CA3102063A1 (en) 2019-12-05
EP3805220B1 (en) 2024-07-31
JPWO2019230858A1 (en) 2021-06-24
EA202092921A1 (en) 2021-04-07
JP2023145723A (en) 2023-10-11
US20240352015A1 (en) 2024-10-24
AU2024200783A1 (en) 2024-02-29
WO2019230858A1 (en) 2019-12-05

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