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SG11202009193VA - Full flow-through process for purifying recombinant proteins - Google Patents

Full flow-through process for purifying recombinant proteins

Info

Publication number
SG11202009193VA
SG11202009193VA SG11202009193VA SG11202009193VA SG11202009193VA SG 11202009193V A SG11202009193V A SG 11202009193VA SG 11202009193V A SG11202009193V A SG 11202009193VA SG 11202009193V A SG11202009193V A SG 11202009193VA SG 11202009193V A SG11202009193V A SG 11202009193VA
Authority
SG
Singapore
Prior art keywords
recombinant proteins
full flow
purifying recombinant
purifying
full
Prior art date
Application number
SG11202009193VA
Inventor
Didier Duthe
Céline Hemet
Benoit Mothes
Jérome Pezzini
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG11202009193VA publication Critical patent/SG11202009193VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
SG11202009193VA 2018-03-27 2019-03-27 Full flow-through process for purifying recombinant proteins SG11202009193VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18305338.8A EP3546475A1 (en) 2018-03-27 2018-03-27 Full flow-through process for purifying recombinant proteins
PCT/EP2019/057687 WO2019185691A1 (en) 2018-03-27 2019-03-27 Full flow-through process for purifying recombinant proteins

Publications (1)

Publication Number Publication Date
SG11202009193VA true SG11202009193VA (en) 2020-10-29

Family

ID=61972052

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202009193VA SG11202009193VA (en) 2018-03-27 2019-03-27 Full flow-through process for purifying recombinant proteins

Country Status (14)

Country Link
US (1) US20210009634A1 (en)
EP (2) EP3546475A1 (en)
JP (1) JP7396997B2 (en)
KR (1) KR102736920B1 (en)
CN (1) CN112189015A (en)
AU (1) AU2019246328A1 (en)
BR (1) BR112020019409A2 (en)
CA (1) CA3095078A1 (en)
IL (1) IL277544B1 (en)
MX (1) MX2020010077A (en)
SG (1) SG11202009193VA (en)
TW (1) TWI828671B (en)
WO (1) WO2019185691A1 (en)
ZA (1) ZA202005801B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202432179A (en) * 2023-02-08 2024-08-16 瑞士商百濟神州瑞士有限責任公司 Ultrafiltration/diafiltration process for a highly concentrated pd1 antibody solution

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090105455A1 (en) * 2004-04-14 2009-04-23 Andreas Herrmann Purified interleukin-15/fc fusion protein and preparation thereof
CA2645739A1 (en) * 2006-03-20 2007-09-27 Medarex, Inc. Protein purification
KR101843915B1 (en) * 2008-08-14 2018-04-02 제넨테크, 인크. Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography
KR101753569B1 (en) * 2010-01-22 2017-07-04 베링거 인겔하임 인터내셔날 게엠베하 Chromatographic method for purifying fc-containing proteins
CA2813747A1 (en) * 2010-10-11 2012-04-19 Chen Wang Processes for purification of proteins
WO2012125735A1 (en) * 2011-03-15 2012-09-20 Abott Laboratories An integrated approach to the isolation and purification of antibodies
US10906934B2 (en) * 2011-03-25 2021-02-02 Genentech, Inc. Protein purification methods
US8506797B2 (en) * 2011-04-10 2013-08-13 Therapeutic Proteins International, LLC Downstream bioprocessing device
WO2013028330A2 (en) * 2011-08-19 2013-02-28 Emd Millipore Corporation Methods of reducing level of one of more impurities in a sample during protein purification
WO2013075740A1 (en) * 2011-11-23 2013-05-30 Sanofi Antibody purification method
BR112014015101A8 (en) * 2011-12-22 2021-06-08 Genentech Inc methods to enhance efficiency of downstream chromatography steps for antibody purification
SG10201701224UA (en) * 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
US9845338B2 (en) * 2012-06-21 2017-12-19 Synthon Biopharmaceuticals Bv Method of purifying an antibody
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
US9650411B2 (en) * 2012-08-07 2017-05-16 Kyowa Hakko Kirin Co., Ltd. Method of purifying protein
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
TWI675041B (en) * 2013-05-06 2019-10-21 法商賽諾菲公司 Continuous multistep process for purifying antibodies
KR101569783B1 (en) * 2013-06-05 2015-11-19 한화케미칼 주식회사 A Method of Antibody Purification
KR20160122754A (en) * 2014-02-19 2016-10-24 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Fractionation method
JP2017025025A (en) * 2015-07-23 2017-02-02 旭化成メディカル株式会社 Protein purification method
JP7032046B2 (en) * 2016-01-22 2022-03-08 旭化成メディカル株式会社 Continuous constant flow rate purification method for bioactive substances
US11180526B2 (en) * 2016-07-13 2021-11-23 Chromacon Ag Purification method and uses thereof
US10941178B2 (en) * 2017-03-17 2021-03-09 Gilead Sciences, Inc. Method of purifying an antibody

Also Published As

Publication number Publication date
JP7396997B2 (en) 2023-12-12
RU2020131568A (en) 2022-04-27
KR20200135371A (en) 2020-12-02
JP2021519303A (en) 2021-08-10
AU2019246328A1 (en) 2020-10-15
IL277544A (en) 2020-11-30
EP3774839A1 (en) 2021-02-17
TW201945385A (en) 2019-12-01
TWI828671B (en) 2024-01-11
MX2020010077A (en) 2020-10-28
CA3095078A1 (en) 2019-10-03
ZA202005801B (en) 2024-07-31
IL277544B1 (en) 2024-12-01
EP3546475A1 (en) 2019-10-02
BR112020019409A2 (en) 2021-01-05
CN112189015A (en) 2021-01-05
WO2019185691A1 (en) 2019-10-03
US20210009634A1 (en) 2021-01-14
KR102736920B1 (en) 2024-12-03

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