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SG11202005502PA - Inertial cell focusing and sorting - Google Patents

Inertial cell focusing and sorting

Info

Publication number
SG11202005502PA
SG11202005502PA SG11202005502PA SG11202005502PA SG11202005502PA SG 11202005502P A SG11202005502P A SG 11202005502PA SG 11202005502P A SG11202005502P A SG 11202005502PA SG 11202005502P A SG11202005502P A SG 11202005502PA SG 11202005502P A SG11202005502P A SG 11202005502PA
Authority
SG
Singapore
Prior art keywords
sorting
cell focusing
inertial
inertial cell
focusing
Prior art date
Application number
SG11202005502PA
Inventor
Ye Ai
Yinning Zhou
Original Assignee
Univ Singapore Technology & Design
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Singapore Technology & Design filed Critical Univ Singapore Technology & Design
Publication of SG11202005502PA publication Critical patent/SG11202005502PA/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0255Investigating particle size or size distribution with mechanical, e.g. inertial, classification, and investigation of sorted collections
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652Sorting or classification of particles or molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883Serpentine channels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0463Hydrodynamic forces, venturi nozzles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202005502PA 2017-12-15 2018-12-14 Inertial cell focusing and sorting SG11202005502PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201710457X 2017-12-15
PCT/SG2018/050615 WO2019117815A1 (en) 2017-12-15 2018-12-14 Inertial cell focusing and sorting

Publications (1)

Publication Number Publication Date
SG11202005502PA true SG11202005502PA (en) 2020-07-29

Family

ID=66819028

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005502PA SG11202005502PA (en) 2017-12-15 2018-12-14 Inertial cell focusing and sorting

Country Status (6)

Country Link
US (1) US20210053061A1 (en)
EP (1) EP3723906A4 (en)
JP (1) JP2021506263A (en)
CN (1) CN111491736B (en)
SG (1) SG11202005502PA (en)
WO (1) WO2019117815A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113769797B (en) * 2021-09-02 2023-03-14 浙江理工大学 Method for measuring diameter of micro-scale particles in fluid-solid two-phase transportation
CN114700126B (en) * 2022-05-06 2024-03-19 季华实验室 Microfluidic sorting chip

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160025B2 (en) * 2003-06-11 2007-01-09 Agency For Science, Technology And Research Micromixer apparatus and methods of using same
US20070263477A1 (en) * 2006-05-11 2007-11-15 The Texas A&M University System Method for mixing fluids in microfluidic channels
US10052571B2 (en) * 2007-11-07 2018-08-21 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
EP2482055A3 (en) * 2007-04-16 2013-10-30 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
WO2008134363A1 (en) * 2007-04-25 2008-11-06 The Regents Of The University Of Michigan Tunable elastomeric nanochannels for nanofluidic manipulation
US7999937B1 (en) * 2008-05-13 2011-08-16 Sandia Corporation Microfluidic devices and methods for integrated flow cytometry
US20120270331A1 (en) * 2011-04-20 2012-10-25 Achal Singh Achrol Microfluidic system and method for automated processing of particles from biological fluid
US10144009B2 (en) * 2013-10-16 2018-12-04 Clearbridge Biomedics Pte Ltd Microfluidics sorter for cell detection and isolation
US9782770B2 (en) * 2014-06-06 2017-10-10 Illumina, Inc. Systems and methods of loading or removing liquids used in biochemical analysis
CN104111190B (en) * 2014-07-18 2016-09-28 国家纳米科学中心 A kind of Double helix micro-fluidic chip
KR101636316B1 (en) * 2014-09-22 2016-07-05 연세대학교 산학협력단 Microfluidic apparatus for isolation, method for isolation using the same, and isolation kit for circulating rare cells using the same
CN105486571A (en) * 2015-11-09 2016-04-13 上海海洋大学 Microfluidic chip used for enriching microbial aerosol and preparation method thereof

Also Published As

Publication number Publication date
EP3723906A1 (en) 2020-10-21
CN111491736B (en) 2022-11-15
JP2021506263A (en) 2021-02-22
CN111491736A (en) 2020-08-04
WO2019117815A1 (en) 2019-06-20
EP3723906A4 (en) 2021-08-25
US20210053061A1 (en) 2021-02-25

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