SG11202000027WA - Improved dual specificity polypeptide molecule - Google Patents
Improved dual specificity polypeptide moleculeInfo
- Publication number
- SG11202000027WA SG11202000027WA SG11202000027WA SG11202000027WA SG11202000027WA SG 11202000027W A SG11202000027W A SG 11202000027WA SG 11202000027W A SG11202000027W A SG 11202000027WA SG 11202000027W A SG11202000027W A SG 11202000027WA SG 11202000027W A SG11202000027W A SG 11202000027WA
- Authority
- SG
- Singapore
- Prior art keywords
- polypeptide molecule
- dual specificity
- improved dual
- specificity polypeptide
- improved
- Prior art date
Links
- 230000009977 dual effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762532713P | 2017-07-14 | 2017-07-14 | |
DE102017115966.5A DE102017115966A1 (en) | 2017-07-14 | 2017-07-14 | Polypeptide molecule with improved dual specificity |
DE102017119866 | 2017-08-30 | ||
US201862658318P | 2018-04-16 | 2018-04-16 | |
DE102018108995 | 2018-04-16 | ||
PCT/EP2018/069157 WO2019012141A1 (en) | 2017-07-14 | 2018-07-13 | Improved dual specificity polypeptide molecule |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000027WA true SG11202000027WA (en) | 2020-02-27 |
Family
ID=62951983
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000027WA SG11202000027WA (en) | 2017-07-14 | 2018-07-13 | Improved dual specificity polypeptide molecule |
SG11202000025SA SG11202000025SA (en) | 2017-07-14 | 2018-07-13 | Improved dual specificity polypeptide molecule |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000025SA SG11202000025SA (en) | 2017-07-14 | 2018-07-13 | Improved dual specificity polypeptide molecule |
Country Status (28)
Country | Link |
---|---|
US (7) | US20190016802A1 (en) |
EP (3) | EP3428194B1 (en) |
JP (4) | JP2020530762A (en) |
KR (2) | KR20200026994A (en) |
CN (2) | CN110914308A (en) |
AU (2) | AU2018298884A1 (en) |
BR (2) | BR112020000769A2 (en) |
CA (2) | CA3069842A1 (en) |
CO (2) | CO2020001029A2 (en) |
CR (2) | CR20200014A (en) |
CY (2) | CY1124091T1 (en) |
DK (2) | DK3652215T3 (en) |
ES (2) | ES2871146T3 (en) |
HR (1) | HRP20211744T1 (en) |
HU (2) | HUE054568T2 (en) |
LT (2) | LT3652215T (en) |
MA (1) | MA46299B1 (en) |
MD (2) | MD3652215T2 (en) |
MX (1) | MX2020011744A (en) |
PE (2) | PE20200614A1 (en) |
PL (2) | PL3428194T3 (en) |
PT (2) | PT3428194T (en) |
RS (2) | RS61817B1 (en) |
SG (2) | SG11202000027WA (en) |
SI (2) | SI3428194T1 (en) |
TW (2) | TWI817302B (en) |
WO (2) | WO2019012138A1 (en) |
ZA (1) | ZA202000842B (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20200614A1 (en) * | 2017-07-14 | 2020-03-11 | Immatics Biotechnologies Gmbh | POLYPEPTIDE MOLECULE WITH ENHANCED DUAL SPECIFICITY |
EP3794035A1 (en) | 2018-05-14 | 2021-03-24 | Immunocore Limited | Bifunctional binding polypeptides |
GB201904328D0 (en) | 2019-03-28 | 2019-05-15 | Immunocore Ltd | Specific binding molecules |
EA202193139A1 (en) | 2019-05-27 | 2022-03-01 | Имматикс Юс, Инк. | VIRAL VECTORS AND THEIR APPLICATIONS IN ADOPTIONAL CELL THERAPY |
US20210032370A1 (en) * | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Recruiting agent further binding an mhc molecule |
DE102019121007A1 (en) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigen binding proteins that specifically bind to MAGE-A |
GB201915282D0 (en) | 2019-10-22 | 2019-12-04 | Immunocore Ltd | Specific binding molecules |
WO2021113748A1 (en) * | 2019-12-05 | 2021-06-10 | Arbele Corp. | Composition of triaxial antibodies and method of making and using thereof |
BR112022016909A2 (en) | 2020-02-24 | 2022-12-06 | Immatics Us Inc | METHODS FOR T-CELL EXPANSION FOR THE TREATMENT OF CANCER AND ASSOCIATED METHODS |
DE102020111571A1 (en) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | WPRE MUTANT CONSTRUCTS, COMPOSITIONS, AND RELATED PROCEDURES |
GB202006629D0 (en) | 2020-05-05 | 2020-06-17 | Immunocore Ltd | Specific binding molecules |
GB202010329D0 (en) | 2020-07-06 | 2020-08-19 | Immunocore Ltd | Specific binding molecules |
TW202227616A (en) | 2020-08-21 | 2022-07-16 | 美商英麥提克斯股份有限公司 | Methods for isolating cd8+ selected t cells |
KR20230135589A (en) | 2020-12-31 | 2023-09-25 | 이매틱스 유에스 인코포레이티드 | CD8 polypeptides, compositions and methods of use thereof |
WO2022184805A1 (en) | 2021-03-03 | 2022-09-09 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding sars-cov-2 antigenic peptides in complex with a major histocompatibility complex protein |
CA3217738A1 (en) | 2021-05-05 | 2022-05-04 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
EP4113120A1 (en) | 2021-06-28 | 2023-01-04 | Immatics Biotechnologies GmbH | Method of characterizing the binding characteristics between a peptide of interest and mhc molecules |
US20230024554A1 (en) | 2021-06-28 | 2023-01-26 | Immatics Biotechnologies Gmbh | Method of characterizing the binding characteristics between a peptide of interest and mhc molecules |
CN115724988B (en) * | 2021-08-26 | 2023-11-17 | 瑅安生物医药(杭州)有限公司 | Polypeptide fusion molecule close to natural molecule |
US20230089392A1 (en) | 2021-09-20 | 2023-03-23 | Immatics US, Inc. | Monocyte depletion of t cells populations for t-cell therapy |
US20230190806A1 (en) | 2021-10-06 | 2023-06-22 | Immatics Biotechnologies Gmbh | Methods of treating metastatic lesions and compositions thereof |
US20230192886A1 (en) | 2021-11-08 | 2023-06-22 | Immatics Biotechnologies Gmbh | Adoptive cell therapy combination treatment and compositions thereof |
US20230142468A1 (en) | 2021-11-08 | 2023-05-11 | Immatics US, Inc. | Methods for generating cell spheroids |
EP4448570A1 (en) * | 2021-12-14 | 2024-10-23 | CDR-Life AG | Dual mhc-targeting t cell engager |
KR20240149435A (en) | 2022-02-20 | 2024-10-14 | 이뮤노코어 리미티드 | HIV-specific binding molecule |
WO2023212697A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Membrane-bound il-15, cd8 polypeptides, cells, compositions, and methods of using thereof |
WO2023212691A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | DOMINANT NEGATIVE TGFβ RECEPTOR POLYPEPTIDES, CD8 POLYPEPTIDES, CELLS, COMPOSITIONS, AND METHODS OF USING THEREOF |
WO2023212655A1 (en) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Il-12 polypeptides, il-15 polypeptides, il-18 polypeptides, cd8 polypeptides, compositions, and methods of using thereof |
WO2023209124A1 (en) | 2022-04-29 | 2023-11-02 | Immatics Biotechnologies Gmbh | Mammalian display platform for multispecific antigen binding proteins |
WO2023215825A1 (en) | 2022-05-05 | 2023-11-09 | Immatics US, Inc. | Methods for improving t cell efficacy |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
WO2024033332A1 (en) | 2022-08-08 | 2024-02-15 | Immatics Biotechnologies Gmbh | Guided positional scanning method |
WO2024130179A1 (en) | 2022-12-16 | 2024-06-20 | Repertoire Immune Medicines, Inc. | T cell receptors binding hpv-16 epitopes |
WO2024146951A1 (en) | 2023-01-06 | 2024-07-11 | Immunocore Limited | Binding molecules against a prame peptide-hla complex |
WO2024146936A1 (en) | 2023-01-06 | 2024-07-11 | Immunocore Limited | Binding molecules against a piwil1 peptide-hla complex |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2018248A1 (en) | 1989-06-07 | 1990-12-07 | Clyde W. Shearman | Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
EP0744958B1 (en) | 1994-01-31 | 2003-06-25 | Trustees Of Boston University | Polyclonal antibody libraries |
WO1998050431A2 (en) | 1997-05-02 | 1998-11-12 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
WO2002002781A1 (en) | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Heterodimeric fusion proteins |
AU2002330162B2 (en) | 2001-10-01 | 2008-08-07 | Takeda Pharmaceutical Company Limited | Multi-chain eukaryotic display vectors and uses thereof |
US7569664B2 (en) | 2002-10-09 | 2009-08-04 | Immunocore Limited | Single chain recombinant T cell receptors |
EP1863842A2 (en) | 2005-04-01 | 2007-12-12 | MediGene Ltd. | High affinity hiv t cell receptors |
EP1868650B1 (en) | 2005-04-15 | 2018-10-03 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US10000757B2 (en) | 2005-05-27 | 2018-06-19 | Ospedale San Raffaele S.R.L. | Gene vector |
AT503861B1 (en) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | METHOD FOR MANIPULATING T-CELL RECEPTORS |
US20100105136A1 (en) | 2006-10-09 | 2010-04-29 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
US20110045007A1 (en) | 2007-05-31 | 2011-02-24 | Genmab A/S | Fusion or linked proteins with extended half life |
JP2011525103A (en) | 2008-01-11 | 2011-09-15 | モルフォシス・アー・ゲー | Display vector and method and use thereof |
EP2258719A1 (en) * | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
US8465743B2 (en) | 2009-10-01 | 2013-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
US10464987B2 (en) | 2009-10-06 | 2019-11-05 | Abbvie Inc. | Human single-chain T cell receptors |
US20130129723A1 (en) | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
EA201492253A1 (en) | 2009-12-29 | 2015-06-30 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | CONSTRUCTORS CONNECTING WITH RON AND METHODS OF THEIR USE |
US20120294857A1 (en) | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
AR084053A1 (en) | 2010-11-30 | 2013-04-17 | Chugai Pharmaceutical Co Ltd | THERAPEUTIC AGENT THAT INDUCES CYTOTOXICITY |
SG10201602159VA (en) | 2011-02-11 | 2016-04-28 | Sloan Kettering Inst Cancer | Hla-restricted, peptide-specific antigen binding proteins |
WO2013026837A1 (en) * | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
UY34317A (en) | 2011-09-12 | 2013-02-28 | Genzyme Corp | T cell antireceptor antibody (alpha) / ß |
BR112015011111A2 (en) | 2012-11-30 | 2017-11-14 | Roche Glycart Ag | multifunctional protein and pharmaceutical formulation |
CA2891493C (en) * | 2013-02-26 | 2022-03-15 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
JP2016512421A (en) | 2013-02-26 | 2016-04-28 | ロシュ グリクアート アーゲー | Bispecific T cell activation antigen binding molecule |
RU2721707C2 (en) | 2013-03-14 | 2020-05-21 | Макродженикс, Инк. | Bispecific molecules, immunoreactive with immune effector cells expressing an activating receptor |
CN105980409B (en) | 2013-11-27 | 2023-07-18 | 酵活生物制药有限公司 | Bispecific antigen binding constructs targeting HER2 |
TWI701261B (en) | 2013-12-17 | 2020-08-11 | 美商建南德克公司 | Anti-cd3 antibodies and methods of use |
CA2943786C (en) | 2014-03-25 | 2023-12-12 | Merial, Inc. | Immunological compositions containing attenuated histophilus somni |
CN106795217B (en) | 2014-07-24 | 2021-08-06 | 蓝鸟生物公司 | BCMA chimeric antigen receptors |
EP2985294A1 (en) | 2014-08-14 | 2016-02-17 | Deutsches Krebsforschungszentrum | Recombinant antibody molecule and its use for target cell restricted T cell activation |
WO2016025880A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using gfr alpha-4 chimeric antigen receptor |
EA201791121A1 (en) * | 2014-11-20 | 2018-04-30 | Ф. Хоффманн-Ля Рош Аг | ACTIVATING T-CELL BISPECIFIC ANTIGEN-BINDING MOLECULES AGAINST FOLRI AND CD3 |
GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
GB201423361D0 (en) | 2014-12-30 | 2015-02-11 | Immatics Biotechnologies Gmbh | Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides |
GB201504502D0 (en) | 2015-03-17 | 2015-04-29 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers |
WO2016154585A1 (en) | 2015-03-26 | 2016-09-29 | Charles Sentman | Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using |
GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
GB201507719D0 (en) | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
IL303905A (en) | 2015-05-18 | 2023-08-01 | Tcr2 Therapeutics Inc | Compositions and methods for tcr reprogramming using fusion proteins |
EP3095792A1 (en) * | 2015-05-19 | 2016-11-23 | Klinikum rechts der Isar der Technischen Universität München | T cell receptor with specificity for myeloperoxidase peptide and uses thereof |
GB201510771D0 (en) | 2015-06-19 | 2015-08-05 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer |
GB201511191D0 (en) | 2015-06-25 | 2015-08-12 | Immatics Biotechnologies Gmbh | T-cell epitopes for the immunotherapy of myeloma |
GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
GB201511792D0 (en) | 2015-07-06 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against esopageal cancer and other cancers |
MY189596A (en) | 2015-07-15 | 2022-02-18 | Immatics Biotechnologies Gmbh | A novel peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
GB201513921D0 (en) | 2015-08-05 | 2015-09-23 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers |
GB201515321D0 (en) | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
US10130693B2 (en) | 2015-08-28 | 2018-11-20 | Immatics Biotechnologies Gmbh | Peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
GB201517538D0 (en) | 2015-10-05 | 2015-11-18 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
WO2017059900A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Cell & Gene Therapies Gmbh | Antigen receptors and uses thereof |
MA45004A (en) | 2015-10-09 | 2019-03-27 | Immatics Biotechnologies Gmbh | ANTI-WT1-HLA SPECIFIC ANTIBODIES |
RU2767209C2 (en) * | 2015-10-23 | 2022-03-16 | Еурека Терапьютикс, Инк. | Chimeric antibody/t-cell receptor structures and their applications |
GB201521746D0 (en) | 2015-12-10 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers |
GB201521894D0 (en) | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
GB201522592D0 (en) * | 2015-12-22 | 2016-02-03 | Immunocore Ltd | T cell receptors |
GB201522667D0 (en) | 2015-12-22 | 2016-02-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
GB201602918D0 (en) | 2016-02-19 | 2016-04-06 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers |
GB201603568D0 (en) | 2016-03-01 | 2016-04-13 | Immatics Biotechnologies Gmbh | Efficient treatment options including peptides and combination of peptide and cell based medicaments for use in immunotherapy against urinary bladder cancer |
GB201603987D0 (en) | 2016-03-08 | 2016-04-20 | Immatics Biotechnologies Gmbh | Uterine cancer treatments |
US11034767B2 (en) | 2016-04-15 | 2021-06-15 | Trustees Of Dartmouth College | High affinity B7-H6 antibodies and antibody fragments |
KR102436129B1 (en) | 2016-06-17 | 2022-08-26 | 메디진 이뮤노테라피스 게엠바하 | T cell receptors and uses thereof |
MX2018015937A (en) | 2016-06-27 | 2019-05-02 | Procter & Gamble | Apparatus and method for assessing tooth-sensitivity treatment by oral-care product. |
AU2017306432A1 (en) | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
WO2018026018A1 (en) | 2016-08-05 | 2018-02-08 | 国立大学法人東北大学 | Treatment and diagnosis of cancer or infectious disease using recognition mechanism of t cell receptor |
WO2018050902A2 (en) | 2016-09-15 | 2018-03-22 | Quadrucept Bio Limited | Multimers, tetramers & octamers |
CN106831996B (en) | 2017-03-31 | 2020-05-19 | 北京智仁美博生物科技有限公司 | Bispecific antibodies with CD3E and/or HER2 targeting function and uses thereof |
WO2018220216A1 (en) | 2017-06-01 | 2018-12-06 | Universität Stuttgart | Heterodimerizing ig domains |
PE20200614A1 (en) * | 2017-07-14 | 2020-03-11 | Immatics Biotechnologies Gmbh | POLYPEPTIDE MOLECULE WITH ENHANCED DUAL SPECIFICITY |
WO2019047932A1 (en) | 2017-09-08 | 2019-03-14 | 科济生物医药(上海)有限公司 | Genetically engineered t cell and application thereof |
JPWO2019151392A1 (en) | 2018-01-31 | 2021-02-04 | 国立大学法人東北大学 | Antigen-specific MHC expression regulation method |
EP3794035A1 (en) | 2018-05-14 | 2021-03-24 | Immunocore Limited | Bifunctional binding polypeptides |
EA202091977A1 (en) | 2018-05-28 | 2021-02-09 | Драгонфлай Терапьютикс, Инк. | MULTI-SPECIFIC BINDING PROTEINS THAT BIND CD33, NKG2D AND CD16 AND METHODS OF APPLICATION |
US20220275043A1 (en) | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
WO2020057610A1 (en) | 2018-09-20 | 2020-03-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel bispecific anti-ctla-4/pd-1 polypeptide complexes |
GB201903767D0 (en) | 2019-03-19 | 2019-05-01 | Quadrucept Bio Ltd | Multimers, tetramers & octamers |
GB201906685D0 (en) | 2019-05-13 | 2019-06-26 | Ultrahuman Six Ltd | Activatable protein constructs and uses thereof |
KR20220075210A (en) | 2019-07-15 | 2022-06-07 | 네오진 테라퓨틱스 비.브이. | Methods for isolating the TCR gene |
DE102019121007A1 (en) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigen binding proteins that specifically bind to MAGE-A |
CN114502578A (en) | 2019-09-06 | 2022-05-13 | 伊莱利利公司 | Proteins comprising T-cell receptor constant domains |
EP4034245A1 (en) | 2019-09-25 | 2022-08-03 | Universität Stuttgart | Trivalent binding molecules |
JP2022549351A (en) | 2019-09-27 | 2022-11-24 | アジェナス インコーポレイテッド | heterodimeric protein |
KR20220098379A (en) | 2019-11-15 | 2022-07-12 | 그릿스톤 바이오, 인코포레이티드 | Antigen-binding protein targeting covalent neoantigens |
CN115103852A (en) | 2019-11-18 | 2022-09-23 | 德国生物新技术公司 | PRAME TCR receptor and uses thereof |
JP2023507729A (en) | 2019-12-17 | 2023-02-27 | ザ・ジョンズ・ホプキンス・ユニバーシティー | MANA Bodies Targeting Tumor Antigens and Methods of Use |
CN110964122B (en) | 2019-12-24 | 2022-04-15 | 南京北恒生物科技有限公司 | T cell receptor fusion proteins and uses thereof |
CA3171906A1 (en) | 2020-03-16 | 2021-09-23 | University Of Southern California | Novel antigen binding domains and synthetic antigen receptors incorporating the same |
US20230130925A1 (en) | 2020-03-16 | 2023-04-27 | University Of Southern California | Methods to prevent, ameliorate and treat complications from viral infections |
WO2021222576A1 (en) | 2020-05-01 | 2021-11-04 | A2 Biotherapeutics, Inc. | Pag1 fusion proteins and methods of making and using same |
AU2021289612A1 (en) | 2020-06-10 | 2023-01-19 | The University Of Melbourne | HIV-1 antibodies |
EP4188416A4 (en) | 2020-07-27 | 2024-08-21 | Univ Arizona | Multifunctional immunoglobulin-fold polypeptides from alternative translational initiation and termination |
WO2022076788A1 (en) | 2020-10-09 | 2022-04-14 | Memorial Sloan Kettering Cancer Center | Compositions targeting ndc80/mhc complexes and uses thereof |
WO2022083668A1 (en) | 2020-10-21 | 2022-04-28 | Nanjing Legend Biotech Co., Ltd. | Use of a chimeric co-stimulatory receptor for cell therapy |
KR20230123474A (en) | 2020-12-21 | 2023-08-23 | 자임워크스 비씨 인코포레이티드 | Stabilized TCR constructs and methods of use |
CA3208717A1 (en) | 2021-02-19 | 2022-08-25 | Preet M. Chaudhary | Single-chain and multi-chain synthetic antigen receptors for diverse immune cells |
-
2018
- 2018-07-13 PE PE2020000056A patent/PE20200614A1/en unknown
- 2018-07-13 WO PCT/EP2018/069151 patent/WO2019012138A1/en active Application Filing
- 2018-07-13 EP EP18183508.3A patent/EP3428194B1/en active Active
- 2018-07-13 US US16/035,412 patent/US20190016802A1/en not_active Abandoned
- 2018-07-13 PL PL18183508T patent/PL3428194T3/en unknown
- 2018-07-13 JP JP2020501174A patent/JP2020530762A/en active Pending
- 2018-07-13 EP EP21191794.3A patent/EP3985029A1/en active Pending
- 2018-07-13 MA MA46299A patent/MA46299B1/en unknown
- 2018-07-13 CN CN201880046726.5A patent/CN110914308A/en active Pending
- 2018-07-13 RS RS20210561A patent/RS61817B1/en unknown
- 2018-07-13 ES ES18740829T patent/ES2871146T3/en active Active
- 2018-07-13 PL PL18740829T patent/PL3652215T3/en unknown
- 2018-07-13 HU HUE18740829A patent/HUE054568T2/en unknown
- 2018-07-13 CN CN201880046721.2A patent/CN110914307A/en active Pending
- 2018-07-13 WO PCT/EP2018/069157 patent/WO2019012141A1/en active Application Filing
- 2018-07-13 AU AU2018298884A patent/AU2018298884A1/en active Pending
- 2018-07-13 KR KR1020207004219A patent/KR20200026994A/en not_active Application Discontinuation
- 2018-07-13 US US16/035,420 patent/US20190016803A1/en not_active Abandoned
- 2018-07-13 HR HRP20211744TT patent/HRP20211744T1/en unknown
- 2018-07-13 MD MDE20200533T patent/MD3652215T2/en unknown
- 2018-07-13 AU AU2018298881A patent/AU2018298881A1/en active Pending
- 2018-07-13 LT LTEP18740829.9T patent/LT3652215T/en unknown
- 2018-07-13 CR CR20200014A patent/CR20200014A/en unknown
- 2018-07-13 US US16/035,429 patent/US20190016804A1/en not_active Abandoned
- 2018-07-13 DK DK18740829.9T patent/DK3652215T3/en active
- 2018-07-13 LT LTEP18183508.3T patent/LT3428194T/en unknown
- 2018-07-13 PT PT181835083T patent/PT3428194T/en unknown
- 2018-07-13 HU HUE18183508A patent/HUE057110T2/en unknown
- 2018-07-13 DK DK18183508.3T patent/DK3428194T3/en active
- 2018-07-13 KR KR1020207004221A patent/KR20200026995A/en not_active Application Discontinuation
- 2018-07-13 MD MDE20190844T patent/MD3428194T2/en unknown
- 2018-07-13 RS RS20211381A patent/RS62544B1/en unknown
- 2018-07-13 US US16/035,403 patent/US11905328B2/en active Active
- 2018-07-13 SI SI201830456T patent/SI3428194T1/en unknown
- 2018-07-13 CA CA3069842A patent/CA3069842A1/en active Pending
- 2018-07-13 SI SI201830285T patent/SI3652215T1/en unknown
- 2018-07-13 CA CA3069610A patent/CA3069610A1/en active Pending
- 2018-07-13 PT PT187408299T patent/PT3652215T/en unknown
- 2018-07-13 SG SG11202000027WA patent/SG11202000027WA/en unknown
- 2018-07-13 PE PE2020000058A patent/PE20200615A1/en unknown
- 2018-07-13 CR CR20200013A patent/CR20200013A/en unknown
- 2018-07-13 EP EP18740829.9A patent/EP3652215B1/en active Active
- 2018-07-13 BR BR112020000769-2A patent/BR112020000769A2/en unknown
- 2018-07-13 ES ES18183508T patent/ES2898210T3/en active Active
- 2018-07-13 BR BR112020000762-5A patent/BR112020000762A2/en unknown
- 2018-07-13 SG SG11202000025SA patent/SG11202000025SA/en unknown
- 2018-07-16 TW TW110149543A patent/TWI817302B/en active
- 2018-07-16 TW TW107124492A patent/TWI762677B/en active
- 2018-07-17 JP JP2018134424A patent/JP6784724B2/en active Active
-
2020
- 2020-01-14 MX MX2020011744A patent/MX2020011744A/en unknown
- 2020-01-28 CO CONC2020/0001029A patent/CO2020001029A2/en unknown
- 2020-02-10 ZA ZA2020/00842A patent/ZA202000842B/en unknown
- 2020-02-11 CO CONC2020/0001491A patent/CO2020001491A2/en unknown
-
2021
- 2021-05-06 CY CY20211100387T patent/CY1124091T1/en unknown
- 2021-11-01 CY CY20211100934T patent/CY1124835T1/en unknown
-
2022
- 2022-03-03 US US17/686,358 patent/US20220185888A1/en not_active Abandoned
- 2022-03-12 US US17/693,323 patent/US20220195044A1/en not_active Abandoned
-
2023
- 2023-05-22 JP JP2023083663A patent/JP2023103451A/en active Pending
- 2023-06-08 US US18/331,556 patent/US20230348598A1/en active Pending
- 2023-11-24 JP JP2023198791A patent/JP2024023385A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA202000842B (en) | Improved dual specificity polypeptide molecule | |
IL275298A (en) | Mitochondria-targeting peptides | |
EP3194980A4 (en) | Improved single molecule peptide sequencing | |
GB201719557D0 (en) | Polypeptide | |
HK1254601A1 (en) | Novel peptide | |
PL3661983T3 (en) | Dual catalyst composition | |
GB201508337D0 (en) | Novel peptides | |
EP3302468A4 (en) | Small molecule analogs of the nemo binding peptide | |
SG11202005653RA (en) | Novel peptide | |
IL271404A (en) | Improved protein expression strains | |
EP3377633C0 (en) | Recombinant protein production | |
EP3309169A4 (en) | Antibody binding specifically to isolated vimentin-derived peptide, or binding fragment of the peptide | |
GB201700557D0 (en) | Novel peptides | |
EP3269808A4 (en) | Improved beta-fructofuranosidase | |
GB201506316D0 (en) | Novel peptide | |
ZA202000636B (en) | Improved dual specificity polypeptide molecule | |
PL3710469T3 (en) | Polypeptides with improved arabinose transport specificity | |
GB201721387D0 (en) | Tumstatin assay | |
GB201715378D0 (en) | Peptides | |
GB201715379D0 (en) | Peptides | |
GB201708471D0 (en) | Polypeptide | |
GB201620022D0 (en) | Novel peptide | |
GB201711620D0 (en) | Peptides | |
GB201707837D0 (en) | Peptides | |
GB201506360D0 (en) | Novel peptide |