SG11201907081TA - Process utilizing pulsed energy to heat treat biological tissue - Google Patents

Abstract

EXPOSURE 4 OFF SET 4-- o 0 0 OFF SET 1 , EXPOSURE 3 o o (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT ill~~~~~~~~ 011101VIIIVIIIVIII olo VIII VIII o111110 oimIE (10) International Publication Number WO 2018/169969 Al (51) International Patent Classification: A61N 7/02 (2006.01) (21) International Application Number: PCT/US2018/022201 (22) International Filing Date: 13 March 2018 (13.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15/460,821 16 March 2017 (16.03.2017) US 15/583,096 01 May 2017 (01.05.2017) US 15/629,002 21 June 2017 (21.06.2017) US 15/918,487 12 March 2018 (12.03.2018) US (71) Applicant: OJAI RETINAL TECHNOLOGY, LLC [US/US]; 283 Came Road, Ojai, California 93023 (US). (72) Inventors: LUTTRULL, Jeffrey K.; 283 Came Road, Ojai, California 93023 (US). CHANG, David B.; 14212 Livingston, Tustin, California 92780 (US). MARGOLIS, Benjamin W. L.; 2879 MacArthur Blvd, Oakland, Califor- nia 94602 (US). (74) Agent: KELLEY, Scott W.; Kelly & Kelley, LLP, 6320 Canoga Avenue, Suite 1650, Woodland Hills, California 91367 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: PROCESS UTILIZING PULSED ENERGY TO HEAT TREAT BIOLOGICAL TISSUE (57) : A process for heat treating biological tissue includes re- peatedly applying a pulsed energy to a target tissue over a period of time • so as to controllably raise a temperature of the target tissue to create a • therapeutic effect to the target tissue without destroying or permanently damaging the target tissue. After the first treatment is concluded the ap- plication of the pulsed energy to the target tissue is halted for an inter- EXPOSURE I OFF SET EXPOSURE 2 0 W O 20 18/ 169969 Al a • OFF SET FIG. 24 val of time. Within a single treatment session a second treatment is per- formed on the target tissue after the interval of time by repeatedly reap- plying the pulsed energy to the target tissue so as to controllably raise the temperature of the target tissue to therapeutically treat the target tissue without destroying or permanently damaging the target tissue. [Continued on next page] WO 2018/169969 Al D ill Published: — with international search report (Art. 21(3))