SG11201901941YA - High purity rna compositions and methods for preparation thereof - Google Patents
High purity rna compositions and methods for preparation thereofInfo
- Publication number
- SG11201901941YA SG11201901941YA SG11201901941YA SG11201901941YA SG11201901941YA SG 11201901941Y A SG11201901941Y A SG 11201901941YA SG 11201901941Y A SG11201901941Y A SG 11201901941YA SG 11201901941Y A SG11201901941Y A SG 11201901941YA SG 11201901941Y A SG11201901941Y A SG 11201901941YA
- Authority
- SG
- Singapore
- Prior art keywords
- ppp
- international
- street
- rna
- rna compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 8
- 230000001225 therapeutic effect Effects 0.000 abstract 4
- 108020004414 DNA Proteins 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 1
- 102000053602 DNA Human genes 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111 111111111 01111 Organization International Bureau (43) International Publication Date . . .., . .. (10) International Publication Number WO 2018/053209 Al 22 March 2018 (22.03.2018) WIP0 I PCT (51) International Patent Classification: MA 02451 (US). BUTORA, Gabor; 200 Technology Cl 2N 15/10 (2006.01) Square, Cambridge, MA 02139 (US). (21) International Application Number: (74) Agent: LOCKHART, Helen C.; Wolf, Greenfield & PCT/US2017/051674 Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (22) International Filing Date: (US). 14 September 2017 (14.09.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/394,711 14 September 2016 (14.09.2016) US HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (71) Applicant: MODERNATX, INC. [US/US]; 320 Bent MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, Street, Cambridge, MA 02141 (US). OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (72) Inventors: HOGE, Stephen; 320 Bent Street, Cambridge, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. MA 02141 (US). ISSA, William; 95 Kimball Road, Ded- ham, MA 02026 (US). MIRACCO, Edward J.; 6 Frost (84) Designated States (unless otherwise indicated, for every Street, Arlington, MA 02474 (US). NELSON, Jennifer; kind of regional protection available): ARIPO (BW, GH, — 465 Washington Street, #2, Brookline, MA 02246 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, RABIDEAU, Amy, E.; 121 Pond Street, Unit 1, Waltham, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = = (54) Title: HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF = = Figure 40 = = = = DNA plasmid = NTPs = = Linearized dsDNA template 2+ = Mg — = = = 5 'PPP - ,-- -\",, .........vappp 5' = 5 '13PP 5 'PPP -A ino NN... 3' Full-length product Run-on transcripts Reverse Abortive/ truncated transcripts 1 complement ,.._ impurities , = 1€ 5'PPP ;€€€€€€€ 5 'P P :.1 5'PPP EM 113 A ioo N N... 3' wituunsww-ppp 5' samonsitutu-ppp 5' Ennwansmeam-ppp 5' meWmammtata-ppp 5' ireamfamaros-PPP 5' CD . IMIH liJilli © ei PP P 5' Kw:mamma-pp p 5' M 0 i n (57) : The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are ---- particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved *1: processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and 1-1 © purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof. ei O [Continued on next page] WO 2018/053209 Al MIDEDIMOMOIDEIREEMONIMEINEMECIONVOIS TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394711P | 2016-09-14 | 2016-09-14 | |
| PCT/US2017/051674 WO2018053209A1 (en) | 2016-09-14 | 2017-09-14 | High purity rna compositions and methods for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201901941YA true SG11201901941YA (en) | 2019-04-29 |
Family
ID=60043282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201901941YA SG11201901941YA (en) | 2016-09-14 | 2017-09-14 | High purity rna compositions and methods for preparation thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US11202793B2 (en) |
| EP (2) | EP4166666A1 (en) |
| JP (2) | JP6983455B2 (en) |
| CN (2) | CN109937253B (en) |
| AU (2) | AU2017326423B2 (en) |
| CA (1) | CA3036831A1 (en) |
| ES (1) | ES2928475T3 (en) |
| MA (1) | MA46240A (en) |
| MX (1) | MX2019002904A (en) |
| SG (1) | SG11201901941YA (en) |
| WO (1) | WO2018053209A1 (en) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5498588A (en) | 1994-09-09 | 1996-03-12 | The Standard Oil Company | Surface modification and promotion of vanadium antimony oxide catalysts |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| JP6881813B2 (en) | 2014-04-23 | 2021-06-02 | モデルナティーエックス， インコーポレイテッド | Nucleic acid vaccine |
| US11007260B2 (en) | 2015-07-21 | 2021-05-18 | Modernatx, Inc. | Infectious disease vaccines |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| US11564893B2 (en) | 2015-08-17 | 2023-01-31 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| EP3364982A4 (en) | 2015-10-22 | 2019-04-17 | ModernaTX, Inc. | Sexually transmitted disease vaccines |
| EP3364981A4 (en) | 2015-10-22 | 2019-08-07 | ModernaTX, Inc. | Human cytomegalovirus vaccine |
| CN108472309A (en) | 2015-10-22 | 2018-08-31 | 摩登纳特斯有限公司 | For varicellazoster virus（VZV）Nucleic acid vaccine |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| WO2017070626A2 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Respiratory virus vaccines |
| MD3386484T2 (en) | 2015-12-10 | 2022-11-30 | Modernatx Inc | Compositions and methods for delivery of therapeutic agents |
| US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
| KR20230074598A (en) | 2016-05-18 | 2023-05-30 | 모더나티엑스, 인크. | Polynucleotides encoding relaxin |
| EP3458107B1 (en) | 2016-05-18 | 2024-03-13 | ModernaTX, Inc. | Polynucleotides encoding jagged1 for the treatment of alagille syndrome |
| EP4166666A1 (en) | 2016-09-14 | 2023-04-19 | ModernaTX, Inc. | High purity rna compositions and methods for preparation thereof |
| EP3528821A4 (en) | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | Human cytomegalovirus vaccine |
| WO2018089851A2 (en) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Influenza vaccine |
| WO2018107088A2 (en) | 2016-12-08 | 2018-06-14 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
| EP3582790A4 (en) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | High potency immunogenic compositions |
| WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| WO2018170256A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Herpes simplex virus vaccine |
| MA52262A (en) | 2017-03-15 | 2020-02-19 | Modernatx Inc | BROAD SPECTRUM VACCINE AGAINST THE INFLUENZA VIRUS |
| US11464848B2 (en) | 2017-03-15 | 2022-10-11 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| EP3595676A4 (en) | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| WO2018187590A1 (en) | 2017-04-05 | 2018-10-11 | Modernatx, Inc. | Reduction or elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | Rna formulations |
| EP4397757A3 (en) | 2017-08-18 | 2024-10-23 | ModernaTX, Inc. | Rna polymerase variants |
| US11866696B2 (en) | 2017-08-18 | 2024-01-09 | Modernatx, Inc. | Analytical HPLC methods |
| MA49922A (en) | 2017-08-18 | 2021-06-02 | Modernatx Inc | PROCESSES FOR HPLC ANALYSIS |
| AU2018326799A1 (en) | 2017-08-31 | 2020-02-27 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| MA50253A (en) | 2017-09-14 | 2020-07-22 | Modernatx Inc | ZIKA VIRUS RNA VACCINES |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| CN113271926A (en) | 2018-09-20 | 2021-08-17 | 摩登纳特斯有限公司 | Preparation of lipid nanoparticles and methods of administration thereof |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| US11851694B1 (en) | 2019-02-20 | 2023-12-26 | Modernatx, Inc. | High fidelity in vitro transcription |
| KR20210142636A (en) | 2019-02-20 | 2021-11-25 | 모더나티엑스, 인크. | RNA polymerase variants for co-transcriptional capping |
| MX2021011031A (en) * | 2019-03-11 | 2021-12-10 | Modernatx Inc | Fed-batch in vitro transcription process. |
| MA55321A (en) | 2019-03-15 | 2022-01-19 | Modernatx Inc | RNA VACCINES AGAINST HIV |
| MX2022001664A (en) | 2019-08-09 | 2022-07-19 | Nutcracker Therapeutics Inc | Microfluidic apparatus and methods of use thereof. |
| CN110812366B (en) * | 2019-11-18 | 2023-11-17 | 珠海丽凡达生物技术有限公司 | mRNA medicine for hormone supplement and preparation method thereof |
| KR20220133224A (en) | 2020-01-28 | 2022-10-04 | 모더나티엑스, 인크. | coronavirus RNA vaccine |
| US20240277830A1 (en) | 2020-02-04 | 2024-08-22 | CureVac SE | Coronavirus vaccine |
| CN115551545A (en) | 2020-02-07 | 2022-12-30 | 摩登纳特斯有限公司 | SARS-COV-2 mRNA structure domain vaccine |
| CN115811986A (en) | 2020-04-22 | 2023-03-17 | 生物技术欧洲股份公司 | Coronavirus vaccine |
| WO2021222304A1 (en) | 2020-04-27 | 2021-11-04 | Modernatx, Inc. | Sars-cov-2 rna vaccines |
| WO2021231929A1 (en) * | 2020-05-15 | 2021-11-18 | Modernatx, Inc. | Rna formulations for high volume distribution |
| WO2021159130A2 (en) | 2020-05-15 | 2021-08-12 | Modernatx, Inc. | Coronavirus rna vaccines and methods of use |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| US20230355743A1 (en) | 2020-09-25 | 2023-11-09 | Modernatx, Inc. | Multi-proline-substituted coronavirus spike protein vaccines |
| US20220136022A1 (en) * | 2020-10-15 | 2022-05-05 | Translate Bio, Inc. | Large Scale Synthesis of Messenger RNA |
| AU2021405281A1 (en) | 2020-12-22 | 2023-07-06 | Glaxosmithkline Biologicals Sa | Rna vaccine against sars-cov-2 variants |
| WO2022150717A1 (en) | 2021-01-11 | 2022-07-14 | Modernatx, Inc. | Seasonal rna influenza virus vaccines |
| JP2024503698A (en) | 2021-01-15 | 2024-01-26 | モデルナティエックス インコーポレイテッド | Mutant strain-based coronavirus vaccine |
| CA3208303A1 (en) | 2021-01-15 | 2022-07-21 | Modernatx, Inc. | Variant strain-based coronavirus vaccines |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| US20240299531A1 (en) | 2021-03-15 | 2024-09-12 | Moderna TX, Inc | Therapeutic use of sars-cov-2 mrna domain vaccines |
| WO2022245888A1 (en) | 2021-05-19 | 2022-11-24 | Modernatx, Inc. | Seasonal flu rna vaccines and methods of use |
| AU2022282559A1 (en) * | 2021-05-26 | 2024-01-04 | Etherna Immunotherapies Nv | Method to reduce double stranded rna by-product formation |
| KR20240021235A (en) * | 2021-06-14 | 2024-02-16 | 2세븐티 바이오, 인코포레이티드 | Single-stranded RNA purification method |
| US20240218353A1 (en) | 2021-06-17 | 2024-07-04 | Modernatx, Inc. | Alternative rna purification strategies |
| EP4396364A1 (en) * | 2021-08-31 | 2024-07-10 | GlaxoSmithKline Biologicals S.A. | Ivt rna manufacturing process |
| EP4419081A1 (en) | 2021-10-22 | 2024-08-28 | Sail Biomedicines, Inc. | Mrna vaccine composition |
| WO2023092069A1 (en) | 2021-11-18 | 2023-05-25 | Modernatx, Inc. | Sars-cov-2 mrna domain vaccines and methods of use |
| KR20240107356A (en) | 2021-11-23 | 2024-07-09 | 세일 바이오메디슨스, 인크. | Bacteria-derived lipid compositions and uses thereof |
| EP4444345A2 (en) | 2021-12-08 | 2024-10-16 | ModernaTX, Inc. | Herpes simplex virus mrna vaccines |
| JPWO2023112886A1 (en) * | 2021-12-16 | 2023-06-22 | ||
| WO2023122080A1 (en) | 2021-12-20 | 2023-06-29 | Senda Biosciences, Inc. | Compositions comprising mrna and lipid reconstructed plant messenger packs |
| WO2023137149A1 (en) * | 2022-01-14 | 2023-07-20 | Modernatx, Inc. | In vitro transcription dna purification and recycling |
| WO2023196914A1 (en) | 2022-04-08 | 2023-10-12 | Modernatx, Inc. | Influenza nucleic acid compositions and uses thereof |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| WO2024015890A1 (en) | 2022-07-13 | 2024-01-18 | Modernatx, Inc. | Norovirus mrna vaccines |
| WO2024020194A1 (en) * | 2022-07-22 | 2024-01-25 | Modernatx, Inc. | Compositions and methods for detecting dsrna |
| WO2024050483A1 (en) | 2022-08-31 | 2024-03-07 | Modernatx, Inc. | Variant strain-based coronavirus vaccines and uses thereof |
| WO2024055941A1 (en) * | 2022-09-13 | 2024-03-21 | Suzhou Abogen Biosciences Co., Ltd. | One-step method for synthesis of circular rna |
| WO2024102434A1 (en) | 2022-11-10 | 2024-05-16 | Senda Biosciences, Inc. | Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs |
| WO2024153794A1 (en) | 2023-01-20 | 2024-07-25 | Astrazeneca Ab | Vaccine |
| US20240277834A1 (en) | 2023-01-20 | 2024-08-22 | Astrazeneca Ab | Nucleic acid molecules |
| WO2024159172A1 (en) | 2023-01-27 | 2024-08-02 | Senda Biosciences, Inc. | A modified lipid composition and uses thereof |
| WO2024163465A1 (en) | 2023-01-30 | 2024-08-08 | Modernatx, Inc. | Epstein-barr virus mrna vaccines |
| WO2024191860A2 (en) | 2023-03-10 | 2024-09-19 | Modernatx, Inc. | Nucleic acid influenza vaccines and respiratory virus combination vaccines |
| WO2024206835A1 (en) | 2023-03-30 | 2024-10-03 | Modernatx, Inc. | Circular mrna and production thereof |
| WO2024215721A1 (en) | 2023-04-10 | 2024-10-17 | Modernatx, Inc. | Lyme disease vaccines |
| WO2024220712A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Vaccine compositions |
| CN116606867B (en) * | 2023-04-28 | 2024-01-26 | 北京启辰生生物科技有限公司 | Preparation method and application for improving mRNA integrity of novel crown full-length S protein |
Family Cites Families (148)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100024A (en) | 1991-02-08 | 2000-08-08 | Promega Corporation | Methods and compositions for nucleic acid detection by target extension and probe amplification |
| US5298422A (en) | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
| US5256555A (en) | 1991-12-20 | 1993-10-26 | Ambion, Inc. | Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US6096503A (en) | 1993-11-12 | 2000-08-01 | The Scripps Research Institute | Method for simultaneous identification of differentially expresses mRNAs and measurement of relative concentrations |
| FR2733762B1 (en) | 1995-05-02 | 1997-08-01 | Genset Sa | METHOD FOR THE SPECIFIC COUPLING OF THE HAIR OF THE 5 'END OF A RNAM FRAGMENT AND PREPARATION OF RNAM AND COMPLETE DNA |
| US6251665B1 (en) | 1997-02-07 | 2001-06-26 | Cem Cezayirli | Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom |
| AU7863200A (en) | 1999-10-06 | 2001-05-10 | Quark Biotech, Inc. | Method for enrichment of natural antisense messenger rna |
| WO2002044196A1 (en) * | 2000-11-28 | 2002-06-06 | University Of Massachusetts | Methods and reagents for introducing a sulfhydryl group into the 5'-terminus of rna |
| US20030154032A1 (en) | 2000-12-15 | 2003-08-14 | Pittman Debra D. | Methods and compositions for diagnosing and treating rheumatoid arthritis |
| US8426194B2 (en) | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| GB0316089D0 (en) | 2003-07-09 | 2003-08-13 | Xo Bioscience Ltd | Differentiation method |
| EP2311994A1 (en) * | 2003-08-01 | 2011-04-20 | Life Technologies Corporation | Compositions and methods for preparing short RNA molecules and other nucleic acids |
| US20140142290A1 (en) | 2003-08-01 | 2014-05-22 | Life Technologies Corporation | Compositions and methods for preparing short rna molecules and other nucleicacids |
| US20050287539A1 (en) * | 2004-06-29 | 2005-12-29 | Emmanuel Labourier | Methods and compositions for preparing capped RNA |
| WO2007014363A2 (en) | 2005-07-27 | 2007-02-01 | Genentech, Inc. | Vectors for inducible expression of hairpin rna and use thereof |
| WO2007024708A2 (en) | 2005-08-23 | 2007-03-01 | The Trustees Of The University Of Pennsylvania | Rna containing modified nucleosides and methods of use thereof |
| US9012219B2 (en) * | 2005-08-23 | 2015-04-21 | The Trustees Of The University Of Pennsylvania | RNA preparations comprising purified modified RNA for reprogramming cells |
| WO2007120863A2 (en) | 2006-04-14 | 2007-10-25 | Epicentre Technologies | Kits and methods for generating 5' capped rna |
| CN101611145B (en) | 2006-12-21 | 2013-08-14 | 诺维信股份有限公司 | Modified messenger RNA stabilizing sequences for expressing genes in bacterial cells |
| DE102006061015A1 (en) | 2006-12-22 | 2008-06-26 | Curevac Gmbh | Process for the purification of RNA on a preparative scale by HPLC |
| WO2009046738A1 (en) | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating lung cancer, particularly of non-small lung cancers (nsclc) |
| KR102171849B1 (en) | 2009-12-07 | 2020-10-30 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Rna preparations comprising purified modified rna for reprogramming cells |
| US8802863B2 (en) | 2010-05-24 | 2014-08-12 | Sirna Therapeutics, Inc. | Amino alcohol cationic lipids for oligonucleotide delivery |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CN103119177A (en) * | 2010-09-21 | 2013-05-22 | 里博克斯艾克斯有限公司 | Microwave-driven rna polymerization by rna polymerases of caliciviruses |
| PT3590949T (en) | 2010-10-01 | 2022-08-02 | Modernatx Inc | Ribonucleic acids containing n1-methyl-pseudouracils and uses thereof |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US20140206752A1 (en) | 2011-05-17 | 2014-07-24 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof for non-human vertebrates |
| EP2755693A4 (en) | 2011-09-12 | 2015-05-20 | Moderna Therapeutics Inc | Engineered nucleic acids and methods of use thereof |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2791364A4 (en) | 2011-12-14 | 2015-11-11 | Moderna Therapeutics Inc | Methods of responding to a biothreat |
| RS63244B1 (en) | 2011-12-16 | 2022-06-30 | Modernatx Inc | Modified mrna compositions |
| EP2793906A4 (en) | 2011-12-21 | 2016-01-13 | Moderna Therapeutics Inc | Methods of increasing the viability or longevity of an organ or organ explant |
| US10201620B2 (en) * | 2011-12-30 | 2019-02-12 | Cellscript, Llc | Making and using in vitro-synthesized ssRNA for introducing into mammalian cells to induce a biological or biochemical effect |
| US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9512456B2 (en) | 2012-08-14 | 2016-12-06 | Modernatx, Inc. | Enzymes and polymerases for the synthesis of RNA |
| US20150307542A1 (en) | 2012-10-03 | 2015-10-29 | Moderna Therapeutics, Inc. | Modified nucleic acid molecules and uses thereof |
| RS63237B1 (en) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminally modified rna |
| WO2014093574A1 (en) | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Modified polynucleotides for altering cell phenotype |
| WO2014160243A1 (en) | 2013-03-14 | 2014-10-02 | The Trustees Of The University Of Pennsylvania | Purification and purity assessment of rna molecules synthesized with modified nucleosides |
| EP2970955B1 (en) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Methods for purification of messenger rna |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2014144039A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Characterization of mrna molecules |
| SI2970948T1 (en) | 2013-03-15 | 2019-04-30 | Glaxosmithkline Biologicals Sa | Rna purification methods |
| US11377470B2 (en) | 2013-03-15 | 2022-07-05 | Modernatx, Inc. | Ribonucleic acid purification |
| WO2014144767A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Ion exchange purification of mrna |
| US20160017313A1 (en) | 2013-03-15 | 2016-01-21 | Moderna Therapeutics, Inc. | Analysis of mrna heterogeneity and stability |
| WO2014152030A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Removal of dna fragments in mrna production process |
| EP3578663A1 (en) | 2013-03-15 | 2019-12-11 | ModernaTX, Inc. | Manufacturing methods for production of rna transcripts |
| EP3052511A4 (en) | 2013-10-02 | 2017-05-31 | Moderna Therapeutics, Inc. | Polynucleotide molecules and uses thereof |
| CA2927393A1 (en) | 2013-10-18 | 2015-04-23 | Moderna Therapeutics, Inc. | Compositions and methods for tolerizing cellular systems |
| JP6881813B2 (en) | 2014-04-23 | 2021-06-02 | モデルナティーエックス， インコーポレイテッド | Nucleic acid vaccine |
| BR112016026980B1 (en) * | 2014-06-10 | 2022-05-03 | Curevac Real Estate Gmbh | Method for synthesizing an RNA molecule of a given sequence |
| US10286086B2 (en) | 2014-06-19 | 2019-05-14 | Modernatx, Inc. | Alternative nucleic acid molecules and uses thereof |
| CA2955250A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| JP2017523777A (en) | 2014-07-17 | 2017-08-24 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | Polynucleotide end modification |
| US20180000953A1 (en) | 2015-01-21 | 2018-01-04 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| WO2016164762A1 (en) | 2015-04-08 | 2016-10-13 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor egf-a and intracellular domain mutants and methods of using the same |
| EP3307305A4 (en) | 2015-06-10 | 2019-05-22 | Modernatx, Inc. | Targeted adaptive vaccines |
| WO2017015457A1 (en) | 2015-07-21 | 2017-01-26 | Modernatx, Inc. | Ebola vaccine |
| US11007260B2 (en) | 2015-07-21 | 2021-05-18 | Modernatx, Inc. | Infectious disease vaccines |
| WO2017019935A1 (en) | 2015-07-30 | 2017-02-02 | Modernatx, Inc. | Multimeric mrna |
| EP3328394A4 (en) | 2015-07-30 | 2019-03-13 | ModernaTX, Inc. | Concatemeric peptide epitope rnas |
| US11564893B2 (en) | 2015-08-17 | 2023-01-31 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| WO2017031241A1 (en) | 2015-08-17 | 2017-02-23 | Modernatx, Inc. | Rna mapping/fingerprinting |
| HUE057613T2 (en) | 2015-09-17 | 2022-05-28 | Modernatx Inc | Compounds and compositions for intracellular delivery of therapeutic agents |
| JP6990176B2 (en) | 2015-10-05 | 2022-02-03 | モデルナティエックス インコーポレイテッド | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| WO2017066789A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Mrna cap analogs with modified sugar |
| EP3364981A4 (en) | 2015-10-22 | 2019-08-07 | ModernaTX, Inc. | Human cytomegalovirus vaccine |
| SG11201803365RA (en) | 2015-10-22 | 2018-05-30 | Modernatx Inc | Herpes simplex virus vaccine |
| CN108472309A (en) | 2015-10-22 | 2018-08-31 | 摩登纳特斯有限公司 | For varicellazoster virus（VZV）Nucleic acid vaccine |
| CN108472354A (en) | 2015-10-22 | 2018-08-31 | 摩登纳特斯有限公司 | Respiratory syncytial virus vaccines |
| EP3364982A4 (en) | 2015-10-22 | 2019-04-17 | ModernaTX, Inc. | Sexually transmitted disease vaccines |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| WO2017070626A2 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Respiratory virus vaccines |
| MA46023A (en) | 2015-10-22 | 2019-07-03 | Modernatx Inc | BROAD SPECTRUM INFLUENZA VACCINE |
| US20180318409A1 (en) | 2015-10-22 | 2018-11-08 | Modernatx, Inc. | Cancer vaccines |
| MD3386484T2 (en) | 2015-12-10 | 2022-11-30 | Modernatx Inc | Compositions and methods for delivery of therapeutic agents |
| AU2016369612B2 (en) | 2015-12-17 | 2023-06-01 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-CoA mutase |
| US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
| EP3405579A1 (en) | 2016-01-22 | 2018-11-28 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
| MA45032A (en) | 2016-05-18 | 2019-03-27 | Fundacion Para La Investig Medica Aplicada | POLYNUCLEOTIDES CODING FOR PORPHOBILINOGEN DESAMINASE FOR THE TREATMENT OF ACUTE INTERMITTEN PORPHYRIA |
| AU2017268399B2 (en) | 2016-05-18 | 2023-01-12 | Modernatx, Inc. | mRNA combination therapy for the treatment of cancer |
| WO2017201317A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polyribonucleotides containing reduced uracil content and uses thereof |
| WO2017201333A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding lipoprotein lipase for the treatment of hyperlipidemia |
| EP3458107B1 (en) | 2016-05-18 | 2024-03-13 | ModernaTX, Inc. | Polynucleotides encoding jagged1 for the treatment of alagille syndrome |
| US11001861B2 (en) | 2016-05-18 | 2021-05-11 | Modernatx, Inc. | Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1 |
| WO2017201349A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding citrin for the treatment of citrullinemia type 2 |
| WO2017201332A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding acyl-coa dehydrogenase, very long-chain for the treatment of very long-chain acyl-coa dehydrogenase deficiency |
| MA45053A (en) | 2016-05-18 | 2019-03-27 | Modernatx Inc | POLYNUCLEOTIDES CODING FOR A CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS |
| KR20230074598A (en) | 2016-05-18 | 2023-05-30 | 모더나티엑스, 인크. | Polynucleotides encoding relaxin |
| AU2017266932B2 (en) | 2016-05-18 | 2023-04-20 | Modernatx, Inc. | Polynucleotides encoding alpha-galactosidase A for the treatment of Fabry disease |
| EP3468537A1 (en) | 2016-06-14 | 2019-04-17 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| EP4166666A1 (en) * | 2016-09-14 | 2023-04-19 | ModernaTX, Inc. | High purity rna compositions and methods for preparation thereof |
| EP3528821A4 (en) | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | Human cytomegalovirus vaccine |
| WO2018081459A1 (en) | 2016-10-26 | 2018-05-03 | Modernatx, Inc. | Messenger ribonucleic acids for enhancing immune responses and methods of use thereof |
| MA46643A (en) | 2016-10-26 | 2019-09-04 | Modernatx Inc | METHODS AND COMPOSITIONS FOR RNA MAPPING |
| EP3538067A1 (en) | 2016-11-08 | 2019-09-18 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| WO2018089851A2 (en) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Influenza vaccine |
| WO2018107088A2 (en) | 2016-12-08 | 2018-06-14 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
| US20180243225A1 (en) | 2017-01-25 | 2018-08-30 | Modernatx, Inc. | Ebola/marburg vaccines |
| US20200032274A1 (en) | 2017-02-01 | 2020-01-30 | Moderna TX, Inc. | Polynucleotide secondary structure |
| CA3051252A1 (en) | 2017-02-01 | 2018-08-09 | Modernatx, Inc. | Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides |
| CN110505877A (en) | 2017-02-01 | 2019-11-26 | 摩登纳特斯有限公司 | RNA cancer vaccine |
| EP3582790A4 (en) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | High potency immunogenic compositions |
| US20200368162A1 (en) | 2017-02-24 | 2020-11-26 | Modernatx, Inc. | Nucleic Acid-Based Therapy of Muscular Dystrophies |
| US11464848B2 (en) | 2017-03-15 | 2022-10-11 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| PT3596041T (en) | 2017-03-15 | 2023-02-28 | Modernatx Inc | Compounds and compositions for intracellular delivery of therapeutic agents |
| MA52262A (en) | 2017-03-15 | 2020-02-19 | Modernatx Inc | BROAD SPECTRUM VACCINE AGAINST THE INFLUENZA VIRUS |
| WO2018170256A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Herpes simplex virus vaccine |
| WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| EP3595676A4 (en) | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| US20200038499A1 (en) | 2017-03-22 | 2020-02-06 | Modernatx, Inc. | Rna bacterial vaccines |
| WO2018187590A1 (en) | 2017-04-05 | 2018-10-11 | Modernatx, Inc. | Reduction or elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| MA49463A (en) | 2017-04-26 | 2021-05-05 | Modernatx Inc | HERPES SIMPLEX VACCINE |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | Rna formulations |
| WO2018232355A1 (en) | 2017-06-15 | 2018-12-20 | Modernatx, Inc. | Rna antibodies |
| US11866696B2 (en) | 2017-08-18 | 2024-01-09 | Modernatx, Inc. | Analytical HPLC methods |
| WO2019036670A2 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | Efficacious mrna vaccines |
| EP4397757A3 (en) | 2017-08-18 | 2024-10-23 | ModernaTX, Inc. | Rna polymerase variants |
| MA49922A (en) | 2017-08-18 | 2021-06-02 | Modernatx Inc | PROCESSES FOR HPLC ANALYSIS |
| MA50253A (en) | 2017-09-14 | 2020-07-22 | Modernatx Inc | ZIKA VIRUS RNA VACCINES |
| US20190192646A1 (en) | 2017-11-03 | 2019-06-27 | Modernatx, Inc. | Salmonella vaccines |
| JP2021504445A (en) | 2017-11-21 | 2021-02-15 | モデルナティーエックス， インコーポレイテッド | Epstein-Barr virus vaccine |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| KR20210038886A (en) | 2018-06-27 | 2021-04-08 | 모더나티엑스, 인크. | Personalized cancer vaccine epitope selection |
| JP2022500443A (en) | 2018-09-13 | 2022-01-04 | モデルナティーエックス， インコーポレイテッド | Modified mRNA for treating progressive familial intrahepatic cholestasis disorder |
| CA3113025A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| JP7410135B2 (en) | 2018-09-19 | 2024-01-09 | モデルナティエックス インコーポレイテッド | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2020061295A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
| EP3876947A4 (en) | 2018-11-07 | 2022-08-31 | ModernaTX, Inc. | Rna cancer vaccines |
| KR20210142636A (en) | 2019-02-20 | 2021-11-25 | 모더나티엑스, 인크. | RNA polymerase variants for co-transcriptional capping |
| MX2021011031A (en) | 2019-03-11 | 2021-12-10 | Modernatx Inc | Fed-batch in vitro transcription process. |
| MA55321A (en) | 2019-03-15 | 2022-01-19 | Modernatx Inc | RNA VACCINES AGAINST HIV |
| JP2022535006A (en) | 2019-05-31 | 2022-08-04 | モデルナティエックス インコーポレイテッド | Proliferating T cell assay |
| US20220348900A1 (en) | 2019-08-14 | 2022-11-03 | Modernatx, Inc. | Processes for purifying downstream products of in vitro transcription |
| CA3154082A1 (en) | 2019-09-11 | 2021-03-18 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| US20220349006A1 (en) | 2019-09-19 | 2022-11-03 | Moderna TX, Inc. | Cap guides and methods of use thereof for rna mapping |
| WO2021142306A1 (en) | 2020-01-10 | 2021-07-15 | Modernatx, Inc. | Variational autoencoder for biological sequence generation |
| US20210228707A1 (en) | 2020-01-28 | 2021-07-29 | Modernatx, Inc. | Coronavirus rna vaccines |
| KR20220133911A (en) | 2020-01-30 | 2022-10-05 | 모더나티엑스, 인크. | Respiratory Virus Immunization Composition |
| CN115551545A (en) | 2020-02-07 | 2022-12-30 | 摩登纳特斯有限公司 | SARS-COV-2 mRNA structure domain vaccine |
| WO2021159130A2 (en) | 2020-05-15 | 2021-08-12 | Modernatx, Inc. | Coronavirus rna vaccines and methods of use |
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