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SG11201810352XA - New antibacterial compounds - Google Patents

New antibacterial compounds

Info

Publication number
SG11201810352XA
SG11201810352XA SG11201810352XA SG11201810352XA SG11201810352XA SG 11201810352X A SG11201810352X A SG 11201810352XA SG 11201810352X A SG11201810352X A SG 11201810352XA SG 11201810352X A SG11201810352X A SG 11201810352XA SG 11201810352X A SG11201810352X A SG 11201810352XA
Authority
SG
Singapore
Prior art keywords
international
roma
co7d
pct
antibacterial compounds
Prior art date
Application number
SG11201810352XA
Inventor
Rosella Ombrato
Gabriele Magaro'
Barbara Garofalo
Guido Furlotti
Giorgina Mangano
De Joannon Alessandra Capezzone
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of SG11201810352XA publication Critical patent/SG11201810352XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 0 11111110111101110111111110101111100111111111110101111111111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/211759 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: CO7D 491/04 (2006.01) CO7D 493/04 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). CO7D 471/04 (2006.01) A61K 31/4985 (2006.01) C07D 401/14 (2006.01) A61K 31/436 (2006.01) Published: C07D 498/04 (2006.01) A61P 31/04 (2006.01) — with international search report (Art. 21(3)) CO7D 513/04 (2006.01) (21) International Application Number: PCT/EP2017/063600 (22) International Filing Date: 05 June 2017 (05.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16173550.1 08 June 2016 (08.06.2016) EP (71) Applicant: AZIENDE CHIMICHE RIUNITE AN- GELINI FRANCESCO A.C.R.A.F. S.P.A. [IT/IT]; Viale Amelia, 70, 00181 ROMA (IT). (72) Inventors: OMBRATO, Rosella; Via Abigaille Zanetta, 68, 00143 ROMA (IT). MAGARO', Gabriele; Via IV No- = - vembre, 18, 00072 Ariccia (RM) (IT). GAROFALO, Bar- _ bara; Via Latina, 49, 00179 ROMA (IT). FURLOTTI, Guido; Via Ferdinando Palasciano, 96, 00151 ROMA (IT). =_ = MANGANO, Giorgina; Via Gran Paradiso, 84, 00139 RO- MA (IT). CAPEZZONE DE JOANNON, Alessandra; Pi- azza dei Vespri Siciliani, 7, 00161 ROMA (IT). Agent: COLOMBO, Stefano, Paolo et al.; MARCHI & = (74) _ — PARTNERS S.r.1., Via Vittor Pisani, 13, 20124 Milano (IT). = Designated States (unless otherwise indicated, for every = (81) = kind of national protection available): AE, AG, AL, AM, = = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = — PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, — TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Designated States (unless otherwise indicated, for every (84) kind of regional protection available): ARIPO (BW, GH, = 1-1 CT ir) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, IN MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 1-1 1-1 ei IN 1-1 (54) Title: NEW ANTIBACTERIAL COMPOUNDS 0 ei (57) : The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their 0 use as antimicrobials.
SG11201810352XA 2016-06-08 2017-06-05 New antibacterial compounds SG11201810352XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16173550 2016-06-08
PCT/EP2017/063600 WO2017211759A1 (en) 2016-06-08 2017-06-05 New antibacterial compounds

Publications (1)

Publication Number Publication Date
SG11201810352XA true SG11201810352XA (en) 2018-12-28

Family

ID=56116327

Family Applications (2)

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SG11201810352XA SG11201810352XA (en) 2016-06-08 2017-06-05 New antibacterial compounds
SG11201810389XA SG11201810389XA (en) 2016-06-08 2017-06-05 New antibacterial compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
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Country Status (27)

Country Link
US (2) US10633366B2 (en)
EP (2) EP3468975B1 (en)
JP (2) JP2019517546A (en)
KR (2) KR20190019083A (en)
CN (2) CN109790157A (en)
AR (2) AR108777A1 (en)
AU (2) AU2017276626A1 (en)
BR (2) BR112018075334A2 (en)
CA (2) CA3025624A1 (en)
CY (1) CY1123194T1 (en)
DK (1) DK3468975T3 (en)
EA (2) EA201892822A1 (en)
ES (1) ES2802233T3 (en)
HR (1) HRP20200894T1 (en)
HU (1) HUE049547T2 (en)
IL (2) IL263283A (en)
LT (1) LT3468975T (en)
MA (1) MA45221A (en)
MD (1) MD3468975T2 (en)
ME (1) ME03738B (en)
MX (2) MX2018015125A (en)
PL (1) PL3468975T3 (en)
PT (1) PT3468975T (en)
RS (1) RS60511B1 (en)
SG (2) SG11201810352XA (en)
SI (1) SI3468975T1 (en)
WO (2) WO2017211759A1 (en)

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EP3468975B1 (en) * 2016-06-08 2020-04-01 Aziende Chimiche Riunite Angelini Francesco A.C.R. New antibacterial compounds
WO2022109360A1 (en) 2020-11-23 2022-05-27 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US11970502B2 (en) 2021-05-04 2024-04-30 Enanta Pharmaceuticals, Inc. Macrocyclic antiviral agents
CN113698412A (en) * 2021-09-01 2021-11-26 临沂大学 Coumarin [4,3-b ] pyrrole derivative and synthesis method and application thereof
US11912714B2 (en) 2021-11-12 2024-02-27 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2023086400A1 (en) 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
WO2023086350A1 (en) 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Alkyne-containing antiviral agents
US11993600B2 (en) 2021-12-08 2024-05-28 Enanta Pharmaceuticals, Inc. Saturated spirocyclics as antiviral agents
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CN115850672B (en) * 2022-11-25 2024-07-19 浙江甬仑聚嘉新材料有限公司 Liquid crystal polymer and preparation method and application thereof

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Publication number Publication date
EP3468975A1 (en) 2019-04-17
ME03738B (en) 2021-01-20
US10640488B2 (en) 2020-05-05
DK3468975T3 (en) 2020-07-13
EA201892815A1 (en) 2019-05-31
AU2017276627A1 (en) 2018-12-20
MX2018015126A (en) 2019-09-02
US10633366B2 (en) 2020-04-28
IL263283A (en) 2018-12-31
CN109415373A (en) 2019-03-01
CY1123194T1 (en) 2021-10-29
LT3468975T (en) 2020-08-10
US20190161472A1 (en) 2019-05-30
PT3468975T (en) 2020-06-23
BR112018075297A2 (en) 2019-03-19
WO2017211759A1 (en) 2017-12-14
WO2017211760A1 (en) 2017-12-14
AU2017276626A1 (en) 2018-12-20
JP2019517546A (en) 2019-06-24
IL263285A (en) 2018-12-31
CN109790157A (en) 2019-05-21
AR108778A1 (en) 2018-09-26
SI3468975T1 (en) 2020-08-31
MX2018015125A (en) 2019-09-02
BR112018075334A2 (en) 2019-03-19
HRP20200894T1 (en) 2020-09-18
EP3468975B1 (en) 2020-04-01
MA45221A (en) 2021-05-19
SG11201810389XA (en) 2018-12-28
KR20190019083A (en) 2019-02-26
US20200095225A9 (en) 2020-03-26
US20190256495A1 (en) 2019-08-22
ES2802233T3 (en) 2021-01-18
HUE049547T2 (en) 2020-10-28
EP3468970A1 (en) 2019-04-17
JP2019517545A (en) 2019-06-24
RS60511B1 (en) 2020-08-31
MD3468975T2 (en) 2020-08-31
PL3468975T3 (en) 2020-09-07
EA201892822A1 (en) 2019-06-28
AR108777A1 (en) 2018-09-26
CA3025624A1 (en) 2017-12-14
KR20190019084A (en) 2019-02-26
CA3025270A1 (en) 2017-12-14

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