SG11201804840SA - Botulinum toxin for primary disorders of mood and affect using neurotransmitter - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization 111111111101111111111111111010111110111010H0IH01111110101111111111111110111111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/100624 Al 15 June 2017(15.06.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 39/08 (2006.01) A61P 25/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 38/16 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2016/065898 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 9 December 2016 (09.12.2016) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 14/966,759 11 December 2015 (11.12.2015) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: REVANCE THERAPEUTICS, INC. GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [US/US]; 7555 Gateway Boulevard, Newark, California TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 94560 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: BORODIC, Gary; DK, 1261 Furnace Brook Park- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, way, Quincy, Massachusetts 02169 (US). ACQUADRO, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Martin; 93 Emerson Road, Wellesley, Massachusetts SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, _ 02481 (US). GW, KM, ML, MR, NE, SN, TD, TG). (74) Agent: WADDELL, Kristine; King & Spalding LLP, Published: = 1185 Avenue of the Americas, New York, New York — with international search report (Art. 21(3)) 10036 (US). = = (54) Title: BOTULINUM TOXIN FOR PRIMARY DISORDERS OF MOOD AND AFFECT USING NEUROTRANSMITTER = (57) : The invention provides methods for treating primary disorders of S s At udt mood and affect, including depressive dis- orders, anxiety, and sleep disorders and CNS disorders comprising the administra- tion of a neurotoxin. = = _ = = \ % \ = = \ 11 ' \ \ N ` N vs, 7r NX\N ks , ,,,,,,,, \,,,,,,,,, \‘ ‘,,,,,; N , , , \ : \' ‘ , , ,: „ . ,, ,,,,,,, ,. • ,,,‘ ei htpottwns t t \ vt4 ,, ,4 , 11 /5 p m , © © FIG 1 11 IN 11 © ei O