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SG11201700066TA - Novel crystalline form of 5-chloro-n-({(5s)-2-oxo-3-[4-(5,6-dihydro-4h-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and pharmaceutical composition containing same - Google Patents

Novel crystalline form of 5-chloro-n-({(5s)-2-oxo-3-[4-(5,6-dihydro-4h-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and pharmaceutical composition containing same

Info

Publication number
SG11201700066TA
SG11201700066TA SG11201700066TA SG11201700066TA SG11201700066TA SG 11201700066T A SG11201700066T A SG 11201700066TA SG 11201700066T A SG11201700066T A SG 11201700066TA SG 11201700066T A SG11201700066T A SG 11201700066TA SG 11201700066T A SG11201700066T A SG 11201700066TA
Authority
SG
Singapore
Prior art keywords
oxazolidin
triazin
thiophene
dihydro
oxo
Prior art date
Application number
SG11201700066TA
Inventor
Soongyu Choi
Jungsub Choi
So-Hyun Yoon
Yoo Hoon Kim
Jae Yeon Kim
Suk Ho Lee
Young Lag Cho
Ho Young Song
Dae Yon Lee
Sung Yoon Baek
Sang Eun Chae
Tae Kyo Park
Sung Ho Woo
Yong Zu Kim
Original Assignee
Green Cross Corp
Legochem Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp, Legochem Biosciences Inc filed Critical Green Cross Corp
Publication of SG11201700066TA publication Critical patent/SG11201700066TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SG11201700066TA 2014-07-18 2014-07-18 Novel crystalline form of 5-chloro-n-({(5s)-2-oxo-3-[4-(5,6-dihydro-4h-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and pharmaceutical composition containing same SG11201700066TA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2014/006555 WO2016010178A1 (en) 2014-07-18 2014-07-18 Novel crystalline form of 5-chloro-n-({(5s)-2-oxo-3-[4-(5,6-dihydro-4h-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and pharmaceutical composition containing same

Publications (1)

Publication Number Publication Date
SG11201700066TA true SG11201700066TA (en) 2017-02-27

Family

ID=55078662

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201700066TA SG11201700066TA (en) 2014-07-18 2014-07-18 Novel crystalline form of 5-chloro-n-({(5s)-2-oxo-3-[4-(5,6-dihydro-4h-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and pharmaceutical composition containing same

Country Status (16)

Country Link
US (1) US9988372B2 (en)
EP (1) EP3170819B1 (en)
JP (1) JP6450840B2 (en)
KR (1) KR102100357B1 (en)
CN (2) CN106661011B (en)
AU (1) AU2014400894B2 (en)
BR (1) BR112017000351B1 (en)
CA (1) CA2955397C (en)
IL (2) IL297649A (en)
MX (1) MX2017000409A (en)
MY (1) MY190477A (en)
PH (1) PH12017500093A1 (en)
RU (1) RU2663617C1 (en)
SG (1) SG11201700066TA (en)
UA (1) UA116182C2 (en)
WO (1) WO2016010178A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3789388B1 (en) * 2018-05-02 2024-01-24 Tianjin Hemay Pharmaceutical Co., Ltd. Crystal form of (s)-n-[5-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4,6-dioxo-5,6-dihydro-4h-thieno[3,4-c]pyrrole-1-yl]acetamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100898361B1 (en) * 2008-07-03 2009-05-20 주식회사 레고켐 바이오사이언스 Fxa inhibitors with cyclic amidoxime or cyclic amidrazone as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
KR101037052B1 (en) * 2009-07-08 2011-05-26 주식회사 레고켐 바이오사이언스 Method for preparing 5-chloro-N-5S-2-oxo-3-4-5,6-dihydro-1,2,4-triazin-14H-ylphenyl-1,3-oxazolidin-5-ylmethylthiophen-2-carboxamide derivatives, and their intermediates

Also Published As

Publication number Publication date
MX2017000409A (en) 2017-05-01
JP2017521500A (en) 2017-08-03
PH12017500093A1 (en) 2017-05-22
WO2016010178A1 (en) 2016-01-21
KR20170023003A (en) 2017-03-02
US9988372B2 (en) 2018-06-05
IL250168A0 (en) 2017-03-30
CA2955397A1 (en) 2016-01-21
AU2014400894B2 (en) 2018-04-19
EP3170819A1 (en) 2017-05-24
RU2663617C1 (en) 2018-08-07
JP6450840B2 (en) 2019-01-09
BR112017000351B1 (en) 2022-10-25
CN110407827B (en) 2023-05-23
MY190477A (en) 2022-04-22
EP3170819B1 (en) 2019-07-10
CA2955397C (en) 2019-01-08
CN106661011B (en) 2020-01-10
AU2014400894A1 (en) 2017-02-02
KR102100357B1 (en) 2020-04-13
NZ727829A (en) 2021-01-29
CN110407827A (en) 2019-11-05
US20170152251A1 (en) 2017-06-01
EP3170819A4 (en) 2018-05-16
BR112017000351A2 (en) 2017-11-07
UA116182C2 (en) 2018-02-12
IL297649A (en) 2022-12-01
CN106661011A (en) 2017-05-10

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