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SG11201607342QA - Drug delivery systems and methods for treatment of bladder cancer with gemcitabine - Google Patents

Drug delivery systems and methods for treatment of bladder cancer with gemcitabine

Info

Publication number
SG11201607342QA
SG11201607342QA SG11201607342QA SG11201607342QA SG11201607342QA SG 11201607342Q A SG11201607342Q A SG 11201607342QA SG 11201607342Q A SG11201607342Q A SG 11201607342QA SG 11201607342Q A SG11201607342Q A SG 11201607342QA SG 11201607342Q A SG11201607342Q A SG 11201607342QA
Authority
SG
Singapore
Prior art keywords
gemcitabine
treatment
methods
drug delivery
delivery systems
Prior art date
Application number
SG11201607342QA
Inventor
Dennis Giesing
Heejin Lee
Karen Daniel
Original Assignee
Taris Biomedical Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taris Biomedical Llc filed Critical Taris Biomedical Llc
Publication of SG11201607342QA publication Critical patent/SG11201607342QA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
SG11201607342QA 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine SG11201607342QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461949215P 2014-03-06 2014-03-06
PCT/US2015/019262 WO2015134911A1 (en) 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine

Publications (1)

Publication Number Publication Date
SG11201607342QA true SG11201607342QA (en) 2016-10-28

Family

ID=52697553

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202101978SA SG10202101978SA (en) 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine
SG11201607342QA SG11201607342QA (en) 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202101978SA SG10202101978SA (en) 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine

Country Status (21)

Country Link
US (3) US20150250717A1 (en)
EP (2) EP4124339A1 (en)
JP (4) JP6901858B2 (en)
KR (1) KR102338079B1 (en)
CN (1) CN106102751A (en)
AU (3) AU2015226901B2 (en)
BR (1) BR112016020381A8 (en)
CA (1) CA2939979C (en)
DK (1) DK3113782T3 (en)
ES (1) ES2930435T3 (en)
HR (1) HRP20221252T1 (en)
HU (1) HUE060704T2 (en)
IL (2) IL311410A (en)
LT (1) LT3113782T (en)
MX (1) MX2016011333A (en)
PL (1) PL3113782T3 (en)
PT (1) PT3113782T (en)
RS (1) RS63675B1 (en)
RU (1) RU2694902C1 (en)
SG (2) SG10202101978SA (en)
WO (1) WO2015134911A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013308465B2 (en) 2012-08-31 2018-05-17 Taris Biomedical Llc Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine
EP3035991B1 (en) 2013-08-19 2020-07-08 TARIS Biomedical LLC Multi-unit drug delivery devices
ES2930435T3 (en) * 2014-03-06 2022-12-13 Taris Biomedical Llc Systems and methods of drug delivery for the treatment of bladder cancer with gemcitabine
SG10201913416PA (en) * 2016-05-06 2020-03-30 Taris Biomedical Llc Method of treating lower tract urothelial cancer
SG11201913251VA (en) 2017-07-25 2020-01-30 Taris Biomedical Llc Methods of treating tumor metastasis
JP2021502347A (en) * 2017-11-08 2021-01-28 タリス バイオメディカル エルエルシー Methods of treatment and maintenance of bladder cancer using gemcitabine
KR20210039403A (en) 2018-08-01 2021-04-09 타리스 바이오메디컬 엘엘씨 How to treat overactive bladder with trospium
US20220370630A1 (en) * 2019-10-03 2022-11-24 Seikagaku Corporation Transmucosal delivery system for pharmaceutical active ingredient to submucosal tissue of bladder
RU2713443C2 (en) * 2019-11-01 2020-02-05 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Method of combined treatment of musculo-invasive bladder cancer t3-t4 n0-+m0
CN112169066B (en) * 2020-10-29 2023-05-12 安徽省立医院(中国科学技术大学附属第一医院) Continuous slow-release drug administration indwelling tube with controller
CN113616666A (en) * 2021-08-24 2021-11-09 傅广波 Use of sub-mucosal injection of gemcitabine into the bladder for the treatment of bladder cancer

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* Cited by examiner, † Cited by third party
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US4111203A (en) * 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US7534241B2 (en) * 2002-09-23 2009-05-19 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
JP2006521897A (en) * 2003-03-31 2006-09-28 アルザ・コーポレーション Osmotic pump with means for dissipating internal pressure
US8361490B2 (en) * 2004-09-16 2013-01-29 Theracoat Ltd. Biocompatible drug delivery apparatus and methods
JP5265359B2 (en) 2005-08-11 2013-08-14 マサチューセッツ インスティテュート オブ テクノロジー Intravesical drug delivery device and method
WO2008013589A2 (en) * 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Treatment of ras-expressing tumors
BRPI0820800B8 (en) 2007-12-11 2021-06-22 Massachusetts Inst Technology implantable medical device for controlled drug release
BRPI0917135A2 (en) 2008-08-09 2015-11-10 Massachusetts Inst Technology medical device for extension and retention in a patient's seminal vesicle, ejaculatory duct, prostate or vas deferens, use of a resorbable elastomer, and osmotic pump device.
JP5872462B2 (en) 2009-06-26 2016-03-01 タリス バイオメディカル エルエルシー Solid drug tablets for implantable drug delivery devices
US9017312B2 (en) * 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
US8721621B2 (en) 2009-09-10 2014-05-13 Taris Biomedical, Inc. Systems and methods for deploying devices to genitourinary sites
HUE053888T2 (en) 2009-12-17 2021-07-28 Taris Biomedical Llc Implantable device with intravesical tolerability
EP2525777B1 (en) * 2010-01-20 2019-05-29 UroGen Pharma Ltd. Material and method for treating internal cavities
US20110218488A1 (en) 2010-03-05 2011-09-08 Taris Biomedical, Inc. Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites
WO2012048114A1 (en) 2010-10-06 2012-04-12 Taris Biomedical, Inc. Time-selective bioresorbable or collapsible drug delivery systems and methods
US9457176B2 (en) 2010-10-06 2016-10-04 Taris Biomedical Llc Implantable drug delivery device with bladder retention feature
BR112013019410A2 (en) * 2011-02-04 2019-09-24 Taris Biomedical Inc implantable device for controlled release of low solubility drug
AU2013308465B2 (en) * 2012-08-31 2018-05-17 Taris Biomedical Llc Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine
BR112015022433B1 (en) * 2013-03-15 2022-06-21 Taris Biomedical Llc Intravesical drug delivery device
WO2014144066A1 (en) 2013-03-15 2014-09-18 Taris Biomedical, Inc Drug delivery devices and methods for drug delivery
EP3035991B1 (en) * 2013-08-19 2020-07-08 TARIS Biomedical LLC Multi-unit drug delivery devices
CN105792880A (en) * 2013-11-05 2016-07-20 塔里斯生物医药公司 Osmotic drug delivery devices, kits, and methods
ES2930435T3 (en) * 2014-03-06 2022-12-13 Taris Biomedical Llc Systems and methods of drug delivery for the treatment of bladder cancer with gemcitabine

Also Published As

Publication number Publication date
BR112016020381A2 (en) 2017-08-15
HRP20221252T1 (en) 2022-12-09
US20220347091A1 (en) 2022-11-03
AU2015226901B2 (en) 2020-05-14
AU2020217383A1 (en) 2020-09-03
NZ723303A (en) 2023-10-27
JP7061595B2 (en) 2022-04-28
WO2015134911A1 (en) 2015-09-11
HUE060704T2 (en) 2023-04-28
KR20160124425A (en) 2016-10-27
CA2939979A1 (en) 2015-09-11
CN106102751A (en) 2016-11-09
SG10202101978SA (en) 2021-04-29
JP6901858B2 (en) 2021-07-14
PT3113782T (en) 2023-01-05
EP3113782B1 (en) 2022-09-28
KR102338079B1 (en) 2021-12-09
AU2022215156B2 (en) 2024-09-05
RS63675B1 (en) 2022-11-30
BR112016020381A8 (en) 2018-05-02
JP7383681B2 (en) 2023-11-20
MX2016011333A (en) 2016-12-07
US20220117886A1 (en) 2022-04-21
ES2930435T3 (en) 2022-12-13
PL3113782T3 (en) 2023-01-23
JP2017508749A (en) 2017-03-30
EP3113782A1 (en) 2017-01-11
LT3113782T (en) 2022-11-25
EP4124339A1 (en) 2023-02-01
AU2022215156A1 (en) 2022-09-01
DK3113782T3 (en) 2022-10-17
IL311410A (en) 2024-05-01
JP2024009034A (en) 2024-01-19
IL247347A0 (en) 2016-11-30
JP2022022235A (en) 2022-02-03
AU2015226901A1 (en) 2016-09-01
AU2020217383B2 (en) 2022-09-08
CA2939979C (en) 2023-03-21
JP2019218410A (en) 2019-12-26
RU2694902C1 (en) 2019-07-18
IL247347B1 (en) 2024-11-01
US20150250717A1 (en) 2015-09-10

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