[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

SG11201604710XA - Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives - Google Patents

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Info

Publication number
SG11201604710XA
SG11201604710XA SG11201604710XA SG11201604710XA SG11201604710XA SG 11201604710X A SG11201604710X A SG 11201604710XA SG 11201604710X A SG11201604710X A SG 11201604710XA SG 11201604710X A SG11201604710X A SG 11201604710XA SG 11201604710X A SG11201604710X A SG 11201604710XA
Authority
SG
Singapore
Prior art keywords
insulin
pharmaceutical formulations
stabilized pharmaceutical
derivatives
analogues
Prior art date
Application number
SG11201604710XA
Inventor
Oliver Bley
Petra Loos
Bernd Bidlingmaier
Walter Kamm
Harald Berchtold
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG11201604710XA publication Critical patent/SG11201604710XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG11201604710XA 2014-01-09 2015-01-08 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives SG11201604710XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461925493P 2014-01-09 2014-01-09
EP14305025 2014-01-09
PCT/EP2015/050220 WO2015104314A1 (en) 2014-01-09 2015-01-08 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Publications (1)

Publication Number Publication Date
SG11201604710XA true SG11201604710XA (en) 2016-07-28

Family

ID=49949602

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201604710XA SG11201604710XA (en) 2014-01-09 2015-01-08 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Country Status (11)

Country Link
US (4) US9839692B2 (en)
EP (1) EP3091995B1 (en)
JP (1) JP6641280B2 (en)
KR (1) KR20160104724A (en)
CN (2) CN112957455A (en)
AU (1) AU2015205624A1 (en)
CA (1) CA2932877A1 (en)
MX (1) MX2016008979A (en)
RU (1) RU2016132342A (en)
SG (1) SG11201604710XA (en)
WO (1) WO2015104314A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA116217C2 (en) 2012-10-09 2018-02-26 Санофі Exendin-4 derivatives as dual glp1/glucagon agonists
SG11201504215PA (en) 2012-12-21 2015-06-29 Sanofi Sa Functionalized exendin-4 derivatives
TWI780236B (en) 2013-02-04 2022-10-11 法商賽諾菲公司 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
EP3080154B1 (en) 2013-12-13 2018-02-07 Sanofi Dual glp-1/gip receptor agonists
RU2016132340A (en) 2014-01-09 2018-02-14 Санофи STABILIZED PHARMACEUTICAL COMPOSITIONS BASED ON INSULIN ASPART
JP7173953B2 (en) * 2014-01-09 2022-11-16 サノフイ Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
CN112957455A (en) * 2014-01-09 2021-06-15 赛诺菲 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
BR112016013832A2 (en) 2014-01-09 2017-08-08 Sanofi Sa USE OF INSULIN ANALOG AND/OR DERIVATIVE, PHARMACEUTICAL FORMULATION AND PROCESS FOR THE PREPARATION OF THE SAME, KIT AND MEDICAL DEVICE
TW201625670A (en) 2014-04-07 2016-07-16 賽諾菲公司 Dual GLP-1/glucagon receptor agonists derived from EXENDIN-4
TW201625668A (en) 2014-04-07 2016-07-16 賽諾菲公司 Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
TW201625669A (en) 2014-04-07 2016-07-16 賽諾菲公司 Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
AR105319A1 (en) 2015-06-05 2017-09-27 Sanofi Sa PROPHARMS THAT INCLUDE A DUAL AGONIST GLU-1 / GLUCAGON CONJUGATE HIALURONIC ACID CONNECTOR
TW201706291A (en) 2015-07-10 2017-02-16 賽諾菲公司 New EXENDIN-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
WO2018237041A1 (en) * 2017-06-22 2018-12-27 The Regents Of The University Of Michigan Fibroblast growth factor receptor 2-specific peptide reagents and methods
WO2020097394A1 (en) 2018-11-07 2020-05-14 Applied Molecular Transport Inc. Delivery constructs for transcytosis and related methods
US10799564B1 (en) 2019-05-06 2020-10-13 Baxter International Inc. Insulin premix formulation and product, methods of preparing same, and methods of using same
CN114599665A (en) 2019-08-16 2022-06-07 应用分子转运公司 Compositions, formulations and interleukin production and purification

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB835638A (en) 1956-12-01 1960-05-25 Novo Terapeutisk Labor As Insulin crystal suspensions having a protracted effect
GB840870A (en) 1957-08-03 1960-07-13 Novo Terapeutisk Labor As Improvements in or relating to insulin preparations
US3091573A (en) 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
US3868358A (en) 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product
US3984696A (en) 1974-12-11 1976-10-05 Medi-Ray, Inc. Radiation guard for X-ray table
JPS6033474B2 (en) 1978-05-11 1985-08-02 藤沢薬品工業株式会社 Novel hyaluronidase BMP-8231 and its production method
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
CA1275922C (en) 1985-11-28 1990-11-06 Harunobu Amagase Treatment of cancer
JPS63107941A (en) 1985-11-28 1988-05-12 Wakunaga Pharmaceut Co Ltd Carcinostatic agent
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
DK257988D0 (en) 1988-05-11 1988-05-11 Novo Industri As NEW PEPTIDES
US4923162A (en) 1988-09-19 1990-05-08 Fleming Matthew C Radiation shield swivel mount
DE3837825A1 (en) 1988-11-08 1990-05-10 Hoechst Ag NEW INSULIN DERIVATIVES, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM
HUT56857A (en) 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
IL93282A (en) 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogs
DE69024953T3 (en) 1989-05-04 2005-01-27 Southern Research Institute, Birmingham encapsulation
US5006718A (en) 1989-07-21 1991-04-09 Lenhart Mark J X-ray shield for X-ray examination table
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
DK155690D0 (en) 1990-06-28 1990-06-28 Novo Nordisk As NEW PEPTIDES
US5272135A (en) 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
DK36392D0 (en) 1992-03-19 1992-03-19 Novo Nordisk As USE OF CHEMICAL COMPOUND
DK39892D0 (en) 1992-03-25 1992-03-25 Bernard Thorens PEPTIDE
US5846747A (en) 1992-03-25 1998-12-08 Novo Nordisk A/S Method for detecting glucagon-like peptide-1 antagonists and agonists
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
DE122006000015I1 (en) 1993-06-21 2006-06-29 Novo Nordisk As Asp B28 insulin crystals
EP2275089A1 (en) 1993-11-19 2011-01-19 Alkermes Controlled Therapeutics, Inc. Preparation of biodegradable microparticles containing a biologically active agent
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
IT1265271B1 (en) 1993-12-14 1996-10-31 Alcatel Italia BASEBAND PREDISTRITORTION SYSTEM FOR THE ADAPTIVE LINEARIZATION OF POWER AMPLIFIERS
DE59712555D1 (en) 1996-06-05 2006-04-06 Roche Diagnostics Gmbh EXENDIN ANALOGUE, PROCESS FOR THE PRODUCTION THEREOF AND THE MEDICAMENTS CONTAINING THEREOF
DE19637230A1 (en) 1996-09-13 1998-03-19 Boehringer Mannheim Gmbh Truncated versions of exendin peptide(s) for treating diabetes
PL189964B1 (en) 1996-06-20 2005-10-31 Novo Nordisk As Insulin preparations containing nacl
ATE369146T1 (en) * 1996-06-20 2007-08-15 Novo Nordisk As INSULIN PREPARATION WITH MANNITOL
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
US5866538A (en) 1996-06-20 1999-02-02 Novo Nordisk A/S Insulin preparations containing NaCl
US6110703A (en) 1996-07-05 2000-08-29 Novo Nordisk A/S Method for the production of polypeptides
EP0966297B2 (en) 1996-08-08 2013-02-27 Amylin Pharmaceuticals, Inc. Regulation of gastrointestinal motility
US5783556A (en) 1996-08-13 1998-07-21 Genentech, Inc. Formulated insulin-containing composition
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
UA65549C2 (en) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Use of glucagon-like peptides such as glp-1, glp-1 analog, or glp-1 derivative in methods and compositions for reducing body weight
WO1998030231A1 (en) 1997-01-07 1998-07-16 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the reduction of food intake
WO1998035033A1 (en) 1997-02-05 1998-08-13 1149336 Ontario Inc. Polynucleotides encoding proexendin, and methods and uses thereof
US5846937A (en) 1997-03-03 1998-12-08 1149336 Ontario Inc. Method of using exendin and GLP-1 to affect the central nervous system
PE79099A1 (en) 1997-06-13 1999-08-24 Lilly Co Eli STABLE INSULIN FORMULATIONS
IL133220A0 (en) 1997-06-13 2001-03-19 Genentech Inc Stabilized antibody formulation
AU749914B2 (en) 1997-08-08 2002-07-04 Amylin Pharmaceuticals, Inc. Novel exendin agonist compounds
WO1999021578A1 (en) 1997-10-24 1999-05-06 Eli Lilly And Company Insoluble insulin compositions
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
EP1032587B2 (en) 1997-11-14 2013-03-13 Amylin Pharmaceuticals, Inc. Novel exendin agonist compounds
CA2310097C (en) 1997-11-14 2014-07-29 Amylin Pharmaceuticals, Inc. Novel exendin agonist compounds
CA2312190A1 (en) 1997-12-05 1999-06-17 Eli Lilly And Company Glp-1 formulations
US5981964A (en) 1997-12-22 1999-11-09 Bruce J. McAuley Adjustable X-ray shield and on-line dosimetry system using same
WO1999040788A1 (en) 1998-02-13 1999-08-19 Amylin Pharmaceuticals, Inc. Inotropic and diuretic effects of exendin and glp-1
JP2003522099A (en) 1998-02-27 2003-07-22 ノボ ノルディスク アクティーゼルスカブ GLP-1 derivative of GLP-1 having a delayed action profile and exendin
IL138214A0 (en) 1998-03-09 2001-10-31 Zealand Pharmaceuticals As Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
ATE269103T1 (en) 1998-03-13 2004-07-15 Novo Nordisk As STABILIZED AQUEOUS GLUCAGON SOLUTIONS CONTAINING DETERGENTS
CA2334222C (en) 1998-06-05 2010-02-09 Technion Research And Development Foundation Ltd. Insulin supplemented infant formula
JP2002526554A (en) 1998-10-07 2002-08-20 メディカル カレッジ オブ ジョージア リサーチ インスティチュート，インコーポレイテッド Glucose-dependent insulin-affinity peptide used as bone-affinity hormone
US6284725B1 (en) 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
US6489292B1 (en) 1998-11-18 2002-12-03 Novo Nordisk A/S Stable aqueous insulin preparations without phenol and cresol
JP2000247903A (en) 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd Long-term stabilized pharmaceutical preparation
JP2007204498A (en) 1999-03-01 2007-08-16 Chugai Pharmaceut Co Ltd Long-term stabilized formulations
US6227819B1 (en) 1999-03-29 2001-05-08 Walbro Corporation Fuel pumping assembly
US6271241B1 (en) 1999-04-02 2001-08-07 Neurogen Corporation Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
NZ514916A (en) 1999-04-30 2004-06-25 Amylin Pharmaceuticals Inc Exendins and exendin agonists linked to polyethylene glycol polymers
WO2000069911A1 (en) 1999-05-17 2000-11-23 Conjuchem, Inc. Long lasting insulinotropic peptides
US6344180B1 (en) 1999-06-15 2002-02-05 Bionebraska, Inc. GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes
EP1076066A1 (en) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
DE19947456A1 (en) 1999-10-02 2001-04-05 Aventis Pharma Gmbh New synthetic derivatives of the C-peptide of proinsulin, useful in the preparation of human insulin or insulin analogs in high yield
ES2276698T3 (en) 1999-10-04 2007-07-01 Novartis Vaccines And Diagnostics, Inc. PHARCEUTICAL COMPOSITIONS CONTAINING A STABILIZED LIQUID POLYPEPTIDE.
WO2001051071A2 (en) 2000-01-11 2001-07-19 Novo Nordisk A/S Transepithelial delivery of glp-1 derivatives
US20010012829A1 (en) 2000-01-11 2001-08-09 Keith Anderson Transepithelial delivery GLP-1 derivatives
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
US6852694B2 (en) 2001-02-21 2005-02-08 Medtronic Minimed, Inc. Stabilized insulin formulations
DE10114178A1 (en) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinc-free and low-zinc insulin preparations with improved stability
EP1377608B1 (en) 2001-04-02 2009-09-16 Novo Nordisk A/S Insulin precursors and a process for their preparation
US7156877B2 (en) 2001-06-29 2007-01-02 The Regents Of The University Of California Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs
MXPA04001560A (en) 2001-08-28 2004-05-17 Lilly Co Eli Pre-mixes of glp-1 and basal insulin.
EP1545460A4 (en) 2001-12-20 2005-11-16 Lilly Co Eli Insulin molecule having protracted time action
AU2003203146A1 (en) 2002-02-07 2003-09-02 Novo Nordisk A/S Use of glp-1 compound for treatment of critically ill patients
DE60335797D1 (en) * 2002-05-07 2011-03-03 Novo Nordisk As SOLUBLE FORMULATIONS CONTAINING MONOMERIC INSULIN AND ACYLATED INSULIN
WO2003094951A1 (en) 2002-05-07 2003-11-20 Novo Nordisk A/S Soluble formulations comprising insulin aspart and insulin detemir
DE10227232A1 (en) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Sour insulin preparations with improved stability
DK1525219T3 (en) 2002-07-04 2009-09-07 Zealand Pharma As GLP-1 and Methods for the Treatment of Diabetes
EP1546200A2 (en) 2002-10-02 2005-06-29 Zealand Pharma A/S Stabilized exendin-4 compounds
MXPA05009565A (en) 2003-03-11 2005-12-02 Novo Nordisk As Pharmaceutical preparations comprising acid-stabilised insulin.
DE10325567B4 (en) 2003-06-05 2008-03-13 Mavig Gmbh Radiation protection arrangement with separable enclosure
JP5518282B2 (en) 2003-09-01 2014-06-11 ノヴォ ノルディスク アー／エス Stable peptide formulation
JP2007537981A (en) 2003-09-19 2007-12-27 ノボ　ノルディスク　アクティーゼルスカブ Novel plasma protein affinity tag
EP1684793B1 (en) 2003-11-13 2011-09-21 Novo Nordisk A/S Pharmaceutical composition comprising an insulinotropic glp-1(7-37) analogue, asp(b28)-insulin, and a surfactant
US20050201978A1 (en) 2003-11-17 2005-09-15 Lipton James S. Tumor and infectious disease therapeutic compositions
ES2727854T3 (en) 2003-11-20 2019-10-21 Novo Nordisk As Peptide formulations containing propylene glycol that are optimal for production and for use in injection devices
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
AU2005245240B2 (en) 2004-05-20 2010-04-29 Scimar Ltd. Use of drug combinations for treating insulin resistance
US20060073213A1 (en) 2004-09-15 2006-04-06 Hotamisligil Gokhan S Reducing ER stress in the treatment of obesity and diabetes
WO2006029634A2 (en) 2004-09-17 2006-03-23 Novo Nordisk A/S Pharmaceutical compositions containing insulin and insulinotropic peptide
ES2774354T3 (en) 2004-10-05 2020-07-20 Novo Nordisk As A pharmaceutical formulation
US20090011976A1 (en) 2004-11-12 2009-01-08 Novo Nordisk A/S Stable Formulations Of Peptides
ES2735533T3 (en) 2004-11-12 2019-12-19 Novo Nordisk As GLP-1 stable formulations
DE102004058306A1 (en) 2004-12-01 2006-07-27 Sanofi-Aventis Deutschland Gmbh Process for the preparation of carboxy-terminally amidated peptides
EP1849024A4 (en) 2005-02-01 2015-08-26 Canberra Ind Inc Maximum entropy signal detection method
CN101193652B (en) 2005-04-08 2011-11-02 安米林药品公司 Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent
CN101180081B (en) 2005-05-25 2015-08-26 诺沃-诺迪斯克有限公司 Stable polypeptide formulations
PL1888031T3 (en) 2005-06-06 2013-04-30 Camurus Ab Glp-1 analogue formulations
DE102005046113A1 (en) 2005-09-27 2007-03-29 Sanofi-Aventis Deutschland Gmbh Preparation of C-amidated peptides, useful as pharmaceuticals, by reaction between precursor peptides in presence of enzyme with activity of trypsin, also new reaction products
KR101105871B1 (en) 2005-09-27 2012-01-16 주식회사 엘지생명과학 hFSF Aqueous Formulation
WO2007044867A2 (en) 2005-10-11 2007-04-19 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US8343914B2 (en) 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
US20090324701A1 (en) 2006-01-20 2009-12-31 Diamedica, Inc. Compositions containing (s)-bethanechol and their use in the treatment of insulin resistance, type 2 diabetes, glucose intolerance and related disorders
US20070191271A1 (en) 2006-02-10 2007-08-16 Dow Pharmaceutical Sciences Method for stabilizing polypeptides lacking methionine
WO2007095288A2 (en) 2006-02-13 2007-08-23 Nektar Therapeutics Methionine-containing protein or peptide compositions and methods of making and using
EP2241327A1 (en) 2006-03-15 2010-10-20 Novo Nordisk A/S Mixtures of Amylin and Insulin
JP2009532422A (en) 2006-04-03 2009-09-10 ノボ・ノルデイスク・エー／エス GLP-1 peptide agonist
EP2015769A4 (en) 2006-04-13 2013-12-25 Ipsen Pharma Pharmaceutical compositions of hglp-1, exendin-4 and analogs thereof
ES2395738T3 (en) 2006-05-09 2013-02-14 Novo Nordisk A/S Insulin derivative
DE102006031962A1 (en) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidated insulin glargine
WO2008023050A1 (en) 2006-08-25 2008-02-28 Novo Nordisk A/S Acylated exendin-4 compounds
US9018161B2 (en) 2006-09-22 2015-04-28 Novo Nordisk A/S Protease resistant insulin analogues
CN1931360B (en) 2006-09-22 2013-02-13 江苏万邦生化医药股份有限公司 Double timephase neo-insulin zinc injection (30%) and prepn process thereof
WO2008124522A2 (en) 2007-04-04 2008-10-16 Biodel, Inc. Amylin formulations
IL290847B2 (en) 2007-04-23 2024-11-01 Intarcia Therapeutics Inc Suspension formulations of insulinotropic peptides and uses thereof
EP2167169B2 (en) 2007-06-14 2016-03-09 Sanofi-Aventis Deutschland GmbH Double chamber cartridges with attachment
JP2010528792A (en) 2007-06-14 2010-08-26 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Double chamber carpul
CN101366692A (en) 2007-08-15 2009-02-18 江苏豪森药业股份有限公司 Stable Exenatide formulation
GB0717399D0 (en) 2007-09-07 2007-10-17 Uutech Ltd Use of GLP-1 analogues for the treatment of disorders associated with dysfunctional synaptic transmission
NZ583991A (en) 2007-11-01 2012-02-24 Merck Serono Sa Luteinizing hormone liquid formulations
EP2217621B1 (en) 2007-11-08 2015-04-22 Novo Nordisk A/S Insulin derivative
CN101861333A (en) 2007-11-16 2010-10-13 诺沃-诺迪斯克有限公司 Pharmaceutical compositions comprising GLP-1 peptides or exendin-4 and a basal insulin peptide
CN101444618B (en) 2007-11-26 2012-06-13 杭州九源基因工程有限公司 Pharmaceutical preparation containing exenatide
WO2009075859A2 (en) 2007-12-11 2009-06-18 Conjuchem Biotechnologies Inc. Formulation of insulinotropic peptide conjugates
NZ586589A (en) 2008-01-09 2012-04-27 Sanofi Aventis Deutschland Novel insulin analogues having an extremely delayed time-action profile
ES2613152T3 (en) 2008-01-09 2017-05-22 Sanofi-Aventis Deutschland Gmbh New insulin derivatives with extremely delayed time / action profile
US8343140B2 (en) 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
TWI394580B (en) 2008-04-28 2013-05-01 Halozyme Inc Super fast-acting insulin compositions
WO2010022870A1 (en) 2008-08-30 2010-03-04 Sanofi-Aventis Deutschland Gmbh Cartridge and needle system therefor
JP5705115B2 (en) 2008-09-10 2015-04-22 ジェネンテック， インコーポレイテッド Compositions and methods for prevention of oxidative degradation of proteins
CN101670096B (en) 2008-09-11 2013-01-16 杭州九源基因工程有限公司 Medicinal preparation containing exenatide
CA2738715C (en) 2008-10-15 2013-07-16 Intarcia Therapeutics, Inc. Highly concentrated drug particles, formulations, suspensions and uses thereof
CA3016451A1 (en) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a glp-1 agonist
JP2009091363A (en) 2008-11-21 2009-04-30 Asahi Kasei Pharma Kk Stabilized aqueous injectable solution of pth
TWI474833B (en) 2009-04-01 2015-03-01 Genentech Inc Treatment of insulin-resistant disorders
EP2437782B1 (en) 2009-06-04 2013-07-24 Alk AG Stabilised composition comprising at least one adrenergic compound
EP2612677B1 (en) 2009-06-26 2015-05-06 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and arginine
WO2011003820A1 (en) 2009-07-06 2011-01-13 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
TW201113032A (en) * 2009-07-06 2011-04-16 Sanofi Aventis Deutschland Slow-acting insulin preparations
MX2012000304A (en) 2009-07-06 2012-01-27 Sanofi Aventis Deutschland Aqueous insulin preparations containing methionine.
WO2011012719A1 (en) * 2009-07-31 2011-02-03 Ascendis Pharma As Long acting insulin composition
AR078161A1 (en) 2009-09-11 2011-10-19 Hoffmann La Roche VERY CONCENTRATED PHARMACEUTICAL FORMULATIONS OF AN ANTIBODY ANTI CD20. USE OF THE FORMULATION. TREATMENT METHOD
US20110118180A1 (en) 2009-11-13 2011-05-19 Sanofi-Aventis Deutschland Gmbh Method of treatment of diabetes type 2 comprising add-on therapy to metformin
ES2534191T3 (en) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
NZ599847A (en) 2009-11-13 2013-09-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
US20110118178A1 (en) 2009-11-13 2011-05-19 Sanofi-Aventis Deutschland Gmbh Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin
US8637458B2 (en) 2010-05-12 2014-01-28 Biodel Inc. Insulin with a stable basal release profile
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
WO2011146972A1 (en) 2010-05-25 2011-12-01 Monash University Methods for the synthesis of dicarba bridges in peptides
EP2389945A1 (en) 2010-05-28 2011-11-30 Sanofi-Aventis Deutschland GmbH Pharmaceutical composition comprising AVE0010 and insulin glargine
US20140148384A1 (en) 2010-08-30 2014-05-29 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
EP2651432A1 (en) * 2010-12-14 2013-10-23 Novo Nordisk A/S Fast-acting insulin in combination with long-acting insulin
TW201236692A (en) 2011-02-02 2012-09-16 Sanofi Aventis Deutschland Prevention of hypoglycaemia in diabetes mellitus type 2 patients
US20120277147A1 (en) 2011-03-29 2012-11-01 Sanofi-Aventis Deutschland Gmbh Prevention of hypoglycaemia in diabetes mellitus type 2 patients
US20130040878A1 (en) 2011-05-13 2013-02-14 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for use in the treatment of diabetes type 2 patients
DK2707017T3 (en) 2011-05-13 2016-01-04 Sanofi Aventis Deutschland LIXISENATIDE AND METFORMIN FOR TREATMENT OF DIABETES TYPE 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
US8735349B2 (en) 2011-05-13 2014-05-27 Sanofi-Aventis Deutschland Gmbh Method for improving glucose tolerance in a diabetes type 2 patient of younger than 50 years and having postprandial plasma glucose concentration of at least 14 mmol/L
CA2839511C (en) 2011-06-17 2018-07-31 Halozyme, Inc. Stable formulations of a hyaluronan-degrading enzyme
HUE027989T2 (en) 2011-08-29 2016-11-28 Sanofi Aventis Deutschland Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
PT2763690E (en) 2011-10-04 2016-03-23 Sanofi Aventis Deutschland Lixisenatide for use in the treatment of stenosis or/and obstruction in the pancreatic duct system
US20130096059A1 (en) 2011-10-04 2013-04-18 Jens Stechl Glp-1 agonist for use in the treatment of stenosis or/and obstruction in the biliary tract
CA2851690C (en) 2011-10-28 2022-07-26 Sanofi-Aventis Deutschland Gmbh Treatment protocol of diabetes type 2
US20130183263A1 (en) 2012-01-17 2013-07-18 Steven Hoffman Pharmaceutical compositions and methods
US8901484B2 (en) 2012-04-27 2014-12-02 Sanofi-Aventis Deutschland Gmbh Quantification of impurities for release testing of peptide products
AR092862A1 (en) * 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd LIQUID FORMULATION OF PROLONGED ACTION INSULIN AND AN INSULINOTROPIC PEPTIDE AND PREPARATION METHOD
TWI780236B (en) 2013-02-04 2022-10-11 法商賽諾菲公司 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
GB201303771D0 (en) 2013-03-04 2013-04-17 Midatech Ltd Nanoparticles peptide compositions
BR112016013832A2 (en) 2014-01-09 2017-08-08 Sanofi Sa USE OF INSULIN ANALOG AND/OR DERIVATIVE, PHARMACEUTICAL FORMULATION AND PROCESS FOR THE PREPARATION OF THE SAME, KIT AND MEDICAL DEVICE
RU2016132340A (en) 2014-01-09 2018-02-14 Санофи STABILIZED PHARMACEUTICAL COMPOSITIONS BASED ON INSULIN ASPART
CN112957455A (en) 2014-01-09 2021-06-15 赛诺菲 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Also Published As

Publication number Publication date
EP3091995A1 (en) 2016-11-16
CN112957455A (en) 2021-06-15
US9839692B2 (en) 2017-12-12
MX2016008979A (en) 2016-10-04
US20230181739A1 (en) 2023-06-15
CA2932877A1 (en) 2015-07-16
US10610595B2 (en) 2020-04-07
US20180125981A1 (en) 2018-05-10
JP2017502052A (en) 2017-01-19
KR20160104724A (en) 2016-09-05
WO2015104314A1 (en) 2015-07-16
RU2016132342A (en) 2018-02-14
CN105960249B (en) 2021-03-16
EP3091995B1 (en) 2024-03-20
JP6641280B2 (en) 2020-02-05
AU2015205624A1 (en) 2016-07-14
CN105960249A (en) 2016-09-21
US20200297852A1 (en) 2020-09-24
US20150216981A1 (en) 2015-08-06
RU2016132342A3 (en) 2018-09-18

Similar Documents

Publication Publication Date Title
SG11201604710XA (en) Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
SG11201604708VA (en) Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
ZA201504582B (en) Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
IL251834B1 (en) Pharmaceutical compositions comprising peptide variants and methods of use thereof
IL246706B (en) Rapid action insulin formulations and pharmaceutical delivery systems
SG11201604706TA (en) Stabilized pharmaceutical formulations of insulin aspart
IL246483A0 (en) Stable glucagon analogues and use for treatment of hypoglycaemia
PT3380525T (en) Pharmaceutical formulations and methods of use thereof
HK1252534A1 (en) Injectable pharmaceutical formulations of lefamulin
IL248090B (en) Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
IL267279A (en) Pharmaceutical formulations of suvorexant
IL254711B (en) Diazepino-indole derivatives and pharmaceutical compositions comprising it
SG10201913433SA (en) Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
IL253788A0 (en) Pharmaceutical formulation of racecadotril
IL250394B (en) Oral composition for delivery of drugs and other substances
HUE053181T2 (en) Pharmaceutical formulations with improved solubility and stability
EP3242668A4 (en) Pharmaceutical formulations of xanthine or xanthine derivatives
IL252080A0 (en) Oral administration of unstable or poorly-absorbed drugs