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SG10202100485XA - Humanized il-6 and il-6 receptor - Google Patents

Humanized il-6 and il-6 receptor

Info

Publication number
SG10202100485XA
SG10202100485XA SG10202100485XA SG10202100485XA SG10202100485XA SG 10202100485X A SG10202100485X A SG 10202100485XA SG 10202100485X A SG10202100485X A SG 10202100485XA SG 10202100485X A SG10202100485X A SG 10202100485XA SG 10202100485X A SG10202100485X A SG 10202100485XA
Authority
SG
Singapore
Prior art keywords
humanized
receptor
Prior art date
Application number
SG10202100485XA
Inventor
Li-Hsien Wang
Sean Stevens
Dore, Jr
Andrew Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10202100485XA publication Critical patent/SG10202100485XA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10202100485XA 2011-10-28 2012-10-29 Humanized il-6 and il-6 receptor SG10202100485XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552900P 2011-10-28 2011-10-28
US201161556579P 2011-11-07 2011-11-07

Publications (1)

Publication Number Publication Date
SG10202100485XA true SG10202100485XA (en) 2021-02-25

Family

ID=47295138

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201400945UA SG11201400945UA (en) 2011-10-28 2012-10-29 Humanized il-6 and il-6 receptor
SG10202100485XA SG10202100485XA (en) 2011-10-28 2012-10-29 Humanized il-6 and il-6 receptor
SG10201600965YA SG10201600965YA (en) 2011-10-28 2012-10-29 Humanized il-6 and il-6 receptor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201400945UA SG11201400945UA (en) 2011-10-28 2012-10-29 Humanized il-6 and il-6 receptor

Family Applications After (1)

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SG10201600965YA SG10201600965YA (en) 2011-10-28 2012-10-29 Humanized il-6 and il-6 receptor

Country Status (28)

Country Link
US (9) US8878001B2 (en)
EP (2) EP2818478B1 (en)
JP (2) JP6120451B2 (en)
KR (2) KR102084927B1 (en)
CN (2) CN104039821A (en)
AU (1) AU2015207889B2 (en)
BR (1) BR112014008529A2 (en)
CA (1) CA2853731C (en)
CY (2) CY1116614T1 (en)
DK (2) DK2818478T3 (en)
ES (2) ES2525368T3 (en)
HK (2) HK1190408A1 (en)
HR (2) HRP20141192T1 (en)
HU (1) HUE033400T2 (en)
IL (4) IL231896B (en)
IN (1) IN2014CN03920A (en)
LT (1) LT2818478T (en)
MX (1) MX358390B (en)
MY (2) MY172726A (en)
PL (2) PL2818478T3 (en)
PT (2) PT2818478T (en)
RS (2) RS53683B1 (en)
RU (2) RU2634417C2 (en)
SG (3) SG11201400945UA (en)
SI (2) SI2663575T1 (en)
SM (1) SMT201400187B (en)
WO (1) WO2013063556A1 (en)
ZA (1) ZA201402635B (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4049535A1 (en) 2009-10-06 2022-08-31 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
CN105861553B (en) 2011-02-15 2020-08-14 再生元制药公司 Humanized M-CSF mice
SG11201400945UA (en) 2011-10-28 2014-04-28 Regeneron Pharma Humanized il-6 and il-6 receptor
US20130261016A1 (en) * 2012-03-28 2013-10-03 Meso Scale Technologies, Llc Diagnostic methods for inflammatory disorders
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
JP6283031B2 (en) 2012-09-07 2018-02-21 イエール ユニバーシティ Genetically modified non-human animals and uses thereof
EP2896291B1 (en) * 2012-09-13 2019-03-20 Chugai Seiyaku Kabushiki Kaisha Gene knock-in non-human animal
EP3939423B1 (en) 2012-11-05 2024-03-06 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
KR102579405B1 (en) 2013-02-20 2023-09-18 리제너론 파아마슈티컬스, 인크. Mice expressing humanized t-cell co-receptors
EP2958937B1 (en) 2013-02-22 2018-08-15 Regeneron Pharmaceuticals, Inc. Mice expressing humanized major histocompatibility complex
GB2513884B (en) 2013-05-08 2015-06-17 Univ Bristol Method and apparatus for producing an acoustic field
CA2925564C (en) 2013-09-23 2023-03-21 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized signal-regulatory protein gene
LT3138397T (en) * 2013-10-15 2019-04-10 Regeneron Pharmaceuticals, Inc. Humanized il-15 animals
ES2700972T3 (en) 2013-11-19 2019-02-20 Regeneron Pharma Non-human animals that have a humanized B cell activating factor gene
ES2703549T3 (en) * 2013-11-19 2019-03-11 Regeneron Pharma Non-human animals that have a gene for a ligand inducer of humanized proliferation
US9612658B2 (en) 2014-01-07 2017-04-04 Ultrahaptics Ip Ltd Method and apparatus for providing tactile sensations
WO2016039801A1 (en) 2014-01-31 2016-03-17 Boehringer Ingelheim International Gmbh Novel anti-baff antibodies
SI3129400T1 (en) 2014-04-08 2020-07-31 Regeneron Pharmaceuticals, Inc. Non-human animals having humanized fc-gamma receptors
JP6598798B2 (en) 2014-05-05 2019-10-30 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Humanized C5 and C3 animals
NO2785538T3 (en) 2014-05-07 2018-08-04
AU2015264427B2 (en) 2014-05-19 2021-09-23 Institute For Research In Biomedicine (Irb) Genetically modified non-human animals expressing human EPO
JP6212659B2 (en) 2014-05-30 2017-10-11 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Humanized dipeptidyl peptidase IV (DPP4) animal
LT3157956T (en) * 2014-06-19 2020-05-11 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized programmed cell death 1 gene
GB2530036A (en) 2014-09-09 2016-03-16 Ultrahaptics Ltd Method and apparatus for modulating haptic feedback
PT3689140T (en) 2014-11-24 2022-07-27 Regeneron Pharma Non-human animals expressing humanized cd3 complex
KR102508175B1 (en) * 2014-12-05 2023-03-09 리제너론 파마슈티칼스 인코포레이티드 Non-human animals having a humanized cluster of differentiation 47 gene
MX2017007636A (en) 2014-12-09 2018-03-28 Regeneron Pharma Non-human animals having a humanized cluster of differentiation 274 gene.
JP6771473B2 (en) 2015-02-20 2020-10-21 ウルトラハプティクス アイピー リミテッドＵｌｔｒａｈａｐｔｉｃｓ Ｉｐ Ｌｔｄ Improved algorithm in the tactile system
EP3916525B1 (en) 2015-02-20 2024-09-18 Ultrahaptics IP Limited Perceptions in a haptic system
DK3280257T3 (en) 2015-04-06 2023-09-04 Regeneron Pharma Humanized T-cell-mediated immune response in non-human animals
SG11201708380WA (en) 2015-04-13 2017-11-29 Regeneron Pharma Humanized sirpa-il15 knockin mice and methods of use thereof
US10818162B2 (en) 2015-07-16 2020-10-27 Ultrahaptics Ip Ltd Calibration techniques in haptic systems
SG11201803409UA (en) 2015-11-20 2018-05-30 Regeneron Pharma Non-human animals having a humanized lymphocyte-activation gene 3
ES2926280T3 (en) 2015-12-08 2022-10-25 Regeneron Pharma Compositions and methods for internalizing enzymes
US11189140B2 (en) 2016-01-05 2021-11-30 Ultrahaptics Ip Ltd Calibration and detection techniques in haptic systems
JP6843872B2 (en) 2016-02-04 2021-03-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Non-human animals carrying the engineered ANGPTL8 gene
KR20230021759A (en) 2016-02-29 2023-02-14 리제너론 파마슈티칼스 인코포레이티드 Rodents having a humanized tmprss gene
CN113907043B (en) 2016-06-03 2023-08-01 瑞泽恩制药公司 Non-human animals expressing exogenous terminal deoxynucleotidyl transferase
US10531212B2 (en) 2016-06-17 2020-01-07 Ultrahaptics Ip Ltd. Acoustic transducers in haptic systems
US10268275B2 (en) 2016-08-03 2019-04-23 Ultrahaptics Ip Ltd Three-dimensional perceptions in haptic systems
US10755538B2 (en) 2016-08-09 2020-08-25 Ultrahaptics ilP LTD Metamaterials and acoustic lenses in haptic systems
CN107815467B (en) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Preparation method and application of humanized gene modified animal model
US10943578B2 (en) 2016-12-13 2021-03-09 Ultrahaptics Ip Ltd Driving techniques for phased-array systems
US10497358B2 (en) 2016-12-23 2019-12-03 Ultrahaptics Ip Ltd Transducer driver
CN108588126B (en) 2017-03-31 2020-04-10 北京百奥赛图基因生物技术有限公司 Preparation method and application of humanized modified animal model of CD47 gene
WO2018177441A1 (en) 2017-03-31 2018-10-04 Beijing Biocytogen Co., Ltd GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
KR102544051B1 (en) 2017-09-29 2023-06-16 리제너론 파마슈티칼스 인코포레이티드 Non-human animals comprising humanized TTR loci and methods of use
US11531395B2 (en) 2017-11-26 2022-12-20 Ultrahaptics Ip Ltd Haptic effects from focused acoustic fields
JP7361031B2 (en) 2017-11-30 2023-10-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Non-human animals containing a humanized TRKB locus
EP3729418A1 (en) 2017-12-22 2020-10-28 Ultrahaptics Ip Ltd Minimizing unwanted responses in haptic systems
US11360546B2 (en) 2017-12-22 2022-06-14 Ultrahaptics Ip Ltd Tracking in haptic systems
SG11202008620VA (en) 2018-03-26 2020-10-29 Regeneron Pharma Humanized rodents for testing therapeutic agents
EP4414556A3 (en) 2018-05-02 2024-10-23 Ultrahaptics IP Limited Blocking plate structure for improved acoustic transmission efficiency
CN116200426A (en) * 2018-07-16 2023-06-02 瑞泽恩制药公司 Non-human animal model of DITRA disease and uses thereof
US11098951B2 (en) 2018-09-09 2021-08-24 Ultrahaptics Ip Ltd Ultrasonic-assisted liquid manipulation
US11378997B2 (en) 2018-10-12 2022-07-05 Ultrahaptics Ip Ltd Variable phase and frequency pulse-width modulation technique
US20220015343A1 (en) * 2018-12-17 2022-01-20 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes
WO2020141330A2 (en) 2019-01-04 2020-07-09 Ultrahaptics Ip Ltd Mid-air haptic textures
WO2020147829A1 (en) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 Humanized transgenic animal
CA3133360A1 (en) 2019-04-04 2020-10-08 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized coagulation factor 12 locus
US11842517B2 (en) 2019-04-12 2023-12-12 Ultrahaptics Ip Ltd Using iterative 3D-model fitting for domain adaptation of a hand-pose-estimation neural network
EP3978607A4 (en) * 2019-05-27 2023-01-25 Transgenic Inc. Exon-humanized mouse
AU2020286382A1 (en) 2019-06-04 2021-11-04 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized TTR locus with a beta-slip mutation and methods of use
JP2022534560A (en) 2019-06-07 2022-08-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Non-human animals containing humanized albumin loci
US11374586B2 (en) 2019-10-13 2022-06-28 Ultraleap Limited Reducing harmonic distortion by dithering
US11553295B2 (en) 2019-10-13 2023-01-10 Ultraleap Limited Dynamic capping with virtual microphones
WO2021090028A1 (en) 2019-11-08 2021-05-14 Ultraleap Limited Tracking techniques in haptics systems
CN111304246B (en) * 2019-12-17 2021-05-04 百奥赛图江苏基因生物技术有限公司 Humanized cytokine animal model, preparation method and application
US11715453B2 (en) 2019-12-25 2023-08-01 Ultraleap Limited Acoustic transducer structures
WO2021154791A1 (en) * 2020-01-28 2021-08-05 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
KR20230004472A (en) 2020-04-21 2023-01-06 리제너론 파마슈티칼스 인코포레이티드 Non-human animals with a humanized CXCL13 gene
US11816267B2 (en) 2020-06-23 2023-11-14 Ultraleap Limited Features of airborne ultrasonic fields
US11886639B2 (en) 2020-09-17 2024-01-30 Ultraleap Limited Ultrahapticons
US20240224964A9 (en) 2022-09-29 2024-07-11 Regeneron Pharmaceuticals, Inc. Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10509586A (en) * 1994-10-14 1998-09-22 ベーアーエスエフ アクツィエンゲゼルシャフト Transgenic non-human animal having a functionally disrupted interleukin-1β converting enzyme gene
PL182089B1 (en) 1994-10-21 2001-11-30 Chugai Pharmaceutical Co Ltd Pharmaceutic compositions for treating diseases caused by production of il-6
US20030082721A1 (en) * 2001-01-17 2003-05-01 Tai-Jay Chang Transgenic animals expressing androgen receptor complex-associated protein
CN1560081A (en) * 2004-02-17 2005-01-05 大连帝恩生物工程有限公司 Preparing human source monoclone antibody by mouse capable of producing human IgGl weight chain-k light chain and application thereof
SI1802193T1 (en) 2004-10-19 2014-08-29 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
US7759541B2 (en) 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
GB2434578A (en) 2006-01-26 2007-08-01 Univ Basel Transgenic animals
EP2041177B1 (en) 2006-06-02 2011-12-14 Regeneron Pharmaceuticals, Inc. High affinity antibodies to human il-6 receptor
CN101506235B (en) * 2006-09-01 2012-07-25 人类多细胞株治疗学公司 Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
FR2942218A1 (en) 2009-02-13 2010-08-20 Eurocave Sa APPARATUS FOR SERVING GLASS OF A LIQUID, IN PARTICULAR WINE
EP4049535A1 (en) 2009-10-06 2022-08-31 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
AU2010339863B2 (en) * 2009-12-21 2014-07-17 Regeneron Pharmaceuticals, Inc. Humanized FcyR mice
CN105861553B (en) 2011-02-15 2020-08-14 再生元制药公司 Humanized M-CSF mice
US10556949B2 (en) 2011-09-30 2020-02-11 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule inducing immune response to target antigen
RS59997B1 (en) 2011-10-28 2020-04-30 Regeneron Pharma Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
SG11201400945UA (en) 2011-10-28 2014-04-28 Regeneron Pharma Humanized il-6 and il-6 receptor
AU2012324016C1 (en) 2011-10-28 2018-02-15 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice

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