SG10202001795XA - Human plasma kallikrein inhibitors - Google Patents

Human plasma kallikrein inhibitors

Info

Publication number: SG10202001795XA
Authority: SG; Singapore
Prior art keywords: human plasma; plasma kallikrein; kallikrein inhibitors; inhibitors; human
Prior art date: 2014-03-07

Application number

SG10202001795XA

Inventor

Pravin Kotian

Yarlagadda Babu

Minwan Wu

Venkat Chintareddy

V Kumar

Weihe Zhang

Original Assignee

Biocryst Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-03-07

Filing date

2015-03-09

Publication date

2020-04-29

2015-03-09 Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc

2020-04-29 Publication of SG10202001795XA publication Critical patent/SG10202001795XA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Ophthalmology & Optometry (AREA)
Immunology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SG10202001795XA 2014-03-07 2015-03-09 Human plasma kallikrein inhibitors SG10202001795XA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201461949808P	2014-03-07	2014-03-07
US201461981515P	2014-04-18	2014-04-18

Publications (1)

Publication Number	Publication Date
SG10202001795XA true SG10202001795XA (en)	2020-04-29

Family

ID=54055948

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG10202001795XA SG10202001795XA (en)	2014-03-07	2015-03-09	Human plasma kallikrein inhibitors
SG11201607267SA SG11201607267SA (en)	2014-03-07	2015-03-09	Human plasma kallikrein inhibitors

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SG11201607267SA SG11201607267SA (en)	2014-03-07	2015-03-09	Human plasma kallikrein inhibitors

Country Status (29)

Country	Link
US (12)	US10125102B2 (en)
EP (3)	EP4180424A1 (en)
JP (4)	JP6574435B2 (en)
KR (2)	KR102510427B1 (en)
CN (2)	CN113307772B (en)
AU (3)	AU2015226855C1 (en)
BR (1)	BR112016020199A8 (en)
CA (2)	CA3164693A1 (en)
CY (2)	CY1123810T1 (en)
DK (2)	DK3113772T3 (en)
EA (1)	EA036251B1 (en)
ES (2)	ES2932406T3 (en)
FR (1)	FR21C1048I2 (en)
HR (2)	HRP20221373T1 (en)
HU (3)	HUE060660T2 (en)
IL (2)	IL280785B2 (en)
LT (3)	LT3828173T (en)
MA (1)	MA53399B1 (en)
MX (2)	MX2020013059A (en)
NL (1)	NL301142I2 (en)
NO (1)	NO2022046I1 (en)
NZ (2)	NZ762034A (en)
PH (1)	PH12016501750A1 (en)
PL (2)	PL3113772T3 (en)
PT (2)	PT3828173T (en)
RS (2)	RS61159B1 (en)
SG (2)	SG10202001795XA (en)
SI (1)	SI3113772T1 (en)
WO (1)	WO2015134998A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6479763B2 (en)	2013-03-25	2019-03-06	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Substituted azole containing tetrahydroisoquinolines as factor XIA inhibitors
GB2517908A (en)	2013-08-14	2015-03-11	Kalvista Pharmaceuticals Ltd	Bicyclic inhibitors
TWI636047B (en)	2013-08-14	2018-09-21	英商卡爾維斯塔製藥有限公司	Heterocyclic derivatives
NO2760821T3 (en)	2014-01-31	2018-03-10
US20170002006A1 (en)	2014-01-31	2017-01-05	Bristol-Myers Squibb Company	Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
PL3113772T3 (en)	2014-03-07	2021-04-06	Biocryst Pharmaceuticals, Inc.	Trifluoromethyl substituted pyrazoles as human plasma kallikrein inhibitors
ES2714283T3 (en)	2014-09-04	2019-05-28	Bristol Myers Squibb Co	Macrocycles of diamide that are inhibitors of FXIa
US9453018B2 (en)	2014-10-01	2016-09-27	Bristol-Myers Squibb Company	Pyrimidinones as factor XIa inhibitors
GB201421083D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	Enzyme inhibitors
GB201421085D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
SG10202003705WA (en) *	2015-10-01	2020-06-29	Biocryst Pharm Inc	Human plasma kallikrein inhibitors
EP3464271B1 (en)	2016-05-31	2020-05-13	Kalvista Pharmaceuticals Limited	Pyrazole derivatives as plasma kallikrein inhibitors
GB201609603D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
SI3716952T1 (en)	2017-11-29	2022-04-29	Kalvista Pharmaceuticals Limited	Dosage forms comprising a plasma kallikrein inhibitor
GB201719881D0 (en)	2017-11-29	2018-01-10	Kalvista Pharmaceuticals Ltd	Solid forms of plasma kallikrein inhibitor and salts thereof
GB201721515D0 (en) *	2017-12-21	2018-02-07	Kalvista Pharmaceuticals Ltd	Dosage forms comprising a plasma kallikrein inhibtor
US20230022157A1 (en)	2018-08-20	2023-01-26	Achillion Pharmaceuticals, Inc.	Pharmaceutical compounds for the treatment of complement factor d medical disorders
AR116951A1 (en)	2018-11-02	2021-06-30	Biocryst Pharm Inc	CRYSTALLINE SALTS FROM A PLASMA CALICREIN INHIBITOR
AU2019387370A1 (en)	2018-11-30	2021-06-10	Nuvation Bio Inc.	Pyrrole and pyrazole compounds and methods of use thereof
US20220160694A1 (en) *	2019-04-08	2022-05-26	Biocryst Pharmaceuticals, Inc.	Plasma kallikrein inhibitors and methods of use thereof in ocular disorders
WO2021025969A1 (en)	2019-08-02	2021-02-11	Teva Pharmaceuticals International Gmbh	Solid state forms of berotralstat
KR20220044276A (en)	2019-08-06	2022-04-07	바이오크리스트파마슈티컬즈,인코포레이티드	Process-scale synthesis of plasma kallikrein inhibitors
WO2021028645A1 (en)	2019-08-09	2021-02-18	Kalvista Pharmaceuticals Limited	Plasma kallikrein inhibitors
EP4017850A1 (en) *	2019-08-21	2022-06-29	Kalvista Pharmaceuticals Limited	Enzyme inhibitors
TW202144331A (en) *	2020-02-13	2021-12-01	德商百靈佳殷格翰國際股份有限公司	Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
CN115210230A (en) *	2020-03-04	2022-10-18	南京明德新药研发有限公司	Heterocyclic compounds
US20230286958A1 (en) *	2020-06-16	2023-09-14	Merck Sharp & Dohme Llc	Plasma kallikrein inhibitors
WO2022060842A1 (en) *	2020-09-15	2022-03-24	The Trustees Of Columbia University In The City Of New York	Systems and methods for predicting graft dysfunction with exosome proteins
CN116375648A (en) *	2023-03-22	2023-07-04	苏州农平科技发展有限公司	Preparation method of Bei Luosi intermediate

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4559157A (en)	1983-04-21	1985-12-17	Creative Products Resource Associates, Ltd.	Cosmetic applicator useful for skin moisturizing
LU84979A1 (en)	1983-08-30	1985-04-24	Oreal	COSMETIC OR PHARMACEUTICAL COMPOSITION IN AQUEOUS OR ANHYDROUS FORM WHOSE FATTY PHASE CONTAINS OLIGOMER POLYETHER AND NEW OLIGOMER POLYETHERS
LU86084A1 (en)	1985-09-20	1987-04-02	Faco Sa	ELECTRIC MASSAGE APPARATUS
US5102417A (en)	1985-11-07	1992-04-07	Expandable Grafts Partnership	Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
DE3633840A1 (en)	1986-10-04	1988-04-14	Hoechst Ag	PHENYLPYRAZOLIC CARBONIC ACID DERIVATIVES, THEIR PRODUCTION AND USE AS PLANT GROWTH REGULATORS AND SAFENERS
US4800882A (en)	1987-03-13	1989-01-31	Cook Incorporated	Endovascular stent and delivery system
US4820508A (en)	1987-06-23	1989-04-11	Neutrogena Corporation	Skin protective composition
US4886062A (en)	1987-10-19	1989-12-12	Medtronic, Inc.	Intravascular radially expandable stent and method of implant
US4992478A (en)	1988-04-04	1991-02-12	Warner-Lambert Company	Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en)	1988-09-12	1990-07-03	University Of New York	Treatment of damaged bone marrow and dosage units therefor
WO1990013332A1 (en)	1989-05-11	1990-11-15	Cedars-Sinai Medical Center	Stent with sustained drug delivery
CA2049973C (en)	1990-02-28	2002-12-24	Rodney G. Wolff	Intralumenal drug eluting prosthesis
US5429634A (en)	1993-09-09	1995-07-04	Pdt Systems	Biogenic implant for drug delivery and method
US5419760A (en)	1993-01-08	1995-05-30	Pdt Systems, Inc.	Medicament dispensing stent for prevention of restenosis of a blood vessel
US6774278B1 (en)	1995-06-07	2004-08-10	Cook Incorporated	Coated implantable medical device
KR20000062284A (en) *	1996-12-23	2000-10-25	블레어 큐. 퍼거슨	Nitrogen containing heteroaromatics as factor Xa inhibitors
US6020357A (en) *	1996-12-23	2000-02-01	Dupont Pharmaceuticals Company	Nitrogen containing heteroaromatics as factor Xa inhibitors
JP2002507968A (en) *	1997-06-19	2002-03-12	デュポンファーマシューティカルズカンパニー	Factor Xa inhibitor having a neutral P1 specific group
ZA985247B (en) *	1997-06-19	1999-12-17	Du Pont Merck Pharma	Guanidine mimics as factor Xa inhibitors.
US6339099B1 (en)	1997-06-20	2002-01-15	Dupont Pharmaceuticals Company	Guanidine mimics as factor Xa inhibitors
AU1724499A (en) *	1997-12-22	1999-07-12	Du Pont Pharmaceuticals Company	Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors
US6271237B1 (en) *	1997-12-22	2001-08-07	Dupont Pharmaceuticals Company	Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors
CA2362381C (en) *	1999-02-10	2009-12-22	Welfide Corporation	Amide compounds and medicinal use thereof
CA2368630A1 (en) *	1999-04-02	2000-10-12	Ruth R. Wexler	Aryl sulfonyls as factor xa inhibitors
US20010044445A1 (en)	1999-04-08	2001-11-22	Bamaung Nwe Y.	Azole inhibitors of cytokine production
US6632815B2 (en)	1999-09-17	2003-10-14	Millennium Pharmaceuticals, Inc.	Inhibitors of factor Xa
US6329527B1 (en)	1999-10-21	2001-12-11	Bristol-Myers Squibb Pharma Company	Synthesis of 1,3,5-trisubstituted pyrazoles
AU2001273040A1 (en) *	2000-06-27	2002-01-08	Du Pont Pharmaceuticals Company	Factor xa inhibitors
UA72632C2 (en)	2000-06-27	2005-03-15	Лабораторіос С.А.Л.В.А.Т., С.А.	Carbamates, derivaties of arylalkylamines
JP2004529853A (en)	2000-09-22	2004-09-30	ブリストル−マイヤーズスクイブファーマカンパニー	Efficient method for producing factor Xa inhibitor
AU2002312788B2 (en)	2001-04-12	2005-11-10	F. Hoffmann-La Roche Ag	Dihydro-benzo [b] [1, 4] diazepin-2-one derivatives as mGluR2 antagonists II
WO2003016282A2 (en)	2001-08-13	2003-02-27	E.I. Du Pont De Nemours And Company	Substituted 1h-dihydropyrazoles, their preparation and use
TWI312274B (en) *	2001-08-13	2009-07-21	Du Pont	Method for controlling particular insect pests by applying anthranilamide compounds
MXPA04002649A (en) *	2001-09-21	2004-06-07	Du Pont	Insecticidal diamides.
TWI283164B (en)	2001-09-21	2007-07-01	Du Pont	Anthranilamide arthropodicide treatment
US7030141B2 (en) *	2001-11-29	2006-04-18	Christopher Franklin Bigge	Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
TW200303309A (en)	2001-12-04	2003-09-01	Bristol Myers Squibb Co	Novel n-[4-(1h-imidazol-1-yl)-2-fluorophenyl]-3-trifluoromethyl)-1h-pyrazole-5-carboxamides as factor Xa inhibitors
TW200302225A (en)	2001-12-04	2003-08-01	Bristol Myers Squibb Co	Substituted amino methyl factor Xa inhibitors
EP1513817A1 (en)	2002-05-24	2005-03-16	Takeda Pharmaceutical Company Limited	1, 2-azole derivatives with hypoglycemic and hypolipidemic activity
WO2003106427A2 (en) *	2002-06-13	2003-12-24	E.I. Du Pont De Nemours And Company	Pyrazolecarboxamide insecticides
DE10229070A1 (en) *	2002-06-28	2004-01-15	Merck Patent Gmbh	Phenyl derivatives 5
US6770729B2 (en)	2002-09-30	2004-08-03	Medtronic Minimed, Inc.	Polymer compositions containing bioactive agents and methods for their use
AU2004218260A1 (en)	2003-01-28	2004-09-16	Aventis Pharma S.A.	N-aryl heteroaromatic products, compositions containing same and use thereof
US7749999B2 (en)	2003-09-11	2010-07-06	Itherx Pharmaceuticals, Inc.	Alpha-ketoamides and derivatives thereof
WO2005094805A1 (en) *	2004-04-01	2005-10-13	Institute Of Medicinal Molecular Design. Inc.	Imine derivative and amide derivative
RU2006139953A (en)	2004-04-13	2008-05-20	Е.И. Дюпон Де Немур Энд Компани (Us)	ANTRANILAMIDE INSECTICIDES
WO2005113522A1 (en)	2004-05-07	2005-12-01	Janssen Pharmaceutica, N.V.	Azole carboxamide inhibitors of bacterial type iii protein secretion systems
US20060069270A1 (en)	2004-09-27	2006-03-30	Rafael Shapiro	Process for the preparation of 1,3,5-trisubstituted pyrazoles via [3+2] cycloaddition
US7381732B2 (en)	2004-10-26	2008-06-03	Bristol-Myers Squibb Company	Pyrazolobenzamides and derivatives as factor Xa inhibitors
EP2564706A1 (en)	2004-11-18	2013-03-06	E. I. du Pont de Nemours and Company	Anthranilamide insecticides
AU2005312721B9 (en) *	2004-12-07	2012-08-02	Toyama Chemical Co., Ltd.	Novel anthranilic acid derivative or salt thereof
US20070060589A1 (en)	2004-12-21	2007-03-15	Purandare Ashok V	Inhibitors of protein arginine methyl transferases
GB0516703D0 (en)	2005-08-15	2005-09-21	Syngenta Participations Ag	Novel insecticides
EP2251336A1 (en)	2005-10-14	2010-11-17	Sumitomo Chemical Company, Limited	Hydrazide compounds as intermediates of pesticides
JP5186751B2 (en) *	2005-10-14	2013-04-24	住友化学株式会社	Hydrazide compounds and their pest control applications
AR056582A1 (en)	2005-10-28	2007-10-10	Lilly Co Eli	PIRAZOLIL UREA COMPOUNDS WITH INHIBITORY ACTIVITY OF CINASA P38 AND PHARMACEUTICAL FORMULATION THAT INCLUDES IT
DK1988777T3 (en)	2006-02-09	2012-01-16	Athersys Inc	Pyrazoles for the treatment of obesity and other cns disorders
EA200802210A1 (en) *	2006-05-16	2009-06-30	Бёрингер Ингельхайм Интернациональ Гмбх	SUBSTITUTED PROLINAMIDES, THEIR RECEIVING AND THEIR USE AS MEDICINES
US7910747B2 (en)	2006-07-06	2011-03-22	Bristol-Myers Squibb Company	Phosphonate and phosphinate pyrazolylamide glucokinase activators
CN101495468A (en) *	2006-07-31	2009-07-29	艾克提弗赛特制药股份有限公司	Inhibitors of plasma kallikrein
EP2051707B1 (en)	2006-07-31	2013-07-17	Activesite Pharmaceuticals, Inc.	Inhibitors of plasma kallikrein
US8188113B2 (en)	2006-09-14	2012-05-29	Deciphera Pharmaceuticals, Inc.	Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US20120225057A1 (en)	2006-10-11	2012-09-06	Deciphera Pharmaceuticals, Llc	Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
CA2668190A1 (en)	2006-11-03	2008-05-15	Irm Llc	Compounds and compositions as protein kinase inhibitors
AU2007333194A1 (en) *	2006-12-08	2008-06-19	Exelixis, Inc.	LXR and FXR modulators
US8338437B2 (en)	2007-02-28	2012-12-25	Methylgene Inc.	Amines as small molecule inhibitors
WO2008134969A1 (en)	2007-04-30	2008-11-13	Sinochem Corporation	Benzamide compounds and applications thereof
CN101298451B (en)	2007-04-30	2013-01-30	中国中化股份有限公司	Benzamide compounds and use thereof
PT2379526E (en) *	2008-12-18	2015-09-17	Bayer Ip Gmbh	Tetrazol-substituted anthranilic acid amides as pesticides
CN102365278B (en)	2009-03-26	2015-05-06	先正达参股股份有限公司	Insecticidal compounds
US8946204B2 (en)	2009-05-07	2015-02-03	Gruenenthal Gmbh	Substituted phenylureas and phenylamides as vanilloid receptor ligands
JP2013515000A (en)	2009-12-18	2013-05-02	アクティベサイトファーマシューティカルズインコーポレイティッド	Prodrugs for inhibitors of plasma kallikrein
CA2786834C (en)	2010-02-01	2018-10-16	Cancer Research Technology Limited	1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
JPWO2011118818A1 (en)	2010-03-26	2013-07-04	味の素株式会社	Amidinoaniline derivatives
CN102285963B (en)	2010-06-21	2014-04-09	中国中化股份有限公司	3-methoxy pyrazolecarboxamide compound and application thereof
EP2606033A1 (en)	2010-08-20	2013-06-26	Grünenthal GmbH	Substituted cyclic carboxamide and urea derivatives as ligands of the vanilloid receptor
US20120115903A1 (en)	2010-11-10	2012-05-10	Gruenenthal Gmbh	Substituted Heteroaromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands
WO2012139930A1 (en)	2011-04-11	2012-10-18	Nerviano Medical Sciences S.R.L.	Pyrazolyl-pyrimidine derivatives as kinase inhibitors
US8691861B2 (en) *	2011-04-13	2014-04-08	Activesite Pharmaceuticals, Inc.	Prodrugs of inhibitors of plasma kallikrein
WO2013036232A2 (en)	2011-09-08	2013-03-14	Deciphera Pharmaceuticals, Llc	Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
EP2776401A1 (en)	2011-11-09	2014-09-17	Grünenthal GmbH	Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an so2-containing group as vanilloid receptor ligands
CN103467380B (en)	2013-09-29	2015-06-24	南开大学	Substituted phenyl pyrazole amide derivative and preparation method and application thereof
PL3113772T3 (en)	2014-03-07	2021-04-06	Biocryst Pharmaceuticals, Inc.	Trifluoromethyl substituted pyrazoles as human plasma kallikrein inhibitors
AR116951A1 (en)	2018-11-02	2021-06-30	Biocryst Pharm Inc	CRYSTALLINE SALTS FROM A PLASMA CALICREIN INHIBITOR
KR20220044276A (en)	2019-08-06	2022-04-07	바이오크리스트파마슈티컬즈,인코포레이티드	Process-scale synthesis of plasma kallikrein inhibitors

2015
- 2015-03-09 PL PL15759254T patent/PL3113772T3/en unknown
- 2015-03-09 SG SG10202001795XA patent/SG10202001795XA/en unknown
- 2015-03-09 DK DK15759254.4T patent/DK3113772T3/en active
- 2015-03-09 PL PL20191747.3T patent/PL3828173T3/en unknown
- 2015-03-09 PT PT201917473T patent/PT3828173T/en unknown
- 2015-03-09 CN CN202110045874.9A patent/CN113307772B/en active Active
- 2015-03-09 ES ES20191747T patent/ES2932406T3/en active Active
- 2015-03-09 AU AU2015226855A patent/AU2015226855C1/en active Active
- 2015-03-09 RS RS20201483A patent/RS61159B1/en unknown
- 2015-03-09 KR KR1020167026786A patent/KR102510427B1/en active IP Right Grant
- 2015-03-09 NZ NZ762034A patent/NZ762034A/en unknown
- 2015-03-09 US US15/123,059 patent/US10125102B2/en active Active
- 2015-03-09 CA CA3164693A patent/CA3164693A1/en active Pending
- 2015-03-09 EA EA201691803A patent/EA036251B1/en unknown
- 2015-03-09 CA CA2941380A patent/CA2941380C/en active Active
- 2015-03-09 NZ NZ724250A patent/NZ724250A/en unknown
- 2015-03-09 WO PCT/US2015/019535 patent/WO2015134998A1/en active Application Filing
- 2015-03-09 HU HUE20191747A patent/HUE060660T2/en unknown
- 2015-03-09 HU HUE15759254A patent/HUE052668T2/en unknown
- 2015-03-09 MA MA53399A patent/MA53399B1/en unknown
- 2015-03-09 RS RS20221083A patent/RS63763B1/en unknown
- 2015-03-09 LT LTEP20191747.3T patent/LT3828173T/en unknown
- 2015-03-09 SG SG11201607267SA patent/SG11201607267SA/en unknown
- 2015-03-09 EP EP22191079.7A patent/EP4180424A1/en active Pending
- 2015-03-09 EP EP15759254.4A patent/EP3113772B8/en active Active
- 2015-03-09 KR KR1020237008388A patent/KR20230042384A/en active IP Right Grant
- 2015-03-09 BR BR112016020199A patent/BR112016020199A8/en not_active Application Discontinuation
- 2015-03-09 IL IL280785A patent/IL280785B2/en unknown
- 2015-03-09 MX MX2020013059A patent/MX2020013059A/en unknown
- 2015-03-09 MX MX2016011468A patent/MX2016011468A/en unknown
- 2015-03-09 ES ES15759254T patent/ES2836373T3/en active Active
- 2015-03-09 CN CN201580022369.5A patent/CN106257976B/en active Active
- 2015-03-09 PT PT157592544T patent/PT3113772T/en unknown
- 2015-03-09 EP EP20191747.3A patent/EP3828173B1/en active Active
- 2015-03-09 HR HRP20221373TT patent/HRP20221373T1/en unknown
- 2015-03-09 LT LTEP15759254.4T patent/LT3113772T/en unknown
- 2015-03-09 SI SI201531442T patent/SI3113772T1/en unknown
- 2015-03-09 DK DK20191747.3T patent/DK3828173T3/en active
- 2015-03-09 JP JP2016555752A patent/JP6574435B2/en active Active
2016
- 2016-08-28 IL IL247518A patent/IL247518B/en active IP Right Grant
- 2016-09-06 PH PH12016501750A patent/PH12016501750A1/en unknown
2018
- 2018-05-11 US US15/977,129 patent/US10329260B2/en active Active
- 2018-06-15 US US16/009,943 patent/US10633345B2/en active Active
2019
- 2019-05-01 US US16/400,798 patent/US10689346B2/en active Active
- 2019-08-16 JP JP2019149385A patent/JP6915003B2/en active Active
2020
- 2020-03-24 US US16/828,763 patent/US11203574B2/en active Active
- 2020-03-24 US US16/828,755 patent/US11192861B2/en active Active
- 2020-04-10 US US16/845,833 patent/US11230530B2/en active Active
- 2020-10-27 AU AU2020260400A patent/AU2020260400B2/en active Active
- 2020-12-01 HR HRP20201916TT patent/HRP20201916T1/en unknown
- 2020-12-08 CY CY20201101164T patent/CY1123810T1/en unknown
2021
- 2021-07-14 JP JP2021116716A patent/JP2021169499A/en active Pending
- 2021-10-08 CY CY2021029C patent/CY2021029I2/en unknown
- 2021-10-25 HU HUS2100045C patent/HUS2100045I1/en unknown
- 2021-10-25 FR FR21C1048C patent/FR21C1048I2/en active Active
- 2021-10-26 LT LTPA2021524C patent/LTC3113772I2/lt unknown
- 2021-11-01 NL NL301142C patent/NL301142I2/en unknown
- 2021-11-09 US US17/522,065 patent/US11685721B2/en active Active
- 2021-11-15 US US17/526,377 patent/US11708332B2/en active Active
- 2021-12-07 US US17/543,929 patent/US11708333B2/en active Active
2022
- 2022-10-25 AU AU2022259742A patent/AU2022259742B2/en active Active
- 2022-11-07 NO NO2022046C patent/NO2022046I1/en unknown
2023
- 2023-04-18 US US18/136,016 patent/US20240150295A1/en active Pending
- 2023-04-18 US US18/136,025 patent/US12116346B2/en active Active
- 2023-11-06 JP JP2023189564A patent/JP2023181543A/en active Pending

Also Published As

Publication number	Publication date
JP2017507160A (en)	2017-03-16
LTPA2021524I1 (en)	2021-11-10
EP3113772A1 (en)	2017-01-11
US20240150296A1 (en)	2024-05-09
PT3828173T (en)	2022-12-05
EP3113772B8 (en)	2020-11-25
AU2022259742B2 (en)	2024-09-05
DK3113772T3 (en)	2020-12-07
IL247518A0 (en)	2016-11-30
FR21C1048I1 (en)	2021-12-10
US20240150295A1 (en)	2024-05-09
LT3113772T (en)	2020-12-28
BR112016020199A2 (en)	2017-08-15
CN106257976A (en)	2016-12-28
US20230100082A1 (en)	2023-03-30
CA3164693A1 (en)	2015-09-11
IL247518B (en)	2021-02-28
IL280785A (en)	2021-04-29
RS63763B1 (en)	2022-12-30
NL301142I1 (en)	2021-11-03
US11230530B2 (en)	2022-01-25
AU2015226855B2 (en)	2020-09-03
MX2020013059A (en)	2022-10-07
NZ724250A (en)	2022-02-25
NZ762034A (en)	2022-02-25
AU2020260400B2 (en)	2022-08-11
HUS2100045I1 (en)	2021-11-29
US20210047275A1 (en)	2021-02-18
US11203574B2 (en)	2021-12-21
KR20230042384A (en)	2023-03-28
AU2022259742A1 (en)	2022-12-01
ES2836373T3 (en)	2021-06-24
EP3113772A4 (en)	2017-08-30
EP3113772B1 (en)	2020-09-09
RS61159B1 (en)	2021-01-29
US10633345B2 (en)	2020-04-28
CY2021029I1 (en)	2022-03-24
EP4180424A1 (en)	2023-05-17
EP3828173B1 (en)	2022-08-31
CA2941380C (en)	2022-09-06
US11708332B2 (en)	2023-07-25
PH12016501750A1 (en)	2016-11-21
US20230094305A1 (en)	2023-03-30
US20170073314A1 (en)	2017-03-16
US20190322626A1 (en)	2019-10-24
PT3113772T (en)	2020-12-15
JP6574435B2 (en)	2019-09-11
HUE052668T2 (en)	2021-05-28
CN113307772B (en)	2024-06-28
IL280785B1 (en)	2024-05-01
CN113307772A (en)	2021-08-27
US10329260B2 (en)	2019-06-25
MX2016011468A (en)	2017-01-23
SI3113772T1 (en)	2021-01-29
EA201691803A1 (en)	2017-02-28
IL280785B2 (en)	2024-09-01
CA2941380A1 (en)	2015-09-11
CY2021029I2 (en)	2022-03-24
US11192861B2 (en)	2021-12-07
AU2015226855A1 (en)	2016-10-13
US20180258049A1 (en)	2018-09-13
JP6915003B2 (en)	2021-08-04
PL3113772T3 (en)	2021-04-06
EA036251B1 (en)	2020-10-20
AU2015226855C1 (en)	2021-02-11
US20230056538A1 (en)	2023-02-23
BR112016020199A8 (en)	2021-07-20
US11685721B2 (en)	2023-06-27
JP2023181543A (en)	2023-12-21
WO2015134998A1 (en)	2015-09-11
HUE060660T2 (en)	2023-04-28
HRP20221373T1 (en)	2023-01-06
CY1123810T1 (en)	2022-03-24
SG11201607267SA (en)	2016-09-29
HRP20201916T1 (en)	2021-01-22
FR21C1048I2 (en)	2022-09-30
NO2022046I1 (en)	2022-11-07
NL301142I2 (en)	2021-12-09
CN106257976B (en)	2021-02-02
US10689346B2 (en)	2020-06-23
LT3828173T (en)	2022-11-10
KR102510427B1 (en)	2023-03-14
AU2020260400A1 (en)	2020-11-26
KR20160130254A (en)	2016-11-10
MA53399A (en)	2021-06-02
US20210078952A1 (en)	2021-03-18
MA53399B1 (en)	2022-10-31
PL3828173T3 (en)	2022-12-19
DK3828173T3 (en)	2022-11-07
JP2021169499A (en)	2021-10-28
US20180354906A1 (en)	2018-12-13
US11708333B2 (en)	2023-07-25
US10125102B2 (en)	2018-11-13
LTC3113772I2 (en)	2023-06-26
US12116346B2 (en)	2024-10-15
ES2932406T3 (en)	2023-01-18
JP2019206588A (en)	2019-12-05
EP3828173A1 (en)	2021-06-02
US20210047276A1 (en)	2021-02-18

Publication	Publication Date	Title
IL280785A (en)	2021-04-29	Human plasma kallikrein inhibitors
IL287113A (en)	2021-12-01	Smyd inhibitors
IL248895A0 (en)	2017-01-31	Phosphatidylinositol -kinase inhibitors
IL291268A (en)	2022-05-01	Human plasma kallikrein inhibitors
SI3097084T1 (en)	2021-01-29	New kallikrein 7 inhibitors
GB201401005D0 (en)	2014-03-05	Inhibitor
GB201418154D0 (en)	2014-11-26	Inhibitors