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SE8902257L - PROCEDURE FOR PREPARATION OF MEDICINAL PARTICLES - Google Patents

PROCEDURE FOR PREPARATION OF MEDICINAL PARTICLES

Info

Publication number
SE8902257L
SE8902257L SE8902257A SE8902257A SE8902257L SE 8902257 L SE8902257 L SE 8902257L SE 8902257 A SE8902257 A SE 8902257A SE 8902257 A SE8902257 A SE 8902257A SE 8902257 L SE8902257 L SE 8902257L
Authority
SE
Sweden
Prior art keywords
drug
preparation
aqueous phase
particles
procedure
Prior art date
Application number
SE8902257A
Other languages
Swedish (sv)
Other versions
SE8902257D0 (en
SE464743B (en
Inventor
B Sjoestroem
Original Assignee
Ytkemiska Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ytkemiska Inst filed Critical Ytkemiska Inst
Priority to SE8902257A priority Critical patent/SE464743B/en
Publication of SE8902257D0 publication Critical patent/SE8902257D0/en
Priority to PCT/SE1990/000426 priority patent/WO1990015593A1/en
Priority to AU59375/90A priority patent/AU5937590A/en
Publication of SE8902257L publication Critical patent/SE8902257L/en
Publication of SE464743B publication Critical patent/SE464743B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for the preparation of submicron size, monodisperse drug-particles of a drug of low water-solubility by emulsifying an organic solution of the drug in an aqueous phase and then removing the organic solvent resulting in drug precipitation, containing the steps: a) emulsifying the organic solution in the presence of an emulsifier comprising a surfactant capable of adsorption on the surface of a precipitated drug-particle; b) removing the organic solvent from the suspension; and c) recovering the precipitated drug-particles from the aqueous phase or storing the same in the original aqueous phase.
SE8902257A 1989-06-21 1989-06-21 PROCEDURE FOR PREPARATION OF MEDICINAL PARTICLES SE464743B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE8902257A SE464743B (en) 1989-06-21 1989-06-21 PROCEDURE FOR PREPARATION OF MEDICINAL PARTICLES
PCT/SE1990/000426 WO1990015593A1 (en) 1989-06-21 1990-06-15 A process for the preparation of drug particles
AU59375/90A AU5937590A (en) 1989-06-21 1990-06-15 A process for the preparation of drug particles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8902257A SE464743B (en) 1989-06-21 1989-06-21 PROCEDURE FOR PREPARATION OF MEDICINAL PARTICLES

Publications (3)

Publication Number Publication Date
SE8902257D0 SE8902257D0 (en) 1989-06-21
SE8902257L true SE8902257L (en) 1990-12-22
SE464743B SE464743B (en) 1991-06-10

Family

ID=20376358

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8902257A SE464743B (en) 1989-06-21 1989-06-21 PROCEDURE FOR PREPARATION OF MEDICINAL PARTICLES

Country Status (3)

Country Link
AU (1) AU5937590A (en)
SE (1) SE464743B (en)
WO (1) WO1990015593A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
DK0644755T3 (en) * 1992-06-10 1997-09-22 Nanosystems Llc Surface Modified NSAID Nanoparticles
US5346702A (en) * 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
US5352459A (en) * 1992-12-16 1994-10-04 Sterling Winthrop Inc. Use of purified surface modifiers to prevent particle aggregation during sterilization
DE4308121A1 (en) * 1993-03-15 1994-09-22 Rhone Poulenc Rorer Gmbh Aqueous liposome system and method for producing such a liposome system
EP0755222A4 (en) * 1994-04-11 2000-03-08 Mallinckrodt Medical Inc Microfluidization of calcium/oxyanion-containing particles
FR2721510B1 (en) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticles filterable under sterile conditions.
SE9403846D0 (en) * 1994-11-09 1994-11-09 Univ Ohio State Res Found Small particle formation
GB0008411D0 (en) * 2000-04-05 2000-05-24 Vectura Ltd Pharmaceutical preparations and their manufacture
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
CA2456806C (en) 2001-08-08 2011-10-18 Brown University Research Foundation Methods for micronization of hydrophobic drugs
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
WO2003026611A2 (en) 2001-09-26 2003-04-03 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
JP2005515224A (en) * 2002-01-14 2005-05-26 ダウ グローバル テクノロジーズ インコーポレイティド Drug nanoparticles from template emulsion
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
DE60309300T3 (en) * 2002-03-20 2011-02-24 Elan Pharma International Ltd. NANOPARTICLE COMPOSITIONS OF ANGIOGENIC INHIBITORS
EP1800666A1 (en) * 2002-03-20 2007-06-27 Elan Pharma International Limited Nanoparticulate compositions of angiogenesis inhibitors
JP4533134B2 (en) * 2002-06-10 2010-09-01 エラン ファーマ インターナショナル，リミティド Nanoparticulate policosanol formulations and novel policosanol combinations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2348334C2 (en) * 1973-09-26 1982-11-11 Boehringer Mannheim Gmbh, 6800 Mannheim New form of preparation of N-4- [2- (5-chloro-2-methoxybenzamido) ethyl] -phenyl-sulfonyl-N'-cyclohexylurea
DE2817453A1 (en) * 1978-04-21 1979-10-31 Rohner Ag Water dispersible granulate and powder contg. insoluble components - e.g. dyes, brighteners and pigments, contain acid polymeric carrier which dissolves in aq. base
CA1282405C (en) * 1984-05-21 1991-04-02 Michael R. Violante Method for making uniformly sized particles from water-insoluble organic compounds
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds

Also Published As

Publication number Publication date
AU5937590A (en) 1991-01-08
SE8902257D0 (en) 1989-06-21
SE464743B (en) 1991-06-10
WO1990015593A1 (en) 1990-12-27

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