SE8403107D0 - Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider - Google Patents

Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider

Info

Publication number: SE8403107D0
Authority: SE; Sweden
Prior art keywords: intermediates; oxides; integer; image; dioxides
Prior art date: 1979-09-04

Application number

SE8403107A

Other languages

English (en)

Other versions

SE456580B (sv

SE8403107L (sv

Inventor

Ronnie Ray Crenshaw

Aldo Antonio Algieri

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-09-04

Filing date

1984-06-08

Publication date

1984-06-08

1984-06-08 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1984-06-08 Publication of SE8403107D0 publication Critical patent/SE8403107D0/sv

1984-06-08 Publication of SE8403107L publication Critical patent/SE8403107L/sv

1988-10-17 Publication of SE456580B publication Critical patent/SE456580B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Lubricants (AREA)

SE8403107A 1979-09-04 1984-06-08 Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider som er h 71-receptorantagonister SE456580B (sv)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US7251779A	1979-09-04	1979-09-04
US11718280A	1980-01-31	1980-01-31
US16383180A	1980-06-07	1980-06-07

Publications (3)

Publication Number	Publication Date
SE8403107D0 true SE8403107D0 (sv)	1984-06-08
SE8403107L SE8403107L (sv)	1984-06-08
SE456580B SE456580B (sv)	1988-10-17

Family

ID=27372107

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
SE8006148A SE449099B (sv)	1979-09-04	1980-09-03	3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och 1,1-dioxider, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande dessa
SE8403109A SE456581B (sv)	1979-09-04	1984-06-08	Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider som er h 71-receptorantagonister
SE8403111A SE461733B (sv)	1979-09-04	1984-06-08	Foerfarande foer framstaellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider
SE8403108A SE456582B (sv)	1979-09-04	1984-06-08	Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider, som er h 71-receptorantagonister
SE8403107A SE456580B (sv)	1979-09-04	1984-06-08	Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider som er h 71-receptorantagonister

Family Applications Before (4)

Application Number	Title	Priority Date	Filing Date
SE8006148A SE449099B (sv)	1979-09-04	1980-09-03	3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och 1,1-dioxider, forfarande for deras framstellning samt farmaceutiska kompositioner innehallande dessa
SE8403109A SE456581B (sv)	1979-09-04	1984-06-08	Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider som er h 71-receptorantagonister
SE8403111A SE461733B (sv)	1979-09-04	1984-06-08	Foerfarande foer framstaellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider
SE8403108A SE456582B (sv)	1979-09-04	1984-06-08	Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider, som er h 71-receptorantagonister

Country Status (23)

Country	Link
US (1)	US4374248A (sv)
AR (1)	AR240559A1 (sv)
AT (2)	AT376978B (sv)
CA (4)	CA1167841A (sv)
CH (2)	CH649764A5 (sv)
CS (1)	CS235951B2 (sv)
CY (2)	CY1360A (sv)
DE (2)	DE3051146C2 (sv)
DK (4)	DK160611C (sv)
FI (1)	FI76795C (sv)
GB (2)	GB2067987B (sv)
HK (2)	HK41387A (sv)
IE (2)	IE51235B1 (sv)
KE (2)	KE3685A (sv)
LU (1)	LU82753A1 (sv)
MY (2)	MY8700585A (sv)
NL (3)	NL189197C (sv)
NO (4)	NO160003C (sv)
NZ (1)	NZ194831A (sv)
PT (1)	PT71764B (sv)
SE (5)	SE449099B (sv)
SG (1)	SG61187G (sv)
ZW (1)	ZW20580A1 (sv)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3175201D1 (en) *	1980-04-30	1986-10-02	Merck & Co Inc	Aminothiadiazoles as gastric secretion inhibitors
US4904792A (en) *	1980-10-02	1990-02-27	Eli Lilly And Company	N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4760075A (en) *	1980-10-02	1988-07-26	Eli Lilly And Company	N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4471122A (en) *	1981-03-03	1984-09-11	Bristol-Myers Company	Thiadiazole histamine H2 -antagonists
EP0065823A1 (en) *	1981-05-13	1982-12-01	Imperial Chemical Industries Plc	Heterocyclic guanidines as histamine H-2 antagonists
IE53068B1 (en) *	1981-06-15	1988-05-25	Merck & Co Inc	Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
ATE19880T1 (de) *	1981-08-24	1986-06-15	Merck & Co Inc	Thiadiazole oxyde mit antisekretorischer wirkung.
GR77847B (sv) *	1981-12-14	1984-09-25	American Home Prod
US4528378A (en) *	1982-03-29	1985-07-09	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4528377A (en) *	1982-03-29	1985-07-09	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4528375A (en) *	1982-03-29	1985-07-09	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
NL8301063A (nl) *	1982-03-29	1983-10-17	Bristol Myers Co	Gesubstitueerde 3,4-diamino-1,2,5-thiadiazolen met histamine h2-receptor antagonistische werkzaamheid; gesubstitueerde ethaandiimidamiden.
US4578471A (en) *	1982-03-29	1986-03-25	Bristol-Myers Company	Substituted amino alkyl pyridyl ethanediimidamides
US4517366A (en) *	1982-03-29	1985-05-14	Bristol-Myers Company	Intermediates for preparing 3,4-diamino-1,2,5-thiadiazoles
FI832519L (fi) *	1982-07-12	1984-01-13	Bristol Myers Co	Farmaceutiska foerfaranden och sammansaettningar
US4520025A (en) *	1982-07-21	1985-05-28	William H. Rorer, Inc.	Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
EP0105732A3 (en) *	1982-10-01	1985-09-04	Beecham Group Plc	Histamine h2 receptor antagonists of the benzisothiazole amino and benzthiadiazine amino series
US4461900A (en) *	1983-03-14	1984-07-24	American Home Products Corporation	4,5-Dihydrothiadiazole 1,1-dioxide derivatives
AT387384B (de) *	1983-03-16	1989-01-10	Bristol Myers Co	Verfahren zur herstellung von thiadiazolderivaten
US4440933A (en) *	1983-03-16	1984-04-03	Bristol-Myers Company	Process for preparing 1,2,5-thiadiazoles
GB2138803B (en) *	1983-04-26	1986-06-18	Shionogi & Co	2-guanidino-4-hydroxymethylthiazole and derivatives thereof
US4543352A (en) *	1983-04-29	1985-09-24	William H. Rorer, Inc.	Naphthalene aminoalkylene ethers and thioethers, and their pharmaceutical uses
DE3326545A1 (de) *	1983-07-22	1985-01-31	Ludwig Heumann & Co GmbH, 8500 Nürnberg	Propan-2-ol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4529731A (en) *	1983-09-22	1985-07-16	American Home Products Corporation	Thiadiazolediamine derivative with histamine H-2 receptor inhibiting properties
US4692531A (en) *	1984-06-22	1987-09-08	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4644006A (en) *	1984-06-22	1987-02-17	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4612309A (en) *	1984-10-23	1986-09-16	William H. Rorer, Inc.	Antisecretory bicyclic benzo-oxy heterocyclic ethers and thioethers
GB8501535D0 (en) *	1985-01-22	1985-02-20	Smith Kline French Lab	Chemical compounds
US4728648A (en) *	1985-02-09	1988-03-01	Smith Kline & French Laboratories Limited	Histamine antagonist triadiazole derivatives, compositions, and method of use therefor
GB8509276D0 (en) *	1985-04-11	1985-05-15	Smith Kline French Lab	Pyridine derivatives
GB8510680D0 (en) *	1985-04-26	1985-06-05	Smith Kline French Lab	Pyridine derivatives
CA1286297C (en) *	1985-06-13	1991-07-16	George S. Sach	Pyridine derivatives
DE3532880A1 (de) *	1985-09-14	1987-03-26	Basf Ag	1,4-disubstituierte pyrazolderivate
GB8610867D0 (en) *	1986-05-02	1986-06-11	Smith Kline French Lab	3-hydroxypyridines
ES2008962A6 (es) *	1987-12-17	1989-08-16	Marga Investigacion	Proceso para la preparacion de nuevos compuestos de 2-guanidinotiazol
DK0515121T3 (da) *	1991-05-21	2000-11-27	Lilly Co Eli	Fremgangsmåde til fremstilling af mellemprodukter for nizatidin og beslægtede forbindelser
US5248673A (en) *	1992-12-23	1993-09-28	Bristol-Myers Squibb Co.	Bisamidine derivatives as thrombin inhibitors
US5821370A (en) *	1994-10-24	1998-10-13	Eli Lilly And Company	Heterocyclic compounds and their preparation and use
US5618816A (en) *	1995-03-02	1997-04-08	Bristol-Myers Squibb Company	Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
US5767280A (en) *	1995-06-01	1998-06-16	Eli Lilly And Company	Process for making heterocyclic compounds
MY139601A (en)	2002-10-09	2009-10-30	Schering Corp	Thiadiazoledioxides and thiadiazoleoxides as cxc-and cc-chemokine receptor ligands
US7338968B2 (en)	2003-12-19	2008-03-04	Schering Corporation	Thiadiazoles AS CXC- and CC- chemokine receptor ligands
EP1697354B1 (en)	2003-12-22	2013-08-07	Merck Sharp & Dohme Corp.	Isothiazole dioxides as cxc- and cc- chemokine receptor ligands
JP2009500328A (ja)	2005-06-29	2009-01-08	シェーリングコーポレイション	Ｃｘｃ−ケモカインレセプターリガンドとしての５，６−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン
CN101253165A (zh)	2005-06-29	2008-08-27	先灵公司	作为cxc－化学活素受体配体的二取代的二唑
EP2822931B1 (en)	2012-03-09	2017-05-03	Inception 2, Inc.	Triazolone compounds and uses thereof
WO2014009293A1 (en)	2012-07-13	2014-01-16	Basf Se	New substituted thiadiazoles and their use as fungicides
DK2935228T3 (en)	2012-12-20	2017-10-30	Inception 2 Inc	TRIAZOLONE COMPOUNDS AND APPLICATIONS THEREOF
WO2015035059A1 (en)	2013-09-06	2015-03-12	Inception 2, Inc.	Triazolone compounds and uses thereof
CN105061360B (zh) *	2015-07-28	2018-06-19	首都师范大学	一种3,4-二氨基-1,2,5-噻二唑的提纯方法
EP4196793A1 (en)	2020-08-11	2023-06-21	Université de Strasbourg	H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL22850A (en) *	1964-03-18	1968-12-26	Merck & Co Inc	3-chloro-1,2,5-thiazdiazole-4-carboxylic acid being an intermediate in the preparation of sulfa drugs
CH482712A (de) *	1964-10-01	1969-12-15	Merck & Co Inc	Verfahren zur Herstellung von 3-Amino-1,2,5-thiadiazolen
US3419573A (en) *	1965-10-15	1968-12-31	Merck & Co Inc	3-chloro-4-oxy-1,2,5-thiadiazoles, and a process for preparing same
US3564000A (en) *	1965-10-15	1971-02-16	Merck & Co Inc	Process for preparing 3-chloro-4-hydroxy-1,2,5-thiadiazole derivatives
DE1770152A1 (de) *	1968-04-08	1971-09-30	Lentia Gmbh	Verfahren zur Herstellung von 3-Amino-4-brom-1,2,5-thiadiazol
US3657237A (en) *	1968-05-22	1972-04-18	Frosst & Co Charles E	Process for making 1 2 5-thiadiazoles in the sinister configuration
US4104381A (en) *	1973-05-03	1978-08-01	Smith Kline & French Laboratories Limited	Pharmacologically active compounds
AT348517B (de) *	1977-01-19	1979-02-26	Chemie Linz Ag	Verfahren zur herstellung von reinem 3-methoxy- 4- (4'-aminobenzolsulfonamido) -1,2,5-thiadiazol
GR62452B (en) *	1977-04-20	1979-04-12	Ici Ltd	Preparation process of guanidine derivatives
US4165378A (en) *	1977-04-20	1979-08-21	Ici Americas Inc.	Guanidine derivatives of imidazoles and thiazoles
US4374836A (en) *	1978-10-16	1983-02-22	Imperial Chemical Industries Ltd.	Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
DE3175201D1 (en) *	1980-04-30	1986-10-02	Merck & Co Inc	Aminothiadiazoles as gastric secretion inhibitors
EP0045155B1 (en) *	1980-07-30	1985-01-02	Imperial Chemical Industries Plc	Guanidine derivatives
ATE19880T1 (de) *	1981-08-24	1986-06-15	Merck & Co Inc	Thiadiazole oxyde mit antisekretorischer wirkung.

1980
- 1980-09-01 DK DK371880A patent/DK160611C/da not_active IP Right Cessation
- 1980-09-01 NL NLAANVRAGE8004967,A patent/NL189197C/xx not_active IP Right Cessation
- 1980-09-01 FI FI802740A patent/FI76795C/sv not_active IP Right Cessation
- 1980-09-02 CY CY136080A patent/CY1360A/xx unknown
- 1980-09-02 NO NO80802576A patent/NO160003C/no unknown
- 1980-09-02 GB GB8028326A patent/GB2067987B/en not_active Expired
- 1980-09-03 PT PT71764A patent/PT71764B/pt not_active IP Right Cessation
- 1980-09-03 DE DE3051146A patent/DE3051146C2/de not_active Expired - Fee Related
- 1980-09-03 IE IE1175/86A patent/IE51235B1/en not_active IP Right Cessation
- 1980-09-03 CA CA000359493A patent/CA1167841A/en not_active Expired
- 1980-09-03 SE SE8006148A patent/SE449099B/sv not_active IP Right Cessation
- 1980-09-03 DE DE3033169A patent/DE3033169C2/de not_active Expired
- 1980-09-03 IE IE1851/80A patent/IE50997B1/en not_active IP Right Cessation
- 1980-09-03 NZ NZ194831A patent/NZ194831A/en unknown
- 1980-09-03 AT AT0443480A patent/AT376978B/de active
- 1980-09-04 CS CS816979A patent/CS235951B2/cs unknown
- 1980-09-04 CH CH6659/80A patent/CH649764A5/de not_active IP Right Cessation
- 1980-09-04 ZW ZW205/80A patent/ZW20580A1/xx unknown
- 1980-09-04 CH CH1760/85A patent/CH658055A5/de not_active IP Right Cessation
- 1980-09-04 LU LU82753A patent/LU82753A1/fr unknown
1981
- 1981-06-23 US US06/276,586 patent/US4374248A/en not_active Expired - Lifetime
1982
- 1982-11-02 CA CA000579079A patent/CA1263114A/en not_active Expired
- 1982-11-02 CA CA000579080A patent/CA1263115A/en not_active Expired
- 1982-11-02 CA CA000431960A patent/CA1248962A/en not_active Expired
1983
- 1983-07-13 CY CY140283A patent/CY1402A/xx unknown
- 1983-07-13 GB GB08318949A patent/GB2132190B/en not_active Expired
- 1983-11-29 AR AR29495183A patent/AR240559A1/es active
1984
- 1984-02-27 AT AT0064584A patent/AT377257B/de not_active IP Right Cessation
- 1984-06-08 SE SE8403109A patent/SE456581B/sv not_active IP Right Cessation
- 1984-06-08 SE SE8403111A patent/SE461733B/sv not_active IP Right Cessation
- 1984-06-08 SE SE8403108A patent/SE456582B/sv not_active IP Right Cessation
- 1984-06-08 SE SE8403107A patent/SE456580B/sv not_active IP Right Cessation
1986
- 1986-06-23 NO NO86862501A patent/NO162664C/no unknown
- 1986-12-23 KE KE3685A patent/KE3685A/xx unknown
1987
- 1987-04-06 NO NO87871421A patent/NO160781C/no unknown
- 1987-04-06 NO NO87871420A patent/NO161737C/no unknown
- 1987-05-28 HK HK413/87A patent/HK41387A/xx unknown
- 1987-07-20 KE KE3742A patent/KE3742A/xx unknown
- 1987-07-28 SG SG611/87A patent/SG61187G/en unknown
- 1987-12-03 HK HK891/87A patent/HK89187A/xx unknown
- 1987-12-31 MY MY1987585A patent/MY8700585A/xx unknown
- 1987-12-31 MY MY1987735A patent/MY8700735A/xx unknown
1990
- 1990-11-09 DK DK269090A patent/DK164700C/da not_active IP Right Cessation
- 1990-11-09 DK DK269190A patent/DK164702C/da not_active IP Right Cessation
- 1990-11-09 DK DK268990A patent/DK164363C/da not_active IP Right Cessation
1992
- 1992-07-09 NL NL9201236A patent/NL9201236A/nl not_active Application Discontinuation
- 1992-07-09 NL NL9201237A patent/NL9201237A/nl not_active Application Discontinuation

Also Published As

Publication number	Publication date
ZW20580A1 (en)	1981-01-21
NO871421D0 (no)	1987-04-06
SE8403111D0 (sv)	1984-06-08
KE3742A (en)	1987-09-04
KE3685A (en)	1987-01-30
CY1360A (en)	1987-08-07
CH649764A5 (de)	1985-06-14
CA1248962A (en)	1989-01-17
SE8403109D0 (sv)	1984-06-08
DK164363C (da)	1992-11-02
HK41387A (en)	1987-06-05
DK164700C (da)	1992-12-21
SE456581B (sv)	1988-10-17
AT377257B (de)	1985-02-25
SE8403109L (sv)	1984-06-08
IE51235B1 (en)	1986-11-12
NZ194831A (en)	1984-11-09
NL189197B (nl)	1992-09-01
AR240559A1 (es)	1990-05-31
CA1167841A (en)	1984-05-22
MY8700735A (en)	1987-12-31
AT376978B (de)	1985-01-25
SE456580B (sv)	1988-10-17
NO162664C (no)	1990-01-31
NO802576L (no)	1981-03-05
NO862501L (no)	1987-03-05
NO160003B (no)	1988-11-21
PT71764B (en)	1983-04-28
DK160611C (da)	1991-09-16
DK268990A (da)	1990-11-09
NO862501D0 (no)	1986-06-23
PT71764A (en)	1980-09-30
DK269090A (da)	1990-11-09
DK164363B (da)	1992-06-15
NO160781C (no)	1989-05-31
IE801851L (en)	1981-03-04
DK160611B (da)	1991-04-02
SE456582B (sv)	1988-10-17
NO160781B (no)	1989-02-20
SE461733B (sv)	1990-03-19
CA1263115A (en)	1989-11-21
CH658055A5 (de)	1986-10-15
CY1402A (en)	1987-12-18
GB2132190B (en)	1985-01-03
US4374248A (en)	1983-02-15
DK164702C (da)	1992-12-21
CS235951B2 (en)	1985-05-15
HK89187A (en)	1987-12-11
FI802740A (fi)	1981-03-05
SE8403111L (sv)	1984-06-08
NO161737B (no)	1989-06-12
DK269190D0 (da)	1990-11-09
LU82753A1 (fr)	1981-04-17
DK269090D0 (da)	1990-11-09
SE449099B (sv)	1987-04-06
GB8318949D0 (en)	1983-08-17
CA1263114A (en)	1989-11-21
NL9201236A (nl)	1993-03-01
DE3051146C2 (de)	1991-05-02
NO160003C (no)	1989-03-01
SE8006148L (sv)	1981-04-15
GB2132190A (en)	1984-07-04
ATA443480A (de)	1984-06-15
DK164700B (da)	1992-08-03
ATA64584A (de)	1984-07-15
SE8403108L (sv)	1984-06-08
NO161737C (no)	1989-09-20
DK268990D0 (da)	1990-11-09
NO871420D0 (no)	1987-04-06
DE3033169C2 (de)	1989-08-03
GB2067987A (en)	1981-08-05
DE3033169A1 (de)	1981-03-19
FI76795B (fi)	1988-08-31
FI76795C (sv)	1988-12-12
DK164702B (da)	1992-08-03
SE8403108D0 (sv)	1984-06-08
GB2067987B (en)	1984-07-11
MY8700585A (en)	1987-12-31
SG61187G (en)	1987-10-23
NL8004967A (nl)	1981-03-06
IE861175L (en)	1981-03-04
NO162664B (no)	1989-10-23
NL189197C (nl)	1993-02-01
NL9201237A (nl)	1993-03-01
DK269190A (da)	1990-11-09
DK371880A (da)	1981-03-05
IE50997B1 (en)	1986-09-03
SE8403107L (sv)	1984-06-08

Publication	Publication Date	Title
SE8403107D0 (sv)	1984-06-08	Mellanprodukter for framstellning av 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider
PT684945E (pt)	2002-12-31	Inibidores de acat a base de alquilamida substituida com pirazol ou isoxazol
DE3060217D1 (en)	1982-04-01	Penicillins, their salts, process for their preparation and therapeutic agents containing these compounds
DK306983A (da)	1984-01-03	Beta-lactamantibiotika, fremgangsmaade til deres fremstilling og midler med indhold deraf
SE8404729D0 (sv)	1984-09-20	2,5-disubstituted-4(3h)-pyrimidones having histamine h?712-receptor antagonist activity
KR830003434A (ko)	1983-06-20	3,4-이치환-1,2,5-티아디아졸-1-옥사이드와 1,1 디옥사이드
ES458846A1 (es)	1978-03-16	Un procedimiento para la preparacion de nuevas cefalospori- nas.

Legal Events

Date	Code	Title	Description
1995-01-31	NAL	Patent in force	Ref document number: 8403107-9 Format of ref document f/p: F
1996-06-24	NUG	Patent has lapsed	Ref document number: 8403107-9 Format of ref document f/p: F

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

Ref document number: 8403107-9

Format of ref document f/p: F

1996-06-24

NUG

Patent has lapsed