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SE8402549L - Substituerade moranolinderivat - Google Patents

Substituerade moranolinderivat

Info

Publication number
SE8402549L
SE8402549L SE8402549A SE8402549A SE8402549L SE 8402549 L SE8402549 L SE 8402549L SE 8402549 A SE8402549 A SE 8402549A SE 8402549 A SE8402549 A SE 8402549A SE 8402549 L SE8402549 L SE 8402549L
Authority
SE
Sweden
Prior art keywords
same
substituted
moranoline derivatives
derivatives
substituted moranoline
Prior art date
Application number
SE8402549A
Other languages
English (en)
Other versions
SE8402549D0 (sv
SE451015B (sv
Inventor
S Matsumura
H Enomoto
Y Aoyagi
Y Yoshikuni
K Kura
M Yagi
I Shirahase
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP53053603A external-priority patent/JPS5943947B2/ja
Priority claimed from JP8260678A external-priority patent/JPS5943948B2/ja
Priority claimed from JP12066178A external-priority patent/JPS5943949B2/ja
Priority claimed from JP571479A external-priority patent/JPS6026387B2/ja
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of SE8402549D0 publication Critical patent/SE8402549D0/sv
Publication of SE8402549L publication Critical patent/SE8402549L/sv
Publication of SE451015B publication Critical patent/SE451015B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE8402549A 1978-05-03 1984-05-11 Substituerade moranolinderivat SE451015B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP53053603A JPS5943947B2 (ja) 1978-05-03 1978-05-03 Ｎ−置換モラノリン誘導体
JP8260678A JPS5943948B2 (ja) 1978-07-06 1978-07-06 置換モラノリン誘導体
JP12066178A JPS5943949B2 (ja) 1978-09-29 1978-09-29 モラノリンのｎ−置換誘導体
JP571479A JPS6026387B2 (ja) 1979-01-20 1979-01-20 シンナミルモラノリン誘導体

Publications (3)

Publication Number Publication Date
SE8402549D0 SE8402549D0 (sv) 1984-05-11
SE8402549L true SE8402549L (sv) 1984-05-11
SE451015B SE451015B (sv) 1987-08-24

Family

ID=27454348

Family Applications (4)

Application Number Title Priority Date Filing Date
SE7903817A SE436874B (sv) 1978-05-03 1979-05-02 N-substituerade moranolinderivat
SE8402549A SE451015B (sv) 1978-05-03 1984-05-11 Substituerade moranolinderivat
SE8402550A SE451016B (sv) 1978-05-03 1984-05-11 N-substituerade derivat av moranolin
SE8402551A SE451017B (sv) 1978-05-03 1984-05-11 Cinnamylmoranolin-derivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7903817A SE436874B (sv) 1978-05-03 1979-05-02 N-substituerade moranolinderivat

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE8402550A SE451016B (sv) 1978-05-03 1984-05-11 N-substituerade derivat av moranolin
SE8402551A SE451017B (sv) 1978-05-03 1984-05-11 Cinnamylmoranolin-derivat

Country Status (9)

Country Link
US (1) US4533668A (sv)
CH (1) CH642629A5 (sv)
DE (1) DE2915037C3 (sv)
DK (1) DK151623C (sv)
FR (1) FR2424910A1 (sv)
GB (1) GB2020278B (sv)
IT (1) IT1116820B (sv)
NL (1) NL175820C (sv)
SE (4) SE436874B (sv)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2925943A1 (de) * 1979-06-27 1981-01-29 Bayer Ag 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
JP2504000B2 (ja) * 1986-09-02 1996-06-05 日本新薬株式会社 グルコシルモラノリン誘導体
JPS6461459A (en) * 1987-08-28 1989-03-08 Nippon Shinyaku Co Ltd Moranoline derivative
GB8827701D0 (en) * 1987-12-09 1988-12-29 Nippon Shinyaku Co Ltd Thrombolytic &c compositions
US5192772A (en) * 1987-12-09 1993-03-09 Nippon Shinyaku Co. Ltd. Therapeutic agents
US4985445A (en) * 1988-02-12 1991-01-15 Meiji Seika Kaisha, Ltd. Cancer cell metastasis inhibitors and novel compounds
EP0350012A3 (en) * 1988-07-08 1990-09-05 Meiji Seika Kaisha Ltd. Antiviral composition
US5258518A (en) * 1992-04-01 1993-11-02 G. D. Searle & Co. 2-substituted tertiary carbinol derivatives of deoxynojirimycin
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5331096A (en) * 1992-04-01 1994-07-19 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
ES2095032T3 (es) * 1992-04-01 1997-02-01 Searle & Co Derivados 2- y 3-amino y azido de 1,5-iminoazucares como compuestos antivirales.
US5268482A (en) * 1992-04-01 1993-12-07 G. D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5206251A (en) * 1992-04-01 1993-04-27 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5216168A (en) * 1992-04-01 1993-06-01 G. D. Searle & Co. 2- and 3- amino and azido derivatives of 1,5-iminosugars
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
US6291657B1 (en) * 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5399567A (en) * 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
JP2001522833A (ja) 1997-11-10 2001-11-20 ジー・ディー・サール・アンド・カンパニー 多剤耐性を治療するためのアルキル化イミノ糖類の使用
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
TR200002323T2 (tr) 1998-02-12 2000-12-21 G.D. Searle & Co. Hepatit virüs enfeksiyonlarının tedavi edilmesi için N-ikameli-1,5-dideoksi 1,5-imino-D-glusitol bileşiklerinin kullanımı
EP1173161A2 (en) 1999-02-12 2002-01-23 G.D. SEARLE & CO. Glucamine compounds for treating hepatitis virus infections
US6545021B1 (en) 1999-02-12 2003-04-08 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
JP2003522791A (ja) * 2000-02-14 2003-07-29 ファルマシア コーポレイション 肝炎ウイルス感染症治療用ｎ‐置換‐１，５‐ジデオキシ‐１，５‐イミノ‐ｄ‐グルシトール化合物の使用
EP1811991B1 (en) * 2004-11-10 2018-11-07 Genzyme Corporation Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis
AT502145B1 (de) * 2005-03-24 2012-01-15 Univ Graz Tech Glycosidase-hemmendes iminoalditol
EP2923699B1 (en) * 2006-05-09 2018-06-20 Genzyme Corporation Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
US8975280B2 (en) * 2006-05-24 2015-03-10 The Chancellor, Masters And Scholars Of The University Of Oxford Deoxynojirimycin and D-arabinitol analogs and methods of using
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
EP2594564B1 (en) 2007-05-31 2016-09-28 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
BRPI0817864A2 (pt) 2007-10-05 2012-12-25 Genzyme Corp uso de um composto derivado de ceramida
CA2731685A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
WO2010039256A1 (en) 2008-10-03 2010-04-08 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
BR112018072298A2 (pt) 2016-05-02 2019-02-12 Florida State University Research Foundation, Inc. tratamento de infecções pelo vírus da zika usando inibidores da alfa-glicosidase
EP4106752A4 (en) 2020-02-21 2024-03-20 Florida State University Research Foundation, Inc. TREATMENT OF HUMAN CORONAVIRUS INFECTIONS USING ALPHA-GLUCOSIDASE-GLYCOPROTEIN PROCESSING INHIBITORS
AU2021269232A1 (en) * 2020-05-07 2022-12-08 Alectos Therapeutics Inc. Non-lysosomal glucosylceramidase inhibitors and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5282710A (en) * 1975-12-29 1977-07-11 Nippon Shinyaku Co Ltd Extraction of effective drug component from mulberry
DE2735316C3 (de) * 1977-08-05 1981-01-29 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von nadeiförmigen, ferrimagnetischen Eisenoxiden

Also Published As

Publication number Publication date
DE2915037C3 (de) 1981-11-05
DE2915037A1 (de) 1979-11-08
SE451016B (sv) 1987-08-24
SE8402551L (sv) 1984-05-11
US4533668A (en) 1985-08-06
IT7948904A0 (it) 1979-05-02
SE8402551D0 (sv) 1984-05-11
CH642629A5 (de) 1984-04-30
SE8402549D0 (sv) 1984-05-11
SE451015B (sv) 1987-08-24
FR2424910A1 (fr) 1979-11-30
GB2020278A (en) 1979-11-14
SE8402550D0 (sv) 1984-05-11
FR2424910B1 (sv) 1981-12-11
SE8402550L (sv) 1984-05-11
GB2020278B (en) 1983-02-23
DK178379A (da) 1979-11-04
NL7903421A (nl) 1979-11-06
NL175820B (nl) 1984-08-01
DK151623B (da) 1987-12-21
NL175820C (nl) 1985-01-02
SE7903817L (sv) 1979-11-04
DE2915037B2 (de) 1981-01-29
SE436874B (sv) 1985-01-28
DK151623C (da) 1988-07-18
SE451017B (sv) 1987-08-24
IT1116820B (it) 1986-02-10

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