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SE8305157L - BIOLOGICALLY ACTIVE 2,5-PIPERAZINDION DERIVATIVES, SET FOR PREPARATION OF THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

BIOLOGICALLY ACTIVE 2,5-PIPERAZINDION DERIVATIVES, SET FOR PREPARATION OF THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
SE8305157L
SE8305157L SE8305157A SE8305157A SE8305157L SE 8305157 L SE8305157 L SE 8305157L SE 8305157 A SE8305157 A SE 8305157A SE 8305157 A SE8305157 A SE 8305157A SE 8305157 L SE8305157 L SE 8305157L
Authority
SE
Sweden
Prior art keywords
derivatives
piperazindion
preparation
pharmaceutical compositions
biologically active
Prior art date
Application number
SE8305157A
Other languages
Swedish (sv)
Other versions
SE8305157D0 (en
SE466654B (en
Inventor
E Kasafirek
J Vanzura
I Krejci
J Krepelka
A Dlabac
M Valchar
Original Assignee
Spofa Vereinigte Pharma Werke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Vereinigte Pharma Werke filed Critical Spofa Vereinigte Pharma Werke
Publication of SE8305157D0 publication Critical patent/SE8305157D0/en
Publication of SE8305157L publication Critical patent/SE8305157L/en
Publication of SE466654B publication Critical patent/SE466654B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel 2,5-piperazinedione derivatives of the general formula I <IMAGE> wherein R<1> is hydrogen, or alkyl with 1 to 5 carbon atoms, R<2> is hydrogen, alkyl with 1 to 9 carbon atoms, hydroxymethyl, benzyl or phenyl or a trimethylene or tetramethylene chain that forms a ring with the adjacent nitrogen atom and n is an integer of 1 to 3. The compounds show effect on the memory of experimental animals and inhibit the development of tolerance to the cataleptic effect after repeated administration of neuroleptics; they are expected to find use in the treatment of memory disturbances, tardive dyskinesias and Parkinson disease.
SE8305157A 1982-10-01 1983-09-23 BIOLOGICALLY ACTIVE 2,5-PIPERAZINDION DERIVATIVES, PREPARED FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SE466654B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS827012A CS231227B1 (en) 1982-10-01 1982-10-01 2,5-pierazindion derivatives

Publications (3)

Publication Number Publication Date
SE8305157D0 SE8305157D0 (en) 1983-09-23
SE8305157L true SE8305157L (en) 1984-04-02
SE466654B SE466654B (en) 1992-03-16

Family

ID=5418454

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8305157A SE466654B (en) 1982-10-01 1983-09-23 BIOLOGICALLY ACTIVE 2,5-PIPERAZINDION DERIVATIVES, PREPARED FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (12)

Country Link
JP (1) JPS5989671A (en)
AT (1) AT388161B (en)
BE (1) BE897843A (en)
CH (1) CH655929A5 (en)
CS (1) CS231227B1 (en)
DE (1) DE3335891C2 (en)
FR (1) FR2533919B1 (en)
GB (1) GB2127807B (en)
HU (1) HU193047B (en)
IT (1) IT1171091B (en)
SE (1) SE466654B (en)
YU (1) YU44751B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS277405B6 (en) * 1986-06-12 1993-03-17 Vyzk Ustav Farm Biochem Sp Peptides with 1-amino-1-cycloalkane carboxylic acid
US5182285A (en) * 1986-11-07 1993-01-26 Spojene Podniky Pro Zdravotnickou Vyrobu Cell-protective composition for preventing or treating of peptic ulcer
GB8822674D0 (en) * 1988-09-27 1988-11-02 Tate & Lyle Plc Preparation of acylated sucrose derivatives
US7202279B1 (en) * 1998-02-11 2007-04-10 Georgetown University Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
US7119091B2 (en) 1999-12-03 2006-10-10 Ono Pharmaceutical Co., Ltd. Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient
KR20030093248A (en) 2001-03-19 2003-12-06 오노 야꾸힝 고교 가부시키가이샤 Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient
JP4047365B2 (en) 2006-01-11 2008-02-13 生化学工業株式会社 Cycloalkanecarboxamide derivative and method for producing the same
ATE509941T1 (en) * 2006-01-11 2011-06-15 Seikagaku Kogyo Co Ltd CYCLOALKYLCARBONYLAMINOSIC ACID ESTER DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF
JP3975226B2 (en) 2006-01-11 2007-09-12 生化学工業株式会社 Cycloalkylcarbonylamino acid derivative and process for producing the same
WO2013020527A1 (en) 2011-08-11 2013-02-14 University Of Veterinary And Pharmaceutical Sciences Brno Faculty Of Pharmacy Utilization of alaptide as transdermal penetration modifier in pharmaceutical compositions for human and veterinary applications containing anti-inflammatory drugs and/or antimicrobial chemotherapeutics
WO2014019556A1 (en) 2012-08-02 2014-02-06 University Of Veterinary And Pharmaceutical Sciences Brno Faculty Of Pharmacy Alaptide : methods of effecting its solubility, membrane permeation and pharmaceutical compositions for human and/or veterinary applications
CN107903303B (en) * 2017-11-20 2021-06-04 陕西慧康生物科技有限责任公司 Liquid phase synthesis method of cyclopeptide Alaptide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1459488A (en) * 1974-03-19 1976-12-22 Wyeth John & Brother Ltd Piperazinedione derivatives

Also Published As

Publication number Publication date
HU193047B (en) 1987-08-28
GB2127807A (en) 1984-04-18
GB2127807B (en) 1987-02-25
FR2533919B1 (en) 1986-10-03
SE8305157D0 (en) 1983-09-23
YU195283A (en) 1986-10-31
IT8323058A1 (en) 1985-03-29
CH655929A5 (en) 1986-05-30
BE897843A (en) 1984-01-16
DE3335891A1 (en) 1984-04-05
GB8324683D0 (en) 1983-10-19
JPS5989671A (en) 1984-05-23
CS701282A1 (en) 1984-01-16
IT1171091B (en) 1987-06-10
AT388161B (en) 1989-05-10
JPH0526782B2 (en) 1993-04-19
SE466654B (en) 1992-03-16
FR2533919A1 (en) 1984-04-06
ATA336683A (en) 1988-10-15
YU44751B (en) 1991-02-28
CS231227B1 (en) 1984-10-15
IT8323058A0 (en) 1983-09-29
DE3335891C2 (en) 1993-11-11

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