SE8206981D0 - N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THERAPEUTICAL APPLICATION - Google Patents
N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THERAPEUTICAL APPLICATIONInfo
- Publication number
- SE8206981D0 SE8206981D0 SE8206981A SE8206981A SE8206981D0 SE 8206981 D0 SE8206981 D0 SE 8206981D0 SE 8206981 A SE8206981 A SE 8206981A SE 8206981 A SE8206981 A SE 8206981A SE 8206981 D0 SE8206981 D0 SE 8206981D0
- Authority
- SE
- Sweden
- Prior art keywords
- group
- hydrogen atom
- derivatives
- vinblastinoyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Vinblastine derivatives of the general formula: <IMAGE> wherein R is an ester of an amino-acid which is possibly protected, attached to the vinblastin-23-oyl moiety by an amide bond, the ester group, which may be straight or branched, containing 2-9 carbon atoms and R1 is a hydrogen atom or a hydroxy group, R2 is a hydrogen atom, a formyl group or a C2-C9 acyl group, R5 is a hydrogen atom or a methyl group or a formyl group, with the provision that compounds where R5 is methyl and R1 is a beta -hydroxy group are excluded; or their addition salts with mineral or organic acids. The compounds are useful as drugs.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU83822A LU83822A1 (en) | 1981-12-08 | 1981-12-08 | N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8206981D0 true SE8206981D0 (en) | 1982-12-07 |
SE8206981L SE8206981L (en) | 1983-06-09 |
SE452622B SE452622B (en) | 1987-12-07 |
Family
ID=19729780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8206981A SE452622B (en) | 1981-12-08 | 1982-12-07 | N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
Country Status (24)
Country | Link |
---|---|
JP (1) | JPS58116491A (en) |
AT (1) | AT390958B (en) |
AU (1) | AU564951B2 (en) |
BE (1) | BE895262A (en) |
CA (1) | CA1198422A (en) |
CH (1) | CH655727A5 (en) |
DD (1) | DD205906A5 (en) |
DE (1) | DE3245269A1 (en) |
DK (1) | DK161833C (en) |
ES (1) | ES8401768A1 (en) |
FR (1) | FR2517680B1 (en) |
GB (1) | GB2111055B (en) |
GR (1) | GR77280B (en) |
HU (1) | HU187803B (en) |
IE (1) | IE55283B1 (en) |
IL (1) | IL67366A (en) |
IT (1) | IT1157126B (en) |
LU (1) | LU83822A1 (en) |
NL (1) | NL8204711A (en) |
NZ (1) | NZ202708A (en) |
OA (1) | OA07270A (en) |
PT (1) | PT75949B (en) |
SE (1) | SE452622B (en) |
ZA (1) | ZA828823B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT34212A (en) * | 1983-04-29 | 1985-02-28 | Omnichem Sa | Process for the production of new vindblastin conjugates |
US4667030A (en) * | 1985-06-17 | 1987-05-19 | Eli Lilly And Company | Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids |
US4675400A (en) * | 1985-06-17 | 1987-06-23 | Eli Lilly And Company | Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids |
JPH075608B2 (en) * | 1986-01-13 | 1995-01-25 | イ−ル−セルタ−ク ソシエテ アノニム | Vinblastine derivative |
US4906086A (en) * | 1987-06-19 | 1990-03-06 | Honda Giken Kogyo Kabushiki Kaisha | Rearview mirror device for motorcycles |
FR2626882B1 (en) * | 1988-02-08 | 1991-11-08 | Ire Celltarg Sa | VINCA DERIVATIVE CONJUGATES COMPRISING A DETERGENT CHAIN IN POSITION C-3 |
JP6250710B2 (en) * | 2013-04-19 | 2017-12-20 | 曁南大学 | Preparation method of vinblastine derivative |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR204004A1 (en) | 1973-04-02 | 1975-11-12 | Lilly Co Eli | PROCEDURES FOR PREPARING VINBLASTIN LEUROSIDINE AND LEUROCRISTINE DERIVATIVES |
US3848234A (en) * | 1973-04-04 | 1974-11-12 | Sperry Rand Corp | Multi-processor system with multiple cache memories |
IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
OA06421A (en) * | 1980-06-10 | 1981-09-30 | Omnium Chimique Sa | Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides. |
-
1981
- 1981-12-08 LU LU83822A patent/LU83822A1/en unknown
-
1982
- 1982-11-24 AU AU90847/82A patent/AU564951B2/en not_active Ceased
- 1982-11-30 IL IL67366A patent/IL67366A/en unknown
- 1982-12-01 CH CH6980/82A patent/CH655727A5/en not_active IP Right Cessation
- 1982-12-01 ZA ZA828823A patent/ZA828823B/en unknown
- 1982-12-03 CA CA000416996A patent/CA1198422A/en not_active Expired
- 1982-12-03 NZ NZ202708A patent/NZ202708A/en unknown
- 1982-12-06 ES ES517942A patent/ES8401768A1/en not_active Expired
- 1982-12-06 NL NL8204711A patent/NL8204711A/en not_active Application Discontinuation
- 1982-12-06 GR GR69997A patent/GR77280B/el unknown
- 1982-12-07 IE IE2906/82A patent/IE55283B1/en not_active IP Right Cessation
- 1982-12-07 HU HU823919A patent/HU187803B/en unknown
- 1982-12-07 AT AT0444982A patent/AT390958B/en not_active IP Right Cessation
- 1982-12-07 SE SE8206981A patent/SE452622B/en not_active IP Right Cessation
- 1982-12-07 DK DK541882A patent/DK161833C/en not_active IP Right Cessation
- 1982-12-07 BE BE0/209661A patent/BE895262A/en not_active IP Right Cessation
- 1982-12-07 FR FR828220476A patent/FR2517680B1/en not_active Expired - Lifetime
- 1982-12-07 DE DE19823245269 patent/DE3245269A1/en not_active Withdrawn
- 1982-12-07 PT PT75949A patent/PT75949B/en not_active IP Right Cessation
- 1982-12-07 IT IT68431/82A patent/IT1157126B/en active
- 1982-12-07 JP JP57214573A patent/JPS58116491A/en active Granted
- 1982-12-08 OA OA57864A patent/OA07270A/en unknown
- 1982-12-08 DD DD82245703A patent/DD205906A5/en not_active IP Right Cessation
- 1982-12-08 GB GB08234965A patent/GB2111055B/en not_active Expired
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU515774B2 (en) | Benzopyran derivatives | |
ES8505659A1 (en) | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them. | |
ES2032750T3 (en) | RAPAMICINE DRUGS. | |
DE3062609D1 (en) | Muramyldipeptide derivatives, process for preparing said compounds and pharmaceutical compositions containing said compounds | |
ES514240A0 (en) | A PROCEDURE FOR THE PREPARATION OF NEW 2-CARBAMIMIDOIL-1-, CARBADESTIAPEN-2-EN-3-CARBOXYLATED ACID DERIVATIVES. | |
SE8406141L (en) | N-ACYLAMINO ACID DIAMIDE DERIVATIVES, SALTS THEREOF, PROCEDURES FOR THE PREPARATION OF THEIR AND ANTIULCER AGENTS CONTAINING THESE | |
DE3474140D1 (en) | Imidazole-ethanol esters | |
FR2620699B1 (en) | PROCESS FOR THE SYNTHESIS OF ALPHA AMINO N ALKYL ACIDS AND THEIR ESTERS. APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES | |
SE8206981D0 (en) | N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THERAPEUTICAL APPLICATION | |
PT91607A (en) | PROCESS FOR THE PREPARATION OF SUBSTITUTED BETA-DIKETONES AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
DK373783D0 (en) | THIENO-THIAZOL DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE | |
EA200001107A1 (en) | DERIVATIVES OF OCTAGIDRO-6,10-DIOXO-6H-PIRIDAZINO [1,2-a] [1,2] DIAZEPIN-1-CARBONIC ACID, METHOD OF OBTAINING AND THEIR APPLICATION FOR OBTAINING TREATMENT OF ACTIVE COMPOUNDS | |
NZ216468A (en) | Substituted phenylacetic acid amide drivatives and pharmaceutical compositions | |
KR930702339A (en) | Epoxy succinic acid derivatives | |
KR900018083A (en) | Epoxy succinic acid derivatives | |
DE3462400D1 (en) | Carboxylic acid derivatives, processes for their production and pharmaceutical preparations containing them | |
GB2013689A (en) | Enkephalin analogues | |
DK369980A (en) | BRANCHED S-ALKYLPHOSPHONO-DITHIOHALOGENIDE INTERMEDIATES AND PROCEDURES FOR PREPARING IT | |
KR840009110A (en) | Process for preparing ester compound of alpha-amino benzyl penicillin | |
ES415404A1 (en) | Procedure for preparing amino-2 benzoic acid derivatives. (Machine-translation by Google Translate, not legally binding) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NUG | Patent has lapsed |
Ref document number: 8206981-6 Effective date: 19930709 Format of ref document f/p: F |