SE7910590L - ANTI-INFLAMMATORY AGENTS - Google Patents
ANTI-INFLAMMATORY AGENTSInfo
- Publication number
- SE7910590L SE7910590L SE7910590A SE7910590A SE7910590L SE 7910590 L SE7910590 L SE 7910590L SE 7910590 A SE7910590 A SE 7910590A SE 7910590 A SE7910590 A SE 7910590A SE 7910590 L SE7910590 L SE 7910590L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- compounds
- mucous membranes
- steroidal antiphlogistics
- inflammatory agents
- Prior art date
Links
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 abstract 2
- 210000004400 mucous membrane Anatomy 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 210000004379 membrane Anatomy 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 229960001047 methyl salicylate Drugs 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000012466 permeate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:Compounds of formula I [R-CCO is acyloxy residue of arbitrary non-steroidal antiphlogistics containing carboxylic acid part; R1 is H, 1-8C alkyl, 3-7C cycloalkyl, 1-8C alkoxyalkyl, etc.; R2 is same as defined in R1, excepting H; R1 and R2 may together form (CH2)n, etc.; n is 3 or 4; X is S, SO, etc.] or non-toxic acid addition salt. EXAMPLE:(Methylthio)methyl 2-hydroxybenzoate. USE:Non-steroidal antiphlogistics. Active by oral or local administration. Low irritant. Permeate easily through the mucous membranes, e.g. the mucous membranes of eyes and the gastric mecous membrane. PROCESS:Compounds of formula I are obtained by reacting compounds of formula R-COOH with compounds of formula II (Z is halogen) in a solvent such as acetonitrile in the presence of an acid acceptor such as triethylamine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97224378A | 1978-12-22 | 1978-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7910590L true SE7910590L (en) | 1980-06-23 |
Family
ID=25519402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7910590A SE7910590L (en) | 1978-12-22 | 1979-12-21 | ANTI-INFLAMMATORY AGENTS |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5589257A (en) |
| DK (1) | DK551579A (en) |
| NO (1) | NO148595C (en) |
| SE (1) | SE7910590L (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR75219B (en) * | 1980-04-21 | 1984-07-13 | Merck & Co Inc | |
| CN106957251B (en) * | 2017-04-06 | 2018-08-21 | 武汉大学 | A method of preparing alkyl thiomethyl ester type compound |
-
1979
- 1979-12-21 NO NO794244A patent/NO148595C/en unknown
- 1979-12-21 JP JP16746179A patent/JPS5589257A/en active Pending
- 1979-12-21 DK DK551579A patent/DK551579A/en not_active Application Discontinuation
- 1979-12-21 SE SE7910590A patent/SE7910590L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO794244L (en) | 1980-06-24 |
| NO148595B (en) | 1983-08-01 |
| NO148595C (en) | 1983-11-09 |
| JPS5589257A (en) | 1980-07-05 |
| DK551579A (en) | 1980-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT1207269B (en) | DIPHENYLBUTYLPIPERAZINCARBOSSAMIDI, THEIR ADDITION SALTS WITH ACIDS AND PHARMACEUTICAL COMPOSITIONS; MANUFACTURING AND USE PROCEDURES. | |
| NL300396I1 (en) | Novel derivatives with naphthalene structures, process for their preparation and the pharmaceutical preparations containing them | |
| IE791565L (en) | Crop cutting apparatus | |
| SE8404019D0 (en) | AGREEMENT OF AGREEMENT | |
| PT88577A (en) | PROCESS FOR THE MANUFACTURE OF NOVEL SUBSTITUTED N- (1-ALKYL-3-HYDROXY-4-PIPERIDINYL) BENZAMIDES | |
| SE7510196L (en) | METHOD OF MAKING NEW 2,3-DIHYDRO-1-BENZOTIEPINE-4-CARBOXYLIC ACID AMIDES | |
| SE7707462L (en) | PROCEDURE FOR PREPARING PENICILLANIC ACID DERIVATIVES | |
| NO161068C (en) | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 7BETA - (((Z) -2-2-AMINOTHIAZOL-4-YL) -2-OXYIMINO-ACE-TAMIDO) -3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS. | |
| SE7411243L (en) | ||
| SE7910590L (en) | ANTI-INFLAMMATORY AGENTS | |
| SE7702130L (en) | PROCEDURE FOR THE PREPARATION OF N- (MARKAPTOACYL) -HISTIDINES | |
| SE8005686L (en) | NEW HALOGEN WINE CAMERA DERIVATIVES JUST SET FOR THEIR PREPARATION | |
| ATE59387T1 (en) | 1,3-DIOXANE-4-YLALENE ACID. | |
| SE7708626L (en) | METHODS OF PREPARING OXIMIN DERIVATIVES OF 3-CARBAMOYLOXIMETHYL-7-AMINOTIAZOLYL-ACETAMIDOCEFALOSPORANIC ACID | |
| ATE56963T1 (en) | PROCESS FOR PRODUCTION OF AMINOTHIAZOOLEACETIC ACID DERIVATIVES. | |
| SE7906681L (en) | FTALAZONDERIVAT | |
| ES8106147A1 (en) | 1,2,4-Triazole-3-thiols as antisecretory agents | |
| DE3362523D1 (en) | Optically active imidazolylpropanol compounds, and their production and use | |
| DK10186A (en) | CARBOXIMIDIC ACID RESIDENTS | |
| FI101700B1 (en) | Process for the preparation of therapeutically useful acid addition salt of an optically active 2-amino-N- (2,6-dimethylphenyl) -N- [3- (3-pyridyl) propyl] propanamide | |
| CH610877A5 (en) | Process for the preparation of o-(2,6-dichloroanilino)phenylacetic acid and of the addition salts of this acid | |
| JPS6470479A (en) | Heterocylic carboxylic acid derivative, production thereof and agricultural and horticultural germicide containing said derivative as active ingredient | |
| JPS5531086A (en) | Prepartion of 5,6-epoxy-1,2,6-trimethyl-tricyclo 5.3.2.02,7 dodecane | |
| HUT45016A (en) | Herbicides containing as active substance derivatives of piridil-phenil-ether and process for production of these derivatives | |
| GB946039A (en) | Nitroaryl phosphonothioate esters |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 7910590-4 |