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SE7702908L - WAY TO PRODUCE NEW LACTON DERIVATIVES OF CYCLOPENTANOL - Google Patents

WAY TO PRODUCE NEW LACTON DERIVATIVES OF CYCLOPENTANOL

Info

Publication number
SE7702908L
SE7702908L SE7702908A SE7702908A SE7702908L SE 7702908 L SE7702908 L SE 7702908L SE 7702908 A SE7702908 A SE 7702908A SE 7702908 A SE7702908 A SE 7702908A SE 7702908 L SE7702908 L SE 7702908L
Authority
SE
Sweden
Prior art keywords
group
those
lacton
cyclopentanol
derivatives
Prior art date
Application number
SE7702908A
Other languages
Swedish (sv)
Other versions
SE436877B (en
Inventor
J Buendia
M Vivat
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE7702908L publication Critical patent/SE7702908L/en
Publication of SE436877B publication Critical patent/SE436877B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

The compounds of formula: <IMAGE> are prepared from corresponding carboxylic acids of formula: <IMAGE> by a reaction capable of converting the carboxyl group to a functional derivative. The meaning of the symbols is given in Claim 1. Of the compounds obtained, those which have a 15-tetrahydropyranyloxy group can be hydrolysed, those which have a hydroxyl group can be esterified, and those which have a secondary alcohol group in position 15 can be oxidised to the corresponding ketone or dehydrated in position 15, 16; finally, the double bond in position 13, 14 and the triple bond of an alkynyl group in position 15 can be hydrogenated. The compounds display a hypotensive activity; they can be employed in the treatment of hypertension (high blood pressure) and of circulatory disorders.
SE7702908A 1976-03-19 1977-03-15 SET TO PREPARE LACTON DERIVATIVES OF CYCLOPENTANOL SE436877B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7608004A FR2344285A1 (en) 1976-03-19 1976-03-19 NEW LACTONS DERIVED FROM CYCLOPENTANOL, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
SE7702908L true SE7702908L (en) 1977-09-20
SE436877B SE436877B (en) 1985-01-28

Family

ID=9170682

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7702908A SE436877B (en) 1976-03-19 1977-03-15 SET TO PREPARE LACTON DERIVATIVES OF CYCLOPENTANOL

Country Status (20)

Country Link
JP (1) JPS52113956A (en)
AT (1) AT357275B (en)
AU (1) AU506760B2 (en)
BE (1) BE852624A (en)
CA (1) CA1094569A (en)
CH (1) CH620688A5 (en)
DE (1) DE2711950A1 (en)
DK (1) DK119377A (en)
ES (1) ES456999A1 (en)
FR (1) FR2344285A1 (en)
GB (1) GB1538717A (en)
HU (1) HU178332B (en)
IE (1) IE45124B1 (en)
IL (1) IL51690A (en)
LU (1) LU76976A1 (en)
NL (1) NL7703056A (en)
PT (1) PT66326B (en)
SE (1) SE436877B (en)
SU (2) SU749364A3 (en)
ZA (1) ZA771654B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2439779A2 (en) * 1976-03-19 1980-05-23 Roussel Uclaf Hypotensive hydroxy cyclopentane carboxylic acid lactone(s)
FR2443466A1 (en) * 1978-12-05 1980-07-04 Roussel Uclaf NOVEL B-LACTONS DERIVED FROM 2-HYDROXY CYCLOPENTANE CARBOXYLIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
DE3722133A1 (en) * 1987-07-04 1989-01-12 Bayer Ag AZOLYL TETRAHYDROPYRAN DERIVATIVES
EP1142886A1 (en) * 2000-04-07 2001-10-10 Aventis Pharma Deutschland GmbH Percyquinnin, a process for its production and its use as a pharmaceutical
CN100417650C (en) * 2006-08-17 2008-09-10 中国科学院昆明植物研究所 Vibralactone, preparation method and medicinal application thereof
JP5652397B2 (en) * 2009-07-28 2015-01-14 小野薬品工業株式会社 Bicyclic compounds and their pharmaceutical uses

Also Published As

Publication number Publication date
DE2711950A1 (en) 1977-09-29
BE852624A (en) 1977-09-19
AT357275B (en) 1980-06-25
GB1538717A (en) 1979-01-24
AU506760B2 (en) 1980-01-24
CH620688A5 (en) 1980-12-15
NL7703056A (en) 1977-09-21
ATA195077A (en) 1979-11-15
FR2344285B1 (en) 1979-02-02
CA1094569A (en) 1981-01-27
SU745366A3 (en) 1980-06-30
IL51690A0 (en) 1977-05-31
SU749364A3 (en) 1980-07-15
IE45124L (en) 1977-09-19
PT66326A (en) 1977-04-01
SE436877B (en) 1985-01-28
JPS52113956A (en) 1977-09-24
FR2344285A1 (en) 1977-10-14
JPS62146B2 (en) 1987-01-06
IE45124B1 (en) 1982-06-30
ZA771654B (en) 1978-04-26
ES456999A1 (en) 1978-01-16
HU178332B (en) 1982-04-28
PT66326B (en) 1979-01-18
LU76976A1 (en) 1977-10-03
IL51690A (en) 1982-02-28
AU2346677A (en) 1978-09-28
DK119377A (en) 1977-09-20

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