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SE0401969D0 - Piperidine derivatives - Google Patents

Piperidine derivatives

Info

Publication number
SE0401969D0
SE0401969D0 SE0401969A SE0401969A SE0401969D0 SE 0401969 D0 SE0401969 D0 SE 0401969D0 SE 0401969 A SE0401969 A SE 0401969A SE 0401969 A SE0401969 A SE 0401969A SE 0401969 D0 SE0401969 D0 SE 0401969D0
Authority
SE
Sweden
Prior art keywords
piperidine derivatives
compounds
formula
arl
enantiomers
Prior art date
Application number
SE0401969A
Other languages
English (en)
Inventor
James Folmer
Fraser Hunt
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0401969A priority Critical patent/SE0401969D0/sv
Publication of SE0401969D0 publication Critical patent/SE0401969D0/sv
Priority to BRPI0514036-6A priority patent/BRPI0514036A/pt
Priority to US11/572,965 priority patent/US20070191358A1/en
Priority to CNA2005800262910A priority patent/CN101014581A/zh
Priority to KR1020077002640A priority patent/KR20070038136A/ko
Priority to EP05763155A priority patent/EP1781630A1/en
Priority to MX2007001225A priority patent/MX2007001225A/es
Priority to RU2007105968/04A priority patent/RU2007105968A/ru
Priority to AU2005267930A priority patent/AU2005267930A1/en
Priority to JP2007524766A priority patent/JP2008508351A/ja
Priority to CA002576073A priority patent/CA2576073A1/en
Priority to PCT/SE2005/001187 priority patent/WO2006014134A1/en
Priority to IL180546A priority patent/IL180546A0/en
Priority to ZA200700685A priority patent/ZA200700685B/xx
Priority to NO20071137A priority patent/NO20071137L/no

Links

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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SE0401969A 2004-08-02 2004-08-02 Piperidine derivatives SE0401969D0 (sv)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SE0401969A SE0401969D0 (sv) 2004-08-02 2004-08-02 Piperidine derivatives
PCT/SE2005/001187 WO2006014134A1 (en) 2004-08-02 2005-07-27 Novel piperidine derivative for the treatment of depression
MX2007001225A MX2007001225A (es) 2004-08-02 2005-07-27 Nuevos derivados de piperidina para el tratamiento de depresion.
AU2005267930A AU2005267930A1 (en) 2004-08-02 2005-07-27 Novel piperidine derivative for the treatment of depression
CNA2005800262910A CN101014581A (zh) 2004-08-02 2005-07-27 用于治疗抑郁的新哌啶衍生物
KR1020077002640A KR20070038136A (ko) 2004-08-02 2005-07-27 우울증 치료를 위한 신규 피페리딘 유도체
EP05763155A EP1781630A1 (en) 2004-08-02 2005-07-27 Novel piperidine derivative for the treatment of depression
BRPI0514036-6A BRPI0514036A (pt) 2004-08-02 2005-07-27 composto, sais farmaceuticamente aceitáveis do mesmo, diastereÈmeros, enanciÈmeros ou misturas do mesmo, uso de um composto, composição farmacêutica, método para a terapia de depressão em um animal de sangue quente, e, processo para preparar um composto
RU2007105968/04A RU2007105968A (ru) 2004-08-02 2005-07-27 Новые пиперидиновые производные для лечения депрессии
US11/572,965 US20070191358A1 (en) 2004-08-02 2005-07-27 Novel piperidine derivative for the treatment of depression
JP2007524766A JP2008508351A (ja) 2004-08-02 2005-07-27 うつ病の治療のための新規なピペリジン誘導体
CA002576073A CA2576073A1 (en) 2004-08-02 2005-07-27 Novel piperidine derivative for the treatment of depression
IL180546A IL180546A0 (en) 2004-08-02 2007-01-04 Novel piperidine derivative for the treatment of depression
ZA200700685A ZA200700685B (en) 2004-08-02 2007-01-24 Novel piperidine derivative for the treatment of depression
NO20071137A NO20071137L (no) 2004-08-02 2007-02-28 Nye piperidinderivater for behandling av depresjon

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JP (1) JP2008508351A (sv)
KR (1) KR20070038136A (sv)
CN (1) CN101014581A (sv)
AU (1) AU2005267930A1 (sv)
BR (1) BRPI0514036A (sv)
CA (1) CA2576073A1 (sv)
IL (1) IL180546A0 (sv)
MX (1) MX2007001225A (sv)
NO (1) NO20071137L (sv)
RU (1) RU2007105968A (sv)
SE (1) SE0401969D0 (sv)
WO (1) WO2006014134A1 (sv)
ZA (1) ZA200700685B (sv)

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EP1966144A1 (en) * 2005-12-20 2008-09-10 Novartis AG Nicotinic acid derivatives as modulators of metabotropic glutamate receptors
DE102006060598A1 (de) * 2006-12-21 2008-06-26 Merck Patent Gmbh Tetrahydrobenzoisoxazole
SK542007A3 (sk) * 2007-04-20 2008-11-06 Unimed Pharma, Spol. S R. O. Substituované sulfónamidy, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
HUP0900281A2 (hu) * 2009-05-05 2011-01-28 Univ Szegedi Kinurénsav-származékok, eljárás a vegyületek elõállítására, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk fejfájás kezelésére
JP2014527043A (ja) * 2011-08-03 2014-10-09 ナショナル タイワン ユニバーシティ Ｓｒｃホモロジー２プロテインチロシンホスファターゼ−１を含むアゴニスト及びその治療方法
CN103254127B (zh) * 2013-05-28 2015-08-19 北京哈三联科技有限责任公司 甘氨酸重摄取抑制剂及其应用
EP3116870A1 (en) 2014-03-13 2017-01-18 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
WO2015138909A1 (en) 2014-03-13 2015-09-17 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists
EP3157917B1 (en) 2014-06-19 2020-03-18 Proteostasis Therapeutics, Inc. Compounds, compositions and methods of increasing cftr activity
CA2971855A1 (en) 2014-12-23 2016-06-30 Proteostasis Therapeutics, Inc. Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis
MA41253A (fr) * 2014-12-23 2017-10-31 Proteostasis Therapeutics Inc Composés, compositions et procédés pour augmenter l'activité du cftr
WO2016105468A1 (en) 2014-12-23 2016-06-30 Proteostasis Therapeutics, Inc. Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis
US10392378B2 (en) 2014-12-23 2019-08-27 Proteostasis Therapeutics, Inc. Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis
WO2017019589A1 (en) 2015-07-24 2017-02-02 Proteostasis Therapeutics, Inc. Compounds, compositions and methods of increasing cftr activity
JP6929276B2 (ja) 2015-10-06 2021-09-01 プロテオステイシス セラピューティクス，インコーポレイテッド 化合物、医薬的に許容される塩又はその立体異性体及び医薬組成物
WO2017177124A1 (en) 2016-04-07 2017-10-12 Proteostasis Therapeutics, Inc. Silicone atoms containing ivacaftor analogues
MA45397A (fr) 2016-06-21 2019-04-24 Proteostasis Therapeutics Inc Composés, compositions et procédés pour augmenter l'activité du cftr
CA3148454A1 (en) * 2019-07-23 2021-01-28 Board Of Regents, The University Of Texas System Bicyclic cx3cr1 receptor agonists

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NZ501277A (en) * 1997-07-01 2002-12-20 Warner Lambert Co -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
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RU2007105968A (ru) 2008-09-10
CN101014581A (zh) 2007-08-08
BRPI0514036A (pt) 2008-05-27
KR20070038136A (ko) 2007-04-09
US20070191358A1 (en) 2007-08-16
JP2008508351A (ja) 2008-03-21
NO20071137L (no) 2007-04-19
IL180546A0 (en) 2007-06-03
MX2007001225A (es) 2007-03-23
WO2006014134A1 (en) 2006-02-09
CA2576073A1 (en) 2006-02-09
AU2005267930A1 (en) 2006-02-09
ZA200700685B (en) 2008-09-25

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