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RU96101160A - Intra-Vaginal Delivery System - Google Patents

Intra-Vaginal Delivery System

Info

Publication number
RU96101160A
RU96101160A RU96101160/14A RU96101160A RU96101160A RU 96101160 A RU96101160 A RU 96101160A RU 96101160/14 A RU96101160/14 A RU 96101160/14A RU 96101160 A RU96101160 A RU 96101160A RU 96101160 A RU96101160 A RU 96101160A
Authority
RU
Russia
Prior art keywords
sleeve
delivery system
support means
active agent
core
Prior art date
Application number
RU96101160/14A
Other languages
Russian (ru)
Other versions
RU2121824C1 (en
Inventor
Лехтинен Матти
Таллинг Кристин
Original Assignee
Лейрас Ой
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI932789A external-priority patent/FI95768C/en
Application filed by Лейрас Ой filed Critical Лейрас Ой
Publication of RU96101160A publication Critical patent/RU96101160A/en
Application granted granted Critical
Publication of RU2121824C1 publication Critical patent/RU2121824C1/en

Links

Claims (12)

1. Внутривлагалищная система доставки, состоящая из гибкого опорного средства и доставочного средства, содержащего активный агент и поддерживаемого опорным средством, отличающаяся тем, что опорное средство (1) состоит из сердечника (1'), имеющего по существу форму разомкнутого кольца, а доставочное средство состоит по меньшей мере из одного гильзоподобного полимерного элемента (2), охватывающего сердечник подобно поясу на отрезке длины сердечника.1. Intravaginal delivery system, consisting of a flexible support means and a delivery means containing an active agent and supported by support means, characterized in that the support means (1) consists of a core (1 '), which is essentially in the form of an open ring, and the delivery means consists of at least one sleeve-like polymer element (2), covering the core like a belt on a length of the core. 2. Система доставки по п.1, отличающаяся тем, что гильзоподобный элемент выполнен из полисилоксана, такого, как полидиметилсилоксана, полиуретана или ЭВА-сополимера. 2. The delivery system according to claim 1, characterized in that the sleeve-like element is made of polysiloxane, such as polydimethylsiloxane, polyurethane or an EVA copolymer. 3. Система доставки по п.1, отличающаяся тем, что опорное средство выполнено из каучука с поперечными связями, такого, как натуральный каучук, бутилкаучука и полидиметилсилоксановых эластомеров, гибких термопластических смол, таких как этилвинилацетат (ЭВА), термопластических эластомеров, таких как сополимеры стирола (СЕБС, СБС, СИС), полиуретаны или термопластические полиолефины. 3. The delivery system according to claim 1, characterized in that the support means is made of cross-linked rubber, such as natural rubber, butyl rubber and polydimethylsiloxane elastomers, flexible thermoplastic resins such as ethyl vinyl acetate (EVA), thermoplastic elastomers such as copolymers styrene (SEBS, SBS, SIS), polyurethanes or thermoplastic polyolefins. 4. Система доставки по п.1, отличающаяся тем, что внутренняя поверхность гильзоподобного элемента соприкасается со слоем материала, который практически препятствует миграции активного агента из гильзоподобного элемента в опорное средство. 4. The delivery system according to claim 1, characterized in that the inner surface of the sleeve-like element is in contact with a layer of material that practically prevents the active agent from migrating from the sleeve-like element into the support means. 5. Система доставки по п.1, отличающаяся тем, что наружная поверхность опорного средства или все опорное средство изготовлено из материала, препятствующего миграции активного агента из гильзоподобного элемента в опорное средство. 5. The delivery system according to claim 1, characterized in that the outer surface of the support means or the entire support means is made of a material that impedes the migration of the active agent from the sleeve-like element into the support means. 6. Система доставки по п.1, отличающаяся тем, что доставочное средство образовано двумя гильзоподобными элементами, каждый из которых содержит иной активный агент. 6. The delivery system according to claim 1, characterized in that the delivery means is formed by two sleeve-like elements, each of which contains a different active agent. 7. Система доставки по п.1, отличающаяся тем, что гильзоподобный элемент содержит прогестагенный или эстрагенный агент. 7. The delivery system according to claim 1, characterized in that the sleeve-like element contains a progestogen or estrogenic agent. 8. Система доставки по п.1, отличающаяся тем, что содержит два гильзоподобных элемента, которые оба содержат один и тот же активный агент. 8. The delivery system according to claim 1, characterized in that it contains two sleeve-like elements, which both contain the same active agent. 9. Система доставки по п.1, отличающаяся тем, что гильзоподобный элемент покрыт мембраной (4), допускающей диффузию активного агента, в особенности полисилоксановой мембраной. 9. The delivery system according to claim 1, characterized in that the sleeve-like element is coated with a membrane (4) that allows diffusion of the active agent, in particular a polysiloxane membrane. 10. Применение системы доставки по любому из пп.1 - 9 для гормональной терапии, такой, как менопаузальная терапия. 10. The use of the delivery system according to any one of claims 1 to 9 for hormone therapy, such as menopausal therapy. 11. Способ изготовления системы доставки по п.1, отличающийся тем, что диаметр гильзоподобного элемента, содержащего активный агент и полимер, увеличивают, например, путем растяжения, т.е. механически или разбуханием, и элемент устанавливают в таком состоянии на элемент сердечника, после чего допускают его сжимание вокруг опорного средства. 11. A method of manufacturing a delivery system according to claim 1, characterized in that the diameter of the sleeve-like element containing the active agent and the polymer is increased, for example, by stretching, i.e. mechanically or by swelling, and the element is mounted in this state on the core element, after which it is compressed around the support means. 12. Способ по п.11, отличающийся тем, что гильзоподобный элемент изготавливают путем соэкструзии с полимерной мембраной, окружающей наружный слой на гильзе при установке на сердечнике. 12. The method according to claim 11, characterized in that the sleeve-like element is made by coextrusion with a polymer membrane surrounding the outer layer on the sleeve when installed on the core.
RU96101160A 1993-06-17 1994-06-15 Intrauterine delivery system RU2121824C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI932789 1993-06-17
FI932789A FI95768C (en) 1993-06-17 1993-06-17 Intravaginal dosing system

Publications (2)

Publication Number Publication Date
RU96101160A true RU96101160A (en) 1998-03-27
RU2121824C1 RU2121824C1 (en) 1998-11-20

Family

ID=8538154

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96101160A RU2121824C1 (en) 1993-06-17 1994-06-15 Intrauterine delivery system

Country Status (24)

Country Link
US (1) US5694947A (en)
EP (1) EP0703802B1 (en)
JP (1) JP3803714B2 (en)
KR (1) KR100312764B1 (en)
CN (1) CN1126574C (en)
AT (1) ATE177657T1 (en)
AU (1) AU674758B2 (en)
BR (1) BR9407118A (en)
CZ (1) CZ284989B6 (en)
DE (1) DE69417232T2 (en)
DK (1) DK0703802T3 (en)
EE (1) EE03202B1 (en)
ES (1) ES2130423T3 (en)
FI (1) FI95768C (en)
GR (1) GR3030565T3 (en)
HU (1) HU217950B (en)
LT (1) LT3455B (en)
LV (1) LV12452B (en)
MY (1) MY113965A (en)
NO (1) NO311498B1 (en)
PL (1) PL176664B1 (en)
RU (1) RU2121824C1 (en)
TW (1) TW286273B (en)
WO (1) WO1995000199A1 (en)

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