RU95102495A - Process for preparing 1-(4′-tolyl)-3-methyl-5- pyrazolone
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Process for preparing 1-(4′-tolyl)-3-methyl-5- pyrazolone
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RU95102495A
RU95102495ARU95102495/04ARU95102495ARU95102495ARU 95102495 ARU95102495 ARU 95102495ARU 95102495/04 ARU95102495/04 ARU 95102495/04ARU 95102495 ARU95102495 ARU 95102495ARU 95102495 ARU95102495 ARU 95102495A
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
FIELD: chemical industry. SUBSTANCE: claimed process for preparing 1-(4′-tolyl)-3-methyl-5- pyrazolone by diazotization of p-toluydine and subsequently reducing p-tolyldiazonium chloride with sulfate-bisulfite mixture resulting from sodium (ammonium) bisulfite and ammonia water at pH of 5.8-7.0 and bisulfite to p-tolyldiazonium molar ratio of 2.49:1 to give p-tolylhydrazine and the latter is condensed with acetoacetic acid amide at pH of 1.9-2.5 and p- tolylhydrazine to acetoacetic acid amide molar ratio of 1: 1-1: 1.1 to obtain the desired white yellowish product having melting temperature of 134 C. EFFECT: more efficient preparation process.
Claims (1)
Способ получения 1-(4'-толил)-3-метил-5-пиразолона диазотированием п-толуидина с последующим восстановлением хлористого п-толилдиазония сульфитно-бисульфитной смесью, полученное из бисульфита натрия (аммония) и аммиачной воды, при pH = 5,8 - 7,0 и мольном соотношении бисульфита и п-толилдиазония 2,49 : 1, получением п-толилгидразина и конденсацией последнего с амидом ацетоуксусной кислоты при рН = 1,9 - 2,5 и мольном соотношении п-толилгидразина и амида ацетоуксусной кислоты 1 : 1 - 1 : 1,1. Получают целевой продукт белого с желтоватым оттенком цвета и температурой плавления 134oС.The method of obtaining 1- (4'-tolyl) -3-methyl-5-pyrazolone by diazotization of p-toluidine followed by reduction of p-tolyldiazonium chloride with a sulfite-bisulfite mixture obtained from sodium bisulfite (ammonium) and ammonia water, at pH = 5, 8-7.0 and a molar ratio of bisulfite and p-tolyldiazonium of 2.49: 1, obtaining p-tolylhydrazine and condensation of the latter with acetoacetic acid amide at pH = 1.9-2.5 and a molar ratio of p-tolylhydrazine and acetoacetic amide 1: 1 - 1: 1.1. Get the target product is white with a yellowish tint and a melting point of 134 o C.
RU95102495A1995-02-231995-02-23Method for synthesis of 1-(4'-tolyl)-3-methyl-5-pyrazolone
RU2075476C1
(en)
METHOD FOR PRODUCING N-(1,1-DIMETHYLETHYL)-4-((5'-ETHOXY-4-CIS-(2-(4-MORPHOLINO)ETHOXY)-2'-OXOSPIRO(CYCLOHEXAN-1,3'- (3H)INDOLE-1'(2H)-YL-SULFONYL)-3-METHOXYBENZAMIDE AND SALTS THEREOF