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RU94043806A - Производные оксазолидин-2-он - Google Patents

Производные оксазолидин-2-он

Info

Publication number
RU94043806A
RU94043806A RU94043806/04A RU94043806A RU94043806A RU 94043806 A RU94043806 A RU 94043806A RU 94043806/04 A RU94043806/04 A RU 94043806/04A RU 94043806 A RU94043806 A RU 94043806A RU 94043806 A RU94043806 A RU 94043806A
Authority
RU
Russia
Prior art keywords
lower alkyl
substituted
hydrogen
coch
nitrile
Prior art date
Application number
RU94043806/04A
Other languages
English (en)
Other versions
RU2133743C1 (ru
Inventor
Боргулиа Янос
Ch]
Брудерер Ханс
Якоб-Ретне Роланд
Ревер Стефан
De]
Original Assignee
Ф.Хоффманн-Ля Рош Аг (Ch)
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг (Ch), Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг (Ch)
Publication of RU94043806A publication Critical patent/RU94043806A/ru
Application granted granted Critical
Publication of RU2133743C1 publication Critical patent/RU2133743C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к производным оксазолидин-2-она общей формулы 1, указанной в описании, где R обозначает водород или низший алкил; а также к фармацевтически приемлемым солям основных соединений формулы 1 с кислотами. Эти новые соединения и их фармацевтически приемлемые соли могут применяться для борьбы или предупреждения состояний депрессии, состояний паники и страха, нарушений умственных функций головного мозга и заболеваний нервно-дегенеративного характера, как болезнь Паркинсона и болезнь Альцгеймера.

Claims (1)

  1. Изобретение относится к производным оксазолидин-2-она общей формулы 1, указанной в описании, где R обозначает водород или низший алкил; а также к фармацевтически приемлемым солям основных соединений формулы 1 с кислотами. Эти новые соединения и их фармацевтически приемлемые соли могут применяться для борьбы или предупреждения состояний депрессии, состояний паники и страха, нарушений умственных функций головного мозга и заболеваний нервно-дегенеративного характера, как болезнь Паркинсона и болезнь Альцгеймера.
RU94043806A 1993-12-13 1994-12-13 Производные оксазолидин-2-она и лекарственное средство на их основе RU2133743C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH370193 1993-12-13
CH3701/93 1993-12-13
CH292794 1994-09-27
CH2927/94 1994-09-27

Publications (2)

Publication Number Publication Date
RU94043806A true RU94043806A (ru) 1996-10-27
RU2133743C1 RU2133743C1 (ru) 1999-07-27

Family

ID=25691748

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94043806A RU2133743C1 (ru) 1993-12-13 1994-12-13 Производные оксазолидин-2-она и лекарственное средство на их основе

Country Status (21)

Country Link
US (1) US5574055A (ru)
EP (1) EP0657440B1 (ru)
JP (1) JP2602635B2 (ru)
KR (1) KR100362295B1 (ru)
CN (1) CN1051308C (ru)
AT (1) ATE191480T1 (ru)
AU (1) AU684319B2 (ru)
CA (1) CA2135861A1 (ru)
CZ (1) CZ291030B6 (ru)
DE (1) DE59409270D1 (ru)
DK (1) DK0657440T3 (ru)
ES (1) ES2145087T3 (ru)
GR (1) GR3033815T3 (ru)
HU (1) HU221809B1 (ru)
IL (1) IL111890A (ru)
NO (1) NO305204B1 (ru)
NZ (1) NZ270083A (ru)
PT (1) PT657440E (ru)
RU (1) RU2133743C1 (ru)
TW (1) TW286317B (ru)
UA (1) UA44691C2 (ru)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332384A1 (de) * 1993-09-23 1995-03-30 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten III
EP0891358A1 (fr) * 1995-10-11 1999-01-20 Synthelabo Composes derives d'oxazolidin-2-one, leur procede de preparation et leur application en therapeutique
FR2751651B1 (fr) * 1996-07-25 1998-09-04 Synthelabo Derives de 3-(benzo[b]thien-3-yl)oxazolidin-2-one, leur procede de preparation et leur application en therapeutique
FR2739856B1 (fr) * 1995-10-11 1997-11-14 Synthelabo Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique
FR2751653B1 (fr) * 1996-07-25 1998-09-04 Synthelabo Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique
DE19601264A1 (de) * 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601627A1 (de) 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
HRP970049A2 (en) * 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
JP3865450B2 (ja) * 1997-02-14 2007-01-10 田辺製薬株式会社 パーキンソニズム治療剤
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
EE200000707A (et) 1998-06-05 2002-04-15 Astrazeneca Ab Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
GB9912417D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2002072066A1 (en) * 2001-02-05 2002-09-19 Pharmacia & Upjohn Company Composition for rectal delivery of an oxazolidinone antibacterial drug
CA2463794A1 (en) 2001-11-29 2003-06-12 Merck & Co., Inc. Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof
AU2004256083B2 (en) 2003-07-02 2007-10-11 Kyorin Pharmaceutical Co., Ltd. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
US7223759B2 (en) * 2003-09-15 2007-05-29 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
WO2007102082A1 (en) * 2006-03-09 2007-09-13 Glenmark Pharmaceuticals Limited High oxazolidinone content solid dosage forms
EP2181993A1 (en) 2006-03-31 2010-05-05 Research Foundation Itsuu Laboratory Antimicrobial oxazolidinone derivatives
RU2470017C2 (ru) * 2007-06-08 2012-12-20 Янссен Фармацевтика Н.В. Производные пиперидина/пиперазина
JO2972B1 (en) * 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2687912C (en) * 2007-06-08 2015-11-03 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
WO2008148851A1 (en) * 2007-06-08 2008-12-11 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
EP2669283A1 (en) 2007-10-02 2013-12-04 Shionogi&Co., Ltd. Oxazolidinone derivative having 7-membered hetero ring
US9107946B2 (en) 2008-06-05 2015-08-18 Janssen Pharmaceutica Nv Drug combinations comprising a DGAT inhibitor and a PPAR-agonist

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1180089A (en) * 1967-10-20 1970-02-04 Delalande Sa Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
FR2380780A2 (fr) * 1977-02-22 1978-09-15 Delalande Sa Application en therapeutique des hydroxymethyl-5 oxazolidinones-2, notamment comme antidepresseurs
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
CA1171865A (en) * 1980-06-04 1984-07-31 Alain Lacour N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
FR2653017B1 (fr) * 1989-10-17 1995-05-05 Delalande Sa Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.
US5182296A (en) * 1989-10-26 1993-01-26 Tanabe Seiyaky Co., Ltd. Naphthyloxazolidone derivatives
CA2112129C (en) * 1992-04-30 1997-10-07 Shingo Yano Oxazolidine derivative and pharmaceutically acceptable salt thereof

Also Published As

Publication number Publication date
HU221809B1 (hu) 2003-01-28
RU2133743C1 (ru) 1999-07-27
EP0657440A1 (de) 1995-06-14
ES2145087T3 (es) 2000-07-01
UA44691C2 (uk) 2002-03-15
KR950017993A (ko) 1995-07-22
CA2135861A1 (en) 1995-06-14
HUT72315A (en) 1996-04-29
KR100362295B1 (ko) 2003-03-03
NO305204B1 (no) 1999-04-19
DE59409270D1 (de) 2000-05-11
CZ312694A3 (en) 1995-08-16
NO944802D0 (no) 1994-12-12
JPH07196634A (ja) 1995-08-01
TW286317B (ru) 1996-09-21
AU8023394A (en) 1995-06-22
NO944802L (no) 1995-06-14
PT657440E (pt) 2000-09-29
AU684319B2 (en) 1997-12-11
EP0657440B1 (de) 2000-04-05
CN1051308C (zh) 2000-04-12
HU9403494D0 (en) 1995-02-28
ATE191480T1 (de) 2000-04-15
IL111890A0 (en) 1995-03-15
IL111890A (en) 1998-12-06
NZ270083A (en) 1996-02-27
JP2602635B2 (ja) 1997-04-23
CN1109054A (zh) 1995-09-27
CZ291030B6 (cs) 2002-12-11
US5574055A (en) 1996-11-12
GR3033815T3 (en) 2000-10-31
DK0657440T3 (da) 2000-09-04

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Effective date: 20031214