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RU94036769A - Алкильные производные тразодона, способ их получения, промежуточные соединения и фармацевтическая композиция - Google Patents

Алкильные производные тразодона, способ их получения, промежуточные соединения и фармацевтическая композиция

Info

Publication number
RU94036769A
RU94036769A RU94036769/04A RU94036769A RU94036769A RU 94036769 A RU94036769 A RU 94036769A RU 94036769/04 A RU94036769/04 A RU 94036769/04A RU 94036769 A RU94036769 A RU 94036769A RU 94036769 A RU94036769 A RU 94036769A
Authority
RU
Russia
Prior art keywords
synthesis
trazodone
pharmaceutical composition
alkyl derivatives
intermediate compounds
Prior art date
Application number
RU94036769/04A
Other languages
English (en)
Other versions
RU2126801C1 (ru
Inventor
Байокки Леандро
It]
Original Assignee
Иституто Ричерка Франческо Анджелини С.п.А. (IT)
Иституто Ричерка Франческо Анджелини С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иституто Ричерка Франческо Анджелини С.п.А. (IT), Иституто Ричерка Франческо Анджелини С.п.А. filed Critical Иституто Ричерка Франческо Анджелини С.п.А. (IT)
Publication of RU94036769A publication Critical patent/RU94036769A/ru
Application granted granted Critical
Publication of RU2126801C1 publication Critical patent/RU2126801C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описываются алкиловые производные тразодона, обладающие фармакологической активностью, фармацевтические составы на их основе, способ получения этих соединений и промежуточные продукты для их синтеза.

Claims (1)

  1. Описываются алкиловые производные тразодона, обладающие фармакологической активностью, фармацевтические составы на их основе, способ получения этих соединений и промежуточные продукты для их синтеза.
RU94036769A 1992-01-17 1993-01-14 Алкильные производные тразодона, способ их получения, промежуточные соединения и фармацевтическая композиция RU2126801C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITM192A000084 1992-01-17
ITMI920084A IT1258790B (it) 1992-01-17 1992-01-17 Alchil derivati del trazodone
ITMI92A000084 1992-01-17
PCT/EP1993/000080 WO1993014091A1 (en) 1992-01-17 1993-01-14 Alkyl derivatives of trazodone with cns activity

Publications (2)

Publication Number Publication Date
RU94036769A true RU94036769A (ru) 1997-04-20
RU2126801C1 RU2126801C1 (ru) 1999-02-27

Family

ID=11361589

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94036769A RU2126801C1 (ru) 1992-01-17 1993-01-14 Алкильные производные тразодона, способ их получения, промежуточные соединения и фармацевтическая композиция

Country Status (25)

Country Link
EP (1) EP0623131B1 (ru)
JP (1) JP2856912B2 (ru)
KR (1) KR100254690B1 (ru)
AT (1) ATE136307T1 (ru)
AU (1) AU671973B2 (ru)
BG (1) BG61841B1 (ru)
BR (1) BR9305752A (ru)
CA (1) CA2128202C (ru)
CZ (1) CZ282910B6 (ru)
DE (1) DE69302087T2 (ru)
DK (1) DK0623131T3 (ru)
ES (1) ES2088270T3 (ru)
FI (2) FI110186B (ru)
GE (1) GEP20001939B (ru)
GR (1) GR3020420T3 (ru)
HU (5) HU218678B (ru)
IT (1) IT1258790B (ru)
NO (2) NO302365B1 (ru)
NZ (1) NZ246598A (ru)
PL (1) PL170913B1 (ru)
RO (1) RO113465B1 (ru)
RU (1) RU2126801C1 (ru)
SK (1) SK280561B6 (ru)
WO (1) WO1993014091A1 (ru)
ZA (1) ZA93292B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1268414B1 (it) * 1993-07-01 1997-02-27 Angelini Francesco Ist Ricerca Enantiomeri farmacologicamente attivi
AU718075B2 (en) * 1993-07-01 2000-04-06 Angelini Ricerche S.P.A. Societa Consortile Intermediates for the preparation of pharmacologically active enantiomers of triazolone compounds
TW200726765A (en) * 2005-06-17 2007-07-16 Bristol Myers Squibb Co Triazolopyridine cannabinoid receptor 1 antagonists
ITMI20051193A1 (it) * 2005-06-24 2006-12-25 Acraf Uso farmaceutico di una 1-3-clorofenil-3-alchilpiperazina
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
RU2706700C1 (ru) 2019-09-24 2019-11-20 Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US100505A (en) * 1870-03-08 Improvement in sash-bolt
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione

Also Published As

Publication number Publication date
GR3020420T3 (en) 1996-10-31
ITMI920084A0 (it) 1992-01-17
RO113465B1 (ro) 1998-07-30
IT1258790B (it) 1996-02-29
CA2128202C (en) 2001-01-23
HU219493B (hu) 2001-04-28
HUT71512A (en) 1995-12-28
JP2856912B2 (ja) 1999-02-10
EP0623131B1 (en) 1996-04-03
GEP20001939B (en) 2000-02-05
NO942668L (no) 1994-09-16
FI20021652A (fi) 2002-09-16
HU9402119D0 (en) 1994-09-28
NO303686B1 (no) 1998-08-17
HU218678B (hu) 2000-10-28
NO942668D0 (no) 1994-07-15
HU9502179D0 (en) 1995-09-28
BG61841B1 (bg) 1998-07-31
PL170913B1 (pl) 1997-02-28
ZA93292B (en) 1993-08-19
NO302365B1 (no) 1998-02-23
DK0623131T3 (da) 1996-08-05
HUT72591A (en) 1996-05-28
NO974462D0 (no) 1997-09-26
HUT70761A (en) 1995-10-30
RU2126801C1 (ru) 1999-02-27
FI943386A0 (fi) 1994-07-15
BR9305752A (pt) 1997-01-28
CZ282910B6 (cs) 1997-11-12
HU9502177D0 (en) 1995-09-28
DE69302087T2 (de) 1996-11-28
HU9502178D0 (en) 1995-09-28
BG98896A (bg) 1995-03-31
CZ173294A3 (en) 1995-02-15
WO1993014091A1 (en) 1993-07-22
CA2128202A1 (en) 1993-07-22
SK84694A3 (en) 1995-04-12
HUT71513A (en) 1995-12-28
FI110186B (fi) 2002-12-13
EP0623131A1 (en) 1994-11-09
AU671973B2 (en) 1996-09-19
ES2088270T3 (es) 1996-08-01
NO974462L (no) 1994-09-16
SK280561B6 (sk) 2000-03-13
FI113266B (fi) 2004-03-31
HU217981B (hu) 2000-05-28
ITMI920084A1 (it) 1993-07-17
ATE136307T1 (de) 1996-04-15
DE69302087D1 (de) 1996-05-09
NZ246598A (en) 1997-08-22
HU217982B (hu) 2000-05-28
HU9502180D0 (en) 1995-09-28
FI943386A (fi) 1994-07-15
JPH07503000A (ja) 1995-03-30
KR100254690B1 (ko) 2000-05-01
AU3350493A (en) 1993-08-03
HU217968B (hu) 2000-05-28
HUT71511A (en) 1995-12-28

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20100115