RU93044129A - BRANCHED ALKYLAMINE DERIVATIVES OF THIAZOLE, METHOD FOR THEIR RECEIVING, USE AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS - Google Patents
BRANCHED ALKYLAMINE DERIVATIVES OF THIAZOLE, METHOD FOR THEIR RECEIVING, USE AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONSInfo
- Publication number
- RU93044129A RU93044129A RU93044129/04A RU93044129A RU93044129A RU 93044129 A RU93044129 A RU 93044129A RU 93044129/04 A RU93044129/04 A RU 93044129/04A RU 93044129 A RU93044129 A RU 93044129A RU 93044129 A RU93044129 A RU 93044129A
- Authority
- RU
- Russia
- Prior art keywords
- radical
- cycloalkyl
- thiazole
- receiving
- alkyl
- Prior art date
Links
- -1 ALKYLAMINE DERIVATIVES OF THIAZOLE Chemical class 0.000 title claims 16
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N Hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- CFHIDWOYWUOIHU-UHFFFAOYSA-N oxomethyl Chemical compound O=[CH] CFHIDWOYWUOIHU-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Claims (1)
в которой R1 обозначает фенильный или нафтильный радикал (в известных случаях замещенные); R2 - атом водорода, галогена, алкильный радикал, оксиметильный или формильный радикал; R3 - алкильный радикал, циклоалкильный радикал, алкенильный радикал, циклоалкилалкильный радикал или фенильный радикал; R4 - атом водорода, алкильный, циклоалкильный или циклоалкилалкильный радикал; R5 - алкильный радикал, циклоалкильный радикал, циклоалкилалкильный радикал, алкенильный радикал или радикал формулы В:
R6 обозначает фенильный пиридильный, имидазолильный, пирролильный, тиенильный, фурильный радикал, в известных случаях замещенные, или циклоалкильный радикал.The invention relates to derivatives of formula 1:
in which R 1 denotes a phenyl or naphthyl radical (in some cases substituted); R 2 is a hydrogen atom, halogen, alkyl radical, hydroxymethyl or formyl radical; R 3 is an alkyl radical, a cycloalkyl radical, an alkenyl radical, a cycloalkyl-alkyl radical or a phenyl radical; R 4 is a hydrogen atom, an alkyl, cycloalkyl or cycloalkylalkyl radical; R 5 is an alkyl radical, a cycloalkyl radical, a cycloalkyl-alkyl radical, an alkenyl radical or a radical of formula B:
R 6 denotes a phenyl pyridyl, imidazolyl, pyrrolyl, thienyl, furyl radical, in some cases substituted, or a cycloalkyl radical.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9207736 | 1992-06-24 | ||
| FR929207736A FR2692893B1 (en) | 1992-06-24 | 1992-06-24 | Branched alkylamino thiazole derivatives, processes for their preparation and pharmaceutical compositions containing them. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93044129A true RU93044129A (en) | 1995-12-27 |
| RU2102389C1 RU2102389C1 (en) | 1998-01-20 |
Family
ID=9431129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93044129A RU2102389C1 (en) | 1992-06-24 | 1993-06-23 | Branched alkylamino derivatives of thiazole or their potential stereoisomers or their additive salts with mineral or organic acid, method for their production, pharmaceutical composition having activity in respect with factor of releasing of corticotropic hormone and alkylamino derivatives of thiazole as intermediate compounds |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5464847A (en) |
| EP (1) | EP0576350B1 (en) |
| JP (1) | JPH0656809A (en) |
| KR (1) | KR100228813B1 (en) |
| CN (1) | CN1035552C (en) |
| AT (1) | ATE159721T1 (en) |
| AU (1) | AU665256B2 (en) |
| BR (1) | BR9302643A (en) |
| CA (1) | CA2099062A1 (en) |
| CZ (1) | CZ125293A3 (en) |
| DE (1) | DE69314855T2 (en) |
| DK (1) | DK0576350T3 (en) |
| ES (1) | ES2110070T3 (en) |
| FI (1) | FI932909A (en) |
| FR (1) | FR2692893B1 (en) |
| GR (1) | GR3025684T3 (en) |
| HK (1) | HK1002632A1 (en) |
| HU (1) | HUT66384A (en) |
| IL (1) | IL106088A (en) |
| IS (1) | IS4040A (en) |
| MX (1) | MX9303770A (en) |
| MY (1) | MY109557A (en) |
| NO (1) | NO303118B1 (en) |
| NZ (1) | NZ247949A (en) |
| PH (1) | PH30921A (en) |
| PL (2) | PL176103B1 (en) |
| RU (1) | RU2102389C1 (en) |
| SG (1) | SG50626A1 (en) |
| SI (1) | SI9300337A (en) |
| TW (1) | TW256834B (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2714059B1 (en) * | 1993-12-21 | 1996-03-08 | Sanofi Elf | Branched amino derivatives of thiazole, processes for their preparation and pharmaceutical compositions containing them. |
| DE4401912A1 (en) * | 1994-01-24 | 1995-07-27 | Basf Ag | Methine dyes in non-linear optics |
| US5646152A (en) | 1994-06-15 | 1997-07-08 | Pfizer Inc. | Methods of administering CRF antagonists |
| US5795905A (en) * | 1995-06-06 | 1998-08-18 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| FR2735777B1 (en) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | 4-PHENYLAMINOTHIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| EP0863882B1 (en) | 1995-10-17 | 2002-02-06 | Janssen Pharmaceutica N.V. | Amino substituted pyrimidines and triazines |
| US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
| US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
| US5861398A (en) * | 1996-08-26 | 1999-01-19 | Alanex Corporation | Benzoperimidine-carboxylic acids and derivatives thereof |
| AU4270297A (en) | 1996-09-16 | 1998-04-02 | Du Pont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
| FR2754258B1 (en) | 1996-10-08 | 1998-12-31 | Sanofi Sa | AMINOTHIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| EP0970082A2 (en) | 1997-02-18 | 2000-01-12 | Neurocrine Biosciences, Inc. | Biazacyclic crf antagonists |
| AU755997B2 (en) * | 1998-11-12 | 2003-01-02 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| IL142893A0 (en) | 1998-11-12 | 2002-04-21 | Neurocrine Biosciences Inc | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
| US6531475B1 (en) * | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| FR2796380B3 (en) * | 1999-07-15 | 2001-08-17 | Sanofi Synthelabo | NOVEL AMINOTHIAZOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| EP1149583A3 (en) * | 2000-04-13 | 2001-11-14 | Pfizer Products Inc. | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues |
| US6699866B2 (en) * | 2001-04-17 | 2004-03-02 | Sepracor Inc. | Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof |
| WO2003006015A1 (en) * | 2001-07-13 | 2003-01-23 | Bristol-Myers Squibb Pharma Company | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands |
| WO2003015777A1 (en) * | 2001-08-13 | 2003-02-27 | Lion Bioscience Ag | Nr1h4 nuclear receptor binding compounds |
| ATE381542T1 (en) * | 2001-08-13 | 2008-01-15 | Phenex Pharmaceuticals Ag | NR1H4 CORE RECEPTOR BINDING COMPOUNDS |
| JP4484439B2 (en) * | 2002-03-14 | 2010-06-16 | 国立大学法人東京工業大学 | VDAC regulator |
| WO2003075923A1 (en) * | 2002-03-14 | 2003-09-18 | Takeda Chemical Industries, Ltd. | Vdac regulator |
| LT3002283T (en) * | 2003-12-26 | 2017-09-11 | Kyowa Hakko Kirin Co., Ltd. | Thiazole derivatives |
| WO2007089679A2 (en) * | 2006-02-01 | 2007-08-09 | Merck & Co., Inc. | Potassium channel inhibitors |
| AU2007312390B2 (en) * | 2006-10-19 | 2013-03-28 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| JP5467735B2 (en) * | 2007-07-02 | 2014-04-09 | 東ソー株式会社 | Cylindrical sputtering target |
| US20170020877A1 (en) | 2014-01-21 | 2017-01-26 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia |
| JP2022500499A (en) | 2018-09-07 | 2022-01-04 | ピク セラピューティクス， インコーポレイテッド | EIF4E Inhibitors and Their Use |
| AU2019393256A1 (en) | 2018-12-07 | 2021-07-29 | Neurocrine Biosciences, Inc. | CRF1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4264134A (en) * | 1978-05-26 | 1981-04-28 | Elliott Brothers (London) Limited | Display arrangements |
| DK150068C (en) * | 1978-06-02 | 1987-06-29 | Pfizer | METHOD OF ANALOGUE FOR THE PREPARATION OF AMINOTHIAZOLES |
| US5232921A (en) * | 1987-03-12 | 1993-08-03 | Sanofi | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions |
| FR2612187B1 (en) * | 1987-03-12 | 1989-07-21 | Sanofi Sa | THIAZOLE DERIVATIVES ACTIVE IN THE CHOLINERGIC SYSTEM, THEIR PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| FR2656610B1 (en) * | 1989-12-29 | 1992-05-07 | Sanofi Sa | DERIVATIVES OF 2-AMINO PHENYL-4 THIAZOLE, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION. |
-
1992
- 1992-06-24 FR FR929207736A patent/FR2692893B1/en not_active Expired - Fee Related
-
1993
- 1993-06-21 IL IL106088A patent/IL106088A/en not_active IP Right Cessation
- 1993-06-22 AU AU41399/93A patent/AU665256B2/en not_active Ceased
- 1993-06-22 SG SG1996007157A patent/SG50626A1/en unknown
- 1993-06-22 EP EP93401603A patent/EP0576350B1/en not_active Expired - Lifetime
- 1993-06-22 PH PH46390A patent/PH30921A/en unknown
- 1993-06-22 DK DK93401603T patent/DK0576350T3/en active
- 1993-06-22 AT AT93401603T patent/ATE159721T1/en not_active IP Right Cessation
- 1993-06-22 DE DE69314855T patent/DE69314855T2/en not_active Expired - Fee Related
- 1993-06-22 NZ NZ247949A patent/NZ247949A/en unknown
- 1993-06-22 ES ES93401603T patent/ES2110070T3/en not_active Expired - Lifetime
- 1993-06-23 SI SI9300337A patent/SI9300337A/en unknown
- 1993-06-23 JP JP5152479A patent/JPH0656809A/en active Pending
- 1993-06-23 RU RU93044129A patent/RU2102389C1/en active
- 1993-06-23 PL PL93321372A patent/PL176103B1/en unknown
- 1993-06-23 HU HU9301850A patent/HUT66384A/en unknown
- 1993-06-23 CN CN93109438A patent/CN1035552C/en not_active Expired - Fee Related
- 1993-06-23 CA CA002099062A patent/CA2099062A1/en not_active Abandoned
- 1993-06-23 NO NO932319A patent/NO303118B1/en not_active IP Right Cessation
- 1993-06-23 US US08/080,172 patent/US5464847A/en not_active Expired - Fee Related
- 1993-06-23 FI FI932909A patent/FI932909A/en unknown
- 1993-06-23 MX MX9303770A patent/MX9303770A/en not_active IP Right Cessation
- 1993-06-23 CZ CZ931252A patent/CZ125293A3/en unknown
- 1993-06-23 IS IS4040A patent/IS4040A/en unknown
- 1993-06-23 PL PL93299445A patent/PL174734B1/en unknown
- 1993-06-23 MY MYPI93001219A patent/MY109557A/en unknown
- 1993-06-24 KR KR1019930011709A patent/KR100228813B1/en not_active IP Right Cessation
- 1993-06-24 BR BR9302643A patent/BR9302643A/en not_active Application Discontinuation
- 1993-08-31 TW TW082107085A patent/TW256834B/zh not_active IP Right Cessation
-
1997
- 1997-12-16 GR GR970403334T patent/GR3025684T3/en unknown
-
1998
- 1998-02-12 HK HK98101081A patent/HK1002632A1/en not_active IP Right Cessation
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