RU2798929C2 - Advanced inhalation device - Google Patents

Abstract

FIELD: medical equipment.

SUBSTANCE: group of inventions relates to an inhalation device for medical liquids for the formation of an aerosol and a method for the formation of an aerosol by means of an inhalation device. The inhalation device comprises a housing (1), inside the said housing (1) a reservoir (2) for storing liquid, a pressure unit. The injection unit contains an outlet pipe (5), a hollow cylindrical part (3) with an internal space configured to accommodate an end part (5A) of the said outlet pipe (5) located upstream of the fluid. The cylindrical part (3) is made with the possibility of linear movement along the outlet pipe (5). The cylindrical part (3) and the outlet pipe (5) form an injection chamber having, due to the linear movement of the cylindrical part (3) relative to the outlet pipe (5), a variable volume for pressurizing the said injection chamber. The injection chamber is in fluid communication with the reservoir (2) and with a nozzle (6) which has a liquid-tight connection with the downstream end part (5B) of the outlet pipe (5). The possibility of the said relative linear movement is provided by means of relative rotation of the rotatable part (1A), which is a part of the first part of the body (1), around the axis (R) of rotation relative to the counterpart (1B), which is a part of the second part of the said body (1) so that the said relative rotation is converted into the said relative linear movement by the drive mechanism. The drive mechanism comprises a cam surface containing a first section (9A) located in the axial direction, having an increasing height, as well as a second section (9B), having a decreasing height. The cam surface is made with the possibility of sliding along the adjacent mating surface. The cam surface is configured to slide on the said mating surface during rotation, resulting in the said transformation. Means (7) are provided for storing potential energy, configured to store energy through the said relative rotation along the first section (9A). It is possible to communicate the specified energy to the specified pumping device when it is released. The cam surface comprises between the first section (9A) having an increasing height and the second section (9B) having a decreasing height, a third section (9C) having a constant height, so that while the said third section (9C) of the said cam surface slides on the mating surface, no linear movement of the cylindrical part (3) relative to the outlet pipe (5) occurs. The dosing cycle, which covers the angle of rotation of the first, second and third sections (9A, 9B, 9C), corresponds to a rotation of 180 degrees. The method for generating an aerosol by means of an inhalation device includes, during rotation of the rotatable part (1A), the first phase — the filling phase, for filling the injection chamber with liquid, and the second phase — the release phase, for ejecting the sprayed liquid from the nozzle (6). Between these two phases there is a third phase, the rest phase, during which, despite further rotation, the volume of the injection chamber remains constant and one dosing cycle is provided by means of a 180 degree rotation.

EFFECT: production of a device that makes it possible to prevent any premature and undesirable release of liquid from the nozzle, avoids a reduction in dosing cycles per tank, and also provides a cost-effective and mechanically reliable technical solution.

14 cl, 16 dwg

Description

Technical field

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a mechanism for ejecting liquid for an inhalation device, as well as a method for ejecting liquid from an inhalation device.

State of the art

Nebulizers or other aerosol generators for liquids have long been known in the art. In particular, such devices are used in medicine for therapeutic and research purposes. In these areas, they serve as inhalation devices for the delivery of active ingredients in the form of aerosols, i. in the form of small liquid droplets distributed in the gas. Such an inhalation device is known in particular from EP 0627230 B1. The main components of said inhalation device are: a reservoir containing a liquid to be aerosolised; a pressure unit for creating a pressure that is high enough to carry out spraying; as well as a device for fine spraying in the form of a nozzle.

An improvement to such an inhalation device is disclosed in patent application PCT/EP 2018/061056 filed by the same applicant as the present invention, the contents of which are incorporated herein in their entirety.

A typical fluid ejection mechanism includes a potential energy store, such as a spring, and a drive unit. By cocking the spring (preferably manually), potential energy is stored in the inhalation device. This energy can subsequently be used to pressurize an injection chamber which is in fluid communication with the nozzle.

WO 2007/128381 A1 discloses yet another mist device for medical fluids, comprising a mechanism for ejecting the fluid. The rotation of the two housing parts relative to each other is converted by said drive unit into a linear movement, which is then used to charge the spring. Said motion transformation is achieved by using at least one pair of helical surfaces that slide over each other. After full cocking rotation, which in the case of the presence of two pairs of surfaces is 180 degrees, each of the initially moving upwards in the axial direction provides a sharp edge with the implementation of a vertical descent (also in the axial direction). The length of said descent corresponds to the pumping movements of the pumping device. Thus, when the edges pass each other, seeking to continue the rotation of the mechanism, the movement in the axial direction is reversed and the potential energy is again released, resulting in the creation of pressure.

Care must be taken to prevent premature and unwanted release of said potential energy. To this end, prior art solutions provide a locking element which stops rotation as soon as both sliding surfaces reach said edges. In other words, just at the very time when said further rotation could lead to said "descent", said locking element prevents any movement in the axial direction. By manually deactivating said locking element (that is, by pressing the release button), the potential energy is purposefully released and used to generate pressure.

In WO 2007/128381 A1, a small amount of liquid is already injected through the liquid-filled channels (injection chamber, nozzle) when the device is charged. By shifting in the axial direction of the locking mechanism so that when the end of the cocking rotational movement is reached, the edges actually only slightly pass each other, which results in some movement in the direction of said "descent" and premature ejection liquid due to the beginning movement of the discharge mechanism in the axial direction. After passing a short distance, the displaced locking mechanism stops said movement. Only on subsequent actuation, which is carried out by actuating (release) the locking mechanism, is a complete pressurizing movement carried out and the desired dose of liquid is finely atomized.

The disadvantage of this premature pumping effect is that some of the liquid ejected before the actual dosing takes place must be released from the nozzle outlet before the actual fine atomization starts. On the other hand, clogging of the nozzle outlets can lead to the formation of spray droplets with undesirable parameters and/or splashing. In addition, the amount of liquid used to carry out pre-injection reduces the total number of possible dosing cycles per reservoir. In addition, the above "release" results in a highly audible clicking sound, which may be perceived as annoying to some users.

Another disadvantage is that great effort is required to construct the locking element of the type described above, which results in an increase in production and assembly costs, as well as an increase in the likelihood of mechanical damage.

Disclosure of the essence of the invention

In a first aspect, the present invention provides an aerosolized medical fluid inhalation device comprising:

- a housing, inside said housing a fluid storage tank, an injection unit, said unit comprising an outlet pipe, a hollow cylindrical part having an internal space configured to accommodate an end part of said outlet pipe located upstream of the fluid medium, wherein:

the specified cylindrical part is made with the possibility of linear movement along the outlet pipe,

the cylindrical part and the outlet pipe form an injection chamber having, due to the linear movement of the cylindrical part relative to the outlet pipe, a variable volume for pressurizing said injection chamber, wherein

- the injection chamber is in fluid communication with the reservoir and with a nozzle that has a liquid-tight connection with the downstream end of the outlet pipe, and at the same time

said relative linear movement can be carried out by relative rotation of the rotatable part, which is part of the first part of the body or connected to it, around the axis of rotation relative to the counterpart, which is part of the second part of the specified body or connected to it, thus, that the specified relative rotation is converted into the specified relative linear movement by means of the drive mechanism, and the specified drive mechanism contains at least one cam surface containing the first section located in the axial direction, having an increasing height, and also the second section having a decreasing height, and the cam surface is made with the possibility of sliding on the adjacent mating surface, and the cam surface is configured to slide on the specified mating surface during rotation, which leads to the specified transformation,

means for storing potential energy are provided, configured to store energy through said relative rotation along the first section, and wherein said energy can be imparted to said pumping device when it is released,

said cam surface comprises, between a first section having an increasing height and a second section having a decreasing height, a third section having a constant height, so that while said third section of said cam surface slides over the mating surface, there is no linear movement of the cylindrical portion relative to the output pipe does not occur, and

- the dosing cycle, which covers the angle of rotation of the first, second and third sections, corresponds to a rotation of 180 degrees.

In a second aspect, the present invention provides a method for generating an aerosol by means of an inhalation device according to any one of the preceding claims, the method comprising, by rotating the rotatable portion, a first phase, a filling phase, for filling the delivery chamber with liquid, and a second phase, a release phase. , for the ejection of a finely dispersed liquid from the nozzle, and between these two phases there is a third phase - the rest phase, during which, despite further rotation, the volume of the injection chamber remains constant.

The task of the invention

The object of the present invention is to provide a device that avoids the disadvantages of the prior art.

The invention should make it possible to prevent any premature and undesirable release of liquid from the nozzle, as well as to avoid a reduction in dosing cycles per reservoir.

The invention should also provide a cost effective and mechanically reliable solution.

Detailed description of the invention

In accordance with the first aspect of the present invention, the object of the present invention is achieved by means of an inhalation device for medical liquids for the formation of an aerosol containing:

- a housing, inside said housing a fluid storage tank, an injection unit, said unit comprising an outlet pipe, a hollow cylindrical part having an internal space configured to accommodate an end part of said outlet pipe located upstream of the fluid medium, wherein:

the specified cylindrical part is made with the possibility of linear movement along the outlet pipe,

the cylindrical part and the outlet pipe form an injection chamber having, due to the linear movement of the cylindrical part relative to the outlet pipe, a variable volume for pressurizing said injection chamber, wherein

- the injection chamber is in fluid communication with the reservoir and with a nozzle that has a liquid-tight connection with the downstream end of the outlet pipe, and at the same time

said relative linear movement can be carried out by relative rotation of the rotatable part, which is part of the first part of the body or connected to it, around the axis of rotation relative to the counterpart, which is part of the second part of the specified body or connected to it, thus, that said relative rotation is converted into said relative linear movement by means of a drive mechanism, wherein said drive mechanism comprises at least one cam surface comprising an axially located first section having an increasing height, as well as a second section having a decreasing height, wherein the cam surface configured to slide on an adjacent mating surface, wherein the cam surface is configured to slide on said mating surface during rotation, resulting in said transformation,

- a means for storing potential energy is provided, configured to store energy through said relative rotation along the first section, and said energy can be communicated to said pumping device when it is released,

Said cam surface comprises, between a first section having an increasing height and a second section having a decreasing height, a third section having a constant height, so that while said third section of said cam surface slides over the mating surface, there is no linear movement of the cylindrical portion relative to the outlet pipe does not occur, and

- the dosing cycle, which covers the angle of rotation of the first, second and third sections, corresponds to a rotation of 180 degrees.

In addition, the object of the present invention is solved by the method according to the second aspect of the invention. Preferred embodiments of the invention are described in the respective dependent claims, the following description, and also in the attached drawings.

The inhalation device serves to medically form an aerosol from medically active liquids for inhalation therapy. In particular, the inhalation device is configured to produce and deliver nebulized aerosols in a metered manner suitable for delivering medically active ingredients to the lungs.

Typically, such an inhalation device comprises a housing, within the housing a liquid storage reservoir and a pumping unit, which is preferably based on the principle of a piston pump or plunger pump. More specifically, said injection unit according to the present invention comprises a hollow cylindrical portion having an internal space for pressurizing the injection chamber. It should be noted that the term "cylindrical part" refers to a part having a cylindrical inner surface; the outer side, as well as the part that does not come into contact with the outlet pipe and/or insulation, need not be cylindrical.

The injection chamber is formed by a cylindrical part and an outlet pipe and has a variable volume to pressurize said injection chamber. The injection chamber is in fluid communication with the reservoir; if necessary, through a non-return valve, which is designed to close in the direction of the tank. In order to achieve volume variability, said outlet pipe is configured to accommodate at least one of its tank-facing inner ends (hereinafter referred to as "upstream end portion") in said cylindrical portion, and the cylindrical portion is configured to linearly move through the outlet pipe.

The nozzle has a liquid-tight connection directly or indirectly with the downstream end of the outlet pipe.

The outlet pipe may be stationary with respect to the body of the device, or at least a part of the body, to which the nozzle is also rigidly attached, directly or indirectly, thus the outlet pipe is also fixed or made without the possibility of movement relative to the nozzle. In another embodiment of the invention, the outlet pipe is movable, and the injection chamber/cylindrical part is stationary with respect to said body. In another embodiment of the invention, both the cylindrical part and the outlet pipe are both movable.

In other words, the cylindrical portion has an internal space configured to accommodate an upstream end portion of said outlet pipe. The cylindrical part is made with the possibility of linear movement along the specified end part in such a way that the volume in the specified cylindrical part is changed by means of a linear relative movement of the specified output pipe or vice versa.

In addition, said relative linear movement can be carried out by means of relative rotation of the rotatable part, which is part of the first part of the body or connected to it, around the axis of rotation with respect to the counterpart, which is part of the second part of the specified body or connected to it. , so that said relative rotation is converted into said relative linear movement by a drive mechanism or the like. Thus, the body contains two parts, one of which is rotatable relative to the other. The drive mechanism comprises at least one cam surface, i.e. a surface configured to slide on an adjacent mating surface or other appropriate component that is guided by a particular shape of the cam surface. The cam surface can be made in the form of a guide that rotates around the main axis of rotation of the device along a curved path. Specifically, the camming surface may be in the form of a closed or endless guide that rotates about the main axis of rotation along a circular or annular path, as described in more detail below.

Said cam surface has or comprises an axially located first section having an increasing height, as well as a second section having a decreasing height. In the present description, the axial direction is a direction that is parallel (or identical) to the longitudinal direction of the injection chamber/cylindrical portion. With relative rotation of the part on which the cam surface is placed and the part on which the mating surface is placed, the cam surface can slide on said mating surface, resulting in said transformation. During said sliding, the cam surface and mating surface remain in contact along the centerline. As a result, by relative rotation of the rotatable part with respect to the counterpart part, the volume of the injection chamber changes. Movement through the first section leads to an increase in volume (and thus to a decrease in pressure in the injection chamber and filling the injection chamber with liquid from the reservoir), and movement through the second section leads to a decrease in volume (and increasing pressure in the injection chamber and ejection of liquid from the nozzle ). It should be understood that, depending on the specific design, opposite effects can also be obtained. However, for clarity, the effect of the respective regions on the volume is described as described above.

In other words, the first drive part has a cam surface and is connected to the first housing part; and the second part (reciprocal part) of the drive has a mating surface and is connected to the second part of the housing; wherein the first part and the second part are rotatable relative to each other such that the cam surface and mating surface slide over each other.

In addition, a means for storing potential energy is provided, which is configured to store energy through said relative rotation along the first section, and said energy can be imparted to said pumping device when it is released, for example, by actuating the releasing means. Preferably, said means for storing potential energy is provided by means of an elastic spring. By stretching said spring, potential energy is conserved, and by allowing it to recompress, energy is released. In yet another embodiment of the invention, the opposite effects occur (compressive spring).

According to the present invention, said camming surface has or comprises, between sections of increasing or decreasing height, a third section having a constant or substantially constant height, so that as long as said mating surfaces slide over said third section, relative linear movement does not occur or practically not happening.

As a result, the rotation of the rotatable part along the third section, which is located between the first and second sections, will not change in the axial direction the relative position of the rotatable part and the counterpart and thus the internal volume of the injection chamber and, therefore, will not change its internal pressure. At the same time, the cocking state of the potential energy storage means is also not changed by said rotation along the third section. In this phase, no premature injection of liquid occurs and thus no liquid is ejected before the actual dosing. No clogging of the nozzle exits due to liquid pre-ejection occurs, which avoids the formation of spray droplets with undesirable parameters and spatter formation. In addition, the total number of possible dosing cycles per container is increased and the aforementioned clicking sound can be avoided if necessary or desired. In addition, the blocking means that could be provided to prevent unintentional actuation of the device can be designed in a simpler manner, resulting in lower manufacturing and assembly costs, as well as a reduction in the likelihood of mechanical damage.

In one embodiment of the invention, the cam surface is located on or connected to the rotatable part, and the counter part provides a mating surface.

In yet another embodiment of the invention, the cam surface is disposed on or connected to the counterpart, and the rotatable portion provides the mating surface.

It should be noted that the term mating surface should be interpreted in a broad sense such that every type of component that serves the purpose of providing sliding engagement with a camming surface falls within the scope of this definition.

In one embodiment of the invention, the mating surface is provided by a second cam surface. Thus, two cam surfaces are present, both simultaneously serving as respective mating surfaces. In other words, the counterpart (or vice versa, the rotatable part) also provides a cam surface, and specifically, a surface having an inverted shape of the corresponding cam surface of the rotatable part (or alternatively, the mate) or one or more of it. plots. This results in maximum mechanical overlap of both parts, reducing mechanical wear.

In another embodiment of the invention, one of the parts has one cam surface, but instead of the second cam surface, the second part (rotatable part or counterpart) provides a corresponding cam.

In yet another embodiment of the invention, instead of a cam, the rotatable part or counterpart can provide a roller or the like. to provide physical engagement with the corresponding cam surface, providing exceptionally low friction and thereby possibly reducing the force required to prime the device.

However, all the embodiments of the invention described above provide essentially comparable effects, namely, they provide an axially variable relative position of the rotatable part and the counterpart part during the relative rotation of these parts.

By designing each section of the cam surface on a plane perpendicular to the axis of rotation ("plane of rotation"), each section can be assigned a specific angle of rotation related to it.

Thus, one dosing cycle covers or includes a respective angle of rotation of the first, second and third sections and optionally other sections, such as an optional fourth section as described below, or an optional fifth section, preferably having a constant height, which can follow the second area. One dosing cycle can be defined as a "sequence" of these sites.

In one embodiment of the inhalation device, if we consider a complete cycle, the 360 degree rotation covers two complete sequences of all these areas at least once. This means that when the rotatable part is rotated through 360 degrees, all the respective sections, namely the first, second, third and potentially the fourth or fifth section, pass twice.

In other words, the sums of the corresponding rotation angles, measured in the specified rotation plane about the rotation axis from the beginning to the end of the corresponding section, are 360 degrees or integer parts of this angle. This means that, depending on the embodiment of the invention, a full 360 degree rotation is required to pass through all sections and thus to fill and release one dose of liquid, or, for example, 1/2, 1/3, ... part of the indicated 360 degrees , that is, 180, 120, ... degrees.

In a preferred embodiment of the invention, the sums of the corresponding rotation angles measured in the specified rotation plane about the rotation axis from the beginning to the end of the corresponding section are 180 degrees or integer parts of this angle. This means that, depending on the embodiment of the invention, a rotation of 180 degrees is required to go through all the sections and thus to fill and release one dose of liquid or, for example, half or one third or another part of the indicated 180 degrees, then there are 90, 60, … degrees or another angle, depending on the number of doses to be ejected with a 180 degree rotation.

Accordingly, two doses are ejected in a 360 degree rotation, which implies that one dose is loaded and ejected at half a full rotation corresponding to 180 degrees. Other preferred integers are three and four.

If an optional fourth and/or fifth section (such as, for example, another section having a constant height or a section designed to prevent further rotation of the rotatable part) is additionally present between or following the above sections, and in particular between the second and first region (i.e., the first region is preceded by said fourth region) or between the third region and the second region (i.e., the fourth region provides a reshaped "end" of the third region) or after the end of the second region, for example, as another region , having a constant length, following the second site, it should be understood that the above is true for all four or five sites, that is, a full 180 degree dosing cycle covers all four or five sites, etc.

The advantage of rotating 180 degrees for one dispensing cycle is that the slope of the first section can be even smaller, since there is more path traveled during rotation, to provide the required relative linear movement to create enough pressure, while in one full rotation two dosing cycles can be realized. This is preferable if the pressure is to be exceptionally high, the volume to be dosed is large, or the force provided for rotation is small (for example, when the device must be manipulated by children), while a full 360-degree rotation cannot be realized, for example, due to design or construction constraints.

Partial rotation to provide one dose is preferred in others in cases.

As stated above, the sum of the rotation angles corresponding to one injection cycle, as previously defined, is 180 degrees. The 180 degree rotation to carry out each dosing cycle proved to be a good compromise in terms of force required to actuate and achievable pressure/volume for a given dose. In this case, moreover, in specific embodiments of the invention, the rotation angle of the third section, that is, the section having a constant or substantially constant height, is 7 ± 6 degrees, or, in other words, from 1 to 13 degrees. Experiments have shown that this range is particularly useful in practice. If the angle corresponding to the third section is too small, for example less than 1°, it becomes increasingly difficult to stop the rotation immediately at the end of this section. On the other hand, larger third sections waste valuable space reserved for other phases of rotation, in particular the phase corresponding to the first section, which is necessary for pressurization and therefore should not be too short/steep.

In another embodiment of the invention, the angle of rotation corresponding to the second portion, ie the portion having decreasing height, is 0 degrees, resulting in an axially oriented portion of the cam surface. In other words, after passing the edge of the third section, the adjacent section abruptly "descends" back to the beginning of the first section, which allows the momentary release of stored energy, leading to a sudden increase in pressure in the pressure chamber. It should be noted that the term "downhill" refers only to the shortening of the distance in the axial direction between the rotatable part and the counterpart, but does not indicate a specific spatial direction. The same applies to the concepts "up" and "down", in cases where they are used.

However, due to the fact that a limited amount of liquid can pass through the nozzle, the volume will decrease over a certain period of time (“ejection time”). Thus, depending on the particular design, the corresponding part may not reach its original position (virtually) immediately, and for one reason or another, an "undefined" intermediate state of its position may occur, in which the cam surface and mating surface may temporarily lose contact. Therefore, in another embodiment of the invention, said angle of rotation is greater than 0 degrees, such as 1, 2 or 3 degrees. As a result, the corresponding part does not "go down", but still guides along the cam surface even during the release phase, which can enhance the stability of the dosing function.

In particular embodiments of the invention, in which one injection cycle, as defined above, is 180 degrees, the angle of rotation of the first section (section having an increasing height) can be up to about 170 degrees, for example, a value ranging from about 150 to 170 degrees, or about 155 to about 165 degrees. In these embodiments of the invention, in addition, the angle of rotation of the second section (the section having a decreasing height) is in the range from about 0 to about 3 degrees, or from about 0 to about 2 degrees, or up to about only 1 degree. In addition, in these embodiments of the invention, the angle of rotation of the third section (a section with a substantially constant height) is in the range from about 1 to about 13 degrees, or from about 3 to about 11 degrees, or from about 5 to about 9 degrees , or from about 6 to about 8 degrees. However, it should be noted that there may be an additional fourth and fifth sections between the first, second and third sections or after the second section. In particular embodiments of the invention, there is a fifth region following the third region (thus preceding the first region of the next dosing or injection cycle, which may typically span an angle of from about 5 to about 15 degrees, or from about 7 to about 10 degrees.

In other specific embodiments of the invention, in which one injection cycle, as defined above, is 180 degrees, the angle of rotation of the first section (section having an increasing height) can be selected in the range from about 165 to about 170 degrees, the angle of rotation of the second section ( section having a decreasing height) may be selected in the range from about 0 to about 2 degrees, and the angle of rotation of the third section (the section having a substantially constant height) may be selected in the range from about 1 to about 13 degrees, and the sum of the angles of rotation , corresponding to different areas when added together is 180 degrees.

In yet another embodiment of the invention, the angle of rotation is less than 0 degrees. This means that there is a "notch" in which the corresponding part will fall before starting a new cycle. This allows reverse rotation, which can help clear the nozzle exit of unwanted spatter or spray droplets, and even draw liquid into the nozzle exit so that the next dispensing cycle can start from a very stable, predetermined state, improving the quality of the device.

In another embodiment of the invention, in addition, there is a means for blocking the actuation of the inhalation device, made with the possibility of preventing a change in the axial direction of the relative position of the rotatable part and the counterpart corresponding to the third section. This means that the actuation blocking means prevents the potential energy saving agent from being accidentally released and thus premature ejection of the medical fluid through the nozzle. Only deliberate deactivation of the blocking means allows said release to take place.

Said device may be provided with a push button that allows further rotation only when it is pressed, or an axially directed recess or protrusion in the third section, resulting in a mechanical obstacle preventing further rotation due to a temporary increase in the necessary force required for rotation, or can be equipped with a retractable mechanical obstacle preventing movement along the specified “descent”.

Preferably, the rotational position in which the blocking means is actuated is at the very end of the third section or immediately after said end. Thus, after unlocking, the release phase can start automatically without further manual rotation.

In one of the embodiments of the invention, said means for blocking actuation is made with the possibility, when it is deactivated, to passively allow further rotation or actively continue to rotate the specified part in such a way that the second section of the cam surface comes into contact with the mating surface. This embodiment of the invention is particularly advantageous if the blocking means is activated before the end of the third section. In this case further rotation is necessary in order to start dosing. This further rotation is then provided either manually or actively during the deactivation of the blocking device, pushing the mating surface over the edge of the third section into the second section.

According to another embodiment of the invention, the blocking means initially (i.e., after actuation, start-up) blocks any movement of the rotatable part relative to the counterpart in the axial direction when the mating surface is in contact with the third section, then is before the ejection phase. When the blocking means is deactivated, it allows said movement in the axial direction to be carried out and the ejection phase starts immediately.

In summary, the blocking means may temporarily prevent either the rotation of the rotatable part as it passes through the third section, or linear movement through said section.

In other embodiments of the invention, the slope of the first section is selected from the group consisting of: constant, increasing, decreasing, and combinations thereof. A constant slope results in a constant amount of increase in the volume of the injection chamber. If the slope increases, the liquid filling rate of the injection chamber at a constant rotation speed also increases as the angle increases. The result is a smooth start of the filling phase.

If a preloaded check valve is present between the reservoir and the plenum chamber, a more abrupt start of the filling phase of the plenum chamber with liquid from the reservoir may be required. This can be achieved by decreasing the angle of inclination, providing the highest speed at the beginning of the specified phase, while in the remainder of the phase the rotational force is reduced.

In addition, combinations of these slopes may be preferred, depending on the specific design requirements.

The invention also relates to a method for generating an aerosol by means of an inhalation device in accordance with the above definition. For brevity, reference is made to the above explanations. In other words, all the possibilities and preferences described for the inhalation device itself also apply to the specified method.

The method includes, during rotation of the rotatable part, the first phase - the "filling phase", for filling the injection chamber with liquid, and the second phase - the "release phase" for ejecting the finely atomized liquid from the nozzle. In accordance with the present invention, between these two phases there is a third phase - the "rest phase", during which, despite further rotation, the volume of the injection chamber remains constant. These three phases correspond to the above three sections. In particular, during the third phase, since there is no relative linear movement of the cylindrical portion, the volume of the injection chamber does not change.

With respect to the method according to the present invention, one dosing cycle is also provided by means of a 180 degree rotation. Thus a 360 degree rotation covers two dosing cycles. However, in other embodiments of the invention, other integer values, such as three or four cycles per 360 degree rotation, are also possible.

In a preferred embodiment of the invention, the entire resting phase occurs with a rotation of 7 ± 6 degrees, that is, from about 1 to about 13 degrees.

It should be understood that the remaining angle for a complete cycle (180 degrees) is given in total to the first and second phases and their respective sections, as described above in relation to the first aspect of the invention.

In specific embodiments of the invention, the term "medical fluid" as used herein refers to a medical fluid in the form of a pharmaceutical composition containing at least one active pharmaceutical ingredient (API), more specifically, at least one inhalable active pharmaceutical ingredient . More specifically, such at least one inhaled active pharmaceutical ingredient may, for example, be selected from long-acting muscarinic receptor antagonists (LRTA), long-acting beta-adrenergic agonists (LAAAs), and inhaled glucocorticoids (ICS), as well as from analgesics; and antidiabetics, either alone or in combination.

Examples of long-acting muscarinic receptor antagonists (LADA) include, but are not limited to, aclidinium bromide, glycopyrronium salts such as, for example, glycopyrronium bromide, revefenacin, tiotropium, such as tiotropium bromide, umeclidinium bromide, oxitropium bromide, flutropium bromide, ipratropium bromide , trospium chloride, tolterodine.

Examples of long acting beta-adrenergic agonists (BAAp) include but are not limited to albuterol, arformoterol, bambuterol, bitolterol, broxterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, ibuterol, indacaterol, isoetarine, isoprenaline, levosalbut amol, mabuterol, meluadrine (meluadrine), metaproterenol, olodaterol, orciprenaline, pirbuterol, caterol, reproterol, rimiterol, ritodrine, salmeterol, salmefamol (salmefamol), soterenot, sulfonterol (sulphonterol), thiaramide, terbutaline, terbuterol.

Examples of inhaled glucocorticoids (ICS) include, but are not limited to, prednisone, prednisone, butixocort propionate, flunisolide, beclomethasone, triamcinolone, budesonide, fluticasone, mometasone, ciclesonide, rofleponide, dexamethasone, etiprednol dichlor quote (etiprednol -dichloroacetat), deflazacort, etiprendol (etiprednol), loteprednol (loteprednol), RPR-106541, NS-126, ST-26.

In addition, active pharmaceutical ingredients may be selected from analgesics such as narcotic analgesics (eg morphine, fentanyl) or non-narcotic analgesics (eg salicylic acid derivatives eg acetylsalicylic acid) or cannabinoids (eg tetrahydrocannabinol), antidiabetic agents, such as insulin.

The medicinal liquid or liquid pharmaceutical composition which can be sprayed or aerosolized by means of the inhalation device of the present invention may contain at least one active pharmaceutical ingredient as described above, but may also contain a mixture of two or more active pharmaceutical ingredients which can be introduced into the body by inhalation.

A medical liquid or pharmaceutical composition that can be aerosolized by means of an inhalation device according to the present invention is preferably presented as a composition suitable or adapted for inhalation use, in other words, as a composition that can be nebulized or aerosolized for inhalation and which is physiologically acceptable for inhalation by the patient.

The medical liquid or pharmaceutical composition which may be administered to the body by means of an inhalation device according to said aspect of the present invention, or may be contained within the inhalation device and reservoir, may be in the form of a dispersion, for example a suspension with a liquid continuous phase and a solid discontinuous phase , or as a solution.

In other embodiments of the invention, the medical fluid or pharmaceutical composition, as described above, may contain, if necessary, one or more physiologically acceptable excipients suitable for inhalation use. Adjuvants that may be present in the composition may include, but are not limited to, one or more buffering agents for adjusting or controlling the pH of the solution, salts, flavoring agents, surfactants, lipids, antioxidants, and co-solvents, which may be used to increase or improve solubility, such as ethanol, or glycol.

In specific embodiments of the invention, the medical fluid, as described above, may be substantially free of propellant.

In other specific embodiments of the invention, the medical fluid as described above may be an aqueous solution in which one or more of the active pharmaceutical ingredients described above are dissolved or solubilized in a carrier liquid solution containing water. Such aqueous solutions may optionally also contain one or more excipients as described above.

Brief description of the drawings

On FIG. 1 shows a simplified schematic sectional view of a typical inhalation device;

On FIG. 2 shows a more detailed sectional view of the inhalation device;

On FIG. 3 is a simplified expanded view of a cam surface rotatable portion having two sequences each consisting of three sections;

On FIG. 4 is a simplified plan view of a rotatable portion having two sequences each consisting of three sections;

On FIG. 5, 6 and 7 show a schematic simplified expanded view of the counterpart with a mating surface;

On FIG. 8, 9 and 10 show the various stages of interaction between the cam surface and the mating part.

On FIG. 11, 12 and 13 show views of a more detailed embodiment of the invention, which is presented in the respective phases corresponding to those shown in FIG. 8, 9 and 10;

On FIG. 14, 15 and 16 show examples of a fourth portion designed to prevent further rotation of the rotatable part.

On FIG. 1 shows a simplified schematic sectional view of a typical inhalation device. On FIG. 1 shows the state before first use.

The inhalation device comprises a housing 1 which is preferably sized and shaped so that it can be held with one hand and can be operated with one finger, such as a thumb (not shown). A reservoir 2 for storing medical fluid is located inside the housing 1. The reservoir 2 shown is designed to be collapsible; this means that during the emptying process, the resilient or at least non-rigid walls warp, so that the vacuum required to extract a certain amount of liquid does not increase or practically does not increase. A similar effect can be achieved if the rigid container has a movable bottom, whereby the internal volume of the container can also be successively reduced (not shown).

In addition, the inhalation device contains a pumping device with a hollow cylindrical part 3, forming a variable volume injection chamber inside the housing 1 to create the required pressure necessary for ejection of the liquid and spraying it. The pumping device may also contain additional, not shown, components (push button, blocking means, etc.).

The hollow cylindrical part 3 is in fluid communication with the reservoir 2 by means of an optional inlet check valve 4. The check valve 4 serves to allow liquid to enter the pressure chamber and blocks the return of liquid to the reservoir 2 upon release of a blocking means not shown.

As a means (7) for storing potential energy, a compression spring is used, which is paired with one of its ends (pointing upwards) with a hollow cylindrical part 3 and which is fixed in the area of the base of the housing (1) (lower part of the drawing).

The inhalation device further comprises an outlet tube 5 with at least one end portion 5A facing the reservoir located upstream of the fluid medium, configured to be accommodated in said hollow cylindrical portion 3. In other words, the outlet tube 5 can at least partially be forced into the hollow cylindrical portion 3 to form the plenum chamber, resulting in a reduction in the internal volume of the plenum chamber. The term "internal volume" describes that volume which extends from the tank-facing inlet of the pressure chamber to where the inner end 5A of the discharge pipe 5 is located. the volume of the injection chamber presently between the check valve 4 and the upstream end portion 5A of the outlet pipe 5 is at its maximum and filled with liquid.

Preferably, in the area that serves to accommodate the outlet pipe 5, the hollow cylindrical part 3 has at least one area with a circular inner cross section, which corresponds (in this case also) to the circular outer cross section of the respective outlet pipe section. Of course, other cross-sectional shapes are also possible.

In accordance with the shown embodiment of the invention, the check valve 4 is located between the tank 2 and the inlet of the pressure chamber.

In addition, the inhalation device comprises a nozzle 6 which has a liquid-tight connection to the downstream end portion 5B of the outlet pipe 5. The nozzle 6 may be any known nozzle suitable for spraying/fine spraying liquid. The nozzle 6 shown as an example uses the principle of atomization by collision of two fluid streams. Preferably, the cross-sections of the fluid channels are relatively small, typically in the order of microns.

Also shown is an optional vent valve 8 within the outlet pipe 5 to prevent backflow of liquid or air into the downstream end portion 5B of the outlet pipe from the outside. An outlet valve 8 is located in the upstream end portion 5A of the outlet pipe 5. Fluid may flow through the outlet valve 8 towards the nozzle 6, but the outlet valve 8 blocks any unwanted backflow of fluid in the opposite direction.

As shown in FIG. 1, the outlet pipe 5 is fixed and fixed to the body 1, which is indicated by the connection in the region of the outward end 5B with the body 1. The outlet pipe 5 is also rigidly attached to the nozzle 6, which, in turn, is also attached to the body 1. On the contrary, the hollow cylindrical part 3 is movable with respect to the housing 1, the outlet pipe 5 and the nozzle 6.

On FIG. 1 does not show the drive mechanism required in accordance with the present invention, by which the relative linear movement of the hollow cylindrical part 3 can be carried out by means of a relative rotation of the rotatable part, which is part of the housing 1 or connected to it, around the axis of rotation R relative to the second part. said body 1 so that said relative rotation can be converted into said relative linear movement.

However, in FIG. 2 shows an embodiment of the invention where these components are visible. Some of the reference numerals as well as the lower parts shown in FIG. 1 (means for storing potential energy, reservoir) are omitted. The injection chamber is located in overlapping sections of the hollow cylindrical part 3 and the outlet pipe 5, no valves are shown. In particular, it can be seen how the body 1, the rotatable part 1A and the counter part 1B are connected to each other. The counterpart 1B is rigidly connected to the housing 1. The rotatable part 1A partially overlaps the counterpart 1B. The rotatable part 1A can, within certain limits, move linearly along the rotation axis R. However, it does not rotate together with the counterpart 1B. The discharge pipe 5 is connected to a part of the body 1, to which the counterpart part 1B is also connected, as well as to a nozzle 6 (not shown), and the hollow cylindrical part 3 is connected to the rotatable part 1A. Thus, by linearly moving the rotatable part 1A, the internal volume of the hollow cylindrical part 3 that forms the blowing chamber can be changed. In this example, moving the rotatable part 1A upwards (i.e. downstream of the fluid, or towards the nozzle) reduces the volume, resulting in ejection of liquid, and moving downwards increases it, leading to (re)filling the injection chamber from the side tank.

On FIG. 3 is a simplified expanded view of a rotatable portion 1A having a bearing portion with two sequences of cam surface portions each including portions 9A, 9B and 9C. The support portion provides the downstream surface of the rotatable portion 1A. Alternatively, the bearing part with the camming surface can be placed in the counter part 1B, or both the rotatable part 1A and the counter part 1B can both contain respective camming surfaces. Obviously, all three options should lead to the same transformation of rotation into linear displacement.

As can be seen in FIG. 3, the first section 9A consists of an ascending slope, while the third section 9C is provided by a "flat" slope. Accordingly, further the next second section 9B is in the form of a "step" or a vertical "descent". In the example shown, the corresponding rotation angle for performing one dosing cycle, that is, rotation from the beginning of the first section 9A to the end of the second section 9B, is 180 degrees. A full 360 degree rotation of the rotatable part 1A relative to the second part 1B would thus comprise two dosing cycles.

On FIG. 4 shows the same example in plan view, that is, in a view parallel to the rotation axis R. Semicircle C indicates the angle of rotation corresponding to one dosing cycle (180 degrees). At the beginning of the indicated corner (leftmost starting point), the first section 9A begins. Arrow 10 points to the beginning of the third section 9C. Just between said third section 9C and the next first section (bold black line, reference numeral omitted) belonging to the second dosing cycle, is the second section 9B. In the view showing the example under consideration, the second portion 9B extends along the viewing direction (parallel to the rotation axis R) and is therefore very short. On the contrary, the third section 9C has a visible length, so that with continued rotation, the specified section can be easily detected by hand. If it is assumed that the primed device is not yet to release a dose, the rotation is stopped anywhere in the third section. With further rotation, the end of the third section 9C is reached and the device is actuated while the counterpart (not shown) slides along the edge of the first section 9A and descends along the second section 9B. Then a new cycle can begin.

On FIG. 5-7 show the mating surface, which in the shown embodiment of the invention is a design feature of the counterpart 1B. Alternatively or additionally, it can also be a structural element of the rotatable part 1A. On FIG. 5, the mating surface has the inverted shape of the cam surface shown in FIG. 3 containing all three sections 9A, 9B, 9C.

On FIG. 6 the mating surface is shortened; while still having a flat portion corresponding to the third portion 9C as well as a sloping portion corresponding to the first portion 9A. On the right side of Fig. 6, the area depicted in dotted lines indicates a fourth section 9D that "interrupts" or shortens the corresponding first section 9A. However, the remaining mating surface is sufficient for the desired cam engagement between the two surfaces/components 1A, 1B.

On FIG. 7 shows a short cam 11 which is also sufficient to effect the desired engagement, but provides a small area of overlap between portions 9A, 9B, 9C (not shown) and their mating surface.

On FIG. 8, 9 and 10 show the various stages of interaction between the cam surface and the mating surface. In this embodiment of the invention, both parts 1A, 1B have for each section 9A, 9B and 9C the same shape or slope of the respective cam surfaces; it is obvious that each of them has an inverted profile of the other. Like parts have the same reference numerals (partially omitted). The relative rotation of the real parts 1A, 1B is shown in the drawings by relative movement; the relative movement of the counterpart 1B to the right corresponds to the intended direction of rotation (filling, rest, release).

On FIG. 8 shows the filling phase in which the counterpart 1B slides over the first portion 9A of the rotatable part 1A, resulting in the linear movement of the counterpart 1B so as to increase the volume of the injection chamber (not shown) and cock the storage means. potential energy (not shown).

On FIG. 9 shows a resting phase in which, despite possible further rotation, no change in volume and filling occurs, since the axially measured distance (or axial position) of parts 1A and 1B remains constant.

On FIG. 10, this distance rapidly decreases as the counterpart 1B descends along the second portion 9B of the rotatable portion 1A. Thus, in this FIG. the release phase is shown.

The device then enters the start of a new dispensing cycle, which will start from the prime state.

The following drawings, Fig. 11, 12 and 13 correspond to the phases which are shown schematically in the preceding FIGS. 8, 9 and 10.

It should be noted that in the illustrated embodiment of the invention, the 180 degree rotation results in a complete dosing cycle including the filling and release phases. In addition, it should be noted that in order to make the respective areas also visible in the best possible way, the sectional planes in the sectional views are not identical.

On FIG. 11 the device is in the charging phase. The mating part 1B is rigidly connected to the body part 1. The rotatable part 1A provides the camming surface. In the phase shown, the sloping portion 9A is in contact with the adjacent mating surface of the counterpart 1B.

On FIG. 12 shows the resting phase. In this state, the portion 9C (flat portion) is in contact with the corresponding mating surface. Further rotation around the rotation axis R will not (immediately) change the position in the axial direction or the distance between the rotatable part 1A and the counterpart 1B.

On FIG. 13 finally shows the release phase. In this phase, the "descending" section 9B slides on the corresponding mating surface, and the distance between the rotatable part 1A and the counter part 1B rapidly decreases due to the driving effect of the energy storage means (not shown) which is currently releasing its energy to guide an injection chamber (not shown) to pressurize it. As a result, liquid is ejected from the nozzle (both not shown).

On FIG. 14, 15 and 16 are shown, not to scale, examples of a fourth portion 9D designed to prevent further rotation of the rotatable part.

In these embodiments of the invention, the fourth section 9D is located at the end of section 9C. According to FIG. 14, the fourth section 9D has an upward slope. Therefore, when the mating surface represented by the cam 11 reaches the fourth section 9D in rotation, climbing this section will require additional energy storage by the potential energy storage means (not shown). At the same time, the user will be able to feel this sudden increase in force required for further rotation and stop further rotation. In addition, without another external force, the rotation will also not continue, which ensures that, for example during storage, no unintentional release of liquid occurs.

On FIG. 15, the fourth section 9D performs an identical function. In this embodiment of the invention, it has the form of an initially ascending and then descending sloping surface ("bump"). Only when the highest point is passed will the ejection phase start.

On FIG. 16, the fourth section 9D provides first a descending and then an ascending inclined surface ("groove"). When the cam reaches the lowest part of the fourth section 9D, it remains in this stable position until additional force is provided to "pull" it out of said section in order to start the ejection.

Compared to an embodiment of the invention without the fourth section 9D, such as, for example, shown in FIG. 8 to 10, in which there is an "original", having a full rotation angle of the third section 9C, the rotation angle of the fourth section covers the percentage of the specified "original" angle, respectively, from 5% to 50% or from 10% to 30%, or from 15% to 25%. The maximum height (or depth, respectively) of the fourth section 9D with respect to the third section 9C is 0.05 mm to 5 mm, or 0.1 mm to 1 mm, or 0.25 mm to 0.5 mm.

List of reference positions

1 - body

1A is a rotatable part

1B - counterpart

2 - reservoir

3 - hollow cylindrical part

4 - check valve

5 - output pipe

5A - located upstream of the fluid end part

5B - downstream end portion

6 - nozzle

7 - means for the conservation of potential energy

8 - exhaust valve

9A - first section

9B - second section

9C - third section

9D - fourth section

10 - arrow

11 - cam

R - axis of rotation

C is a semicircle.

The following list of numbered items are embodiments that the present invention includes:

1. An inhalation device for liquids (F) for medical purposes for the formation of an aerosol, containing:

- a body (1), inside said body (1) a reservoir (2) for storing liquid (F), an injection unit, said unit comprising an outlet pipe (5), a hollow cylindrical part (3) having an internal space configured to placement of the end part (5A) of the specified outlet pipe (5) located upstream of the fluid, and:

the specified cylindrical part (3) is made with the possibility of linear movement along the outlet pipe (5),

the cylindrical part (3) and the outlet pipe (5) form an injection chamber, which, due to the linear movement of the cylindrical part (3) relative to the outlet pipe (5), has a variable volume for creating pressure in the specified injection chamber, while

- the injection chamber is in fluid communication with the tank (2) and with the nozzle (6), which has a liquid-tight connection with the end part (5B) of the outlet pipe (5) located downstream of the fluid, and at the same time

- the specified relative linear movement can be carried out by means of relative rotation of the rotatable part (1A), which is part of the first part of the housing (1) or connected to it, around the axis (R) of rotation relative to the counterpart (1B), which is part or connected to the second part of said housing (1) in such a way that said relative rotation is converted into said relative linear movement by means of a drive mechanism, said drive mechanism comprising at least one cam surface having a first section located in the axial direction (9A ) having an increasing height, as well as a second section (9B) having a decreasing height, wherein the cam surface is configured to slide along the adjacent mating surface, wherein the cam surface is configured to slide along said mating surface during rotation, which leads to the specified transformation,

- a means (7) for storing potential energy is provided, configured to store energy through said relative rotation along the first section (9A), and said energy can be communicated to said blower when it is released,

characterized in that said cam surface comprises between the first section (9A) having an increasing height and the second section (9B) having a decreasing height, a third section (9C) having a constant height, so that while said third section (9C ) of said cam surface slides on the mating surface, no relative linear movement occurs.

2. The inhalation device according to claim 1, wherein

- the cam surface is located on or connected to the rotatable part (1A) and the mating part (1B) provides a mating surface, or

the cam surface is located on or connected to the mating part (1B) and the rotatable part (1A) provides the mating surface.

3. The inhalation device according to claim 1 or 2, wherein the mating surface is provided by a second cam surface or cam (11) or roller.

4. The inhalation device according to any one of 1 to 3, wherein the dosing cycle covering the rotation angle of the first, second and third sections (9A, 9B, 9C) corresponds to a rotation of 360 degrees or integer parts thereof.

5. The inhalation device of claim 4, wherein the sum of the rotation angles of claim 4 is 180 degrees.

6. The inhalation device of claim 5, wherein the rotation angle of the third portion (9C) is 7±6 degrees.

7. An inhalation device according to any one of the preceding claims, wherein the rotation angle of the second portion (9B) is 0 degrees, resulting in an axially oriented cam surface portion.

8. An inhalation device according to any one of the preceding claims, further comprising a means for blocking actuation of the inhalation device, configured to prevent the relative position of the rotatable part (1A) and the counterpart (1B) from changing in the axial direction, corresponding to the third plot (9C).

9. The inhalation device according to claim 8, in which the specified means for blocking actuation is made with the possibility, when it is deactivated

- passively allow further rotation, or actively continue to rotate the rotatable part (1A) so that the second section (9B) of the cam surface comes into contact with the mating surface, or

- allow previously blocked relative movement in the axial direction of the rotatable part (1A) relative to the counterpart (1B) corresponding to the second section (9B).

10. An inhalation device according to any one of the preceding claims, wherein the angle of inclination of the first section (9A) is selected from the group consisting of constant, increasing, decreasing, and combinations thereof.

11. A method for generating an aerosol by means of an inhalation device according to any of the preceding claims, wherein the method comprises, by rotating the rotatable part (1A), a first phase, a filling phase for filling the delivery chamber with liquid, and a second phase, a release phase, for ejection of a finely dispersed liquid from the nozzle (6), characterized in that between these two phases there is a third phase - the rest phase, during which, despite further rotation, the volume of the injection chamber remains constant.

12. The method of claim 11 wherein one dosing cycle is provided by a 180 degree rotation.

13. The method according to claim 11 or 12, wherein the entire rest phase is completed with a rotation of 7 ± 6 degrees.

Claims (27)

1. An inhalation device for medical liquids for the formation of an aerosol, containing: - body (1), inside said body (1) there is a tank (2) for storing liquid, an injection unit, moreover, said unit contains an outlet pipe (5), a hollow cylindrical part (3) having an internal space made with the possibility of accommodating the above along the fluid medium of the end part (5A) of the specified output pipe (5), moreover: the specified cylindrical part (3) is made with the possibility of linear movement along the outlet pipe (5), the cylindrical part (3) and the outlet pipe (5) form an injection chamber, which, due to the linear movement of the cylindrical part (3) relative to the outlet pipe (5), has a variable volume for creating pressure in the specified injection chamber, while - the injection chamber is in fluid communication with the tank (2) and with the nozzle (6), which has a liquid-tight connection with the end part (5B) of the outlet pipe (5) located downstream of the fluid, and at the same time - the possibility of said relative linear movement is provided by relative rotation of the rotatable part (1A), which is part of the first part of the body (1), around the axis (R) of rotation relative to the counterpart (1B), which is part of the second part of the specified body ( 1) in such a way that said relative rotation is converted into said relative linear movement by means of a drive mechanism, said drive mechanism comprising at least one cam surface comprising a first section (9A) located in the axial direction, having an increasing height, as well as a second a section (9B) having a decreasing height, wherein the cam surface is configured to slide along the adjacent mating surface, the cam surface being configured to slide along said mating surface during rotation, which leads to the specified transformation, - a means (7) is provided for storing potential energy, made with the ability to accumulate energy through the specified relative rotation along the first section (9A), and at the same time, it is possible to report the specified energy to the specified pumping device when it is released, said cam surface comprises between the first section (9A) having an increasing height and the second section (9B) having a decreasing height, a third section (9C) having a constant height, so that while said third section (9C) of said cam surface slides on the mating surface, there is no linear movement of the cylindrical part (3) relative to the outlet pipe (5), and - a dispensing cycle that covers the angle of rotation of the first, second and third sections (9A, 9B, 9C), corresponds to a rotation of 180 degrees. 2. The inhalation device according to claim 1, wherein - the cam surface is located on the rotatable part (1A) and the counter part (1B) provides a mating surface, or - the cam surface is located on the mating part (1B) and the rotatable part (1A) provides the mating surface. 3. An inhalation device according to claim 1 or 2, wherein the mating surface is provided by means of a cam (11). 4. The inhalation device according to any one of the preceding claims, wherein the rotation angle of the third portion (9C) is 7±6 degrees. 5. An inhalation device according to any one of the preceding claims, wherein the rotation angle of the first section (9A) is selected in the range of 165 to 170 degrees, the rotation angle of the second section (9B) is selected in the range of 0 to 2 degrees, and the rotation angle of the third section ( 9C) is selected in the range from 1 to 13 degrees, with the sum of the rotation angles corresponding to the various regions adding up to 180 degrees. 6. An inhalation device according to any one of the preceding claims, wherein the cam surface comprises a fourth portion (9D). 7. The inhalation device according to claim 6, wherein the fourth region (9D) is an increasing region or a decreasing and increasing region located between the third region (9C) and the second region (9B). 8. An inhalation device according to claim 6 or 7, wherein the device comprises a fifth section, the fifth section being a section having a constant height following the second section (9B). 9. An inhalation device according to any one of the preceding claims, wherein the rotation angle of the second portion (9B) is 0 degrees, resulting in an axially oriented cam surface portion. 10. An inhalation device according to any one of the preceding claims, further comprising a means for blocking actuation of the inhalation device, configured to prevent a change in the relative position in the axial direction of the rotatable part (1A) and the mating part (1B), corresponding to the third plot (9C). 11. The inhalation device according to claim 10, in which the specified means for blocking actuation is made with the possibility, when it is deactivated allow previously blocked relative movement in the axial direction of the rotatable part (1A) relative to the counterpart (1B) corresponding to the second section (9B). 12. An inhalation device according to any one of the preceding claims, wherein the angle of inclination of the first section (9A) is constant. 13. A method for generating an aerosol by means of an inhalation device according to any one of the preceding claims, wherein the method includes, by rotating the rotatable part (1A), a first phase, a filling phase, for filling the discharge chamber with liquid, and a second phase, a release phase, for ejecting the nebulized fluid from the nozzle (6), while between these two phases there is a third phase - the resting phase, during which, despite further rotation, the volume of the injection chamber remains constant, and one dosing cycle is provided by rotating 180 degrees. 14. The method according to claim 12 or 13, in which the entire rest phase occurs during rotation of 7 ± 6 degrees.

Images