RU2749369C2 - Method for treating extensive superficial skin lesions - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: present invention relates to a method for treating extensive superficial lesions of the skin, including, against the background of drug therapy, topical application of an effective amount of a drug, which is used as an agent containing ingredients, in wt %: hydroxypropyl cellulose 5.0; lidocaine hydrochloride, calculated as anhydrous substance 5.0; 2-allyloxyethanol 4.0; nipagin (methyl parahydroxybenzoate) 0.15; nipazole (propyl parahydroxybenzoate) 0.05; purified water 85.8.

EFFECT: increasing efficiency and reducing the duration of treatment.

1 cl, 4 ex

Description

The invention relates to the field of pharmaceuticals and medicine and relates to reducing the intensity of symptoms of a skin disorder in a subject, where the skin disorder is selected from the group consisting of acne and chickenpox viral infection, where the symptoms are selected from the group consisting of skin redness, itching, rash, dropsy, blisters.

The skin is the most extensive organ and separates the inside of the body from the external environment. It has several important functions, including protecting the body from microorganisms that can cause infections, touching the environment, regulating body temperature, and maintaining body homeostasis.

Conditions that lead to skin irritation, pollution, or inflammation can cause symptoms such as redness, swelling, burning, and itching. Allergies, irritants, genetic makeup, and certain diseases and immune system problems can cause a variety of skin disorders. New topical formulations are required to treat skin disorders.

The current general scheme for the treatment of skin diseases has the following stages:

1. Deep cleansing of the skin;

2. Antibacterial therapy;

3. Elimination of dysbiosis, deficiency of vitamins and microelements;

4. Suppression of foci of chronic infection and parallel treatment of major chronic diseases by appropriate specialists;

5. In severe cases of the disease, retinoids are used.

(Glubokova I.B. State of the traditional method of treating acne // Abstracts of the 3rd National Congress of Aesthetic Medicine, M., September 5-7, 2003. - Bulletin of Aesthetic Medicine, 2003. - No. 3, T. 2. - P. 207-209.).

The disadvantage of this method is that the treatment is long and consists of several courses (one course of treatment for at least 6 months), and without treatment, painful rashes persist for decades.

A known method of treating acne by topical application of the drug butol against the background of drug treatment.

(RF patent 2269944, IPC А61В 17/00, publ. 20.02.2006, bull. No. 5)

The disadvantages of this method are that butol can cause allergic reactions, in addition, this drug has no antipruritic and analgesic effect.

A method of treating skin disorders by topically applying a therapeutically effective amount of a peptide selected from the group consisting of pGLU-ASN-TRP-LYS-C8, pGLU-ASN-TRP-THR and pGLU-ASN-TRP.

(RF patent No. 2583137, IPC A61K 38/06, publ. 05/10/2016, bull. No. 13)

The disadvantages of using peptides are possible allergic reactions, and there is also no antipruritic, analgesic and bacteriostatic effect.

The objective of the invention is to create an effective method for treating extensive superficial skin lesions using a drug that has an antipruritic and analgesic effect, which allows for a quick healing effect, complete elimination of scars, to prevent further development of the pathological process of the skin and the formation of residual effects on the skin without allergic reactions.

The technical result consists in increasing the efficiency and reducing the duration of treatment.

This is achieved by the fact that in the inventive method for treating extensive superficial skin lesions, including, against the background of drug therapy, the local application of an effective amount of a drug, which is used as a drug containing ingredients, masses. %: hydroxypropyl cellulose - 5.0%; lidocaine hydrochloride (in terms of anhydrous substance) - 5.0%; 2-allyloxyethanol - 4.0%; nipagin (methyl parahydroxybenzoate) - 0.15%; nipazole (propyl parahydroxybenzoate) - 0.05%; purified water - 85.8%.

The present invention provides a method for treating a skin disorder in a subject, where the skin disorder is selected from the group consisting of acne and chickenpox viral infection, where the symptoms are selected from the group consisting of skin redness, itching, rash, dropsy, blisters.

The active ingredients 2-allyloxyethanol and lidocaine have a wide spectrum:

1. Relieve inflammation and redness,

2. Suppress the activity of bacteria that can cause acne,

3. They have an antiseptic and anti-inflammatory effect,

4. Improve the regeneration of skin cells,

5. Prevents the formation of scars on the skin,

6. Possess antipruritic effect.

The term "subject" includes all animals. In one embodiment, the subject being treated is a mammal. In a preferred embodiment, the mammal is a human.

The term "treatment" refers to the use of a therapeutic agent effective to ameliorate symptoms associated with skin disorders, reduce the severity, provide amelioration or cure of the disorder. The inventive method of treatment can be carried out without time limitation or as a prophylactic treatment.

A "therapeutically effective amount for the skin" is an amount of active ingredient that provides the desired pharmacological effect, i. E. cure a skin disorder. This amount depends on a number of parameters, such as the exact composition of the composition containing the active ingredient and the carrier, the site of administration, the source of the skin disorder, etc. Those skilled in the art can easily determine the amount after performing a small amount of dose-response experiments, for example, by applying a given composition in a range of concentrations to a specific area of the body.

Implementation of the method.

Against the background of drug therapy for skin inflammations, a drug containing the following ingredients is topically applied 2-3 times a day, masses. %: hydroxypropyl cellulose - 5.0%; lidocaine hydrochloride (in terms of anhydrous substance) - 5.0%; 2-allyloxyethanol - 4.0%; nipagin (methyl parahydroxybenzoate) - 0.15%; nipazole (propyl parahydroxybenzoate) - 0.05%; purified water - 85.8%.

Example 1.

Oleg K. 04/03/1999 Applied at the age of 19.

Dz .: Papular acne

The patient was prescribed a complex treatment of acne: a combination of drugs for internal use (antibiotics of the tetracycline series) and external use, including prophylaxis using the proposed agent.

The agent was applied pointwise 2 times a day: in the morning and in the evening on cleansed skin. Apply, wait to dry completely, do not rinse.

On the 2nd day of application, there was an improvement in the skin: inflammation decreased, redness subsided.

At the end of the course of treatment - 1 month daily, the complete disappearance of inflammation and traces of acne was noted. No scars remain in the place of knots and deep pustules, the skin acquires an even color.

Example 2.

Konstantin T. 03/12/2011 Applied at the age of 8.

Dz .: Chickenpox. Second day of rashes. Temperature 37.8

Moderately pronounced manifestations of a macular vesicular rash on the skin of the body, scalp, face.

The patient was prescribed a complex treatment; the claimed agent was used as an antipruritic and anti-inflammatory agent.

The agent was applied pointwise from the second day of the disease. On the first day, 3 times a day. In the first 10 minutes, itching and irritation were completely eliminated. An improvement in the skin was observed: the inflammation decreased.

From the 2nd day of treatment according to the claimed method, the vesicle rash decreased. The eruptions of the elements became smaller, rudimentary and often did not reach the bubble stage.

In the following days (3-4 days), hemorrhagic crusts formed, which gradually dried out and fell off.

At the end of the course of treatment - 4 days, noted the complete disappearance of inflammation and traces of vesicles. No scars remain in place of the nodes, the skin acquires an even color.

Example 3.

Nicole S. 28.01.2014 Applied at the age of 5.

Dz .: Chickenpox. Temperature 37.5. The rash appeared at night. Symptoms of intoxication are absent. Rash is not abundant on the skin of the body and face

The treatment was carried out according to the claimed method.

The agent was applied pointwise as itching occurred - 3-4 times a day. In the first 10 minutes, itching and irritation were completely eliminated. An improvement in the skin was observed: the inflammation decreased.

From the 2nd day of treatment, the vesicle rash decreased. The eruptions of the elements became smaller, rudimentary and often did not reach the bubble stage.

In the following days, hemorrhagic crusts formed, which gradually dried out and fell off.

At the end of the course of treatment - 3 days, noted the complete disappearance of inflammation and traces of vesicles. No scars remain in place of the nodes, the skin acquires an even color.

Example 4.

Galina T. April 12, 1983 Applied at the age of 35.

Dz .: Chickenpox. Moderate form - body temperature 38.6-39.5 ° C, symptoms of intoxication are moderately expressed. The rash is profuse, including on the mucous membranes and scalp.

The patient was prescribed treatment according to the claimed method. The product was applied pointwise. On the first day, 3 times a day and as itching occurs. In the first 10 minutes, itching and irritation were completely eliminated.

From the 3rd day of treatment, the rash elements became smaller, rudimentary and often did not reach the stage of vesicles.

In the following days, hemorrhagic crusts formed, which gradually dried out and fell off.

At the end of the course of treatment - 6 days, the disappearance of the vesicles was noted. At the site of the rash, minor scars remain, the skin acquires an even color.

The advantages of treating the symptoms of chickenpox according to the claimed method include:

- ease of use,

- colorlessness,

- fast action.

Thus, the treatment of skin disorders according to the claimed method accelerates the healing process, prevents the formation of scars on the skin, prevents the development of infection by bacteria and microbes, has an antipruritic, antiseptic and anti-inflammatory effect, which shortens the treatment time.

Claims (2)

A method of treating extensive superficial skin lesions, including, against the background of drug therapy, the local application of an effective amount of a drug, which is used as a tool containing ingredients, wt. %: Hydroxypropyl cellulose 5.0 Lidocaine hydrochloride, calculated as anhydrous substance 5.0 2-allyloxyethanol 4.0 Nipagin (methyl parahydroxybenzoate) 0.15 Nipazole (propyl parahydroxybenzoate) 0.05 Purified water 85.8