RU2486181C2 - Пиримидилциклопентаны как ингибиторы акт-протеинкиназ - Google Patents
Пиримидилциклопентаны как ингибиторы акт-протеинкиназ Download PDFInfo
- Publication number
- RU2486181C2 RU2486181C2 RU2010103813/04A RU2010103813A RU2486181C2 RU 2486181 C2 RU2486181 C2 RU 2486181C2 RU 2010103813/04 A RU2010103813/04 A RU 2010103813/04A RU 2010103813 A RU2010103813 A RU 2010103813A RU 2486181 C2 RU2486181 C2 RU 2486181C2
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- Prior art keywords
- compound according
- alkyl
- phenyl
- paragraph
- fluoro
- Prior art date
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- 0 CC(C1)c2c(N(CC3)CCN3C(C(CCCCN)c3cc(*)c(*)cc3)=O)ncnc2C1O Chemical compound CC(C1)c2c(N(CC3)CCN3C(C(CCCCN)c3cc(*)c(*)cc3)=O)ncnc2C1O 0.000 description 6
- FSRSVUZZWCRRDS-UHFFFAOYSA-N CC(C1)c2c(N(CC3)CCN3C(C(CNCCOC)c(cc3)ccc3Cl)=O)ncnc2C1O Chemical compound CC(C1)c2c(N(CC3)CCN3C(C(CNCCOC)c(cc3)ccc3Cl)=O)ncnc2C1O FSRSVUZZWCRRDS-UHFFFAOYSA-N 0.000 description 1
- RZAGAOSSFREPSR-UHFFFAOYSA-N CCCNCC(C(N(CC1)CCN1c1c(C(C)CC2O)c2ncn1)=O)c([s]1)ccc1Cl Chemical compound CCCNCC(C(N(CC1)CCN1c1c(C(C)CC2O)c2ncn1)=O)c([s]1)ccc1Cl RZAGAOSSFREPSR-UHFFFAOYSA-N 0.000 description 1
- LQQYZKBYMLCQFF-HZPDHXFCSA-N CCCNC[C@@H](C(N(CC1)CCN1c1c([C@H](C)CC2)c2ncn1)=O)c([s]1)ccc1Br Chemical compound CCCNC[C@@H](C(N(CC1)CCN1c1c([C@H](C)CC2)c2ncn1)=O)c([s]1)ccc1Br LQQYZKBYMLCQFF-HZPDHXFCSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94813807P | 2007-07-05 | 2007-07-05 | |
| US60/948,138 | 2007-07-05 | ||
| US2008808P | 2008-01-09 | 2008-01-09 | |
| US61/020,088 | 2008-01-09 | ||
| PCT/US2008/069144 WO2009006567A2 (en) | 2007-07-05 | 2008-07-03 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010103813A RU2010103813A (ru) | 2011-08-10 |
| RU2486181C2 true RU2486181C2 (ru) | 2013-06-27 |
Family
ID=40076864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010103813/04A RU2486181C2 (ru) | 2007-07-05 | 2008-07-03 | Пиримидилциклопентаны как ингибиторы акт-протеинкиназ |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8618097B2 (es) |
| EP (1) | EP2170863B1 (es) |
| JP (2) | JP5628028B2 (es) |
| KR (2) | KR101650956B1 (es) |
| CN (2) | CN103396409B (es) |
| AR (1) | AR067413A1 (es) |
| AU (1) | AU2008272830B8 (es) |
| BR (1) | BRPI0813999A2 (es) |
| CA (1) | CA2692502C (es) |
| CO (1) | CO6251283A2 (es) |
| CR (1) | CR11229A (es) |
| EC (1) | ECSP109937A (es) |
| ES (1) | ES2551352T3 (es) |
| HK (1) | HK1147255A1 (es) |
| MA (1) | MA31679B1 (es) |
| NZ (1) | NZ582692A (es) |
| RU (1) | RU2486181C2 (es) |
| SG (1) | SG185274A1 (es) |
| TW (1) | TWI450720B (es) |
| WO (1) | WO2009006567A2 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2805511C2 (ru) * | 2018-04-04 | 2023-10-18 | Эрвинэс Оперейшнс, Инк. | Модуляторы протеолиза и соответствующие способы применения |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2068878B1 (en) | 2006-09-20 | 2019-04-10 | Aerie Pharmaceuticals, Inc. | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| ES2394759T3 (es) | 2008-01-08 | 2013-02-05 | Array Biopharma, Inc. | Pirrolopiridinas como inhibidores de quinasa |
| US8372842B2 (en) | 2008-01-09 | 2013-02-12 | Array Biopharma Inc. | Pyrazolopyridines as kinase inhibitors |
| CA2714888C (en) | 2008-01-09 | 2017-03-14 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| BRPI0906798A2 (pt) | 2008-01-09 | 2015-07-14 | Array Biopharma Inc | Pirimidil ciclopentanos hidroxilados como inibidores de proteína quinase akt |
| JP5635910B2 (ja) | 2008-01-09 | 2014-12-03 | アレイ バイオファーマ、インコーポレイテッド | ＡＫＴタンパク質キナーゼ阻害剤としての５Ｈ−シクロペンタ［ｄ］ピリミジン |
| KR101624752B1 (ko) | 2008-01-09 | 2016-05-26 | 어레이 바이오파마 인크. | Ａｋｔ 단백질 키나제 저해물질로써의 수산화된 피리미딜 시클로펜탄 |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| EP2424842B1 (en) | 2009-05-01 | 2015-10-28 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| MX2012011887A (es) | 2010-04-16 | 2012-11-30 | Genentech Inc | Foxo 3a como biomarcador predictivo para la eficacia del inhibidor de la via de quinasa pi3k/akt. |
| SG194050A1 (en) | 2011-04-01 | 2013-11-29 | Genentech Inc | Biomarkers for predicting sensitivity to cancer treatments |
| HUE051254T2 (hu) | 2012-05-17 | 2021-03-01 | Genentech Inc | Egy AKT-gátló pirimidin-ciklopentán vegyület amorf formája, annak kompozíciói és eljárásai |
| WO2013192345A1 (en) | 2012-06-20 | 2013-12-27 | Novartis Ag | Complement pathway modulators and uses thereof |
| RU2015140573A (ru) | 2013-02-25 | 2017-03-30 | Дженентек, Инк. | Способы и композиции для обнаружения и лечения устойчивого к лекарственным средствам мутанта акт |
| CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US10550087B2 (en) | 2015-11-17 | 2020-02-04 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| KR102568079B1 (ko) | 2016-08-31 | 2023-08-17 | 에어리 파마슈티컬즈, 인코포레이티드 | 안과용 조성물 |
| JP2020515583A (ja) | 2017-03-31 | 2020-05-28 | アエリエ ファーマシューティカルズ インコーポレイテッド | アリールシクロプロピル−アミノ−イソキノリニルアミド化合物 |
| CN112154146A (zh) * | 2018-03-06 | 2020-12-29 | 西奈山伊坎医学院 | 丝氨酸苏氨酸激酶(akt)降解/破坏化合物和使用方法 |
| EP3774777A2 (en) * | 2018-04-04 | 2021-02-17 | Arvinas Operations, Inc. | Modulators of proteolysis and associated methods of use |
| EP3810145A4 (en) | 2018-06-21 | 2022-06-01 | Icahn School of Medicine at Mount Sinai | LINKS TO DEGRADING / DESTRUCTING WD40-REPEAT-DOMAIN-RPOTEIN 5 (WDR5) AND THEIR USE |
| WO2020056345A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US12103924B2 (en) | 2020-06-01 | 2024-10-01 | Icahn School Of Medicine At Mount Sinai | Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use |
| WO2023109540A1 (zh) * | 2021-12-17 | 2023-06-22 | 中国医药研究开发中心有限公司 | 具有akt激酶抑制活性的杂环化合物及其制备方法和医药用途 |
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| WO2008021928A2 (en) * | 2006-08-11 | 2008-02-21 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| WO2008029907A1 (fr) * | 2006-09-08 | 2008-03-13 | Kyowa Hakko Bio Co., Ltd. | Agent améliorant l'hypertension |
| WO2008144380A1 (en) * | 2007-05-17 | 2008-11-27 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| WO2009102568A1 (en) * | 2008-02-13 | 2009-08-20 | Bristol-Myers Squibb Company | Conformationally restricted biphenyl derivatives for use as hepatitis c virus inhibitors |
| EA200900298A1 (ru) * | 2006-08-11 | 2009-10-30 | Бристол-Маерс Сквибб Компани | Ингибиторы вируса гепатита с |
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| EA201000196A1 (ru) * | 2007-08-08 | 2010-06-30 | Бристол-Маерс Сквибб Компани | Кристаллическая форма дигидрохлорида метил((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((метоксикарбонил)амино)-3-метилбутаноил)-2-пирролидинил)-1н-имидазол-5-ил)-4-бифенилил)-1н-имидазол-2-ил)-1-пирролидинил)карбонил)-2-метилпропил)карбамата |
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