RU2316309C1 - Irrigator liquid - Google Patents

Abstract

FIELD: medical engineering.

SUBSTANCE: liquid contains alkaline metal citrate, potassium Potassium citrate is introduced as r, and additionally has miramistin. as the alkaline metal citrate. The ingredients are to be taken in known quantitative proportions.

EFFECT: enhanced effectiveness in cleaning periodontal pockets; wide range of antimicrobial activity; prevented soft tissue diseases in oral cavity.

3 tbl

Description

The invention relates to the field of therapeutic and prophylactic dentistry and relates to therapeutic and prophylactic means for caring for the oral cavity.

Known antiseptic, which includes miramistin and a diluent (RF patent No. 2164135, IPC A61K 31/14, 2001).

This composition is used in ophthalmology as an antiseptic, but it is not used in dentistry.

Known oral care products containing sodium fluoride, disodium phosphate, glycerin, xidiphone, methylene blue, saccharin, perfume, dye, surfactant and water (RF patent 2088210, IPC A61K 7/16, 1997).

This remedy has anti-inflammatory, anti-seizure, anticaries, antiparadantose action, prevents the formation of tartar.

The disadvantage of this tool is a narrow spectrum of antimicrobial action due to the fact that it does not provide inhibition of a wide range of bacteria, for example gram-negative.

Closest to the claimed is an oral care product containing sodium citrate, potassium aluminum sulfate, lactic and succinic acid, thymol, propylene glycol, sweetener, perfume and water (RF patent No. 2201203, CL. A61K 7/16, 2003 .).

The product has anti-inflammatory effect, reduces inflammation of the oral mucosa and periodontium, has analgesic, hemostatic effect, does not cause allergies. The disadvantage of this product is the complexity of its preparation, associated with the problem of the low solubility of thymol, which is a preservative, which leads to an increase in the cost of the finished product and the undesirable use of a preservative.

The problem to which the claimed technical solution is directed is to create a therapeutic and prophylactic fluid for an oral care irrigator that has a wide spectrum of antimicrobial activity, reduces bleeding of dental tissue, prevents the formation of plaque and ensures the prevention of soft tissues of the oral cavity.

The specified technical result is achieved due to the fact that miramistin is additionally added to the composition of the oral care fluid containing irrigator containing alkali metal citrate, fragrance alum, perfume, dye and water, and potassium citrate is introduced as alkali metal citrate in the following ratio components, wt.%:

miramistin 0.0001-0.0015 potassium citrate 0.4-0.6 potassium alum 0.2-0.4 perfume 0.08-0.1 dye 0.02-0.03 deionized water rest

The main component of the claimed funds is miramistin. It is included in the amount of 0.0001-0.0015 wt.%. When miramistin is introduced into the composition in an amount of less than 0.0001 wt.%, The antimicrobial effect of the drug decreases, and in an amount of more than 0.0015 wt.% The effect does not change.

Miramistin has a wide spectrum of antimicrobial activity, active against both gram-positive and gram-negative bacteria, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of macro cultures and microbial associations. Miramistin is more effective against gram-positive bacteria (staphylococci, streptococci, etc.), has a detrimental effect on pathogens such as gonococci, pale treponema, trichomonads, chlamydia, as well as herpes viruses.

Miramistin has an antifungal effect on yeast-like, dermatophins, ascomycetes and other pathogenic fungi. Under its action, the resistance of bacteria and fungi to antibiotics decreases. Miramistin does not have a local irritant effect and is not allergenic, congenic and mutagenic.

Another component of the mixture - potassium citrate - creates an anti-carious effect, prevents the formation of plaque, has a hemostatic effect, and ensures the prevention of diseases of the soft tissues of the oral cavity. The composition of the funds potassium citrate introduced in an amount of 0.4-0.6 wt.%. With this amount of potassium citrate, the required acidity of the solution is provided.

Aluminum alum has a hemostatic and antiseptic property, in addition, they are an enveloping, astringent that protects the inflamed mucous membrane. The amount of aluminum alum in the proposed tool introduced 0.2-0.4 wt.%. This amount in combination with other components is necessary and sufficient for the manifestation of these properties.

As a perfume, perfumes with a mint content can be added to the composition. The amount of perfume is 0.08-0.1 wt.%. With less fragrance, the smell becomes weak, with a larger amount - sharp, which reduces the consumer properties of the claimed funds.

The dye gives the product a pleasant appearance, for example light green or lemon. This component is introduced into the composition in an amount of 0.02-0.03 wt.%.

A method of preparing liquid for an irrigator for oral care.

0.6 g of potassium citrate is dissolved in a small amount of deionized water, then 0.3 g of potassium alum is added to the resulting solution, then 0.001 g of miramistin, 0.09 g of mint flavoring, 0.02 g of dye. The mixture is thoroughly mixed. Then bring the volume of liquid for the irrigator with deionized water to 100 wt.%. The liquid is applicable in irrigators, since it does not contain surfactants and will not foam at a pressure of 8 atmospheres. Using an irrigator will allow you to clean periodontal pockets of food debris, while gum massage is also performed.

Examples of oral irrigator fluid are shown in table 1.

Table 1 The components of the liquid for the irrigator, wt.% Content of components in a liquid one 2 3 Miramistin 0.0001 0,0008 0.0015 Potassium citrate 0.6 0.5 0.4 Alum Potassium Alum 0.4 0.3 0.2 Perfume 0.08 0.09 0.1 Dye 0.02 0,025 0,03 Deionized water rest rest rest

The claimed fluid for irrigator for oral care was tested in a dental clinic for 305 people aged 18 to 72 years. This is primarily the clinic staff, students of the Institute of Dentistry and patients of the clinic. The fluid was used in conjunction with the Irrigator device for the prevention of periodontitis to effectively clean the interdental space and gum pockets from the accumulation of food debris. The fluid was applied under pressure to hard and soft tissues, massaging the gums, allowing to remove food debris from periodontal pockets and improving blood circulation. The procedure was carried out for each of the patients once a day for 2-3 minutes for two weeks.

The distribution of patients using the claimed fluid depending on the indications is shown in table 2. The effect on the dental health level is shown in table 3.

table 2 No. p / p Diagnosis Number of patients Composition number Patient count one Prevention of periodontitis 90 one thirty 2 29th 3 31 2 cleansing of the interdental space and gingival pockets 118 one 39 2 41 3 38

Table 3. Composition number Indications for use Number of patients Result after 2 weeks of use Quality Number of patients As a percentage one Prevention of periodontitis thirty Significant improvement eighteen 62% Improvement 12 38% No improvement 0 0% Worsening 0 0% one cleansing the interdental space of the gingival pockets 39 Significant improvement 28 71.8% Improvement 10 25.6% No improvement one 2.6% Worsening 0 0% 2 Prevention of periodontitis 29th Significant improvement 23 79.3% Improvement 5 17.2% No improvement one 3.5% Worsening 0 0% 2 cleansing the interdental space of the gingival pockets 31 Significant improvement 17 54.8% Improvement fourteen 45.2% No improvement 0 0% Worsening 0 0% 3 Prevention of periodontitis 31 Significant improvement eighteen 58.1% Improvement eleven 35.5% No improvement 2 6.4% Worsening 0 0% 3 cleansing the interdental space of the gingival pockets 38 Significant improvement twenty 52.6% Improvement 17 44.7% No improvement one 2.7% Worsening 0 0%

The claimed liquid for irrigator has a wide spectrum of antimicrobial action, it has a particularly positive effect on soft tissues of the oral cavity, and also provides for the prevention of diseases of the oral cavity, is effective for cleaning the interdental space and gum pockets of food debris, preventing the formation of plaque. The simplicity of the production of liquid for irrigator will ensure its wide distribution in dentistry.

Claims (1)

An oral care irrigator fluid containing alkali metal citrate, potassium alum, perfume, color and water, characterized in that it additionally contains miramistin, and potassium citrate is introduced as an alkali metal citrate in the following ratio, wt.%: miramistin 0.0001-0.0015 potassium citrate 0.4-0.6 potassium alum 0.2-0.4 perfume 0.08-0.1 dye 0.02-0.03 deionized water rest