RU2366648C2 - Reaction product of selenium dioxide and aliphatic haloid carboxylic acids, method for making product, solution of product and therapy of benign, virus, premalignant and malignant nonmetastasing skin affections, dysontogenetic lesions of visible mucous membranes and other skin diseases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to a new product in the form of solution for treatment of benign, virus, premalignant and malignant nonmetastasing skin affections, dysontogenetic lesions of visible mucous membranes, skin mycoses, wrinkle correction and senile pigment spots. The product represents a compound of general formula H₂SeO₃·x·[R-CXY-(CH₂)_m-COOH], where x=2-6 prepared from reaction of selenium dioxide and haloid carboxylic acids of general formula R-CXY-(CH₂)_m-COOH, where R = phenyl, alkyl of general formula C_nH_2n+1; n=1-5, X=H or Y, Y=F, CI, Br or J, m = 0-10. Besides, the invention concerns a product in the form of solution for treatment benign, virus, premalignant and malignant nonmetastasing skin affections, dysontogenetic lesions of visible mucous membranes, skin mycoses, wrinkle correction and senile pigment spots, containing 0.1-50 wt % of said product, 1-99 wt % of haloid carboxylic acids and the rest - water. Also the invention concerns method of treatment of various skin diseases, including topic applications of the product.

EFFECT: improved clinical effectiveness of the product and method of treatment.

6 cl, 3 dwg, 1 tbl, 68 ex

Description

The invention can be used in dermatology, oncology, genital urology, aesthetic medicine, plastic surgery, ophthalmology and gynecology.

Currently, such methods of treating various skin tumors as electrocauterization, plastic surgery, cryosurgery, radiation therapy, laser surgery, photodynamic therapy, interferon therapy, chemotherapy, including the Mohs method (using zinc chloride in combination with trichloroacetic acid, are widely known and widely used) acid), vaccination and the use of pharmaceuticals. However, the listed treatment methods are not always effective in terms of obtaining a satisfactory result, especially in cases of multiple primary or recurrent tumors, due to dissemination of malignant cells and relapse of tumors. In addition, for example, with surgical methods of treatment, difficulties arise in the treatment of lesions in the eyes, nose, genitals, irreversible complications develop, the formation of gross scars, keloids and adhesions, with impaired organ function.

However, along with the listed methods and treatment methods, it is known to use selenium-based formulations as antitumor agents intended for the prevention or palliative treatment of tumors of internal organs rather than skin and mucous membranes - see, in particular, US Patent No. 4824955 patent No. 0095663 and some other sources.

Also known from the prior art is a complex herbal composition with haloethanol acid described in European Application No. 1293498. However, the known composition does not act selectively, i.e. not only on neoplastic cells, it affects healthy cells, causing their necrosis. After treatment, a secondary infection occurs, gross scars and keloids are observed. Tumors are not completely eliminated; the percentage of their relapses is high.

The task underlying the creation of this invention is to further improve the means of combating benign, viral, precancerous and malignant non-metastatic lesions (tumors) of the skin, dysplastic lesions of the mucous membrane, as well as means for the correction of wrinkles and senile age spots, fungal skin lesions and nails, by creating a composition for topical application, described by the formula below.

The clinical result is the absence of toxicity and side effects in the treatment of lesions such as benign, viral, precancerous and malignant non-metastatic skin lesions, dysplastic (i.e., pre-tumor) lesions of the visible mucous membranes of the oral cavity, eyes, nose, genitals, and for the correction of wrinkles and age spots, fungal infections of the skin and nails by their intravital devitalization.

This clinical result is achieved by the product of the interaction of selenium dioxide with aliphatic halocarboxylic acids of the General formula

R-CXY- (CH ₂ ) _m -COOH,

where R = aryl, cycloalkyl, alkyl of the general formula C _n H _{2n + 1} ;

n = 1-5, X = H or Y, Y = F, Cl, Br or J, m = 0-10,

representing a compound of the general formula

H ₂ SeO ₃ · x · [R-CXY- (CH ₂ ) _m —COOH], where x = 2-6.

This clinical result is also achieved by the method of producing this product, in which selenium dioxide is added to the halocarboxylic acid or its aqueous solution, stirred at a temperature of 20-215 ° C for 5-480 minutes and then filtered off from the precipitate.

The concentration of the aqueous solution of halocarboxylic acids is preferably in the range of 1-98 wt.%.

The reaction temperature is preferably 20-215 ° C.

To ensure the prolonged action of the drug, a compound from the class of hydroxy and oxo acids can be added to the reaction mixture [for example, citric C (OH) (COOH) (CH ₂ COOH) ₂ , salicylic HOC ₆ H ₄ COOH, milk CH ₃ CH (OH) COOH, pyruvic, _CH3 SOSOON, levulinic, CH ₃ COCH ₂ CH ₂ COOH, mesoxalic, CO (COOH) _2, etc.], and other desired additives in an amount of 0.1-10 wt.%.

This clinical result is also achieved by a solution of said product containing 0.1-50 wt.% Of the product, 1-99 wt.% Of halocarboxylic acids and the rest is water.

This clinical result is also achieved by a method of treating benign, viral, precancerous and malignant non-metastatic skin lesions, dysplastic lesions of visible mucous membranes, correction of wrinkles and senile age spots, as well as fungal diseases of the skin and nails, including the use of the above-mentioned product

In this case, the product is used in the form of ointments, solution, cream, paste or gel.

The invention is illustrated by the following General methods and examples.

To 0.1-0.6 g-mol of concentrated special halocarboxylic acid, add 5 ml of water and 0.006-0.125 g-mol of chemical grade selenium dioxide, mix at a temperature of 20-215 ° С for 20-480 min until the precipitate is almost completely dissolved, then cooled to room temperature and filtered through a G4 glass filter. A clear solution is obtained, the color of which, depending on the acid taken and its concentration, changes from colorless to slightly yellow.

Example 1

To 45 ml of concentrated 2,2-dichloropropionic acid (62.5 g, 0.437 g mol), 5 ml of distilled water and 0.66 g (0.006 g mol) of selenium dioxide are added, heated at a temperature of 105 ° C with stirring for 60 min, cooled to room temperature, filtered and a clear yellow solution was obtained.

Example 2

To 45 ml of concentrated 2-chloropropionic (56.6 g, 0.522 g mol) acid add 5 ml of distilled water and 0.66 g (0.006 g mol) of selenium dioxide, heated at a temperature of 90 ° C with stirring for 80 minutes, it is cooled to room temperature, 4.8 g (0.025 g mol) of citric acid are added, [НOOССН ₂ С (ОН) (СОО) СН ₂ СОО = С ₆ Н ₈ O ₇ , m.v. 192], filtered and a clear straw-colored solution is obtained.

Example 3

5 ml of distilled water and 0.66 g (0.006 g mol) of selenium dioxide are added to 45 ml of concentrated 6-chlorocaproic acid (48.0 g, 0.319 g mol), heated at a temperature of 200 ° С with stirring for 30 min , cooled to room temperature, filtered and a clear solution of light yellow color is obtained.

Example 4

To 45 ml of concentrated 9-chlorocapric acid [ClCH ₂ (CH ₂ ) ₈ COOH, C ₁₀ H ₁₉ ClO ₂ , m.v. 206.4] (46.0 g, 0.223 g mol), 5 ml of distilled water and 0.66 g (0.006 g mol) of selenium dioxide are added, heated at a temperature of 215 ° C with stirring for 20 minutes, cooled to room temperature temperature, filtered and get a clear straw-colored solution.

Example 5

To 45 ml of concentrated 2-iodopropionic (m.v. 199.95, 77.2 g, 0.386 g mol) add 5 ml of distilled water, 4.5 g (0.05 g mol) of lactic [CH ₃ CH (OH) COOH, C ₃ H ₆ O ₃ , m.v. 90] acids, 6.9 g (0.05 g mol) of salicylic acid [NOC ₆ H ₄ COOH, C ₇ H ₆ O ₃ m.v. 138] and 0.66 g (0.006 g mol) of selenium dioxide, heated at a temperature of 20 ° C. with stirring for 40 minutes, cooled to room temperature, filtered and a clear yellow solution was obtained.

The reaction conditions with other halocarboxylic acids are presented in the table.

In the presence of an excess of free acid, it can be considered as a solution of H ₂ SeO ₃ in the corresponding halocarboxylic acid, which is confirmed by high resolution NMR spectra on ¹ H, ¹³ C and ⁷⁷ Se nuclei.

As an example, figure 1-3 presents the NMR spectra of ¹ H (600 MHz), NMR ¹³ C- { ¹ H} (150 MHz) and the NMR spectrum of ⁷⁷ Se (114.45 MHz), the preparation obtained at based on 2.2-dichloropropionic acid.

Figure 1 shows the NMR spectrum of ¹ H (600 MHz, BRUKER AVANCE-600 spectrometer) of the preparation H ₂ SeO ₃ · x · (CH ₃ CCl ₂ COOH). Chemical shifts in the δ-scale. The ratio of the integral intensities of the signals of the CH ₃ group (at 1.96 ppm) and the COOH group (10.8 ppm) makes it possible to determine the ratio of acid and water concentrations.

Figure 2 shows the NMR spectrum of ¹³ C- { ¹ H} of the preparation H ₂ SeO ₃ · x · (CH ₃ CCl ₂ COOH).

Chemical shifts in the δ-scale.

Signal assignment: 34.9 ppm - CH ₃ CCl ₂ COOH; 81.4 ppm - CH ₃ CCl ₂ COOH;

169.23 ppm - CH ₃ CCl ₂ C UN.

Figure 3 shows the NMR spectrum of ⁷⁷ Se- { ¹ H} of the preparation H ₂ SeO ₃ · x · (CH ₃ CCl ₂ COOH).

(114.45 MHz, BRUKER AVANCE-600 spectrometer)

Mass fractions of selenium dioxide, halocarboxylic acid and water in preparations for treating various skin diseases can vary from 0.1-25 wt.% For SeO ₂ , 1-99 wt.% For acid R-CXY- (CH ₂ ) _m - COOH and 1-99 wt.% For water, depending on the medical purpose.

The claimed compound is a transparent, colorless, slightly viscous liquid, acidity in the pH range from 0.8 to 6.9. Chemically and biologically, the composition is stable for at least five years, non-toxic. The concentration of selenium in the composition depends on the chemical components used and is in the range from 1.0 to 10000 mg / l, while the composition is intended only for topical (i.e. topical) application in the form of applications. The recommended dose for simultaneous use of the composition depends on the size of the lesion (for example, a tumor) and can vary from 0.01 to 0.2 ml. When using the anhydride form, distilled water is added to it before use.

The composition does not have systemic teratogenic, embryotoxic or carcinogenic properties, is not adsorbed by the body (there is no absorption of the composition into the blood), since its exposure limits are limited only by the area of the treated area of pathologically altered tissues. In the process of application, there is an immediate dehydration and intravital tissue fixation, with which the composition came into contact. Visually, the initial effect of the action of the composition manifests itself in the form of a color change of the pathologically changed tissue to white-yellowish-gray and the appearance of edema around it and hyperemia of the surrounding skin or visible mucous membrane. Microscopically at this moment around the treated area there is an infiltration of mononuclear cells, micro- and macrophages. Subsequently, devitalized pathological tissue mummifies (dries), changing color to dark brown. Mummified scabs are separated only after complete re-capitalization, spontaneously, after 2-3 weeks. Healing takes place without complications, especially in the absence of a secondary infection, without leaving significant scars and scars, deformations of adjacent tissues or impaired organs. Significant side effects, as well as any contraindications in laboratory and clinical trials, were not detected. It should also be added that the mechanism of the therapeutic effect of the claimed composition in the treatment of all of the above lesions of the skin and visible mucosa, as well as the correction of wrinkles and age spots, is similar, except that the correction of wrinkles and age spots is achieved by a less concentrated solution of the composition (1-20% ) than that used to treat skin and mucosal lesions (21-99%).

The mechanism of action of the composition described above is due to its intravital fixing effect, immunomodulating and anti-angiogenic properties, the ability to interrupt the growth and vital activity of malignant, hyper-, meta- and dysplastic cells, by:

a) angiocoagulation, dehydration and selective devitalization of pathologically altered cells and tissues, skin neoplasms and dysplastic lesions of visible mucous membranes;

b) local immunostimulating and general immunomodulatory effects;

c) antineoplastic, antibacterial and antiviral effects;

d) accelerated regeneration and re-epithelization of healthy skin and mucous membranes surrounding the tumor tissue.

The composition causes the associated signal transduction in macrophages and mononuclear blood cells, infiltrating the surrounding tissue, intravital obliteration and coagulation of blood vessels, providing blood supply to the tumor and lymphatic vessels providing lymphatic drainage of the tumor. The composition is an effective stimulator of local immunity, reducing the effect of immunosuppression associated with the development of the tumor.

According to experimental, immunological, histochemical, electron microscopic studies, it was found that the claimed composition after topical application, in addition to selective devitalizing effects on the pathological focus, can cause two possible categories of immune reactions:

a) an innate (non-specific) immune response that activates granulocytes, micro- and macrophages, their phagocytosis, which are known to produce cytokines, antitumor and antimicrobial peptides;

b) an adaptive (specific) immune response that proceeds more slowly, but is a specific reaction, with the formation of activated T and B lymphocytes. Clinically, it manifests itself in the form of a transient form of an intense local immune response - hyperemia, hyperthermia, edema, induction, but without necrosis, secondary infection, ulcerations, which do not require additional medical manipulations, since they are protective reactions of the body.

Summarizing the benefits of using the composition, we can highlight the main results:

- treatment using a herring composition due to its selective penetration and local devitalizing effect is limited to local changes in the neoplastic tissue, followed by their independent rejection, without the formation of any significant (visible) scars or scars;

- the treatment process does not require anesthesia, does not have a damaging effect on nearby healthy areas and can take place on an outpatient basis, without limiting the patient's daily activities.

The following examples reflect the results of experimental and clinical trials, as well as the practical application of the claimed composition in the treatment of various neoplastic skin lesions and dysplastic lesions of the mucous membranes, as well as fungal lesions of the skin and nails. It should be noted at the same time that under the term "lignite compound" in epicrisis under No. 7-10, 16, 17, 25, 27, 36, 42, 44, 52, 56, 63, a compound of selenium with monochloropropionic acid was used in epicrisis under No. 2-6, 13-15, 18-20, 28-33, 35, 39, 45, 48, 53, 54, 57, 60, 61, 67, 68, the compound of selenium with dichloropropionic acid, in epicrisis under No. No. 22, 46, 55, 66 — compound of selenium with pentafluoropropionic acid, in epicrisis under No. 11, 12, 23, 24, 37, 40, 51, 62, 65 — compound of selenium with monoiodopropionic acid, in epicrisis under No. 1 , 21, 22, 34, 38, 41, 47, 50, 64 — compound of selenium with monobromopropionic acid, discharge summaries under №№26, 49, 59 - compound selenium hlorkapronovoy acid, and discharge summaries under №№43, 58 - compound selenium hlorkaprinovoy acid (* names of diseases are listed in accordance with the histological classification of skin tumors (WHO, 1996):

1. Genital warts *.

2. Intradermal melanocytic nevus *

3. Epidermal nevus *

4. Seborrheic keratosis *

5. Borderline melanocytic nevus *

6. Sour cream melanocytic nevus *

7. Halo nevus *

8. Spitz Nevus *

9. Pigmented spindle cell nevus of Reed *

10. Cellular blue nevus *

11. Congenital melanocytic nevus *

12. Dysplastic melanocytic nevus *

13. Superficially spreading melanoma *, in situ

14. Melanoma type malignant lentigo *, stage 1

15. Nodular modular melanoma *, in situ

16. Lentigo simple (simplex) *

17. Inflammatory linear warty epidermal nevus *

18. Clear cell acanthoma *

19. Skin horn

20. Keratoacanthoma *

21. Simple wart *

22. Plantar wart *

23. Flat wart *

24. Molluscum contagiosum *

25. Radiation keratosis *

26. Arsenic keratosis

27. Oral leukoplakia

28. Intraepidermal squamous cell cancer *, stages 1, 2

29. Infiltrating squamous cell carcinoma *, stages 1, 2

30. Modular basal cell carcinoma *, stages 1, 2

31. Superficial basal cell carcinoma *, stages 1, 2

32. Metatypical skin cancer *

33. Syringoma *

34. Sebaceous adenoma *

35. Pigmented hair epidermal nevus

36. Seborrheic nevus *

37. Trichoepithelium *

38. Trichofolliculoma *

39. Pigmented basal cell carcinoma *, stages 1, 2

40. Funnel cyst *

41. Capillary malformation (Nevus Unna) *

42. Nevus Flaming *

43. Nevus teleangiectatic

44. Venous malformation (blue vesiculate nevus) *

45. Angiokeratoma *

46. Pyogenic granuloma *

47. Capillary hemangioma *

48. Kaposi's sarcoma *, stage 1

49. Cystic lymphangioma *

50. Fibroma *

51. Xanthoma *

52. Fibrous papule *

53. Primary cutaneous non-endocrine carcinoma (tumor from Merkel cells) * 1, 2 stages

54. Neurofibromatosis - ectodermal form

55. Fibroepithelial polyp *

56. Warty diskeratoma *

57. Large-cell acanthoma

58. Benign lichen-shaped keratosis *

59. Tar keratosis

60. Warty squamous cell carcinoma *

61. Seborrheic carcinoma *, stage 1, 2

62. Angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma) *

63. Benign fibrous histiocytoma *

64. Atypical fibroxanthoma *, stage 1

65. Hair tumor (proliferating tricholemal cyst) *

66. Lipomatous nevus

67. Facial wrinkles

68. Fungal infection of the skin and nails

Epicrisis number 1

Patient B. born in 1986, turned to the RCCH and PS (Moscow) with a complaint about the appearance of warts on the foreskin of the penis. The duration of the disease was 1.5 months. On examination, four soft warty fibroepithelial formations on a narrow flesh-colored leg, with outgrowths resembling cauliflower, 4.0 × 3.0 × 2.0 mm, 2.5 × 2.0 × 2.5, were found on examination of the inner leaflet mm, 3.0 × 2.5 × 2.0 mm and 5.0 × 3.5 × 3.0 mm. During DNA diagnostics of scraping with existing condylomas, the human papillomavirus 16 (HPV 16) was detected. General clinical examination of blood and urine - without pathological abnormalities. RPHA with Treponema palliduum antigen, RIF and Wasserman reaction are negative. The conclusion of the dermatologist: genital warts. A biopsy of one of the genital warts was performed. The histological conclusion: genital warts. After obtaining the consent of the patient, without anesthesia, an application of herbal composition to condylomas was performed at a dose of 0.1 ml. 15 minutes after the application, genital warts turned yellow, a slight swelling and hyperemia of the skin appeared around them, after 24 hours the warts became darker and mummified. After 12-14 days after treatment, condylomas freely separated from the skin of the foreskin, at the place of their attachment to the skin, within 30-36 days, areas of hyperemia were observed in an area corresponding to the area of the base of the genital warts. Subsequent monitoring of the patient during the period did not reveal recurrence of genital warts.

Epicrisis №2

A patient X. born in 1975, turned to the RCCH and PS (Moscow) with a complaint about the presence of a birthmark in the lower abdomen, injured when wearing clothes. According to the patient, the birthmark prevented him from childhood. Previously consulted by an oncologist, birthmark removal recommended. An objective examination of the anterior abdominal wall in its lower third almost along the midline of the abdomen had a papillomatous formation of an oval shape 2.4 × 1.2 cm in size, with a pronounced brown leg, painless on palpation. The conclusion of the dermatologist after examination: intradermal nevus. A biopsy of the nevus was performed. The histological conclusion: intradermal melanocytic nevus. Given the large size of the nevus and its constant traumatization, it was decided to carry out the destruction of the nevus with a selenium composition. After obtaining the consent of the patient, without anesthesia, an application of the herbal composition to the nevus was performed at a dose of 0.1 ml. After 15-20 minutes, the nevus changed color to more gray-yellow, after 25-30 minutes a thin strip of hyperemic skin appeared around the nevus, and after 24 hours the nevus turned black and mummified. No general toxic or other side effects were observed. From 14 days to 24 days after application, the mummified nevus tissue has separated from the underlying skin. At the location of the nevus, a section of hyperemic skin was exposed, which subsequently, slowly, within 30-50 days, acquired the usual color for the surrounding skin. Subsequent monitoring of the patient did not reveal any pathological changes on the skin at the location of the nevus or other areas of the skin.

Epicrisis number 3

Patient S., born in 1971, turned to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor-like formation on the left shoulder. The duration of the disease was several years. When viewed on the flexion surface of the shoulder in the upper third, a tumor-like formation in the form of a body-colored plaque, round in shape with a diameter of 1.5 cm, on a narrow base, with an uneven surface protruding above the skin up to 0.5 cm was determined. Consulted by a dermatologist, conclusion: soft papillomatous epidermal nevus. A biopsy of the nevus was performed, the histological conclusion was: epidermal nevus. With the consent of the patient, an application of the herbal composition to the nevus was performed at a dose of 0.1 ml. 20 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 30 minutes, a slight swelling of the skin around the nevus appeared, and after 24 hours there was a darkening and mummification of the nevus. No systemic toxic or side effects were recorded. After 25 days, the mummified scabs of the nevus spontaneously separated from the underlying skin. At the location of the nevus, for 40 days, a hyperemia site was observed in the area corresponding to the area of application of the selenium-containing drug. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №4

Patient N., born 1950, turned to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the occurrence of a flat warty formation on the scalp in the auricle. The duration of the disease was more than 10 years. When viewed on the occipital part of the head to the left behind the auricle, formation of an irregular shape 3.3 × 2.8 cm in size was determined, with an uneven warty surface, clear borders, yellowish-brown in color protruding 3-4 mm above the skin, covered with greasy crusts. Consulted by a dermatologist, conclusion: seborrheic keratosis. A biopsy of the indicated area of the skin, histological conclusion: seborrheic keratosis. After obtaining the consent of the patient, without anesthesia, an application of selenium-containing preparation was performed on the skin affected by keratosis, in a dose of 0.1 ml. 15 minutes after application, the treated skin surface changed to gray, after 20-25 minutes a thin strip of hyperemia and slight edema appeared around it, and after 24 hours there was a darkening and mummification of the skin altered by keratosis. 24 days after application, the mummified scabs were separated by fragments from the underlying skin areas. At the site of its location, within 48 days, there was a plot of moderate hyperemia in the area corresponding to the area of application of selenium-containing drug. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of seborrheic keratosis.

Epicrisis №5

Patient G. 1982 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a birthmark in the palm of the right hand. The specified birthmark appeared shortly after birth, gradually increasing in size. When viewed on the palm surface of the right hand, a brown spot with a diameter of 11 mm, uniformly pigmented, without hair was determined. The conclusion of the dermatologist: nevus. Performed a biopsy of the nevus, the histological conclusion: borderline melanocytic nevus. Considering the melanoma risk of the indicated localization of the border nevus, it was decided to carry out its local destruction with the help of a village composition. After obtaining the consent of the patient, an application of the herbal composition to the nevus was performed at a dose of 0.1 ml 20 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin around the nevus appeared, and after 20 hours there was a darkening and mummification of the nevus. No systemic toxic or side effects were recorded. After 25 days, the mummified scabs spontaneously separated from the palmar surface. At the location of the nevus, within 50 days, a section of hyperemia was observed in the area corresponding to the area of application of the selenium-containing drug. Subsequent monitoring of the patient during the period did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №6

Patient L., born 1986 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a birthmark on the back. The indicated spot is noted from childhood. When viewed on the back on the left in the mid-scapular line at the level of the 8th rib, a pigmented papule of oval shape with a diameter of 5 × 6 mm, without hair, was determined. The conclusion of the dermatologist: nevus. Performed a biopsy of the nevus, histological conclusion: mixed melanocytic nevus. Given the increased trauma of the nevus underwear, it was decided to carry out its local destruction with the help of the village composition. After obtaining the consent of the patient, an application of the herbal composition to the nevus was performed at a dose of 0.05 ml. 20 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the nevus appeared, and after a day there was a darkening and mummification of the nevus. No systemic toxic or side effects were recorded. After 22 days, the mummified scabs separated from the underlying skin. At the location of the nevus, within 50 days, a section of hyperemia was observed in the area corresponding to the area of application of the selenium-containing drug. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis number 7

Patient B. 1972 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a birthmark on the left forearm. The indicated spot appeared after pregnancy in 2000. On examination, on the outer surface of the left forearm, in the middle third, a papule of brown color was rounded in shape with a diameter of 4 mm, around which there was a zone of depigmented skin with a diameter of 11 mm. The conclusion of the dermatologist: halo nevus. Performed a biopsy of the nevus, histological conclusion: nevus with signs of inflammatory infiltration. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of the nevus using a herbal composition. After obtaining consent, an application of selenium-containing preparation to the nevus was performed at a dose of 0.05 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the nevus appeared, and after a day there was a darkening and mummification of the nevus. No systemic toxic or side effects were recorded. After 28 days, the mummified scabs separated from the underlying skin. At the location of the nevus, within 50 days, a section of hyperemia was observed in the area corresponding to the area of application of the selenium-containing drug. Subsequent monitoring of the patient during the period did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №8

Patient A., born 1994 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the appearance of a nodule in the forehead. The indicated nodule arose several months ago and is rapidly increasing in size. When viewed in the forehead on the right, above the eyebrow, a hemispherical knot of pink color was determined, with a smooth surface with a diameter of 5 mm, without hair. The conclusion of the dermatologist: Spitz nevus. December 15, 2003, a biopsy of the nevus was performed, the histological conclusion was: spindle cell nevus. Given the results of a histological examination and the insistent request of the patient’s parents, it was decided to carry out local destruction of the nevus using a herring composition. After obtaining the consent of the patient and his parents, an application of selenium-containing preparation on the nevus was performed at a dose of 0.05 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 20 minutes, a slight swelling of the skin around the nevus appeared, and after 20 hours there was a darkening and mummification of the nevus. No systemic toxic or side effects were recorded. After 23 days, the mummified scabs spontaneously separated from the underlying skin. At the location of the nevus, for 40 days, a site of hyperemia was observed, and then increased skin pigmentation, in an area corresponding to the area of application of a selenium-containing preparation. Subsequent monitoring of the patient during the period did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №9

Patient B. 1971 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a pigmented plaque on the right thigh. The indicated plaque appeared a few years before treatment. When viewed on the front surface on the right thigh in the upper third, a blue-black papule, rounded in shape with a diameter of 6 mm, was determined. The conclusion of the dermatologist: Nevus Reed. Performed a biopsy of the nevus, the histological conclusion: pigmented spindle cell nevus of Reed. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of the nevus using a herbal composition. After obtaining consent, an application of selenium-containing preparation to the nevus was performed at a dose of 0.05 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the nevus appeared, and after a day there was a darkening and mummification of the nevus. No systemic toxic or side effects were recorded. After 30 days, the mummified scabs separated from the underlying skin. At the location of the nevus, within 45 days, a hyperemia site was observed in the area corresponding to the area of application of the selenium-containing drug. Subsequent monitoring of the patient during the period did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis number 10

Patient S. born in 1970 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a pigmented node on the left buttock. The specified node appeared at the age of 15. When viewed on the left gluteal region in the outer-lower quadrant, a knot of blue color was determined, with an uneven surface of a round shape, with a diameter of 2.5 mm. The conclusion of the dermatologist: blue nevus. Performed a biopsy of the nevus, histological conclusion: cell blue nevus. Considering the results of histological examination and the size of the nevus, it was decided to carry out local destruction of the nevus using a selenium composition. After obtaining the consent of the patient, an application of the herbal composition to the nevus was performed, at a dose of 0.2 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a moderate swelling of the skin and a strip of hyperemia around the nevus appeared, and after a day there was a darkening and mummification of the nevus. No systemic toxic or side effects were recorded. After 42 days, the mummified scabs of the nevus separated from the underlying skin. At the location of the nevus, within 60 days, the site of retraction and hyperemia of the skin was observed in the area corresponding to the area of application of the selenium-containing preparation. Subsequent monitoring of the patient during the period did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis number 11

Patient I., born 1975 He appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a large birthmark on his back. The specified birthmark was found immediately at birth and increased in size with growth. When viewed on the back in the interscapular region with the transition to the right axillary region, there was a formation with a warty surface, with an uneven brown color, 28 × 24 cm in size, covered with hair. The conclusion of the dermatologist: congenital giant hair nevus. Performed a biopsy of the nevus, the histological conclusion: congenital melanocytic nevus. Considering the results of histological examination and the size of the nevus, it was decided to carry out local destruction of the nevus using a selenium composition. After obtaining the consent of the patient, an application of the herbal composition to the nevus was performed at a dose of 1.8 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a moderate swelling of the skin and a thin strip of hyperemia around the nevus appeared, and after a day darkening and mummification of the nevus were observed. No systemic toxic or side effects were recorded. In the period from 35 to 45 days after application, exfoliation of mummified scabs of nevus from the underlying skin was observed. At the location of the nevus, within 60 days, a section of skin hyperemia was observed, followed by pigmentation in an area corresponding to the area of application of a selenium-containing preparation. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №12

Patient B., born in 1963 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of age spots on the skin of the back. These spots appeared two years before treatment. The patient's father was treated for melanoma. When viewed on the skin of the back on its right half at the level of the 10th rib, there were three formations with an uneven warty surface, with a motley color of dark brown color, with fuzzy borders, with a diameter of 7.0, 6.0 and 5.5 mm. At the base of the formations, a zone of hyperemia was determined. The conclusion of the dermatologist: dysplastic nevus. Performed a biopsy of the nevus, the histological conclusion: dysplastic melanocytic nevus. Given the results of a histological examination, the high melanoma risk of the nevus, it was decided to carry out local destruction of the nevus with the help of a herring composition. After obtaining the consent of the patient, an application of the herbal composition to the nevus was performed, at a dose of 0.25 ml. 20 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a moderate swelling of the skin and a thin strip of hyperemia around the nevus appeared, and after a day darkening and mummification of the nevus were observed. No systemic toxic or side effects were recorded. In the period from 40 to 45 days after application, exfoliation of mummified scabs of nevus from the underlying skin was observed. At the location of the nevus, within 60 days, a section of skin hyperemia was observed, followed by pigmentation in an area corresponding to the area of application of a selenium-containing preparation. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis number 13

Patient D., born in 1967 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a brown spot on the right lower leg. According to the patient, the existence of a spot was calculated for a period of more than 15 years, however, during the last 5-6 months, a change in the color of the spot and an increase in its area was noted. When viewed on the outer surface of the right lower leg in the upper third, there was a brown spot with pinkish-gray and black blotches, slightly rising above the skin level, with distinct irregularly shaped edges and a corolla of hyperemia around the spot, 7 × 8 mm in size, with a glossy surface. After consulting a dermatologist who suspected melanoma, a biopsy was performed, the histological conclusion was: superficially spreading melanoma, stage I. Given the results of histological examination, it was decided to carry out local destruction of melanoma with the help of a herring composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor at a dose of 0.2 ml was performed. 20 minutes after the application, the surface of the tumor turned yellowish-gray. After 30 minutes, moderate swelling of the skin and a strip of hyperemia around the tumor appeared, and after 20 hours its darkening and mummification were observed. No systemic toxic or side effects were recorded. In the period from 40 to 45 days after application, exfoliation of mummified scabs of the tumor from the underlying skin was observed. At the location of the nevus, within 60 days, a section of skin hyperemia was observed, followed by pigmentation in an area corresponding to the area of application of a selenium-containing preparation. Observation of the patient during the period did not reveal any pathological changes in the skin at the location of the tumor or its metastases to the surrounding skin, nearby lymph nodes or metastases to distant organs and tissues.

Epicrisis №14

Patient J., born in 1940 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a brown spot on the skin of the neck. This stain appeared several years ago before treatment, however, over the past 2-3 years it began to increase in size. When viewed from the left side of the neck, there was a brown spot in some places of black color, with a dull surface of irregular shape with clear borders, 36 × 42 mm in size. The conclusion of the dermatologist: melanoma type malignant lentigo. Performed a biopsy of the tumor, the histological conclusion: melanoma type malignant lentigo. Given the results of histological examination, it was decided to carry out local destruction of melanoma with the help of a herring composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed, at a dose of 0.2 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 20 minutes, moderate swelling of the skin and a strip of hyperemia around the tumor appeared, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. In the period from 40 to 50 days after application, exfoliation of mummified scabs of the tumor from the underlying skin was observed. At the location of the tumor, for 60 days, a section of skin hyperemia was observed followed by pigmentation in an area corresponding to the area of application of the selenium-containing preparation. Observation of the patient in the subsequent period did not reveal any pathological changes in the skin at the location of the tumor or its metastases in the surrounding skin, nearby lymph nodes or metastases in distant organs and tissues.

Epicrisis №15

Patient S. 1949 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a brown color on the skin of the chest. The specified node appeared at the site of the birthmark about a year ago, the last two months began to increase rapidly. When viewed from the front surface of the chest to the right above the nipple along the midclavicular line, there was a light brown knot with clear rounded borders with a diameter of 6 mm with a smooth shiny surface. The conclusion of the dermatologist: nodular melanoma. A biopsy was performed, the histological conclusion was: nodular modular melanoma, stage I. Given the results of histological examination, it was decided to carry out local destruction of melanoma with the help of a herring composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed, at a dose of 0.2 ml. 20 minutes after the application, the surface of the tumor turned yellowish-gray. After 25 minutes, moderate swelling of the skin and a strip of hyperemia around the tumor appeared, and after 24 hours its darkening and mummification were observed. No systemic toxic or side effects were recorded. In the period from 40 to 42 days after application, exfoliation of mummified scabs of the tumor from the underlying skin was observed. At the location of the tumor, for 55 days, a section of skin hyperemia was observed, followed by pigmentation in the area corresponding to the area of application of the selenium-containing preparation. Subsequent monitoring of the patient during the period did not reveal any pathological changes in the skin at the location of the tumor or its metastases in the surrounding skin, nearby lymph nodes or metastases in distant organs and tissues.

Epicrisis number 16

Patient O. born in 1987 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the appearance of dark brown spots on the back. These spots appeared at the age of 9-10 years, but were small, weakly pigmented and did not cause concern. The last 3-4 months, the spots have darkened and increased in size. When viewed from the back on the left, at the level of the 6-7th ribs, three pigmented spots of dark brown color were defined, with clear borders, rounded in diameter with 6.0, 8.0 and 9.0 mm in diameter, without hair. The conclusion of the dermatologist: youthful lentigo. Performed a biopsy of one of the spots, the histological conclusion: lentigo simple (simplex). Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of age spots with the help of a herring composition. After obtaining the consent of the patient, the application of the herbal composition on the spots was performed, at a dose of 0.15 ml. 15 minutes after application, the surface of the spots turned yellowish-gray. After 20 minutes, a slight swelling of the skin and a strip of hyperemia around the spots appeared, and after a day their darkening and mummification were observed. No systemic toxic or side effects were recorded. After 25 days, the mummified scabs separated from the underlying skin. At the spot location, for 38 days, a hyperemia site was observed in the area corresponding to the application area with a selenium-containing preparation. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the lentigo.

Epicrisis №17

A patient Z. born in 1975, went to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of itchy nodules on the left thigh. These nodules appeared in childhood, repeated attempts at their local treatment had no effect. When viewed on the posterior surface of the left thigh in the upper and middle third, linearly located psoriasis-like papules were determined. Consulted by a dermatologist, conclusion: inflammatory linear warty epidermal nevus. A biopsy of the nevus, a histological conclusion: an inflammatory linear warty epidermal nevus. With the consent of the patient, an application of the herbal composition to the nevus was performed at a dose of 0.1 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 30 minutes, a slight swelling of the skin around the nevus appeared, and after 24 hours there was a darkening and mummification of the nevus. No systemic toxic or side effects were recorded. After 21 days, the mummified scabs of the nevus spontaneously separated from the underlying skin. At the location of the nevus, within 45 days, a hyperemia site was observed in the area corresponding to the area of application of the selenium-containing drug. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №18

Patient B., born in 1942 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor on the right lower leg. The specified tumor appeared several years before treatment. When viewed on the outer surface of the right lower leg in the middle third, a domed tumor, round in shape with a diameter of 8 mm, brown, with an uneven surface was determined. Around the formation, a peeling zone of the skin, partially covered with crusts, was determined. The conclusion of the dermatologist: clear cell acanthoma. Performed a biopsy of the tumor, the histological conclusion: clear cell acanthoma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the tumor with the help of a herring composition. After obtaining consent, an application of selenium-containing preparation on the tumor was performed at a dose of 0.1 ml. 17 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after a day, darkening and its mummification were observed. No systemic toxic or side effects were recorded. After 36 days, the mummified scabs of the tumor separated from the underlying skin. At the location of the tumor, for 56 days, a section of hyperemia and skin retraction was observed in the area corresponding to the area of application of the selenium-containing preparation. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the tumor.

Epicrisis №19

Patient X. born in 1948 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor in the forehead. The indicated tumor appeared a few years before treatment, gradually increasing in size. On examination, a cone-shaped tumor of red-pink color with a smooth surface, dense consistency, 4.0 mm in diameter and 6.0 mm in height was determined on the skin of the left superciliary region. The conclusion of the dermatologist: skin horn. Performed a biopsy of the tumor, histological conclusion: skin horn. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the tumor using a herbal composition. After obtaining the consent of the patient, the application of the herbal composition on the tumor was performed, in a dose of 0.1 ml. 20 minutes after the application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after a day they were darkened and mummified. No systemic toxic or side effects were recorded. After 35 days, the mummified scabs of the tumor separated from the underlying skin. At the location of the tumor, within 48 days, a section of hyperemia was observed in the area corresponding to the area of application of the selenium-containing drug. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the skin horn.

Epicrisis №20

Patient S. born in 1949 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor on the right cheek. The described tumor appeared five months ago and rapidly increased in size. On examination, the skin of the right cheek had a dome-shaped tumor, 2.1 cm in diameter, of a crimson color with a crater-like depression in the center, filled with keratose masses of gray-brown color. Around the tumor was determined by a dense roller of pink color. The conclusion of the dermatologist: giant keratoacanthoma. Performed a biopsy of the tumor, the histological conclusion: keratoacanthoma in the stabilization stage. Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed, at a dose of 0.2 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin around the tumor appeared, and after 24 hours, the tumor was darkened and mummified. No systemic toxic or side effects were recorded. After 32 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of the tumor, for 50 days, there was a site of hyperemia, and then increased skin pigmentation, in an area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal recurrence of the tumor.

Epicrisis №21

Patient Z., born in 1977, turned to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of warts on the skin of the right hand. These warts appeared several months ago, increasing quantitatively and in size. When viewed on the back surface of the right hand near the 1st and 2nd fingers, multiple dense round epidermal papules with a diameter of 1.0 to 5.0 mm, with a rough surface of a pale pink color, were determined. The conclusion of the dermatologist: simple warts. A biopsy of the largest wart was performed, histological conclusion: a simple wart. In agreement with the patient, an application of the herbal composition on the warts was performed at a dose of 0.15 ml. 15 minutes after application, the surface of the warts turned yellowish-gray. After 25 minutes, a slight swelling of the skin around the warts appeared, and after 20 hours they were darkened and mummified. No systemic toxic or side effects were recorded. After 22 days, the mummified scabs of warts spontaneously separated from the underlying skin. At the location of the warts, within 42 days, areas of hyperemia were observed in the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the warts or their recurrence.

Epicrisis №22

A patient born in 1980, went to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of warts on the heel of his left leg. These warts appeared about 1 year ago, after an injury to the skin of the foot. When viewed on the plantar surface of the left foot in the heel area, there were three dense rounded formations with clear boundaries with a diameter of 6.0, 8.0 and 9.0 mm, with a rough surface, pink in color, with small black dots, painful on palpation. The conclusion of the dermatologist: plantar warts. A biopsy of one of the warts was performed, histological conclusion: plantar wart. With the consent of the patient, an application of the herbal composition to the warts was performed at a dose of 0.2 ml. 10 minutes after application, the surface of the warts turned yellowish-gray in color, and after 20 hours they were darkened and mummified. No systemic toxic or side effects were recorded. After 35 days, the mummified scabs of warts spontaneously separated from the underlying skin. At the location of the warts, within 28 days, areas of hyperemia were observed in the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the warts or their recurrence.

Epicrisis №23

Patient D. born in 1986, went to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of warts on the skin of her hands. These warts appeared several months ago, initially single, then multiple. When examined on the back surface of the hands and forearms, three dozen flat dense papules of a polygonal shape from 1.0 to 3.0 mm in size were found, with a smooth surface of light brown color, rising above the skin level. The conclusion of the dermatologist: flat warts. A biopsy of one of the large warts was performed, the histological conclusion was a flat wart. With the consent of the patient, an application of the herbal composition to the warts was performed at a dose of 0.2 ml. 15 minutes after application, the surface of the warts turned yellowish-gray. After 25 minutes, a slight swelling of the skin around the warts appeared, and after a day their darkening and mummification were observed. No systemic toxic or side effects were recorded. After 20 days, the mummified scabs of warts spontaneously separated from the underlying skin. At the location of the warts, for 40 days, hyperemia sites were observed in the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the warts or their recurrence.

Epicrisis №24

A patient born in 1991, came to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the appearance of small nodules on her hands. These formations arose a few weeks before treatment, after playing with peers with the same nodules on their hands. When viewed on the back of the hands and the inner surface of the forearms, up to a dozen translucent nodules were determined, dome-shaped in diameter from 1.0 to 4.0 mm, with a depression in the center, with a smooth surface, well defined. Dermatologist's conclusion: molluscum contagiosum. Microscopic examination of the separated horn mass revealed intracellular cytoplasmic inclusions. The presence of the molluscum contagiosum virus was also confirmed by polymerase chain reaction. With the consent of the patient's parents, an application of the herring composition to the nodules of the molluscum contagiosum was performed at a dose of 0.15 ml. 20 minutes after application, the surface of the nodules acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin around the nodules appeared, and after 20 hours their darkening and mummification were observed. No systemic toxic or side effects were recorded. After 25 days, the mummified scabs spontaneously separated from the underlying skin. At the location of the nodules, for 40 days, hyperemia sites were observed in the area corresponding to the area of application by the selection composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the molluscum contagiosum or its recurrence.

Epicrisis №25

Patient R., born in 1932 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the appearance of a focus of redness and peeling of the skin on the left cheek. The disease is about 1 year old. When viewed on the left cheek, a skin area was determined, with not very clear boundaries, 2.5 × 3.2 cm in size, covered with dirty brown horn masses, upon removal of which a hyperemic slightly rough skin surface was opened. The conclusion of the dermatologist: actinic (solar) keratosis. A biopsy of the altered skin area was performed, histological conclusion: radiation keratosis, hyperplastic type. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of the keratosis-affected area of the skin using a herbal composition. After obtaining the consent of the patient, the application of the herbal composition on the changed area of the skin was performed, at a dose of 0.15 ml. 12 minutes after the application, its surface acquired a yellowish-gray color. After 25 minutes, a slight edema and a strip of hyperemia appeared around it, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 30 days, the mummified scabs separated from the underlying skin. At the location of keratosis, for 50 days, a hyperemia site was observed in the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient during the period did not reveal any pathological changes in the skin at the location of keratosis.

Epicrisis №26

Patient F., born in 1938, turned to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of foci of altered skin on the palms of the hands and soles of the feet. The duration of the disease was several years, the number of lesions during this time increased, as did their size. For professional duties, the patient had previously had contact with arsenic compounds for a long time. When viewed on the plantar surface of the feet and hands, there were multiple dirty gray papules with a hyperkeratic surface, with a diameter of 0.5 to 4.0 mm. The conclusion of the dermatologist: arsenic keratosis. A biopsy of one of the papules was performed, the histological conclusion was keratosis, with signs of moderate dysplasia. With the consent of the patient, an application of the herbal composition on papules was performed at a dose of 0.2 ml. 15 minutes after application, the surface of the papules turned yellowish-gray in color, and a day later they were darkened and mummified. No systemic toxic or side effects were recorded. After 45 days, the mummified scabs separated from the underlying skin. At the location of the papules, within 40 days, hyperemia sites were observed in the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the papules or their recurrence.

Epicrisis №27

Patient A., born in 1948 appealed to the clinic of aesthetic medicine in Kiron (Israel) 07/23/2001 with a complaint about the presence of plaque on the mucous membrane of the left cheek. The duration of the disease was several years. When examined on the mucous membrane of the left cheek 4.0 cm from the corner of the mouth, a grayish-white plaque slightly raised above the mucosa, irregular in shape, with a uniform surface, hard to the touch, 3.2 × 1.9 in size was detected by the contact line of the teeth. see Conclusion of a dermatologist: leukoplakia of the oral cavity. 07/26/2001, a biopsy of the changed area of the mucosa was performed. The histological conclusion: oral leukoplakia. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of the mucosal area affected by leukoplakia using a selenium-containing preparation. 08/15/2001, after obtaining the consent of the patient, the application of selenium-containing preparation on the changed area of the mucosa was performed, in a dose of 0.1 ml. 15 minutes after application, the mucous membrane turned yellow. After 25 minutes, a slight swelling of the mucous membrane appeared at the place of application, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 25 days, the mummified scabs separated from the underlying mucosa. At the location of leukoplakia, within 30 days, there was a section of hyperemia in the area corresponding to the area of application of the selenium-containing drug. Follow-up of the patient from October 2001 to November 2002 did not reveal any pathological changes in the mucosa at the location of leukoplakia.

Epicrisis №28

Patient P., born in 1929 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the appearance of a plaque on the skin of the left hand. The duration of the disease was more than eight years. When examining the outer surface of the left forearm on the skin in the lower third, a plaque of irregular outlines, raised above the skin, was formed by the fusion of reddish lenticular papules with slight peeling and clear borders, 4.8 × 4.2 cm in size. White scales located on the surface of the plaque were easily removed without signs of bleeding, exposing a red, wet surface. Dermatologist Conclusion: Bowen's Disease. A biopsy of the changed area of the skin was performed, the histological conclusion: intraepidermal squamous cell carcinoma (Bowen's disease). Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the affected area of the skin using the herring composition. After obtaining the consent of the patient, the application of the herbal composition on the changed skin area was performed, at a dose of 0.2 ml. 15 minutes after application, its surface turned yellowish-gray. After 25 minutes, a slight swelling and a strip of hyperemia appeared around her, and after a day her darkening and mummification were observed. No systemic toxic or side effects were recorded. After 30 days, the mummified scabs separated from the underlying skin. At the location of the tumor, within 50 days, a section of hyperemia was observed in the area corresponding to the area of application by the selection composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the tumor or its recurrence.

Epicrisis №29

Patient Z., 1934 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor on the left shoulder. The specified tumor appeared two years before treatment, gradually increasing in size. When viewed on the outer surface of the left shoulder in the lower third, a dome-shaped knot was found, red-pink in color, covered with rounded crusts with a diameter of 17 mm, dense texture, sedentary, bleeding with minor trauma. Around the formation, a peeling zone of the skin, partially covered with crusts, was determined. Dermatologist's opinion: infiltrating squamous cell carcinoma of the skin. Performed a biopsy of the tumor, the histological conclusion: infiltrating squamous cell carcinoma of the skin. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the tumor with the help of a herring composition. After obtaining consent, the application of the herbal composition on the tumor was performed, at a dose of 0.2 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after a day, darkening and its mummification were observed. No systemic toxic or side effects were recorded. After 33 days, the mummified scabs of the tumor separated from the underlying skin. At the location of the tumor, for 56 days, a section of hyperemia and skin retraction was observed in an area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the tumor, its metastases or recurrence.

Epicrisis №30

Patient S. born in 1939 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a nodule on the nose. The described tumor appeared about a year and a half ago and slowly increased in size. When viewed from the left wing of the nose closer to the tip, there was a waxy translucent nodule, firm to the touch, 4 mm in diameter, with a smooth surface, with translucent full-blooded capillaries. The conclusion of the dermatologist: basal cell carcinoma, nodular form. Performed a biopsy of the site, the histological conclusion: nodular basal cell carcinoma, stage I. Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition to the tumor was performed at a dose of 0.05 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after 24 hours the tumor was darkened and mummified. No systemic toxic or side effects were recorded. After 45 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of the tumor, for 52 days, there was a site of hyperemia, and then increased pigmentation, in an area corresponding to the area of application. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the tumor, its metastases or recurrence.

Epicrisis №31

Patient K., born in 1937 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of plaques on the skin of the back. The duration of the disease was several years. When viewed at the level of the lower angle of the scapula, in the paravertebral region on the right, there was a plaque-shaped rounded lesion, pink in color, with areas of peeling and crust formation, 2.7 cm in diameter, the edge of which consisted of small shiny translucent nodules. Dermatologist's conclusion: superficial basal cell carcinoma. Tumor biopsy performed, histological conclusion: superficial basal cell carcinoma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the affected area of the skin using the herring composition. After obtaining the consent of the patient, the application of the herbal composition on the tumor was performed at a dose of 0.15 ml. 15 minutes after application, its surface turned yellowish-gray. After 25 minutes, a slight swelling and a strip of hyperemia appeared around her, and after a day her darkening and mummification were observed. No systemic toxic or side effects were recorded. After 36 days, the mummified scabs separated from the underlying skin. At the location of the tumor, within 60 days, there was a section of hyperemia in the area corresponding to the area of application. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the tumor, metastases or its recurrence.

Epicrisis number 32

Patient Sh., 1939 He appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of education in the field of the right temple. The indicated formation appeared about two years ago, slowly increasing in size. When examined in the right temporal region, an ulcerative tumor lesion of irregular shape was determined, with uneven ragged edges, an uneven bottom, bright pink in color, a depth of 1.5-2.0 mm, partially covered with a dark brown crust. The size of the tumor lesion was 1.4 × 1.2 cm, around it there was a zone of hyperemia, 2-3 mm wide. Dermatologist's conclusion: metatypical skin cancer. Tumor biopsy performed, histological conclusion: metatypical skin cancer. Given the results of histological examination, it was decided to carry out local destruction of the tumor using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed at a dose of 0.15 ml. 10 minutes after application, the tumor surface turned yellowish-gray. After 25 minutes, moderate swelling of the skin appeared and hyperemia around the tumor intensified, and after 24 hours its darkening and mummification were observed. No systemic toxic or side effects were recorded. In the period from 38 to 41 days after application, exfoliation of mummified scabs of the tumor from the underlying skin was observed. At the location of the tumor, within 50 days, a section of skin hyperemia was observed, followed by pigmentation in an area corresponding to the area of application. Observation of the patient after treatment did not reveal any pathological changes in the skin at the location of the tumor or its metastases in the surrounding skin, nearby lymph nodes or metastases in distant organs and tissues.

Epicrisis №33

Patient S. born in 1986 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of nodules in the lower eyelids, neck, navel. The duration of the disease was more than a year. When viewed on the skin of the lower eyelids, the front surface of the neck and near the navel, there were multiple, symmetrical, dense, rounded nodules, flesh-colored, with a diameter of 1.0 to 3.0 mm, slightly rising above the skin level. The conclusion of the dermatologist: syringoma, disseminated form. A biopsy of one of the nodules in the navel region was performed; histological conclusion: syringoma. Given the results of the histological examination and the patient’s urgent request, it was decided to carry out local destruction by syringing using a herring composition. After obtaining the consent of the patient, an application of the herbal composition was performed on all available syringomas, in a dose of 0.2 ml. 15 minutes after application, the surface of the skin above the syringes turned yellowish-gray. After 25 minutes, a slight swelling of the skin appeared around them, and after 20 hours there was a darkening and mummification of the skin areas treated with the herbal composition. No systemic toxic or side effects were recorded. After 35 days, the mummified scabs spontaneously separated from the underlying skin. At their location, hyperemia was observed for 45 days, and then increased skin pigmentation, in an area corresponding to the area of application of a selenium-containing preparation. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the syring.

Epicrisis №34

Patient S., born in 1940 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a node on the left cheek. The described tumor appeared several years ago, slowly increasing in size. On examination, on the left cheek there was a node towering above the skin, hard to the touch, with a diameter of 9-10 mm, covered with unchanged skin. The conclusion of the dermatologist: adenoma of the sebaceous gland. Performed a biopsy of the tumor, the histological conclusion: adenoma of the sebaceous gland. Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition to the tumor was performed at a dose of 0.15 ml. 10 minutes after application, the surface of the skin above the tumor acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin appeared, and after 24 hours there was a darkening and mummification of the skin and the underlying tumor. No systemic toxic or side effects were recorded. After 45 days, the mummified scabs of the tumor spontaneously separated, and at the location of the tumor, for 50 days, a site of hyperemia and retraction of the skin, and then its increased pigmentation, was observed, according to the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the tumor, its metastases or recurrence.

Epicrisis №35

Patient B. 1976 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of age spots on the skin of the back. Spots appeared in 12-14 years, gradually increasing in size. When viewed on the skin of the back, there were multiple spots of brown and dark brown in color, irregular in shape with a serrated border, rough surface, covered with thick dark hair, sizes from 3.0 × 4.0 mm to 8.0 × 15 mm. The conclusion of the dermatologist: pigmented hair epidermal nevus (Becker nevus). A biopsy of one of the nevuses was performed, the histological conclusion was: pigmented hair epidermal nevus. Given the results of a histological examination, it was decided to carry out local destruction of the nevus with the help of a village composition. After obtaining the consent of the patient, an application of the herbal composition to the nevi was performed at a dose of 0.35 ml. 15 minutes after the application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a moderate swelling of the skin and a thin strip of hyperemia around the nevi appeared, and after a day there was a darkening and their mummification. No systemic toxic or side effects were recorded. In the period from 35 to 45 days after application, exfoliation of mummified scabs of nevuses from the underlying skin was observed. At the location of the nevi, within 65 days, areas of skin hyperemia were observed, followed by pigmentation in an area corresponding to the area of application by the herbal composition. Observation of the patient after treatment did not reveal any pathological changes in the skin at the location of the nevi.

Epicrisis №36

Patient X. born in 1958 appealed to the clinic of aesthetic medicine in Kiron (Israel) November 6, 2003 with a complaint about the presence of plaque on the scalp. The indicated plaque appeared in childhood, gradually increased in size. When viewed on the skin of the occipital part of the head on the right, a flat, soft, elastic with a shiny surface plaque, oval in shape, dimensions 1.8 × 2.7 mm, height 2.0-3.0 mm, was determined. The conclusion of the dermatologist: nevus of the sebaceous glands (Yadasson). November 10, 2003 a biopsy of the nevus was performed. The histological conclusion: seborrheic nevus. Given the results of histological examination and the threat of malignant transformation, it was decided to carry out local destruction of the nevus using selenium-containing preparation. 12/03/2003, after obtaining the consent of the patient, the application of selenium-containing preparation on the nevus was performed at a dose of 0.15 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the nevus appeared, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 35 days, the mummified scabs of the nevus separated from the underlying skin. At the location of the nevus, within 45 days, a hyperemia site was observed in the area corresponding to the area of application of the selenium-containing drug. Subsequent monitoring of the patient for two years after treatment did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №37

Patient Z., 1967 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor on the skin of the scalp. The specified tumor appeared in adolescence, gradually increasing in size. When viewed in the temporal region of the scalp on the left, a dense, movable flesh-colored papule of round shape, 1.6 cm in diameter was determined. Dermatologist's conclusion: trichoepithelioma. Performed a biopsy of the tumor, the histological conclusion: trichoepithelioma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the tumor with the help of a herring composition. After obtaining consent, an application of the herbal composition to the tumor was performed at a dose of 0.15 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after a day, darkening and its mummification were observed. No systemic toxic or side effects were recorded. After 38 days, the mummified scabs of the tumor separated from the underlying skin. At the location of the tumor, for 50 days, there was a site of hyperemia and a slight retraction of the skin in an area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the tumor, or its recurrence.

Epicrisis №38

Patient S., born in 1969 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor on the left cheek. The described tumor appeared several years ago and slowly increased in size. When viewed on the skin of the right cheek, a dense, movable, dome-shaped knot of normal skin color was determined, 1.1 cm in diameter, with an enlarged pore at its apex and a hair bundle growing from it. The conclusion of the dermatologist: trichofolliculoma. Performed a biopsy of the tumor, the histological conclusion: highly differentiated tumor of the hair follicle (trichofolliculoma). Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed at a dose of 0.15 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after 24 hours the tumor was darkened and mummified. No systemic toxic or side effects were recorded. After 42 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of the tumor, for 50 days, there was a site of hyperemia, and then increased skin pigmentation, in an area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal recurrence of the tumor.

Epicrisis №39

Patient T., born in 1937 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a pigmented node on the skin of the back. The described tumor appeared several years ago and slowly increased in size. When viewed in the suprascapular region on the right, a dense, flat, with an uneven surface, node was found, almost black, with a diameter of 1.2 cm. Dermatologist's conclusion: basal cell carcinoma, nodular form. Performed a biopsy of the tumor, the histological conclusion: pigmented basal cell carcinoma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed at a dose of 0.1 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after 24 hours the tumor was darkened and mummified. No systemic toxic or side effects were recorded. After 42 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of the tumor, for 50 days, a section of hyperemia was observed, and then increased pigmentation, in the area corresponding to the area of application with the herbal composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the tumor, its metastases or recurrence.

Epicrisis №40

Patient S. 1972 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of multiple nodules on the skin of the chest. These nodules appeared about more than ten years ago, gradually increasing in size. On examination, on the front surface of the chest there are multiple nodes towering above the skin, white, hard to the touch, with a diameter of 2.0 to 8.0 mm. Dermatologist's conclusion: multiple epidermal cysts. A biopsy of one of the cysts was performed, the histological conclusion was a funnel cyst. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of the cysts using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition was performed on all available epidermal cysts, at a dose of 0.25 ml. 15 minutes after application, the surface of the skin above the cysts acquired a yellowish-gray color. After 25 minutes, a slight swelling and a strip of hyperemia of the skin appeared, and after 24 hours there was a darkening and mummification of the skin with the underlying tissue of the cysts. No systemic toxic or side effects were recorded. After 35-45 days, the mummified scabs spontaneously separated, and at the location of the cysts, for 45-55 days, areas of hyperemia and retraction of the skin, and then its increased pigmentation, were observed, according to the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the cysts or their recurrence.

Epicrisis №41

Patient O. born in 1987 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a red spot on the back of the neck. This stain was detected at birth. When viewed on the back of the neck, a red spot with telangiectasias, irregularly shaped with clear borders, 6.0 × 8.0 cm in size was determined from the midline of the dermatologist. Conclusion of a dermatologist: congenital telangiectasia (Unna nevus). A spot biopsy was performed, histological conclusion: capillary malformation (congenital telangiectasia). Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the spot using a herring composition. After obtaining the consent of the patient, an application of the herbal composition to the skin with telangiectasia was performed at a dose of 0.2 ml. 15 minutes after application, the surface of the skin with telangiectasia acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the spot appeared, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 25-35 days, the mummified scabs of the spot were separated from the underlying skin. At the location of telangiectasia, for 45 days, a site of hyperemia was observed, followed by increased pigmentation in the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the telangiectasia.

Epicrisis №42

Patient M., born in 1983 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a pink spot on the right cheek. The indicated spot was found at birth and increased in size as they mature. On examination, on the right cheek there was a spot of irregular shape, bright pink in color, with clear borders, disappearing by dioscopy, measuring 41 × 36 mm. The conclusion of the dermatologist: the nevus is flaming (a spot of the color of port wine). Given the data of the clinical examination and the results of dioscopy, it was decided to carry out local destruction of the flaming nevus with the help of a herring composition. After obtaining the consent of the patient, an application of herbal composition was performed on the skin area with nevus, in a dose of 0.1 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 20 minutes, moderate swelling of the skin and a strip of hyperemia around the nevus appeared, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. In the period from 32 to 36 days after application, exfoliation of the mummified scabs of the flaming nevus from the underlying skin was observed. At the spot location, for 50 days, a section of skin hyperemia was observed, followed by pigmentation in an area corresponding to the area of application by the herbal composition. Observation of the patient did not reveal any pathological changes in the skin at the location of the flaming nevus.

Epicrisis №43

Patient S. born in 1979 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a skin area with thin dilated vessels on the forehead. These skin changes were detected at birth and increased in size as they grew. When viewed on the skin of the forehead closer to the center, there was a skin area with a diffuse network of dilated vessels, disappearing by dioscopy, measuring 15 × 28 mm. The conclusion of a dermatologist: teleangiectatic nevus. Considering the clinical data and the results of dioscopy, it was decided to carry out local destruction of the telangiectatic nevus using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition to the skin area affected by the nevus was performed in a dose of 0.1 ml. 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a moderate swelling of the skin and a thin strip of hyperemia around the nevus appeared, and after a day darkening and its mummification were observed. No systemic toxic or side effects were recorded. In the period from 32 to 40 days after application, exfoliation of mummified scabs of nevus from the underlying skin was observed. At the location of the nevus, for 62 days, a section of skin hyperemia was observed, followed by pigmentation in an area corresponding to the area of application. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №44

Patient T., born 1960 appealed to the clinic of aesthetic medicine in Kiron (Israel) 05/24/2000 with a complaint about the presence of a dark purple spot on the chest. The described spot appeared in early childhood and increased in size with growth. When viewed on the skin of the anterior surface of the chest, at the level of the 4th rib, near the outer edge of the sternum, a node of cyanotic-crimson color, a soft-elastic consistency with a clear boundary, with a wrinkled surface under which the nodules of dilated veins were visible, was measured in size 1.8 × 2.5 cm. The conclusion of the dermatologist: venous malformation (blue vesiculate nevus). Considering the clinical data and the patient’s desire, it was decided to carry out local destruction of the nevus using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition to the nevus was performed at a dose of 0.1 ml 15 minutes after application, the surface of the nevus acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the nevus appeared, and after 24 hours its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 40-45 days, the mummified scabs of the nevus spontaneously separated from the underlying skin. At the location of the tumor, within 50 days, there was a plot of hyperemia and retraction of the skin, and then its increased pigmentation, in an area corresponding to the area of application. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the nevus.

Epicrisis №45

Patient N., born 1963 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a nodule on the right thigh. The indicated nodule was discovered at birth and slowly increased as it grew. When viewed on the anteromedial surface of the right thigh in the upper third, a hyperkeratotic vascular nodule, dark red in color, of irregular configuration, easily bleeding, with a diameter of 5.0 mm was determined. The conclusion of the dermatologist: angiokeratoma limited. Performed a biopsy, the histological conclusion: angiokeratoma. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of angiokeratoma with the help of a herbal composition. After obtaining consent, an application of the herbal composition to the region of angiokeratoma was performed, at a dose of 0.05 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the angiokeratoma appeared, and after a day, darkening and its mummification were observed. No systemic toxic or side effects were recorded. After 33-36 days, the mummified scabs of the tumor separated from the underlying skin. At the location of angiokeratoma, for 55 days, a site of hyperemia was observed, followed by pigmentation, in an area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the angiokeratoma.

Epicrisis №46

Patient S. 1976 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a node on the right cheek. The described node appeared about six months ago, after a stab wound. On examination, on the right cheek there was a densely elastic, domed papule of bright red color, with a shiny, easily bleeding surface, 10 mm in diameter. The conclusion of the dermatologist: pyogenic granuloma. Performed a biopsy of the granuloma, the histological conclusion: pyogenic granuloma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition to the granuloma was performed at a dose of 0.1 ml. 15 minutes after application, the surface of the pyogenic granuloma acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the granuloma appeared, and after 24 hours, darkening and its mummification were observed. No systemic toxic or side effects were recorded. After 40-43 days, the mummified scabs of granulomas spontaneously separated, and at its location, for 50 days, a section of skin hyperemia was observed, and then its increased pigmentation, according to the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the pyogenic granuloma.

Epicrisis №47

Patient S. 1950 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of several nodules on the abdomen, which appeared several years ago and gradually increased in size. When examined on the skin of the anterior abdominal wall, there were six randomly arranged rounded domed nodules of soft consistency of violet-red color, 2.0-4.0 mm in diameter. The conclusion of the dermatologist: senile angioma. A biopsy of one of the nodules was performed, histological conclusion: capillary hemangioma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the nodules using the herring composition. After obtaining the consent of the patient, an application of the herbal composition to the nodules was performed at a dose of 0.1 ml. 15 minutes after application, the surface of the angiomas turned yellowish-gray. After 25 minutes, a moderate swelling of the skin and a strip of hyperemia around the angiomas appeared, and after a day there was a darkening and mummification of the angiomas. No systemic toxic or side effects were recorded. After 30-35 days, the mummified scabs of angiomas separated from the underlying skin. At their location, over 65 days, areas of skin hyperemia were observed in the area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the angiomas.

Epicrisis №48

Patient T., born in 1938 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of spots on the skin of the feet. These spots appeared about one year ago and slowly increased in size. When viewed on the back surface of the feet, painless reddish-cyanotic spots of irregular shape, with a smooth surface, clear edges, sizes from 0.9 × 1.2 cm to 3.6 × 3.8 cm were symmetrically determined. In the immediate vicinity of these spots were single hemorrhagic rashes in the form of ecchymoses. The conclusion of the dermatologist: Kaposi's sarcoma, spotted stage. When examining the patient’s blood, antibodies to type 1 and type 2 HIV were not detected. 12/10/2000, a tumor biopsy was performed. Histological conclusion: Kaposi's sarcoma, stage of the spot. Considering the results of histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a selenium-containing preparation. 12.24.2000, after obtaining the consent of the patient, the application of selenium-containing preparation on the tumor was performed, at a dose of 0.25 ml. 25 minutes after application, the surface of the spots turned yellowish-gray. After 35 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after 24 hours its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 40-55 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of the tumor, for 70 days, there was a site of hyperemia, and then increased pigmentation, in an area corresponding to the area of application of a selenium-containing drug. Subsequent monitoring of the patient for five years after treatment did not reveal any pathological changes in the skin at the location of the tumor, its metastases or recurrence.

Epicrisis №49

Patient O. born in 1989 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint for the presence of vesicles on the skin of the neck and armpits. These vesicles were found at birth and slowly increased in size. When viewed on the front surface of the neck, armpits, groups of vesicles located on the edematous, densified base, ranging in size from 3.5 to 5.5 mm, were determined. When piercing one of the bubbles, lymph was released. The conclusion of the dermatologist: cystic lymphangioma. Given the results of the histological examination and the desire of the patient’s parents, it was decided to carry out local destruction of all available lymphangiomas with the help of a herring composition. After obtaining the consent of the patient’s parents, the application of the herbal composition on lymphangiomas was performed at a dose of 0.15 ml. 15 minutes after the application, the surface of the lymphangiomas turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the lymphangiomas appeared, and after 24 hours they were darkened and mummified. No systemic toxic or side effects were recorded. After 32-38 days, the mummified scabs of lymphangiomas spontaneously separated from the underlying skin. At their location, for 52 days, areas of hyperemia and then hyperpigmentation of the skin were observed, in an area corresponding to the area of application. Subsequent monitoring of the patient after treatment did not reveal recurrence of lymphangiomas.

Epicrisis №50

Patient I., born in 1963 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint for the presence of tumors on the neck, chest, axillary hollows. Tumors appeared several years ago and slowly increased in size. When viewed on the front surface of the neck, under the mammary glands and in the armpits, there were more than a dozen tumors on a narrow stalk, round or oval in shape, of soft consistency, covered with loose skin of pink color, with a diameter of 1.0 to 7.0 mm. Dermatologist's conclusion: multiple soft fibromas. A biopsy of one of the tumors was performed, histological conclusion: skin fibroma. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of all existing tumors using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition to all existing fibromas was performed, at a dose of 0.2 ml. 15 minutes after application, the surface of the tumors turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumors appeared, and after 24 hours they were darkened and mummified. No systemic toxic or side effects were recorded. After 21-28 days, the mummified scabs of tumors spontaneously separated from the underlying skin. At the location of the tumors, within 30 days, areas of hyperemia were observed followed by hyperpigmentation, in the area corresponding to the area of application of the selenium-containing drug. Observation of the patient after treatment did not reveal recurrence of tumors.

Epicrisis №51

Patient R., born 1949 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint for the presence of plaques on the upper eyelids. These plaques appeared several years ago, gradually increasing in size. When viewed on the skin of the upper eyelids, symmetrically, closer to the inner corners of the eyes, there were slightly raised soft yellow plaques 2.5 × 0.9 cm in size. Dermatologist's conclusion: xanthelasma. A biopsy of one of the plaques was performed, histological conclusion: xanthoma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of xanthelasma using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition to the plaque region was performed at a dose of 0.15 ml. 15 minutes after application, the surface of the plaques acquired a yellowish-gray color. After 25 minutes, a moderate swelling of the skin and a strip of hyperemia around the plaques appeared, and after a day their darkening and mummification were observed. No systemic toxic or side effects were recorded. After 30-38 days, the mummified xanthomas separated from the underlying skin. At their location, for 45 days, areas of skin hyperemia were observed, followed by hyperpigmentation in an area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the xanthoma.

Epicrisis №52

Patient N., born in 1967 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a nodule on the right cheek. The indicated nodule appeared several years before treatment and slowly increased in size. On examination, a dense, domed papule, reddish in color, with a smooth surface with a diameter of 5.0 mm, was determined on the right cheek near the wing of the nose. The conclusion of the dermatologist: fibrous papule. Performed a biopsy of the tumor, the histological conclusion: fibrous papule. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the fibrous papule using a herbal composition. After obtaining consent, an application of selenium-containing preparation was performed on the tumor area, at a dose of 0.05 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the fibrous papule appeared, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 32 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of angiofibroma, for 40 days, a site of hyperemia and then hyperpigmentation was observed, in an area corresponding to the area of application. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the fibrous papule.

Epicrisis №53

Patient L., born in 1935 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor on the neck. The indicated tumor appeared about a year ago and increased in size. On examination, a tight knot with fuzzy borders 1.4 cm in diameter was determined on the back of the neck. The skin above it was slightly pink in color, with a slight ulceration at the top of the knot. The conclusion of the dermatologist: merkelioma. Performed a biopsy of the tumor, the histological conclusion: primary cutaneous neuroendocrine carcinoma (a tumor from Merkel cells). Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed at a dose of 0.15 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after 24 hours the tumor was darkened and mummified. No systemic toxic or side effects were recorded. After 38-42 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of the tumor, for 52 days, there was a site of hyperemia, and then increased skin pigmentation, in an area corresponding to the area of application by the herbal composition. Subsequent monitoring of the patient after treatment did not reveal tumor metastases or its recurrence.

Epicrisis №54

Patient A., born in 1961, turned to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of multiple tumors on the body. These tumors appeared in adolescence, combined with multiple spots that occurred in the first years of life, and lesions of the iris. When examined on the patient’s body, a lot of randomly located coffee-with-milk stains and more than two dozen soft consistency tumors covered with unchanged skin with a diameter of 1.0 to 4.0 cm were determined. When pressed, the tumor easily moved into subcutaneous tissue, approximately each the third tumor was on a leg. Consulted by a dermatologist, conclusion: neurofibromatosis, skin form. Given the clinical data and the patient’s desire, it was decided to carry out local destruction of the tumors using a herbal composition. In agreement with the patient, an application of the herbal composition to the existing tumors was performed, in a dose of 1.5 ml. 15 minutes after application, the surface of the tumors turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumors appeared, and after 24 hours they were darkened and mummified. No systemic toxic or side effects were recorded. After 29-37 days, the mummified scabs of tumors spontaneously separated from the underlying skin. At their location, for 55 days, areas of hyperemia and then hyperpigmentation were observed in the area corresponding to the area of application. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of tumors or their recurrence.

Epicrisis №55

Patient Sh., 1949 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of tumors on the neck in the axillary and inguinal areas. These tumors appeared several years ago before treatment and slowly increased in size. When viewed on the lateral surfaces of the neck, in the armpits and in the inguinal folds, there were more than a dozen round, soft, inelastic outgrowths on the leg, compressed at the base, dark red in diameter from 1.0 to 5.0 mm. The conclusion of the dermatologist: multiple fibroepithelial polyps (acrochordones). A biopsy of one of the tumors was performed, histological conclusion: fibroepithelial polyp. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of all existing tumors using a herbal composition. After obtaining the patient’s consent, an application of the herbal composition was performed on all available fibroepithelial polyps, at a dose of 0.2 ml. 15 minutes after application, the surface of the tumors turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumors appeared, and after 24 hours they were darkened and mummified. No systemic toxic or side effects were recorded. After 24-29 days, the mummified scabs of tumors spontaneously separated from the underlying skin. At the location of the tumors, within 36 days, there were areas of hyperemia with subsequent hyperpigmentation, in the area corresponding to the area of application. Observation of the patient after treatment did not reveal any pathological changes on the skin at the location of the tumors or their recurrence.

Epicrisis №56

Patient S. born in 1939 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of nodules on the face, neck and neck. These nodules appeared several years before treatment, gradually increasing in size. When viewed on the skin of the face, back of the neck, on the occipital region of the head, there were more than a dozen randomly arranged solitary papules of red-brown color with umbilical depression and hyperkeratosis in the center, with a diameter of 2.0-6.0 mm. The conclusion of the dermatologist: warty diskeratoma. A biopsy of one of the nodules was performed, the histological conclusion was: warty diskeratoma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the nodules using the herring composition. After obtaining the consent of the patient, an application of the herbal composition to the nodules was performed at a dose of 0.2 ml. 15 minutes after application, the surface of the nodules acquired a yellowish-gray color. After 25 minutes, a moderate swelling of the skin and a strip of hyperemia appeared around them, and after a day their darkening and mummification were observed. No systemic toxic or side effects were recorded. After 32-36 days, the mummified scabs of tumors separated from the underlying skin. At their location, within 50 days, areas of hyperemia of the skin were observed in an area corresponding to the area of application. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the nodules or their recurrence.

Epicrisis №57

Patient S., born in 1946 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of nodes on the forearms and legs. These nodes appeared a few years before treatment and slowly increased in size. When viewed on the outer surface of the forearms and on the anterior surface of the lower legs, there were more than a dozen flat papules with a clearly defined border, slightly pigmented, located on an erymatous base, 0.2-0.8 cm in diameter. Dermatologist's conclusion: multiple large-cell acanthomas. A biopsy of one of the nodes was performed, histological conclusion: large-cell acanthoma. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of the nodes with the help of a herring composition. After obtaining the consent of the patient, an application of the herbal composition to all available nodes was performed, at a dose of 0.25 ml. 15 minutes after application, the surface of the nodes acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia appeared around them, and after 24 hours there was a darkening and their mummification. No systemic toxic or side effects were recorded. After 30-40 days, the mummified scabs of nodes spontaneously separated from the underlying skin. At their location, for 35-50 days, there were areas of hyperemia, and then increased skin pigmentation, in an area corresponding to the area of application. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the nodes or their recurrence.

Epicrisis №58

Patient K., b. 1956 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a node on the skin of the right shoulder. The duration of the disease was several years. When viewed on the outer surface of the right shoulder in the middle third, there was a solitary papule of violet color, with a Wickham net, 0.9 cm in diameter. Dermatologist's conclusion: benign lichen-like keratosis. A node biopsy was performed, the histological conclusion confirmed the opinion of a dermatologist: benign lichen-like keratosis. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of the site using a herbal composition. After obtaining the consent of the patient, the application of the herbal composition on the node in a dose of 0.15 ml was performed. 15 minutes after application, its surface acquired a yellowish-gray color. After 25 minutes, a slight swelling and a strip of hyperemia appeared around it, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 28 days, the mummified scabs separated from the underlying skin. At the site of the site, within 50 days, there was a section of hyperemia in the area corresponding to the area of application. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the site of the node or its recurrence.

Epicrisis №59

Patient P. 1946 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of warty nodes on his right hand. These nodes appeared several years ago; their appearance was preceded by the formation of gray easily tearing small nodules. At the same time, the patient worked for many years at the refinery. When viewed on the back surface of the right hand and forearm, there were multiple papules, with a warty surface, pale grayish in color, with a diameter of 3-5 mm. The conclusion of the dermatologist: tar keratosis. A biopsy of one of the papules was performed, the histological conclusion was: tarry keratosis. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the papules using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition was performed on all available papules, at a dose of 0.2 ml. 15 minutes after application, the surface of the papules turned yellowish-gray. After 25 minutes, a slight swelling of the skin around the papules appeared, and after 24 hours they were darkened and mummified. No systemic toxic or side effects were recorded. After 20-28 days, the mummified scabs of papules spontaneously separated, and at their location, for 30 days, there were areas of hyperemia with subsequent hyperpigmentation, in an area corresponding to the area of application. Further monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the papules or their recurrence.

Epicrisis №60

Patient S., born in 1929 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a tumor on the neck. The described tumor appeared about a year and a half ago and slowly increased in size. When viewed in the supraclavicular region at the base of the neck, a mushroom-shaped node with a warty surface of dense consistency, on a wide base, easily bleeding with minimal trauma, was brown-red in size 1.6 × 1.5 × 1.2 cm. It was determined by a dermatologist: warty squamous cell carcinoma. Performed a biopsy of the tumor, the histological conclusion: warty squamous cell carcinoma, stage I. Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed at a dose of 0.25 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the tumor appeared, and after 24 hours its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 24-28 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of the tumor, for 50 days, there was a plot of hyperemia and skin retraction, and then hyperpigmentation, in an area corresponding to the area of application. Subsequent monitoring of the patient after treatment did not reveal recurrence of the tumor or its metastases.

Epicrisis No. 61

Patient K., b. 1953 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a nodule on the eyelid of the left eye. The indicated nodule appeared about a year ago and slowly increased in size. When viewed along the edge of the upper eyelid in the region of the inner corner of the left eye, a firm, round, painless nodule of a whitish color 4.0 mm in diameter was determined. The conclusion of the dermatologist: sebaceous carcinoma. Performed a biopsy of the nodule, the histological conclusion: sebaceous carcinoma. Given the results of the histological examination and the patient’s desire, it was decided to carry out local destruction of the nodule with the help of a herring composition. After obtaining the consent of the patient, an application of selenium-containing preparation on the nodule was performed at a dose of 0.05 ml. 15 minutes after application, its surface acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the nodule appeared, and after 24 hours, it was darkened and mummified. No systemic toxic or side effects were recorded. After 32 days, the mummified scabs of the nodule spontaneously separated from the underlying skin. At the site of the nodule, for 35 days, a site of hyperemia was observed, followed by hyperpigmentation, in an area corresponding to the area of application. Observation of the patient after treatment did not reveal recurrence of nodules or its metastases.

Epicrisis №62

Patient G. 1972 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of multiple nodes on the head, neck and mouth. These nodules appeared more than six months ago and gradually increased in size. When viewed on the skin of the scalp, near the auricles, on the lateral surface of the neck on the left and on the mucous membrane of the left cheek, there were multiple randomly located pulsating nodes of soft consistency, red, with a diameter of 3.0 mm to 10.0 mm. The conclusion of the dermatologist: angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma). Performed a biopsy of one of the nodes, the histological conclusion: angiolymphoid hyperplasia with eosinophilia. Considering the clinical data and the results of histological examination, it was decided to carry out local destruction of hemangiomas with the help of a village composition. After obtaining the consent of the patient, an application of the herbal composition was performed on all available hemangiomas, in a dose of 0.4 ml. 15 minutes after application, the surface of the epithelial hemangioma acquired a yellowish-gray color. After 25 minutes, a moderate swelling of the skin and a thin strip of hyperemia around the hemangiomas appeared, and after a day their darkening and mummification were observed. No systemic toxic or side effects were recorded. In the period from the 27th to the 36th day after application, exfoliation of mummified scabs of hemangiomas from the underlying skin was observed. At their location, for 43 days, areas of skin hyperemia were observed followed by pigmentation in an area corresponding to the area of application. Observation of the patient after treatment did not reveal any pathological changes in the skin at the location of the epithelioid hemangioma.

Epicrisis No. 63

Patient O. born in 1978 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a node on the left lower leg. The specified node appeared about a year ago, presumably - after an injury and slowly increased in size. When viewed on the outer surface of the left lower leg in the middle third, a dense intradermal rounded knot with blurred borders and edges merging with normal skin, slightly rising above its level, blue-black in color, 1.6 cm in diameter was determined.Dermatologist's conclusion: benign fibrous histiocytoma ( dermatofibroma). Performed a biopsy of the node, the histological conclusion: benign fibrous histiocytoma. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of dermatofibroma using a herbal composition. After obtaining consent, an application of the herbal composition to the site of the node was performed, in a dose of 0.1 ml. 15 minutes after application, the surface of the node acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia appeared around it, and after a day its darkening and mummification were observed. No systemic toxic or side effects were recorded. After 29 days, the mummified scabs of the site separated from the underlying skin. At its location, for 46 days, there was a site of hyperemia, and then hyperpigmentation, in the area corresponding to the area of application. Subsequent monitoring of the patient did not reveal any pathological changes in the skin at the location of the dermatofibroma.

Epicrisis number 64

Patient S., born in 1928 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a fast-growing node on the skin of the neck. The specified node appeared three months before treatment and rapidly increased in size. On examination, on the right side of the neck, a tight knot with a smooth surface, red, 1.6 cm in diameter was determined. Dermatologist's conclusion: atypical fibroxanthoma. Performed a biopsy of the node, the histological conclusion: atypical fibroxanthoma. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of the site using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition to the tumor was performed at a dose of 0.15 ml. 15 minutes after application, the surface of the node acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the node appeared, and after 24 hours, a darkening and mummification of the node was observed. No systemic toxic or side effects were recorded. After 32 days, the mummified scabs of the site spontaneously separated from the underlying skin. At the site of the site, for 46 days, there was a site of hyperemia, and then increased pigmentation, the area corresponding to the area of application. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the site of the site, its metastases or recurrence.

Epicrisis №65

Patient E., born in 1935 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of a node on the scalp. The specified node appeared several years before treatment and slowly increased in size. When viewed from the skin of the parietal region of the head, there was a dense solitary node raised above the skin level, with ulceration in the center, 1.9 cm in diameter. Dermatologist's conclusion: hair tumor. Performed a biopsy of the node, the histological conclusion: hair tumor (proliferating tricholemal cyst). Given the results of the histological examination and the patient’s desire, it was decided to carry out local tumor destruction using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition on the tumor was performed at a dose of 0.25 ml. 15 minutes after application, the surface of the tumor turned yellowish-gray. After 25 minutes, a slight swelling of the skin and a strip of hyperemia appeared around her, and after 24 hours, her darkening and mummification were observed. No systemic toxic or side effects were recorded. After 33 days, the mummified scabs of the tumor spontaneously separated from the underlying skin. At the location of the tumor, for 40 days, there was a site of hyperemia, and then increased skin pigmentation, according to the area of the corresponding application area. Subsequent monitoring of the patient after treatment did not reveal any pathological changes in the skin at the location of the hair tumor or its recurrence.

Epicrisis №66

Patient R., born 1983 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the presence of nodes on the buttocks and hips. These nodes were discovered at birth and slowly increased in size as they grew. When examined on the buttocks and the back of the thighs, more than a dozen dome-shaped nodes, soft consistency, covered with smooth skin-colored skin, with a diameter of 5.0 to 15.0 mm, were randomly determined. The conclusion of the dermatologist: lipomatous nevi. A biopsy of one of the nodes was performed, histological conclusion: adipose tissue. Considering the results of histological examination and the patient’s desire, it was decided to carry out local destruction of all existing lipomatous nevi using a herbal composition. After obtaining the consent of the patient, an application of the herbal composition was performed on all available nevi in a dose of 0.4 ml. 15 minutes after application, the surface of the nodes acquired a yellowish-gray color. After 25 minutes, a slight swelling of the skin and a strip of hyperemia around the nodes appeared, and after 24 hours they were darkened and mummified. No systemic toxic or side effects were recorded. After 29-35 days, the mummified scabs of the nevi spontaneously separated from the underlying skin. At their location, within 45 days, areas of hyperemia were observed with skin retraction and subsequent hyperpigmentation, according to the area of the corresponding application area. Observation of the patient after treatment did not reveal a recurrence of lipomatous nevi.

Epicrisis №67

Patient I., born in 1952 appealed to the clinic of aesthetic medicine in Kiron (Israel) with a complaint about the increased formation of wrinkles on the skin on the face. Small superficial wrinkles appeared in the patient several years ago, attempts to eliminate them using cosmetics were unsuccessful. When viewed on the skin of the face in the cheeks, around the eyes, nasolabial folds, forehead, a grid of small shallow wrinkles was determined, giving the skin a flabby appearance. The conclusion of the dermatologist: facial wrinkles. Considering the clinical data and the patient’s desire, it was decided to conduct a deep peeling of the facial skin using a herbal composition. After obtaining the consent of the patient with the help of a tampon, a 10% aqueous solution of selenium-containing preparation was applied to skin areas with excessive wrinkle formation, in a dose of 1.5 ml. After 20 minutes after application, the surface of the skin of the face acquired a light yellow color, and after 24 hours, surface mummification of the epidermis was observed. No systemic toxic or side effects were recorded. After 9-10 days, the mummified scabs of the epidermis spontaneously separated from the underlying skin. After that, her mild hyperemia was noted for 10 days. As a result, three weeks after the application, a significant decrease in the number of fine wrinkles on the skin of the face was observed, and in some areas (cheeks) they almost disappeared. Further monitoring of the patient after peeling did not reveal any pathological changes on her skin.

Epicrisis №68

Patient D., born in 1975, turned to the RCCH and PS (Moscow) with complaints of itchy red wet spots between the toes, destruction and exfoliation of the nails on the I and II toes. Prescription of the disease: candidiasis of the skin of the feet. When examined in the interdigital spaces I-II, II-III, III-IV of the toes of both legs, there were exudative pale pink spots with a touch, the nails on the I and II toes were corroded and peeled in the distal sections, the subungual beds had yellowish coloration. Microscopic examination of scrapings from affected areas of the skin revealed Druze fungus. The conclusion of the dermatologist: candidiasis of the skin of the feet with subungual lesion. After obtaining the consent of the patient, without anesthesia, an application of the herbal composition to the affected areas of the skin was performed, at a dose of 0.2 ml. After 12-15 minutes, the treated skin areas turned yellow, a slight swelling and hyperemia appeared around them, and after 20-24 hours they darkened and mummified. After 10-14 days after treatment, the mummified areas were freely separated from the skin, and areas of hyperemia remained in their place for 24-28 days. Subsequent monitoring of the patient revealed no recurrence of candidiasis.

No. Acid, its structural formula and mol. weight R X Y M The amount of acid RCXY (CH ₂ ) _m -COOH Amount of SeO ₂ m.v. = 110.98 Temperature Reaction time The ratio of acid: selenium dioxide Acid concentration g g mole g g mole ° C min moth % one 2-chloro-propionic CH ₃ CHClCOOH 108.52 CH ₃ N Cl 0 65.1 0.6 0.66 0.006 90 150 100: 1 95.0 2 Also CH ₃ N Cl 0 65.1 0.6 2.66 0.024 90 120 25: 1 98.0 3 Also CH ₃ N Cl 0 65.1 0.6 6.66 0.06 85 90 10: 1 70.0 four Also CH ₃ N Cl 0 65.1 0.6 16.6 0.15 80 60 4: 1 50,0 5 Also CH ₃ N Cl 0 65.1 0.6 22.2 0.2 75 180 3: 1 45.0 6 Also CH ₃ N Cl 0 65.1 0.6 33.3 0.3 85 210 2: 1 25.0 7 2-bromo-propionic CH ₃ CHF-COOH 152.92 CH ₃ N Br 0 15.3 0.1 0.11 0.001 70 240 100: 1 45.0 8 2-fluoro-propionic CH ₃ CHFCHOO 92.07 CH ₃ N F 0 18.4 0.2 0.11 0.001 fifty 120 200: 1 50,0 9 2-chloro-2-bromo-propionic CH ₃ CBrClCOOH 187.42 CH ₃ Cl Br 0 37.5 0.2 0.22 0.002 60 90 100: 1 45.0 10 Pentafluoropropionic CF ₃ CF ₂ COOH 164.0 CF ₃ F F 0 32.8 0.2 0.22 0.002 fifty 40 100: 1 50,0 eleven 2-chloro-butyric CH ₃ CH ₂ CHClCOOH 122.52 C ₂ H ₅ N Cl one 24.5 0.2 0.22 0.002 75 120 100: 1 65.0 12 2-chloro-valerianic CH ₃ (CH ₂ ) ₂ CHClCOOH 136.52 C ₃ H ₇ N Cl 2 27.3 0.2 0.11 0.001 90 one hundred 200: 1 50,0 13 2-chloro-caproic CH ₃ (CH ₂ ) ₃ CHClCOOH 150.52 C ₄ H ₉ N Cl 3 45.1 0.3 0.11 0.001 180 60 300: 1 90.0 fourteen 2-chloro-caprylic CH ₃ (CH ₂ ) ₄ CHClCOOH 164.52 C ₅ H ₁₁ N Cl four 32.9 0.2 0.11 0.001 200 thirty 200: 1 90.0 fifteen Phenylchloroacetic C ₆ H ₅ CHClCOOH 170.45 C ₆ H ₅ N Cl 0 17.0 0.1 0.11 0.001 215 thirty 100: 1 95.0

Claims (6)

1. The product in the form of a solution for the treatment of benign, viral, precancerous and malignant non-metastatic skin lesions, dysplastic lesions of visible mucous membranes, fungal skin diseases, correction of wrinkles and age spots, which is a compound of the general formula
H ₂ SeO ₃ · x · [R-CXY- (CH ₂ ) _m —COOH], where x = 2-6,
obtained by the interaction of selenium dioxide with halocarbon
acids of the general formula
R-CXY- (CH ₂ ) _m -COOH,
where R = phenyl, alkyl of the general formula C _n H _{2n + 1} ;
n = 1-5, X = H or Y, Y = F, Cl, Br or J, m = 0-10. 2. The method of obtaining the product according to claim 1, characterized in that selenium dioxide is added to the halocarboxylic acid or its aqueous solution, stirred at a temperature of 20-215 ° C. for 5-480 minutes and then filtered off from the precipitate. 3. The method according to claim 2, characterized in that the concentration of the aqueous halocarboxylic acid solution used in the synthesis of the product according to claim 1, is in the range of 1-98 wt.%. 4. The product in the form of a solution for the treatment of benign, viral, precancerous and malignant non-metastatic skin lesions, dysplastic lesions of visible mucous membranes, fungal skin diseases, correction of wrinkles and senile pigment spots, containing 0.1-50 wt.% Product according to claim 1 , 1-99 wt.% Halocarboxylic acids and the rest is water. 5. A method for the treatment of benign, viral, precancerous and malignant non-metastatic skin lesions, dysplastic lesions of visible mucous membranes, fungal skin diseases, correction of wrinkles and senile age spots, including the topical use of the product according to claim 1 in the form of applications. 6. The method according to claim 5, characterized in that the product is used in the form of ointments, solution, cream, paste or gel.

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