RU2201208C1 - Composition for cosmetic care of problem skin - Google Patents

Abstract

FIELD: cosmetic industry, particularly, remedies for skin care. SUBSTANCE: composition includes primary nutrient and specific additive. Used as primary nutrient is benzyl-dimethyl[3- (miristoilamino)propyl]ammonium chloride. As specific additives may be used aqueous, aqueous-glycerine and/or aqueous-perfumizing solutions, extracts, solutions of gel-formers, aqueous-emulsion cream bases or emulsions. Proposed composition possesses antiacne, antimycotic, and antiinflammatory activity, and also softening, regenerating, conditioning action on problem skin of body, face, feet, head and hair. EFFECT: higher efficiency. 7 cl, 4 tbl

Description

 The invention relates to the cosmetic industry, in particular to the means of preventive care for problem skin.

 Known means for the cosmetic care of problem skin in the form of lotions (US Pat. RF 2029544, 2083186), gels (US Pat. RF 2085105, 2085187, 2089177, 2093141, 2116066, 2136268). The disadvantage of these funds is the presence in the composition of ethyl alcohol, which overdries the skin, or a narrow application, or lack of effectiveness and a limited range of therapeutic and prophylactic effects, or a very multicomponent composition.

 Closest to the claimed technical solution is a gel for the skin of the hands, including, wt%: polyethylene oxide per mol. weighing 1560 Yes - (1.0-2.5), chlorhexidine (0.02-0.07), water - the rest.

 The disadvantages of this tool include a narrow purpose - protective properties due to the formation of a film. Chlorhexidine is used only as a preservative for a solution of polyethylene oxide, as at a concentration above 0.07%, it creates an irritating effect on the skin of the hands. The use of such a gel for facial skin or otherwise is impossible. In addition, it does not have therapeutic properties for problem skin.

It is proposed to use benzyl-dimethyl [3- (myristoylamino) propyl] ammonium chloride as an agent for the cosmetic treatment of problem skin in effective amounts, in particular in the composition, wt%:
Benzyl dimethyl [3- (myristoylamino) propyl] ammonium chloride - 0.01 - 0.5
Target Supplement - Up to 100
At the same time, water, water-glycerin and / or water-perfume solutions, gel-forming solutions, in particular cellulose derivatives, for example hydroxyethyl cellulose, water-emulsion, cream bases, oil / water or water / oil emulsions can be used as a target additive , various floral, herbal extracts, as well as detergent compositions for skin and hair.

 The proposed tool allows you to expand the spectrum of action and the effectiveness of cosmetic care for problem skin of the face, head, body, arms and legs due to the manifestation of anti-dandruff, anti-acne, antifungal effects while softening, regenerating, conditioning and anti-inflammatory action of the agent.

 Depending on the target additive used, the proposed tool can be either a lotion, or a gel, or a cream, or shampoo.

The proposed tool is prepared depending on the chosen cosmetic form, either by mixing the finished target additive with the calculated amount of benzyl-dimethyl [3- (myristoylamino) propyl] ammonium chloride or its 10% aqueous solution, or by directly mixing the calculated amounts of all ingredients at a temperature of 20 ÷ 70 ^o C.

 Benzyl dimethyl [3- (myristoylamino) propyl] ammonium chloride is approved by the Ministry of Health of the Russian Federation as a drug for the prevention of sexually transmitted diseases called Miramistin (VFS 42-2047-91) and is produced by the domestic industry. Other components of the proposed product are traditionally used in cosmetics.

 In the table. 1 shows 12 examples of options for the proposed tool, confirming, but not exhausting all possible combinations and directions of its application.

 In the table. 2 presents the results of evaluating the effectiveness of anti-acne forms of the proposed funds. The studies were conducted on a group of volunteers of both sexes in an amount of 20 people for each cosmetic form aged 15 to 28 years old with a diagnosis of oily skin complicated by acne. We used ND for research methods: "Instructions for the experimental and clinical testing of cosmetics" (Ministry of Health of the USSR, 06/01/86), "Temporary list of indicators", approved by the Civil Code of the Russian Federation of Health Sciences 21.12.93, SanPin 1.2.681-97, accredited testing methods perfumery and cosmetic products of the Institute of Beauty, on the basis of which tests were conducted.

 As can be seen from the data table. 2, all anti-acne cosmetic forms of the claimed funds had a pronounced sebostatic effect and a pronounced effect on the elements of acne.

 From the above results, it follows that the claimed cosmetic products can be recommended for intensive care for oily skin complicated by acne. The observed clinical effect in terms of parameters: lipid content in the skin, total acne load is high.

 In some cases, regression of acne was observed, which indicates the regenerative effect of the proposed remedy.

 In the table. 3 shows the results of the evaluation of the anti-dandruff effect of the claimed drug. Studies were carried out on two groups of volunteers of 20 people each, aged 28 to 45 years, male. The diagnosis is dandruff. Used the same ND as in previous studies of anti-acne forms.

 As can be seen from the table. 3, both cosmetic forms have anti-dandruff effect and, according to the methods of the Institute of Beauty, can be recommended for intensive cleansing care for oily skin of the scalp and hair in the presence of dandruff. The clinical effect of the parameter anti-dandruff effect is high.

 In addition, all volunteers noted the softening and conditioning effect of the product on all types of hair.

 In the table. 4 presents the results of evaluating the effectiveness of the antifungal action of the proposed drug. The studies were carried out in vitro with respect to some cultures of dermatophytes, yeast-like fungus Candida, and fungi of the genera Aspergillus and Penicillium. As can be seen from the table, the claimed tool in the form of forms intended for therapeutic and preventive cosmetic care for problem skin affected by fungi has a pronounced fungicidal effect.

 Studies on volunteers suffering from fungal infections of the feet showed that after 1-2 days of daily 1-2 times the use of the drug in any cosmetic form, itching decreases and subjective sensations improve. After 1-2 weeks there was a persistent improvement. The skin of the feet acquired a healthy appearance, became softer and more elastic. In the case of fungal nail damage, the healing effect was observed after 3-4 weeks, when the growth of a new healthy nail was noticeable. However, a complete improvement of the nail can be obtained only after the patient is completely replaced by a new and healthy one, if all this time, the affected nail is treated with lotion and gel or cream 2 times a day.

 The effectiveness of the anti-inflammatory effect of the claimed drug was tested on 60 volunteers of both sexes aged 25 to 60 years, in which the skin was treated either after mosquito and horsefly bites, or after sunburn, or after shaving. To relieve itching, burning sensation, redness, swelling, a single application of lotion or gel according to the table was enough. 1. With severe sunburn, a second application of the drug was required, depending on the degree of hyperemia, from 2 to 5 times. Healing of light abrasions, scratches after shaving took place without complications already from a single treatment, and with cuts of the skin of both the face and legs, repeated application was required 1-2 times to the places of cuts.

 Anti-inflammatory shampoo was used by 3 male men who, in the absence of dandruff, had itchy scalp after washing with ordinary shampoos.

 After washing the hair with shampoo according to the claimed agent (Table 1), the itching disappeared and did not appear even with daily shampooing with this shampoo.

The inventive tool in all variants of cosmetic forms is stable and does not reduce efficiency when stored at a temperature of 24 ^o With at least 2 years.

 In general, the introduction of benzyl dimethyl [3- (myristoylamino) propyl] ammonium chloride into cosmetics for problematic skin provides a healing, refreshing and cleansing effect. Tools can be the basis for makeup.

 The tool heals abrasions, scratches, protects the skin from peeling, redness, irritation.

 Practical industrial use of the proposed technical solution and the appropriateness of its use in cosmetology is not in doubt.

Claims (6)

1. The tool for the care of problematic skin, including the active principle and the target additive, characterized in that the active principle is benzyl dimethyl [3- (myristoylamino) propyl] ammonium chloride in the following ratio, wt. %:
Benzyl dimethyl [3- (myristoylamino) propyl] ammonium chloride - 0.01-0.5
Target Supplement - Up to 100
2. The tool according to p. 1, characterized in that as the target additive contains water or a water-glycerin and / or water-perfume solution or an aqueous flower-herb extract.  3. The tool according to p. 1, characterized in that as the target additive contains a solution of a gelling agent.  4. The tool according to p. 3, characterized in that as a gelling agent contains derivatives of cellulose.  5. The tool according to paragraphs. 3 and 4, characterized in that as a gelling agent contains hydroxyethyl cellulose, for example tylose.  6. The tool according to p. 1, characterized in that as the target additive contains a water-emulsion cream base, or an oil / water emulsion, or a water / oil emulsion.  7. The tool according to p. 1, characterized in that as the target additive contains a detergent composition for the body and / or hair.

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