RU2201254C1 - Method for treating pathological syndrome and medicinal preparation - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: the suggested method deals with obtaining medicinal preparations with no pronounced side effects and treating different diseases. Method for treating pathological syndrome deals with introduction of super-low doses of antibodies obtained due to multiple successive dilution and environmental impact into the body, to antigen - membranous protein or receptor participating in developing pathological syndrome and/or favoring physiological mechanisms the nonfulfillment of which leads to development of pathological syndrome. Medicinal preparation contains activated form of super- low doses of monoclonal, polyclonal or natural antibodies to membranous protein or receptor participating in development of pathological syndrome and/or favoring physiological mechanisms the nonfulfillment of which leads to development of pathological syndrome, prepared due to multiple successive dilution and environmental impact, predominantly by homeopathic technology. For the purpose to obtain antibodies one should use cellular membrane-bound, intracellular or soluble receptors, predominantly human ones. EFFECT: higher efficiency of therapy and development of new medicinal preparations. 39 cl, 209 ex, 1 tbl

Description

 The invention relates to medicine and can be used to obtain drugs that do not have pronounced side effects, and the treatment of various diseases.

 The use of antibodies for the treatment of pathological syndromes is known from the prior art (SU 1131508 A, A 61 K 39/00, 1984; SU 1730144 A1, C 12 N 7/00, 1992).

 Medicines (serums, immunoglobulins) based on antibodies used in therapeutic doses are also known (for example, see the Russian Drugs Register. Encyclopedia of Medicines, 7th ed., 2000, pp. 358-359), including antibodies to membrane antigens or receptors, in particular to a receptor that binds epidermal growth factor (see Pharmaceutical Bulletin, 5 (204), 02/13/2001, article "New drugs for the treatment of cancer"), which are used to treat cancer.

 However, the use of these drugs can be associated with undesirable side effects in connection with the introduction of significant doses of foreign protein into the body. In this case, antibodies to the receptor block this receptor or cause immunological reactions aimed in some cases at the destruction of the cell carrying this receptor, which limits the scope of their therapeutic use.

 The invention is aimed at increasing the effectiveness of the treatment of pathological syndromes by using activated forms of antibodies to membrane proteins and receptors according to fundamentally new indications - for regulating the pathological syndrome, as well as creating new drugs that do not have pronounced side effects.

 The solution of this problem is ensured by the fact that in the treatment of a pathological syndrome, activated forms of ultra-low doses of antibodies obtained by repeated serial dilution and external exposure are introduced into the body, to the antigen - a membrane protein or receptor involved in the formation of a pathological syndrome and / or mediating physiological mechanisms, violation which leads to the formation of a pathological syndrome.

 The drug contains an activated form of ultralow doses of monoclonal, polyclonal or natural antibodies to a membrane protein or receptor involved in the formation of a pathological syndrome and / or mediating physiological mechanisms, the violation of which leads to the formation of a pathological syndrome, prepared by repeated serial dilution and external exposure, mainly by homeopathic technology.

 At the same time, antibodies to cholinergic receptors are used to obtain an activated form of ultra-low doses of antibodies.

 At the same time, antibodies to hormone receptors - derivatives of amino acids, in particular adrenoreceptors, dopamine receptors, serotonin, histamine, purines, imidazoline receptors, GABA receptors, amino acid receptors, pineal gland hormone receptor (melatone) are used to obtain an activated form of ultra-low doses of antibodies.

 At the same time, antibodies to eicosanoids receptors are used to obtain an activated form of ultra-low doses of antibodies.

 At the same time, antibodies to lipoprotein receptors are used to obtain an activated form of ultra-low doses of antibodies.

 In this case, to obtain an activated form of ultra-low doses of antibodies, antibodies are used against proteins that bind nitric oxide (NO).

 At the same time, antibodies to steroid receptors are used to obtain an activated form of ultra-low doses of antibodies.

 At the same time, antibodies to protein-peptide hormone receptors, in particular kinin receptors, opiate receptors, hypothalamic releasing factor receptors, pituitary hormone receptors, neuropeptide receptors, thyroid hormone receptors, parathyroid hormone receptors, parathyroid hormone receptors, are used to obtain an activated form of ultralow doses of antibodies glands, receptors of hormones of the enterin system, receptors of peptide regulators of the vascular wall, receptors of growth factors, receptors of cytokines, immunoglobulin receptors, differentiation cluster receptors (CD-systems), complement system component receptors, T-lymphocyte receptors, B-lymphocyte receptors, thymus hormone receptors, adhesion factor receptors and cell-cell interactions.

 In addition, intracellular or soluble receptors, predominantly human, are used to obtain antibodies. In this case, it is possible to isolate a fragment from the polypeptide structure of the molecule that is involved in binding to an endogenous or exogenous substance or signal transduction.

 It is preferable to use a mixture of various, mainly hundred, homeopathic dilutions.

 It has been experimentally confirmed that when activated (potentiated) forms of antibodies to the membrane protein or receptor are introduced into the body, it is not suppression, but modification of the activity and / or functional state of the latter that determines the therapeutic effectiveness of the claimed solution.

 Obtained in accordance with the invention, the drug is a new pharmacological preparation, which is characterized by the presence of specific pharmacological activity, the absence of side effects, environmental cleanliness and low cost.

 The drug is prepared as follows.

 For the treatment of a specific disease or pathological syndrome by experimental clinical methods, a membrane protein or receptor is identified that mediates physiological mechanisms, the violation of which leads to the formation of this disease or pathological syndrome.

 The primary polypeptide structure of this protein is determined and a key fragment is synthesized that is involved in binding to an endogenous or exogenous substance or in transmembrane signal transmission to the cell. This fragment is used as an immunogen to immunize laboratory animals to obtain immune antibodies, or in hybridoma technology to produce monoclonal antibodies. The resulting antibodies are purified by affinity chromatography.

 The method of obtaining immune and monoclonal antibodies is described, for example, in the book: Immunological methods. / Ed. G. Fremel. M .: Medicine, 1987, p. 9-33.

 The method of obtaining natural antibodies is described in the book: Natural antibodies to low molecular weight compounds. M.A. Myagkova. M .: MGUL, 2001, p. 70-114.

 The isolated antibodies are sequentially diluted repeatedly and subjected to external influences to obtain ultra-low or low doses, for example, according to the homeopathic potentiation technology (see Homeopathic medicines. Guide for the description and manufacture. V. Schwabe. M., 1967, p. 12-38) . In this case, a uniform decrease in concentration is made by successive dilution of 1 volume part of the starting substance (antibodies) in 9 volume parts (for decimal dilution D) or in 99 volume parts (for hundred dilution C) of a neutral solvent with multiple vertical shaking of each dilution obtained and using mainly separate containers for each subsequent dilution to obtain the desired dose (potency).

 External processing in the process of reducing the concentration can also be carried out by ultrasound, electromagnetic or other physical effects.

 The drug prepared in this way is used mainly in dosage forms and dilutions accepted in homeopathic practice, in the form of alcohol or aqueous solutions or tablets (granules), obtained by soaking the filler in the dosage form with a potentized solution or by directly introducing the latter into a liquid dosage form.

 The following are examples of the effects of activated forms of ultra-low doses of antibodies to various classes, groups and types of receptors.

Antibodies to cholinergic receptors
M-cholinergic receptors
Example 1. Patient K., 65 years old, complained of eye pain after taking pilocarpine for glaucoma. A method is proposed in the form of eye drops of a potentiated solution of polyclonal antibodies to M-cholinergic receptors in homeopathic dilution of C20. When re-examined after 7 days, pain relief was noted. It is recommended to continue the course of treatment.

 Example 2. Oral administration to rats of 0.1 ml of a potentiated solution of antibodies to M1-cholinergic receptors in homeopathic dilution of C50 caused a decrease in conjunctival edema and secretion of tear fluid with the introduction of acetylcholine.

 Example 3. Incubation of isolated atria with a solution of antibodies to M2-cholinergic receptors in the homeopathic potency of C20 leads to an increase in cell permeability of the drug for K ions by an average of 25%.

 Example 4. Patient L., 58 years old, complained of dry mouth after taking pyrene. The appointment of a solution of potentiated antibodies to the M3 cholinergic receptor in homeopathic dilution of C50 in 10 ml 3 times a day allowed to reduce the severity of the side effect of the ganglion blocker.

 Example 5. Patient K., 63 years old, complained of a heartbeat after installing drops of scopolamine when examining the fundus. Oral administration of a solution of monoclonal antibodies to phospholipase C, coupled with M-cholinergic receptors, in homeopathic dilution of C100 allowed to reduce tachycardia.

 Example 6. In an experiment with an isolated segment of the ileum of rats, the preparation of polyclonal antibodies to the M-cholinergic receptor in the form of a combination of homeopathic dilutions C30 and C200 potentiated an increase in the permeability for K ions under the action of acetylcholine.

 Example 7. Oral administration to rats of 0.1 ml of a solution of potentiated antibodies to the M5 cholinergic receptor in homeopathic dilution of C40 led to an increase in heart rate by 30%.

Antibodies to H-cholinergic receptors
Example 8. Patient A., 52 years old, complained of cramps of the lower extremities. Electrolyte abnormalities and diabetes were not detected. A history of sciatic nerve neuralgia. After 2 days of oral administration, 3 times a day, 5 ml of a solution of potentiated polyclonal antibodies to N-cholinergic receptors in homeopathic dilution C30, a decrease in the intensity of convulsive reactions and pain was noted.

 Example 9. Adding to the incubation medium of isolated neurons of the cerebral cortex a solution of antibodies to the α1-subunit of the H-cholinergic receptor in homeopathic dilution of C30 potentiated the depolarization caused by acetylcholine.

 Example 10. Isolated myocytes reacted by changing the membrane potential by 20% in response to the introduction into the incubation medium of potentiated antibodies to the β-subunit of the H-cholinergic receptor in a homeopathic dilution of C100.

 Example 11. In an experiment on isolated neurons of rat cerebral cortex, it was found that antibodies to the α-subunit of the H-cholinergic receptor in the homeopathic potency C30 modulate the transmembrane potential of cells and stimulate the response to acetylcholine.

 Example 12. In an experiment on an isolated rat heart, it was found that introducing into the incubation medium 1% of potentiated antibodies to the γ-subunit of the H-cholinergic receptor in homeopathic dilution of C50 leads to an increase in the concentration of Na ions in atrial myocytes.

 Example 13. Patient G., 47 years old, complained of back pain. The examination revealed rigidity of the muscles of the shoulder girdle and diagnosed with osteochondrosis of the cervical spine, radiculopathy. To reduce muscle stiffness as part of combination therapy, an oral administration of 3 ml per day of 10 ml of a solution of antibodies to the skeletal muscle N-cholinergic receptor in homeopathic dilution C30 was prescribed. When re-examined after a week, a decrease in muscle hypertonicity and the disappearance of pain were noted.

Antibodies to receptors of hormones derived amino acids
Antibodies to adrenergic receptors
Example 14. Patient K., 48 years old, complained of headaches, palpitations associated with emotional stress. An examination revealed an increase in blood pressure to 175/90 mm Hg. The use of a potentiated solution of antibodies to alpha-adrenergic receptors in homeopathic dilution of C30, 1 teaspoon at night, is proposed. With repeated treatment after 2 weeks, there was a tendency to normalize blood pressure (at the time of treatment 150/80). It is recommended to continue the course of treatment.

 Example 15. 3-day administration of a solution of antibodies to adrenergic receptors in homeopathic potency C24 in 1 ml per os caused an increase in the level of glucose and free fatty acids in Chinese hamsters, which indicates the stimulation of glycogenolysis and lipolysis.

 Example 16. The introduction into the incubation medium of rat hepatocytes of antibodies against calmodulin in homeopathic dilution of C30 leads to a decrease in the intensity of adrenaline-induced glycogenolysis. The presence of a specific biological activity of a homeopathic preparation was noted.

 Example 17. Patient Z., 61 years old, complained of dyspnea periodically occurring at night, a wet cough. A history of bronchial asthma. An overnight intake of 1 tablespoon of a potentiated solution of polyclonal antibodies to cAMP phosphodiesterase in homeopathic dilution C100 with the aim of stopping the attacks is proposed. After 5 days, when visiting the patient again, a decrease in the intensity of violations was noted.

 Example 18. On a model of isolated enterocytes of the small intestine of rats, it was shown that incubation of cells with a potentiated solution of polyclonal antibodies to adenylate cyclase in homeopathic dilution of C24 leads to an increase in Na ion transport and modulation of the transmembrane potential.

Antibodies to α-adrenergic receptors
Example 19. Patient M., 67 years old, took clonidine as an antihypertensive agent, complained of drowsiness and impaired coordination of movements. Antibodies to α2-adrenergic receptors were prescribed in homeopathic potency C20, 1 tablespoon at night and a dose reduction of clonidine was recommended. After 4 days, subjectively observed the elimination of side effects of clonidine while maintaining the antihypertensive effect. Subsequently, the patient was transferred to monotherapy with a potentiated antibody drug.

 Example 20. Patient R., 56 years old, took prazosin as an antihypertensive agent. She complained of persistent dizziness and nausea. The administration of antibodies to α1-adrenergic receptors in homeopathic dilution of C50 was prescribed, 1 teaspoon 3 times a day. When re-contacted after a week, complaints of dizziness were noted.

 Example 21. Patient D., 62 years old, with complaints of urination disorders, underwent treatment with Omnic. After 2 weeks, no significant improvements were noted and an additional administration of antibodies to the α1A adrenergic receptor subtype in the homeopathic potency of C30 was prescribed, 5 drops 3 times a day. After a week of combination therapy, the patient noted an improvement in urination. It is recommended to continue the course of treatment.

 Example 22. Patient C., 58 years old, with a diagnosis of benign prostatic hyperplasia underwent treatment with prazosin to improve urination. He complained of dizziness, tinnitus. These symptoms were associated with the hypotensive effect of prazosin. Additionally, a solution of potentiated antibodies to α1B subtype of adrenergic receptors was prescribed in homeopathic dilution of C20, 1 teaspoon at night. After a week, the patient noted a decrease in the symptoms of hypotension to an acceptable level, as well as an increase in its therapeutic effect, which allowed to reduce the dose of prazosin.

 Example 23. In an experiment on an isolated rabbit ureter, it was shown that introducing monoclonal antibodies to α1L-adrenergic receptors into the incubation medium in homeopathic potency C60 decreased tone and increased organ lumen. The conclusion is made about the prospects of the drug for the treatment of urinary disorders.

 Example 24. Patient L., 45 years old, complained of decreased sexual function. Assigned joint administration of yohimbine and potentiated antibodies to α2-adrenergic receptors in homeopathic dilution of C20. After 2 weeks, an improvement in erection was noted, it was recommended to continue the course of treatment.

 Example 25. In an experiment on an isolated uterus of rats, it was found that coadministration of adrenaline and a potentiated solution of antibodies to α-adrenoreceptors in a homeopathic dilution of C40 into the incubation medium causes an increase in muscle contractions by 15-20% more than administration of adrenaline alone.

 Example 26. The introduction into the incubation medium of guinea pig synaptosomes of antibodies to α2-adrenergic receptors in the homeopathic potency of C30 led to an inhibition of serotonin release by 20-30%.

 Example 27. An increase in the membrane potential of isolated rat hepatocytes was observed when antibodies to α1-adrenergic receptors were introduced into the incubation medium in the homeopathic potency of C20.

 Example 28. Incubation of a suspension of human platelets with a 1% solution of antibodies to the α2-adrenergic receptor in homeopathic potency C40 led to the stimulation of aggregation.

Antibodies to β-adrenergic receptors
Example 29. Incubation of isolated guinea pig myocardiocytes with adrenaline stimulated the consumption of oxygen and glucose. The introduction into the environment of 2% of monoclonal antibodies to the β1-adrenergic receptor in homeopathic dilution of C20 caused a decrease in energy metabolism.

 Example 30. Patient F., 39 years old, with a diagnosis of bronchial asthma, complained of a decrease in the effectiveness of salbutamol and a worsening of asthma attacks. Intended administration of potentiated antibodies to β2-adrenergic receptors in homeopathic dilution of C40, 1 teaspoon 3 times a day. After a week, a decrease in the frequency and strength of seizures was noted. The conclusion about the effectiveness of the therapy is made.

 Example 31. Addition to a suspension of human lymphocytes of a 1% solution of potentiated antibodies to the β1-adrenergic receptor in homeopathic dilution of C40 in combination with the PHA mitogen leads to a significant decrease in the blast transformation reaction parameters after 72 hours.

 Example 32. Incubation of isolated rat uterine myocytes with 5% antibodies to β2-adrenergic receptor in homeopathic potency C50 leads to a decrease in transmembrane potential and a decrease in contractile activity 10 minutes after the start of incubation.

 Example 33. Patient Sh., 46 years old, complained of palpitations and pain behind the sternum after exercise. Recommended intake of a solution of polyclonal antibodies to β1-adrenergic receptor in homeopathic dilution of C30, 1 teaspoon 3 times a day. After a week at the second visit, a decrease in the frequency and intensity of seizures was noted.

 Example 34. Patient E., 54 years old, complained of difficulty breathing and shortness of breath. A history of coronary heart disease, prolonged use of anaprilin. The administration of an oral solution of polyclonal antibodies to the β-adrenergic receptor in the homeopathic potency of C20 allowed for 10 days to reduce pulmonary manifestations and continue taking anaprilin. The conclusion is made about the effectiveness of the used homeopathic remedy for stopping the side effects of anaprilin.

Antibodies to dopamine receptors
Example 35. Patient L., 29 years old, underwent treatment with haloperidol in connection with hallucinations. He complained of tremors and impaired coordination of movements 5 days after the start of the drug. The drug was prescribed a solution of polyclonal antibodies to dopamine receptors in homeopathic dilution of C40, 1 teaspoon 2 times a day. When re-examined after a week, a decrease in tremor, a subjective improvement in coordination of movements was noted. Taking an antibody preparation reduced haloperidol doses.

 Example 36. In an experiment on a brain section of rats, it was shown that incubation with a solution of monoclonal antibodies to the dopamine D2 receptor in the homeopathic potency of C40 for 1 hour reduced the release of norepinephrine by 12%.

 Example 37. Patient A., 56 years old, complained of nausea, heaviness in the epigastrium and burping rotten. An examination revealed a violation of gastric motility in the presence of chronic gastritis. As part of complex therapy, an oral administration of a solution of polyclonal antibodies to the dopamine D2a receptor in dopamine homeopathic potency C20 of 10 ml 2 times a day in combination with a diet is prescribed. After 5 days, the patient noted the elimination of the symptoms of the disease.

 Example 38. Administration to mice for 6 days of monoclonal antibodies to D1a dopamine receptor subtype in homeopathic dilution of C40 leads to an increase in the concentration of dopamine receptor mRNA in the hypothalamus. A homeopathic medicine modulates the activity of dopaminergic structures at the level of translation of the genome.

 Example 39. In order to identify the biological effect of the preparation of monoclonal antibodies to the dopamine D1 receptor, a solution of antibodies in homeopathic dilution C30 was administered orally to WISTAR rats. After animal euthanasia, the dopamine concentration in the central nervous system was determined. It was shown that 30 minutes after administration, the release of dopamine in the caudate nucleus increases. It is concluded that there is a biological effect of a homeopathic remedy.

Example 40. Oral administration to rats of 200 μl of a solution of monoclonal antibodies to the D1d receptor in homeopathic potency C40 led to modulation of ³ H-dopamine binding in samples of the cerebral cortex. It is concluded that there is a specific effect of a homeopathic preparation on the properties of receptors.

 Example 41. Patient R., 63 years old, complained of the inefficiency of clozapine prescribed to him in connection with a phobia. It is proposed to supplement the therapy with an aqueous solution of antibodies to the dopamine D3 receptor Dopamine in the form of a mixture of homeopathic dilutions of C50 and C200, 20 drops 3 times a day. After 2 days of treatment, the patient noted the elimination of nocturnal phobias, it is recommended to continue combination therapy.

 Example 42. The preparation of monoclonal antibodies to the D4 receptor in the form of a solution of homeopathic dilution C30 was administered orally to rats in 100 μl. 20 minutes after the administration, a 25 percent decrease in the level of cAMP in the cerebral cortex and cerebellum was noted, which is typical for the activation of D4 receptor structures. It is concluded that there is a biological effect of an antibody solution similar to dopamine.

 Example 43. Sections of rat hypothalamus were incubated in a medium containing 3% monoclonal antibodies to dopamine D5 receptors in homeopathic dilution C40. An increase in the hydrolysis of 3H-phosphoinositol diphosphate was recorded after 15 minutes of incubation. The conclusion is made about the ability of the studied drug to influence the intracellular signal transmission systems associated with D5 receptors.

 Example 44. Patient R., 65 years old, complained of tremors. A history of Parkinson's disease, long-term therapy with levodopa. The conclusion is made about reducing the effectiveness of the drug. The appointment in addition to levodopa of polyclonal antibodies to the dopamine receptor in the form of a solution in homeopathic dilution of C30 of 10 drops at night allowed to reduce the manifestations of parkinsonism.

 Example 45. Oral administration to rats of 100 μl of a solution of antibodies to D2b receptors in homeopathic dilution of C50 led to stimulation of the transport of potassium ions in the intestinal wall. A homeopathic medicine is thus able to modulate the motility of the gastrointestinal tract.

Serotonin Receptor Antibodies
Example 46. Patient M., 57 years old, complained of feelings of anxiety and anxiety for no apparent reason. Polyclonal antibodies to serotonin receptors in a homeopathic potency of C40, 1 teaspoon per dose, have been proposed. When re-examined after 5 days, these complaints are absent. The conclusion about the effectiveness of the therapy is made.

 Example 47. Patient M., aged 39, received therapy with sumatriptan, an agonist of 5HT1D serotonin receptors for migraine. The purpose of co-administration of a potentiated solution of monoclonal antibodies to the 5HT1 receptor in the form of a mixture of homeopathic dilutions of C50 and C200 allowed to reduce the dose of sumatriptan, as well as the intensity and frequency of seizures.

 Example 48. Patient R., 48 years old, complained of insomnia and tremor. A history of prolonged mental overstrain. Reception within 7 days of a solution of monoclonal antibodies to the 5HT2 receptor of serotonin in potency C40, 1 teaspoon at night allowed to normalize sleep.

 Example 49. Patient S., 36 years old, complained of mood depression, decreased performance for no apparent reason. The appointment of a potentiated solution of antibodies to the 5HT4 receptor of serotonin in homeopathic dilution of C40 was prescribed. On a second visit, an improvement in mood and the elimination of feelings of depression were noted.

 Example 50. In an experiment to study aggregation, a 1% solution of antibodies to the 5HT2 serotonin receptor was added to a platelet suspension. A change in ADP-stimulated aggregation was observed in the presence of the drug in homeopathic dilution of C50.

 Example 51. Patient L., 45 years old, complained of intolerable nausea during road trips. Recommended administration of antibodies to the 5HT1 receptor of serotonin in homeopathic dilution of C30 10 drops before the trip. A positive effect of the drug was noted, which allowed to reduce the manifestations of kinetosis.

 Example 52. The introduction of a 5% solution of monoclonal antibodies to 5HT4 receptors in the incubation medium of a rat brain slice in homeopathic dilution of C40 contributed to an increase in the release of labeled serotonin by 15%. The conclusion is made about the ability of the drug to regulate the reuptake of serotonin.

 Example 53. The preparation of monoclonal antibodies to the 5HT3 receptor of serotonin in homeopathic potency C20 was applied to the surface of an isolated rabbit uterine horn. A significant increase in contractile activity of an isolated organ was recorded.

 Example 54. Patient L., 32 years old, complained of itching of the skin. Oral administration of a preparation of antibodies to the 5HT1 receptor of serotonin in the form of a mixture of homeopathic dilutions of C20 and C200, 1 tablet 3 times a day, reduced undesirable symptoms. It is recommended to continue the course of treatment.

 Example 55. An experiment was conducted to evaluate the biological activity of a homeopathic preparation of monoclonal antibodies to imipramine receptors. A sample in the form of a 2% solution in homeopathic dilution of C30 was introduced into the incubation medium of rat brain slices. It was found that the drug stimulates the absorption of serotonin from the incubation medium.

Imidazoline Receptor Antibodies
Example 56. Patient P., 52 years old, complained of headaches and fatigue. During the examination, a diagnosis of hypertension of the 1st degree was made. A homeopathic preparation of antibodies to imidazoline receptors in a potency of C40 is prescribed for 1 tablespoon at night. When re-examined after 7 days, the elimination of headaches and normalization of blood pressure were noted. The conclusion about the effectiveness of the therapy is made.

Antibodies to histamine receptors
Example 57. Patient I., 35 years old, complained of drowsiness and mood depression after taking tavegil for allergic rhinitis. The appointment of a potentiated solution of polyclonal antibodies to histamine receptors in homeopathic dilution of C24. Upon repeated treatment, the patient noted an increase in mental activity, objectively - a decrease in the severity of symptoms of the underlying disease. It is recommended to continue the course of treatment.

 Example 58. Patient O., 51 years old, complained of asthma attacks and unproductive cough. A history of bronchial asthma. A solution is proposed for potentiated monoclonal antibodies to the histamine H1 receptor in homeopathic dilution of C40, 10 drops 3 times a day. On a second visit, a decrease in the frequency and intensity of seizures was noted. It is recommended to continue the course of treatment.

 Example 59. Patient L., 46 years old, with a diagnosis of acute gastritis in the acute stage, was prescribed for oral administration a solution of monoclonal antibodies to the histamine H2 receptor in homeopathic dilution of C60 in 5 ml 2 times a day. 3 days after the start of the course of treatment, the elimination of symptoms of exacerbation (pain, feeling of fullness, nausea) was noted.

 Example 60. The preparation of antibodies to the histamine H3 receptor in homeopathic potency C30 modulated the contractile activity of an isolated rabbit heart when introduced into the incubation medium in an amount of 1%. The concentration of norepinephrine in the incubation medium increased. A conclusion was drawn on the effect of the drug on the release of norepinephrine.

 Example 61. Patient S., 35 years old, was assigned a beta-block histamine receptor blocker for vestibular disorders. She complained of nausea associated with a side effect of the drug. Recommended intake of a solution of potentiated polyclonal antibodies to histamine H3 receptors in homeopathic dilution of C40 10 drops 2 times a day. Elimination of nausea after taking the antibody preparation allowed continued beta-serum therapy.

Purine Receptor Antibodies
Example 62. Patient R., 47 years old, complained of attacks of shortness of breath and wheezing. Examination was diagnosed with bronchial asthma. Prescribed: polyclonal rabbit antibodies to purine receptors in homeopathic dilution C200 1 tablet 3 times a day. 7 weeks after the start of treatment, the patient noted a decrease in the frequency and severity of attacks.

 Example 63. The preparation of 1% antibodies to the adenosine receptor in homeopathic dilution of C50 was introduced into the incubation medium of mouse thymocytes together with the mitogen phytohemagglutinin. After 72 hours, the blast transformation reaction parameters were taken into account. It was found that the preparation of antibodies in potency C50 caused a decrease in the proliferative activity of thymocytes.

 Example 64. Patient M., 57, complained of shortness of breath, swelling of the lower extremities. A history of myocardial infarction, post-infarction cardiosclerosis. The diagnosis of circulatory failure 2B. Previously, the patient received a cocarboxylase preparation, the effect was weakly expressed. In addition, a preparation of antibodies to purine A2 receptors was prescribed in homeopathic dilution of C50. After 7 days at the second examination, the patient notes a decrease in shortness of breath, an improvement in general condition. It is recommended to continue the course of treatment.

GABA Receptor Antibodies
Example 65. The preparation of monoclonal antibodies to GABA (homeopathic dilution C30) in an experiment on rats modulated the bioelectric activity of the cerebral cortex after oral administration of 0.5 ml of an aqueous solution. It is concluded that the drug has an effect on the electrophysiological characteristics of neurons.

 Example 66. Isolated rat striated muscle, when 1% monoclonal antibodies to GABA-B receptors were introduced into the incubation medium in homeopathic dilution of C50, reduced the contractile response to acetylcholine.

 Example 67. Patient G., 41 years old, complained of sleep disturbances. The appointment of a homeopathic preparation of antibodies to the GABA-A receptor in the form of an aqueous solution in a potency of C20 of 10 drops at bedtime was prescribed. After a week of intake, normalization of sleep was noted.

 Example 68. When studying the anticonvulsant activity of antibodies to the benzodiazepine receptor, convulsive syndrome in mice was modeled in a maximum electric shock test. The animals were applied through corneal electrodes with electrical stimuli (50 Hz, 50 mA) lasting 0.2 seconds. The maximum tonic extension of the hind limbs occurring in 100% of the control animals was evaluated. Before the test, the mice of the experimental group were orally administered monoclonal antibodies to the benzodiazepine receptor (a mixture of homeopathic dilutions C12 + C30) 0.2 ml of the solution 2 times 30 and 10 minutes before electrical stimulation. In animals treated with the drug, convulsive syndrome developed in 55% of cases and was on average 30% less pronounced.

 Example 69. The preparation of monoclonal antibodies to the benzodiazepine receptor in a homeopathic dilution of C200 was introduced into the incubation medium of rat brain cortex sections in an amount of 1%. Measurement of the transmembrane potential of neurons showed an increase in the depolarization threshold after drug administration. It is concluded that there is a specific receptor activity of the drug.

 Example 70. Monoclonal antibodies to the gamma subunit of the GABA-A receptor in homeopathic dilution of D12 caused an increase in the transport of C1 ions in isolated neurons of the guinea pig cortex.

 Example 71. Polyclonal antibodies to the components of the chlorine channel in the homeopathic potency C40 increased the threshold for depolarization of Chinese hamster neurons by oral administration of 0.1 ml.

Antibodies to Amino Acid Receptors
Example 72. The biological activity of the preparation of polyclonal antibodies to excitatory amino acid receptors in the form of a solution in homeopathic dilution of C70 was studied in a model of hypoxic hypoxia. The chamber with the animals was purged with nitrogen and the moment of death was recorded. It was found that oral administration of antibodies significantly increases the resistance of mice to hypoxic effects - increases the life time and the number of surviving animals.

 Example 73. When studying the effect of activated ultra-low doses of antibodies to the NMDA receptor on the course of ischemic stroke, local brain ischemia was induced in rats by unilateral ligation of the middle cerebral artery under general anesthesia. Antibodies to the NR1 fragment of the N-methyl-D-aspartate receptor (a mixture of homeopathic dilutions C200 + C1000) were administered orally (0.4 ml of an aqueous solution to a rat) once a day for 3 days before ischemia, and then in the 1st group - every hour, 0.1 ml of an aqueous solution during the day, in the 2nd group - daily for 30 days. In the 1st group (short-term follow-up), the degree of locomotor ataxia was assessed 24 hours after occlusion, then after the cervical dislocation in animals the size of the focus of ischemic necrosis was evaluated (staining of 2,3,5-triphenyltetrazolium chloride - TTX).

 Example 74. In the 2nd group of rats (with long-term follow-up), the degree of locomotor ataxia was assessed daily for 30 days after occlusion, then after cervical dislocation in animals the size of the site of post-ischemic damage in the cerebral hemisphere on the side of occlusion was assessed (TTX stain). It was revealed that in the groups receiving the drug, the degree of locomotor ataxia was significantly lower than in the control. The sizes of the focus of ischemic necrosis 24 hours after occlusion and the focus of postischemic changes 30 days after occlusion were also significantly smaller in groups of rats treated with potentiated antibodies to the NMDA receptor.

 Example 75. Antibodies to the NMDA receptor in homeopathic dilution of C100 were introduced into the incubation medium of rat brain slices together with NMDA. The synergistic effect of NMDA and antibody solution on the level of cGMP in brain sections was established.

 Example 76. Patient G., 26 years old, underwent treatment for exacerbation of epilepsy. As part of complex therapy, an oral administration of a solution of polyclonal antibodies to kainate receptors in homeopathic dilution of C200 was prescribed. The patient noted a decrease in the frequency and intensity of seizures, as evidenced by electroencephalographic examination.

 Example 77. Patient K., 43 years old, complained of tremors and cramps of the lower extremities that arose after mental overstrain. It is recommended to take a solution of monoclonal antibodies to quisqualate receptors in a homeopathic dilution of C50 of 10 drops per night. When re-applying after a week, a decrease in these complaints was registered. It is recommended to continue the course of treatment.

 Example 78. Antibodies to AMPA receptors in homeopathic dilution of C50 were introduced into the culture of rat embryo neurons. After 10 minutes of incubation, an increase in the concentration of Ca ions inside the cells was detected, which indicates the presence of biological activity of ultra-low doses of antibodies.

 Example 79. Monoclonal antibodies to glutamate receptors in homeopathic dilution of C50 when added to the incubation medium reduced the sensitivity of guinea pig brain section cells to cyanide. The intensity of glucose consumption in the experimental group decreased when sodium cyanide was introduced into the incubation medium to a final concentration of 0.01 M by 40%, while in the control experiment there was a 70% decrease in the indicator. It is concluded that there is a specific protective antihypoxic activity of the drug.

 Example 80. Patient Z., 57 years old, complained of pain and cramps of the lower extremities. The appointment of antibodies to glycine receptors in homeopathic dilution of C30 1 tablet 3 times a day allowed to reduce the intensity of convulsive reactions.

 Example 81. The introduction into the incubation medium of rat brain slices of a 1% solution of antibodies to aspartic acid receptors in homeopathic dilution of C100 led to a change in the transmembrane potential of neurons.

Epiphysis hormone receptor antibodies
Example 82. Patient N., 45 years old, complained of sleep disturbance. The administration of an oral solution of antibodies to the melatonin receptor in a potency of C40 of 10 ml per night was prescribed. After 4 days, the patient noted normalization of sleep. It is recommended to continue the course of treatment.

Antibodies to eicosanoid receptors
Example 83. Patient L., 66 years old, complained of nausea and lack of appetite. Examination revealed an exacerbation of chronic gastritis. A history of long-term use of ibuprofen for osteochondrosis with radiculopathy. A preparation of polyclonal antibodies to prostaglandin receptors was prescribed in a homeopathic dilution of C200 10 ml 4 times a day. After 4 days, the patient noted an improvement in appetite and a decrease in nausea, which allowed to continue the course of treatment for the underlying disease.

 Example 84. The anti-inflammatory activity of a monoclonal antibody preparation for the prostaglandin receptor E was studied. Oral administration to rats of 0.1 ml of homeopathic dilution C50 solution reduced the severity of the inflammatory reaction in the model of hind limb edema caused by formaldehyde. The conclusion is made about the presence of anti-inflammatory activity of a homeopathic remedy.

 Example 85. The biological activity of the preparation of antibodies to the prostaglandin F receptor was studied on a model of an isolated rat uterine horn. It was found that the introduction of antibodies into the incubation medium in homeopathic dilution of C50 (1 ml / 100 ml of medium) potentiates the contractile activity of an isolated organ.

 Example 86. Patient U., 51 years old, complained of pain in the joints of the lower extremities. A history of gout. The reception of monoclonal antibodies to cyclooxygenase in homeopathic dilutions of C100 and C200 of 10 ml 3 times a day is proposed. With repeated treatment, a decrease in soreness and swelling of the knee joints was noted. The conclusion about the effectiveness of the therapy is made.

 Example 87. Patient E., 62 years old, complained of pain in the hands. Based on the results of the examination, the diagnosis of metabolic polyarthritis was made. Concomitant peptic ulcer disease did not allow a course of treatment with standard anti-inflammatory drugs. Recommended oral administration of a preparation of antibodies to COX-2 (cyclooxygenase of the second type) in potency C50. After 5 days, the patient noted an improvement in well-being, a decrease in the intensity of pain in the joints of the hands.

 Example 88. Patient R., 47 years old, was hospitalized for exacerbation of coronary heart disease. Concomitant diseases - peptic ulcer, bronchial asthma - limited the possibilities of drug therapy. After discharge from the hospital, a long-term administration of a preparation of antibodies to thromboxane receptors in a homeopathic dilution of C20 is prescribed, 1 tablet per night. 3a 6 months of follow-up, no exacerbations of coronary heart disease were noted, the patient and the attending physician evaluated the results positively. It is recommended to continue the course of treatment.

 Example 89. In an experiment on human platelets, the introduction into the incubation medium of a 1% solution of thromboxane A2 platelet receptor antibodies in homeopathic dilution of C20 led to a decrease in ADP-stimulated aggregation.

 Example 90. Patient B., 54 years old, complained of attacks of shortness of breath and dry cough. A diagnosis of mild bronchial asthma has been made. The reception of a solution of antibodies to the leukotriene receptor in homeopathic potency C30 is proposed. After 7 days of administration, the elimination of cough was noted. It is recommended to continue the course of treatment.

 Example 91. Patient M., 38 years old, complained of urticaria and itching. A history of bronchial asthma, urticaria symptoms developed after prescribing zafirlukast antagonist leukotriene receptors as adjunctive therapy. It is recommended to take a homeopathic preparation of antibodies to the CysLT receptor of leukotrienes in a C50 potency of 20 drops 3 times a day, which eliminated the side effect and continued therapy.

 Example 92. Patient T., 57 years old, complained of pain in the lower extremities. According to the examination, thrombophlebitis was diagnosed. As part of complex therapy, the administration of potentiated antibodies to the prostacyclin receptor in homeopathic dilution of C100 was prescribed for 10 drops 3 times a day, which allowed to reduce the severity of the thrombus formation process. The results of 14 days of taking the drug by the patient and the attending physician are evaluated positively.

 Example 93. Patient E., 61 years old, received a course of inhalation treatment with the herbal preparation Gingko biloba for dry cough. Due to the lack of effectiveness, an additional solution of antibodies to the FAT receptor in homeopathic dilution of C100 was orally administered 10 drops 3 times a day, which eliminated the cough.

Antibodies to Lipoprotein Receptors
Example 94. Patient K., 58 years old, complained of heart attacks. An examination revealed an elevated cholesterol content, was diagnosed with coronary heart disease, atrial fibrillation, and paroxysmal form. As part of complex therapy, polyclonal antibodies to LDL receptors are prescribed in the form of a mixture of homeopathic dilutions of C30 and C200, 10 drops 3 times a day. After 30 days of taking the drug, there was a tendency to normalize cholesterol levels, a decrease in the severity of symptoms of arrhythmia. It is recommended to continue the course of treatment.

Antibodies to Nitric Oxide Binding Proteins (NO)
Example 95. In an experiment on isolated vascular wall myocytes, it was found that a homeopathic preparation of antibodies to the NO-binding site of guanylate cyclase in homeopathic dilution of D6 promotes an increase in cGMP level when introduced into the incubation medium to a final concentration of 5%.

Steroid Receptor Antibodies
Example 96. With the introduction of a solution of antibodies to the glucocorticoid receptor in rats, an increase in the level of glucose in the blood serum of experimental animals was observed. The drug was administered as a solution in potency C40 of 0.4 ml orally. The animals were slaughtered by decapitation under ether anesthesia 30 minutes after administration.

 Example 97. Patient M., 46 years old, complained of overwork. Diagnosed with functional asthenia. Reception within 5 days of 10 ml of a solution of antibodies to the glucocorticoid receptor in homeopathic potency C40 allowed to increase physical performance, normalize sleep.

 Example 98. Patient U., 42 years old, complained of dizziness, impaired sexual function. Examination revealed hypotension against the background of psychoemotional overstrain. A homeopathic preparation of antibodies to the androgen receptor in a homeopathic dilution of C30 of 10 drops per night is proposed. Conducted therapy contributed to the normalization of sexual function after 5 days of treatment.

 Example 99. Patient D., 51 years old, complained of palpitations, hot flashes, fluctuations in blood pressure and mood, dyspnea attacks. The survey did not reveal organic disorders. Climacteric syndrome is diagnosed. The appointment of a polyclonal antibody preparation to estrogen receptors in a homeopathic dilution of C100, 1 tablet per night, eliminated these symptoms. The patient subjectively evaluates the results of treatment positively.

 Example 100. Patient S., 27 years old, complained of pain from the lower abdomen, spotting outside of menstruation. A history of endometriosis, prolonged use of oral contraceptives. Additionally, a homeopathic preparation of antibodies to progesterone receptors in homeopathic dilution of C200 was prescribed. Oral administration of 5 ml 3 times a day allowed to reduce the severity of symptoms after 2 weeks of treatment.

 Example 101. Patient N., 58 years old, complained of shortness of breath and swelling. On examination, heart failure was detected against a background of cardiosclerosis. The preparation of monoclonal antibodies to the aldosterone receptor was prescribed in homeopathic dilution of C30 in the form of an aqueous solution. Taking a homeopathic remedy 3 times a day for 10 drops allowed to reduce the symptoms of fluid retention.

 Example 102. Patient S., 12 years old, was admitted with complaints of cramps and increased muscle tone. Examination revealed symptoms of hypocalcemia. Recommended intake of calcium and vitamin D3 preparations in combination with monoclonal antibodies to the ergocalciferol receptor in homeopathic dilution of C50 1 tablet 2 times a day. Conducted therapy has eliminated the symptoms of hypocalcemia.

 Example 103. In an experiment on an isolated segment of the small intestine, it was found that introducing into the incubation medium 1% of antibodies to the vitamin D3 receptor in homeopathic dilution of C60 enhances the biotransport of calcium ions through the intestinal wall.

Antibodies to receptors of protein-peptide hormones
Antibodies to kinin receptors
Example 104. Patient I., 43 years old, complained of a dry cough for 3 weeks. During the examination, an exacerbation of chronic obstructive bronchitis was diagnosed. Antibodies to the bradykinin receptor are suggested in homeopathic dilution of C100, 10 drops 4 times a day. After 5 days, a repeated examination noted the elimination of cough and a decrease in obstructive changes in the lungs.

 Example 105. Patient B., 57 years old, suffering from allergic dermatitis for a long time, complained of skin itching. The administration of a preparation of polyclonal antibodies to kinin receptors in a homeopathic dilution of C50 was administered orally 3 times a day, 5 ml each. After 4 days, a decrease in itching was noted. Subjectively, the patient noted improvement in well-being. It is recommended to continue the course of treatment.

 Example 106. In an experiment on an isolated segment of the rat ileum, it was found that antibodies to the kinin receptor in homeopathic dilution of C50 when introduced into the medium (2%) stimulate contractile activity during incubation for 30 minutes.

 Antibodies to B1 kinin receptors.

 Example 107. Antibodies to the kinin receptor type B1 in homeopathic dilution of C40 with oral administration to rats of 0.1 ml each reduced the antihypertensive response to histamine administration. The conclusion is made about the presence of biological activity in antibodies in ultra-low doses.

Antibodies to B2 kinin receptors
Example 108. The preparation of monoclonal antibodies to the kinin receptor type B2 in a homeopathic dilution of C50 was introduced into the incubation medium of isolated vascular wall myocytes to a final dilution of 1%. Stimulation of the transmembrane current of Ca ions was observed, which indicates the presence of a specific biological activity of the drug.

Leptin Receptor Antibodies
Example 109. Patient Sh., 29 years old, is observed for alimentary obesity 3 tbsp. Body mass index (BMI) is 35 kg / m ² . Repeated diet therapy, as well as taking anorexigenic drugs were ineffective. The patient was prescribed: polyclonal rabbit antibodies to the leptin receptor (a mixture of homeopathic dilutions C200 + C1000) 1 tablet 2 times a day in combination with dosed physical activity. A month after the start of treatment, the patient noted a general improvement in well-being, increased tolerance to physical activity; body mass index decreased from 35 to 32 units. 2 months after the start of treatment, BMI = 29, along with a decrease in weight, the patient notes a natural decrease in appetite and an increase in exercise tolerance. It is recommended to continue taking the drug 1 tablet every other day.

Opiate Receptor Antibodies
Example 110. Patient G., 23 years old, was treated for drug dependence. A history of taking opiate drugs during the year. The administration of antibodies to opiate receptors in the homeopathic dilution of C1000 10 ml 5 times a day as part of complex therapy eliminated depression and reduced the intensity of withdrawal symptoms.

Antibodies to mu1 opiate receptors
Example 111. Patient I., 68 years old, received tram as a symptomatic treatment of pain due to cancer. I complained about the lack of effectiveness of the drug. A technique is proposed together with a tramal for antibodies to μ ₁ receptors of opiates in homeopathic dilution of C50 of 10 drops per dose. The patient noted the elimination of pain. It is recommended to continue the course of treatment.

Antibodies to mu2-opiate receptors
Example 112. Patient G., 19 years old, was taken to an emergency room with symptoms of severe alcohol intoxication, respiratory failure, bradycardia. The appointment as a part of complex therapy of a solution of antibodies to μ ₂ opiate receptors in homeopathic dilution of C40 10 ml 3 times a day allowed to reduce the severity of respiratory depression and normalize heart rate.

Antigens to sigma opiate receptors
Example 113. Patient B., 21 years old, was taken to a hospital in a state of psychomotor agitation associated with the use of an unidentified drug. An examination revealed a violation of the perception of the shape and color of surrounding objects, dysphoria. Reception of monoclonal antibodies to opiate σ-receptors in the form of a solution in homeopathic dilution of C60 in 10 ml 3 times a day allowed to reduce the severity of productive symptoms.

Antibodies to Delta Opiate Receptors
Example 114. In an experiment on a segment of the small intestine of a rat, it was found that the preparation of monoclonal antibodies to opiate δ receptors in homeopathic dilution D24 modulated the contractile activity of an isolated organ when a 1% aqueous solution was introduced into the incubation medium.

Kappa opiate receptor antibodies
Example 115. Patient A., 57 years old, complained of drowsiness and dizziness after taking tram. The drug was prescribed in connection with post-traumatic pain syndrome. The administration of an oral solution of antibodies to opiate κ receptors in homeopathic dilution of C40 of 10 drops 3 times a day eliminated dizziness and sedation.

Epsilon-opiate receptor antibodies
Example 116. Antibodies to opiate ε-receptors were administered orally to guinea pigs in the form of an aqueous solution in homeopathic dilution of C40 in 0.1 ml once daily for 7 days. The control animals were injected with a solvent. After decapitation of animals under ether anesthesia, the level of pituitary hormones in the blood serum was determined. A significant change in the concentration of prolactin and gonadotropins in the group of animals treated with the drug was recorded.

Antibodies to receptors of hypothalamic releasing factors
Antibodies to corticoliberin receptors
Example 117. Patient K., 43 years old, complained of dizziness, headache, and tinnitus. The examination revealed a decrease in blood pressure to 100/60 mm Hg. and a preliminary diagnosis of hypothalamic crisis. It is recommended that monoclonal antibodies to the corticoliberin receptor be taken as a tonic in the form of a solution in homeopathic dilution of C60, 10 drops per night. With repeated treatment after 7 days, an improvement in well-being, stabilization of blood pressure was noted.

Antibodies to gonadoliberin receptors
Example 118. Patient L., 45 years old, complained of decreased sexual function, irritability. An examination of organic disorders was not detected. The appointment of a preparation of polyclonal antibodies to gonadoliberin receptors in homeopathic dilution of C40 of 10 ml 3 times a day helped to improve mood and eliminate erectile dysfunction.

Prolactoliberin Receptor Antibodies
Example 119. Patient R., 52 years old, complained of periodic redness of the skin, a feeling of heat, palpitations, fluctuations in blood pressure and mood. The survey did not reveal organic disorders. Climacteric syndrome is diagnosed. It is recommended to take monoclonal antibodies to the prolactoliberin receptor in homeopathic dilution of C50, 15 drops per night. With repeated treatment after 10 days, a decrease in the vegetative manifestations of menopausal syndrome was noted. The results of treatment are evaluated positively.

Thyroliberin Receptor Antibodies
Example 120. Patient A., 34 years old, complained of palpitations, pain in the heart, anxiety, sleep disturbance. Based on the results of the examination, thyrotoxicosis was diagnosed. As part of the complex therapy, antibodies to the thyroliberin receptor are prescribed in homeopathic dilution of C50, 10 drops per night. When re-examined after 7 days, a decrease in these symptoms was noted. It is recommended to continue the course of treatment.

Antibodies to somatoliberin receptors
Example 121. A solution of antibodies to somatoliberin receptors in homeopathic dilution of C50 was introduced into the incubation medium of adenohypophysis cells to a final dilution of 1% by volume of medium. A tendency to stimulate the secretion of somatopropic hormone was recorded after 24 hours of incubation.

Antibodies to somatostatin receptors
Example 122. Incubation of the primary monolayer culture of the adenohypophysis with a solution of potentiated antibodies to the somatostatin receptor in the homeopathic
dilution of C40 leads to a significant change in the level of intracellular Ca after 15 minutes of incubation, which indicates the presence of biological activity of the drug.

Antibodies to pituitary hormone receptors
Growth hormone receptor antibodies
Example 123. In the experiment, stimulation of the proliferative activity of a human fibroblast culture was observed when a solution of polyclonal antibodies to the somatotropic hormone receptor in homeopathic potency C50 was introduced into the incubation medium, the incubation time was 24 hours.

Antibodies to thyroid stimulating hormone receptors
Example 124. Patient M., 23 years old, complained of drowsiness, lethargy, and frequent infectious diseases. The examination revealed a lack of thyroid function. The administration of a preparation of antibodies to the thyroid-stimulating hormone receptor in homeopathic dilution of C50 of 5 ml 3 times a day made it possible to reduce the symptoms of hypothyroidism - normalization of blood pressure and improvement in general condition were observed after 2 weeks of therapy.

Antibodies to luteinizing hormone receptors
Example 125. Patient P., 35 years old, complained of menstrual irregularities. The examination revealed anovulatory cycles. Prescribed: antibodies to the luteinizing (luteotropin) hormone receptor in homeopathic dilution C200, 1 tablet every other day. After 30 days of taking the drug, the menstrual cycle returned to normal.

Antibodies to follicle-stimulating hormone receptors
Example 126. Patient G., 31 years old, was undergoing treatment for infertility. Recommended administration of antibodies to follicle-stimulating hormone receptors in LM5 homeopathic potency, 1 tablet every other day. After two months of treatment, pregnancy was reported.

Prolactin Receptor Antibodies
Example 127. Patient D., 25 years old, complained of a lack of lactation 2 weeks after delivery. The reception of monoclonal antibodies to the prolactin receptor in homeopathic potency C60 of 10 ml 3 times a day is proposed. After 3 days, the patient noted the stimulation of milk production.

Antibodies to receptors of melanocyte stimulating hormone
Example 128. Patient M., 28 years old, complained of fatigue and pain in the eyes. An examination revealed an increase in intraocular pressure. Recommended administration of antibodies to melanotropin receptors (intermedin, melanocytostimulating hormone) in homeopathic potency C50 5 ml 3 times a day. When re-examined after 4 days, normalization of intraocular pressure was recorded.

ACTH receptor antibodies
Example 129. In an experiment on cell culture of the adrenal glands, an increase in cAMP level was recorded after a 1% solution of antibodies to the adrenocorticotropic hormone receptor (corticotropin) was added to the incubation medium in a homeopathic dilution of C30.

Antibodies to vasopressin receptors
Example 130. A decrease in blood pressure was registered in rats with hereditary hypertension after oral administration of 0.1 ml of antibodies to the vasopressin receptor in homeopathic potency C40.

Antibodies to oxytocin receptors
Example 131. Investigated the concentration of calcium ions in the uterus of rats when exposed to a solution of antibodies to the oxytocin receptor. An increase in the level of intracellular calcium in rat uterine tissue was recorded after oral administration of 0.05 ml of a solution of potentiated antibodies to the oxytocin receptor in homeopathic dilution of D6.

Antibodies to neuropeptide receptors
Antibodies to neuropeptide Y receptors
Example 132. Patient K., 64 years old, underwent rehabilitation after an ischemic stroke. Reception of monoclonal antibodies to the neuropeptide Y receptor in the form of a solution in homeopathic dilution of C40, 10 drops 3 times a day for 10 days, significantly accelerated the regression of aphasia, intellectual and mnestic disorders.

Antibodies to neurotensin receptors
Example 133. Patient D., 41 years old, complained of headaches, nausea. The examination revealed an increase in blood pressure to 160/90. Diagnosed with hypertension. The administration of antibodies to the neurotensin receptor in homeopathic potency of C50 of 5 ml per appointment 3 times a day was prescribed. After 5 days, the patient noted normalization of health. It is recommended to continue the course of treatment.

Antibodies to Akt4-10 peptide receptors
Example 134. An experiment was conducted to evaluate the psychotropic activity of homeopathic dilutions of the preparation of antibodies to the peptide receptor akt4-4-10. The rats were injected with a mixture of homeopathic dilutions C12, C30 in the form of a solution of 0.1 ml orally. It was found that the drug accelerates the production and helps to fix conditioned reflexes.

Antibodies to receptors of substance P
Example 135. Patient L., 57 years old, complained of impaired memory and concentration. The administration of monoclonal antibodies to the substance P receptor was prescribed in homeopathic potency C200, 10 drops 3 times a day. After 7 days of admission, the patient noted an improvement in memory. It is recommended to continue the course of treatment.

Delta Sleep Peptide Antibodies
Example 136. Patient G., 48 years old, complained of insomnia. Recommended administration of a solution of antibodies in potency C50 to the delta-sleep peptide receptor, 20 drops per night. After 3 days, the patient noted an improvement in falling asleep and an increase in the duration of sleep.

Thyroid hormone receptor antibodies
Thyroxine Receptor Antibodies
Example 137. Patient L., 32 years old, complained of tachycardia, increased blood pressure, mood swings, sleep disturbance. Examination revealed thyrotoxicosis. The administration of a preparation of antibodies to the thyroxin receptor in a homeopathic dilution of C200 was prescribed, 10 drops 3 times a day. After 7 days, the patient noted improvement in well-being.

Antibodies to the hormones of the parathyroid glands
Thyrocalcitonin Receptor Antibodies
Example 138. A change in the concentration of calcium and phosphate in the blood serum of rats was recorded after 7 days of oral administration of 0.1 ml of a solution of antibodies to the thyrocalcitonin receptor in homeopathic potency C40.

Parathyroid hormone receptor antibodies
Example 139. Patient Sh., 46 years old, complained of cramps of the lower extremities. The appointment of calcium gluconate in combination with a solution of antibodies to the parathyroidin receptor (parathyroid hormone) of 10 ml per reception in homeopathic potency C50. The treatment allowed to eliminate convulsive reactions.

Pancreatic hormone receptor antibodies
Antibodies to insulin receptors
Example 140. In an experiment on a cell culture of fibroblasts, the biological activity of monoclonal antibodies to the insulin receptor was evaluated. It was established that introducing into the incubation medium 1% homeopathic potency of C30 led to stimulation of proliferative activity of cells after 4 hours of incubation.

 Example 141. Patient V., 60 years old, is observed by an endocrinologist for type 2 diabetes mellitus, subcompensated, with a risk of microangiopathy and hypercholesterolemia, obese (BMI = 30). Sugar-lowering drugs and insulin preparations do not allow sufficient control of the level of glycemia. The patient was prescribed: monoclonal antibodies to the insulin receptor alpha (a mixture of homeopathic dilutions D6 + C12 + C30), 5 drops of an alcohol solution 2 times a day. With daily monitoring of the level of glycemia, carried out a week after the start of treatment, a significant decrease in insulin tolerance was revealed. 3 weeks after the start of treatment, the patient was canceled insulin, because glycemia was controlled by mannil. 5 weeks after the start of treatment, the patient noted an improvement in overall health, an increase in exercise tolerance; BMI decreased to 27. Fasting glucose levels of 6 mmol / L. The patient was transferred to monotherapy with a preparation of antibodies to the insulin receptor, 1 tablet 2 times a day.

Glucose Carrier Antibodies
Example 142. Patient M., 48 years old, suffering from insulin-dependent diabetes mellitus, complained of the lack of effectiveness of insulin therapy. A preparation of antibodies to the glucose transporter in a homeopathic dilution of C1000 was prescribed in conjunction with the diet, 1 tablet 2 times a day. A 10-day administration of an antibody preparation reduced signs of insulin tolerance. It is recommended to continue the course of treatment.

Glucagon receptor antibodies
Example 143. Patient R., 26 years old, complained of intolerance to hunger, dizziness, nausea, weakness. The examination revealed hypotension, bradycardia, a tendency to hypoglycemia. A course of monoclonal antibodies to the glucagon receptor is recommended. Oral administration of antibodies in homeopathic potency of C60 in 10 ml allowed to normalize blood pressure and improve hunger tolerance after 7 days of therapy.

Gastrointestinal hormone receptor antibodies
Gastrin-releasing peptide receptor antibodies
Example 144. Patient R., 46 years old, complained of heaviness in the stomach, nausea, heartburn. Examination revealed chronic gastritis in the acute stage. Prescribed: antibodies to the receptor for the gastrin-releasing peptide in homeopathic dilution of C200, 1 tablet 2 times a day. After 3 days of admission, the patient was normalized.

Antibodies to gastrin receptors
Example 145. Patient G., 52 years old, complained of nausea, lack of appetite. Identified atrophic gastritis with low acidity. Recommended intake of polyclonal antibodies to the gastrin receptor in homeopathic dilution of C80 in 10 ml 3 times a day. Upon repeated examination after 5 days, normalization of gastric secretion was noted.

Enterogastrin Receptor Antibodies
Example 146. Patient N., 42 years old, complained of belching, heartburn, flatulence. Examination revealed chronic gastritis in the acute stage. Reception of monoclonal antibodies to the enterogastrin receptor in homeopathic dilution of C50 allowed normalizing well-being after 2 days of taking 20 drops 3 times a day.

Secretin Receptor Antibodies
Example 147. An experiment was conducted to study the biological activity of ultra-low doses of antibodies to the secretin receptor. After administering 1 ml of the drug, pancreatic secretion of enzymes and bicarbonate was recorded in the dog at a homeopathic dilution of D100. The modulating effect of the homeopathic remedy is registered.

Cholecystokinin Receptor Antibodies
Example 148. Patient M., 57 years old, complained of nausea, pain in the right hypochondrium. An examination revealed cholelithiasis. The appointment of a preparation of monoclonal antibodies to cholecystokinin in homeopathic dilution of C50 in 10 ml 3 times a day allowed to eliminate the pain syndrome.

Motilin Receptor Antibodies
Example 149. Patient L., 56 years old, complained of atonic constipation. An examination of the organic pathology of the intestine was not detected. The administration of antibodies to the motilin receptor in homeopathic potency C40 of 5 ml 3 times a day was prescribed. After 7 days of admission, the patient noted an improvement in intestinal evacuation function.

Antibodies to receptors of vaso-intestinal peptide
Example 150. The introduction into the incubation medium of the primary culture of pancreatic cells of a 1% solution of antibodies to the receptor of the vaso-intestinal peptide in homeopathic dilution of C30 led to an increase in the level of cAMP after 10 minutes of incubation.

Antibodies to bombesin receptors
Example 151. Oral administration to rats of ultra-low potentiated doses of antibodies to the bombesin receptor in homeopathic potency C50 led to an increase in the level of intracellular calcium in pancreatic cells. The conclusion about the presence of specific activity of antibodies
Pancreatic Polypeptide Receptor Antibodies
Example 152. Patient O., 39 years old, underwent treatment for obesity. As part of the complex therapy, ultra-low doses of antibodies to the pancreatic polypeptide receptor in the homeopathic potency C1000 of 10 ml 3 times a day are prescribed. There was a decrease in appetite and an increase in exercise tolerance 7 days after taking the drug.

Antibodies to receptors of peptide regulators of the vascular wall
Antibodies to endothelin receptors
Example 153. Patient I., 57 years old, complained of pain in the heart, interruptions in the heart. Diagnosed with coronary heart disease. As part of complex therapy, monoclonal antibodies to the endothelin receptor are prescribed in the homeopathic potency of C40 orally, 10 drops 3 times a day. Upon repeated examination, a decrease in the manifestations of arrhythmia and angina pectoris was noted. Patient results are evaluated positively. It is recommended to continue the course of treatment.

Antibodies to hyperpolarizing relaxation factor receptors
Example 154. Patient M., 37 years old, is observed for hypertension of the 1st degree (blood pressure 150/90). The appointment of ultra-small potentiated doses of antibodies to the receptor of the hyperpolarizing relaxation factor in homeopathic dilution of C30, 1 tablet 2 times a day, allowed to normalize blood pressure.

Antibodies to receptors of the endothelial natriuretic peptide
Example 155. In an experiment on isolated arterial myocytes, the biological activity of an antibody preparation to an ENUP receptor, an endothelial natriuretic peptide, was recorded. A solution of antibodies in homeopathic potency C50 caused a change in the membrane potential of myocytes when added to the incubation medium at a concentration of 1%.

 Antibodies to angiotensin receptors.

Antibodies to angiotensin 2 receptors
Example 156. When studying the effect of activated forms of ultralow doses of antibodies (AT) to the angiotensin 2 receptor on blood pressure (BP) of ISIAH rats with hereditary arterial hypertension of the ISIAH line, caudal arterial blood pressure was evaluated after 5 days of administration of per os potentiated polyclonal rabbit anti-C-terminal antibodies a fragment of the human angiotensin 2 receptor in the form of a mixture of homeopathic dilutions C12 + C30 + C200 in 0.5 ml of an aqueous solution.

 The results of measuring blood pressure before and after drug administration are presented in the table.

 From the data given in the table it follows that the drug has a pronounced hypotensive effect.

 Example 157. Patient D., 56 years old, received captopril for hypertension. He complained of coughing. Cough is found to be a side effect of captopril. The recommended intake of monoclonal antibodies to the angiotensin II receptor in homeopathic potency C50, 1 tablet 3 times a day, allowed to reduce the dose of captopril while maintaining the hypotensive effect.

Vascular Permeability Receptor Antibodies
Example 158. The preparation of antibodies to the receptor of the TFP-vascular permeability factor in homeopathic dilution of C30 was introduced into the medium of the incubation of an artery segment together with norepinephrine. It was found that the antibody solution potentiated the constrictor activity of norepinephrine.

Antibodies to atrial natriuretic peptide receptors
Example 159. Patient B., 46 years old, complained of pain in the heart, dizziness. An examination revealed hypertension of the 2nd degree. Recommended intake of antibodies to the PNUP receptor - atrial natriuretic peptide in homeopathic dilution of C50 10 drops 3 times a day. Upon repeated examination, normalization of blood pressure, improvement of well-being were registered.

Antibodies to growth factor receptors
Erythropoietin Receptor Antibodies
Example 160. Patient L., 34 years old, complained of dizziness, weakness, fatigue. A history of 3 births. An examination revealed a decrease in hemoglobin levels. Diagnosed with iron deficiency anemia. Taking iron preparations did not give a pronounced effect. The administration of monoclonal antibodies to the erythropoietin receptor in homeopathic potency C50, 1 tablet 3 times a day, reduced the severity of anemia symptoms after 3 weeks of treatment.

Platelet Growth Factor Receptor Antibodies
Example 161. Patient G., 68 years old, complained of subcutaneous hemorrhage. Examination revealed multiple petechiae. Assigned monoclonal antibodies to the platelet growth factor receptor in homeopathic potency C200 in 5 ml of an aqueous solution 3 times a day. When re-examined after 10 days, a tendency to a decrease in the number of new hemorrhages was noted.

Antibodies to vascular growth factor receptors
Example 162. Patient M., 56 years old, complained of pain in the heart, arrhythmia. According to the results of the examination, a diagnosis of coronary heart disease, angina pectoris was diagnosed. The appointment of ultra-low potentiated doses of antibodies to the receptor for vascular growth factor in homeopathic potency C50 of 10 drops 3 times a day allowed to reduce the severity of symptoms of arrhythmia and angina pectoris. It is recommended to continue the course of treatment.

Antibodies to nerve growth factor receptors
Example 163. Patient A., 61 years old, was undergoing rehabilitation after an ischemic stroke. In connection with paresis of the lower extremities, the appointment of potentiated by homeopathic technology antibodies to nerve growth factor receptors in a dilution of C30 1 tablet 2 times a day was prescribed. After 14 days of therapy, an increase in the volume of voluntary movements, an increase in the strength and sensitivity of the lower extremities, was noted.

Antibodies to endothelial growth factor receptors
Example 164. When cultivating the human umbilical cord endothelium in the presence of antibodies to the endothelial growth factor receptor in homeopathic dilution C50, it was found that antibodies stimulate cell proliferation by 15%, indicating the presence of specific biological activity.

Antibodies to epidermal growth factor receptors
Example 165. Patient O., 63 years old, applied for recurrent common trophic ulcers of the medial surfaces of both lower legs (in the lower third). Ulcers are caused by varicose veins of the lower extremities, however, surgical treatment is impossible due to the condition of the skin. Treatment for 3 months with drugs that stimulate regeneration (solcoseryl, actovegin, derinat) did not give a pronounced effect. Prescribed: rabbit polyclonal antibodies to the epidermal growth factor receptor (a mixture of homeopathic dilutions C30 + C200 + C1000) 1 tablet 2 times a day. With a second appearance after 2 weeks, a 2-fold decrease in the area of trophic ulcers was revealed; 4 weeks after the start of treatment, trophic ulcers completely epithelized.

 Example 166. Patient M., 67 years old, complained of a trophic ulcer of the lower limb. Appointment of applications of antibodies to the epithelial growth factor receptor in homeopathic dilution of C50 (aqueous solution) allowed to stimulate healing after 7 days of treatment.

Hepatocyte Growth Factor Receptor Antibodies
Example 167. The primary culture of human hepatocytes was grown in the presence of a 2% aqueous solution of antibodies to the hepatocyte growth factor receptor in homeopathic dilution C40. A stimulating effect on cell proliferation was revealed after 24 hours of incubation (by 20%).

Antibodies to receptors of insulin-like growth factors
Example 168. In a rat experiment, the biological activity of antibodies to the somatomedin receptor (IGF-1) was evaluated. The drug was administered orally for 7 days in the form of a solution in 0.1 ml potency of C30. In the experimental group recorded weight gain of animals, which indicates the anabolic effect of ultra-low doses of antibodies.

Antibodies to Mesenchymal Growth Factor Receptors
Example 169. Patient M., 51 years old, complained of pain in the back and joints. Examination revealed metabolic polyarthritis, osteochondrosis. The administration of polyclonal antibodies to the mesenchymal growth factor receptor in homeopathic potency C50 by oral administration of 5 ml of an aqueous solution 3 times a day is proposed. A 7-day course of treatment reduced the severity of pain.

Fibroblast growth factor receptor antibodies
Example 170. An experiment was conducted to assess the effect of ultra-low doses of antibodies to the fibroblast growth factor receptor on the level of secondary messengers. It was established that introducing into the incubation medium 1% homeopathic dilution of C50 antibodies caused a change in cAMP level after 10 minutes, which indicates the presence of specific biological activity.

Antibodies to cytokine receptors
Antibodies to Interleukin Receptors
Example 171. Patient R., 51 years old, complained of coughing for 2 months after suffering pneumonia against the background of chronic bronchitis. The administration of polyclonal antibodies to interleukin 4 receptors was prescribed in the form of homeopathic dilution of C50, 1 tablet 3 times a day. Upon repeated treatment after 7 days, the patient noted an improvement in well-being, a decrease in cough.

 Example 172. Patient M., 46 years old, complained of itchy skin. Diagnosed with atopic dermatitis. The appointment of antibodies to interleukin 1 (IL-1) in the homeopathic potency of C30, 5 ml 3 times a day, eliminated itching after 7 days of administration.

 Example 173. The intensity of the blast transformation reaction of the proliferation of mouse thymocytes in the presence of antibodies to IL-2 receptors (interleukin 2) was evaluated. It was established that the introduction into the incubation medium of a 1% solution of antibodies in the homeopathic potency of C60 modulates the proliferative activity of thymus cells.

Interferon Receptor Antibodies
Example 174. Patient L., 38 years old, complained of a rash on her lips after an acute respiratory illness. After the examination, a diagnosis of herpes infection was made. Polyclonal antibodies to the interferon alpha receptor were prescribed in the form of a mixture of homeopathic dilutions C12, C50, C200, 1 tablet 4 times a day. After 3 days, the elimination of the symptoms of the disease was noted.

Example 175. In a mouse experiment, polyclonal antibodies to interferon receptors α and β in homeopathic dilution of C200 increased the survival of animals under conditions of keeping at low temperatures. The drug was administered orally in the form of a solution of 0.1 ml. The animals were kept on a standard vivarium diet at 12 ^o C. After 5 days, survival in the experimental group was 25% higher than in the control.

Gamma Interferon Receptor Antibodies
Example 176. Patient D., 23 years old, was undergoing chemotherapy for hip osteosarcoma. The severity of side effects (vomiting) has led to the abandonment of chemotherapy. The appointment of monoclonal antibodies to the interferon γ receptor in homeopathic potency C40 in 10 ml of an aqueous solution 3 times a day allowed to reduce nausea and continue the course of treatment. A decrease in the size of the tumor was also noted.

Antibodies to receptors of granulocytic and granulocyte-macrophage growth factors
Example 177. Patient Yu., 54 years old, complained of subfebrile temperature, cough for 3 weeks. The administration of monoclonal antibodies to granulocyte colony stimulating factor (CSF) and granulocyte-macrophage CSF in homeopathic dilution of C70 of 10 drops per dose 3 times a day was prescribed. With repeated treatment after 7 days, normalization of temperature, improvement of well-being were noted. It is recommended to continue the course of treatment.

GM-CSF receptor antibodies
Example 178. An increase in the activity of rat peritoneal macrophages was recorded after introducing into the incubation medium 1% monoclonal antibodies to granulocyte-macrophage colony stimulating factor receptors in homeopathic dilution of C50.

G-CSF receptor antibodies
Example 179. The preparation of antibodies to granulocyte colony-stimulating factor receptors in homeopathic potency C60 was administered to mice 2 times a day orally in 0.1 ml of 7 days. An increase in the number of granulocytes was revealed, which indicates the presence of a specific biological activity of the drug.

Antibodies to macrophage colony stimulating factor receptors
Example 180. The preparation of antibodies to macrophage colony stimulating factor receptors increased the number of macrophages in mice by administering 0.1 ml of an oral solution in C50 homeopathic potency for 5 days. The conclusion is made about the presence of the biological activity of the drug.

Antibodies to TNF alpha receptors
Example 181. An increase in the life expectancy of mice with breast-induced tumors was injected with monoclonal antibodies to the tumor necrosis factor alpha receptor in homeopathic potency C50. The drug was administered orally in the form of a solution of 0.1 ml 1 time per day for 4 weeks.

 Example 182. An experiment was conducted to evaluate the biological activity of a preparation of monoclonal antibodies to a tumor necrosis factor α receptor. An increase in Ca level was detected in HeLa culture cells 5 minutes after introducing into the incubation medium 1% of antibodies in homeopathic dilution of C70, which indicates the presence of the biological activity of the homeopathic preparation.

Antibodies to TNF beta receptors
Example 183. Patient S., 78 years old, complained of an increase in the size of the age spots on the right lower leg. The administration of monoclonal antibodies to the tumor necrosis factor β was prescribed in the form of a solution in homeopathic potency C60, 10 ml 2 times a day. For 3 weeks of observation, disease progression was not detected. The conclusion about the effectiveness of antibodies.

Oncostatin Receptor Antibodies
Example 184. Ultra-low doses of monoclonal antibodies to the oncostatin receptor were introduced into the mouse sarcoma cell culture. It was established that the preparation of antibodies in homeopathic potency C50 reduces the proliferative activity of tumor cells.

Transforming Growth Factor Beta Receptor Antibodies
Example 185. Patient P., 61 years old, complained of stomach pain. Gastroscopy revealed an ulcer of lesser curvature of the stomach with a diameter of 1 cm. In connection with the ineffectiveness of traditional therapy, it was additionally proposed to take monoclonal antibodies to the receptor of transforming growth factor β in homeopathic potency C20, 1 tablet 3 times a day. After 2 weeks, a repeated examination showed epithelialization of the mucosal defect.

Activin Receptor Antibodies
Example 186. In a rat experiment, the effect of monoclonal antibodies to the activin receptor on uterine contractility was evaluated. A solution of antibodies in homeopathic potency C60 was administered orally to animals in 0.1 ml of 7 days. After euthanasia, contractile activity of uterine tissue was evaluated. Potentiated antibodies were found to modulate oxytocin-stimulated contractile activity of rat uterine horn.

Inhibin Receptor Antibodies
Example 187. Patient P., 34 years old, complained of pain in the inguinal region. A history of adnexitis, an adhesive process in the abdominal cavity. The administration of antibodies to the inhibin receptor in the homeopathic potency of C30, 10 drops per dose 3 times a day, eliminated pain after 5 days of treatment.

Chemokine Receptor Antibodies
Example 188. Patient B., 57 years old, complained of lower back pain with radiation to the lower extremities. Diagnosed with radicular syndrome, sciatica. As part of complex therapy, oral administration of monoclonal antibodies to the RANTES chemokine receptor in the homeopathic potency of C200 was prescribed orally in a dose of 5 ml of an aqueous solution 3 times a day. After 3 days, the elimination of pain was recorded.

 Example 189. Patient V., 59 years old, suffering from rheumatoid arthritis, complained of increased pain in the knee joints. The reception of antibodies to the interleukin 8 receptor (chemokine) in homeopathic potency C70 of 5 ml 3 times a day is proposed. A decrease in pain was recorded after 4 days of taking the drug.

Antibodies to Immunoglobulin Receptors
Example 190. Patient P., 47 years old, complained of pain in the spine. On examination, a diagnosis of osteochondrosis was made. Taking a preparation of antibodies to immunoglobulin receptors in the form of a solution in homeopathic potency C50 eliminated the pain syndrome.

 Example 191. Patient U., 56 years old, complained of attacks of suffocation and dry cough that occur at night. Diagnosed with bronchial asthma. The administration of monoclonal antibodies to the poly Ig receptor in the form of a solution in homeopathic potency of C50 of 10 drops per appointment was prescribed. For 3 weeks of admission, no repeated attacks were recorded.

Antibodies to Fc Receptors Immunoglobulins
Example 192. Patient D., 57 years old, complained of a runny nose, sneezing, and itchy nose. Diagnosed with allergic rhinitis. The purpose of the preparation of monoclonal antibodies to the Fc receptor in the form of a solution in the homeopathic potency of C50 eliminated the symptoms of the disease after 2 days of taking 1 tablet 3 times a day.

Antibodies to CD receptors (cluster of differentiation)
Example 193. Patient S., 46 years old, was undergoing treatment for eczema. She complained of itching and the lack of effectiveness of local therapy. The appointment of a solution of antibodies to CD4 in homeopathic potency C70 10 drops 3 times a day allowed to reduce the severity of clinical manifestations. It is recommended to continue the course of treatment.

 Example 194. An experiment was conducted to evaluate the biological activity of ultra-low potentiated doses of antibodies to CD20 (calcium channel B lymphocytes). It was found that the introduction of 1% of the drug into the incubation medium of human lymphocytes in homeopathic dilution of C50 increased the intracellular concentration of Ca ions. It is concluded that the drug has biological activity.

Antibodies to the receptors of the components of the complement system
Example 195. Patient O., 67 years old, was undergoing treatment for trophic foot ulcers against diabetes mellitus. The administration of antibodies to the complement receptor C4 in homeopathic dilution of C50 orally 1 tablet 3 times a day allowed to accelerate healing and reduce the severity of the inflammatory reaction.

 Example 196. In an experiment, monoclonal antibodies to the complement C3b receptor reduced the intensity of erythrocyte hemolysis when 1% homeopathic dilution in potency D6 was added to the incubation medium. It is concluded that there is a specific biological activity of the homeopathic remedy.

Antibodies to the receptors of histocompatibility complex components
Example 197. In a mouse experiment, polyclonal antibodies to the T-cell receptor in homeopathic potency C50 improved the survival rate of the skin flap by oral administration of 0.1 ml for 7 days.

 Example 198. Patient K., 64 years old, with a diagnosis of ankylosing spondylitis, complained of treatment failure. The administration of antibodies to the immunoglobulin receptors of B-lymphocytes in homeopathic dilution of C50 was administered orally in 5 ml of an aqueous solution 3 times a day. Conducted therapy has reduced the severity of pain 5 days after the start of treatment.

Thymus hormone receptor antibodies
Thymosin alpha receptor antibodies
Example 199. Antibodies to the thymosin α1 receptor in homeopathic potency C50 stimulated the sensitivity of rosette-forming spleen cells of thimectomized mice to the inhibitory effect of azathioprine, which indicates the presence of a specific differentiating activity in the preparation.

Antibodies to receptors for adhesion factors and cell-cell interactions
Example 200. Patient R., 65 years old, complained of poor healing of a burn of the hand. The preparation of antibodies to selectin receptors was prescribed in a homeopathic dilution of C50 orally, 5 ml 3 times a day. Stimulation of epithelialization of the wound surface after 5 days of therapy was noted.

 Example 201. The stimulation of the reaction of blast transformation of lymphocytes in mice that were orally administered monoclonal antibodies to the mannosophosphate receptor in the form of an aqueous solution in homeopathic dilution of C60 in 0.1 ml daily for 7 days was noted.

 Example 202. An increase in the concentration of Ca ions in the cells of the primary human fibroblast culture was registered, into which 1% polyclonal antibodies to integrin receptors were added in homeopathic dilution of C70.

 Example 203. Monoclonal antibodies to occludin receptors caused a change in the membrane potential of keratinocytes in a primary cell culture when 1% of antibodies were added to the medium in homeopathic dilution C50.

 Example 204. Patient R., 67 years old, complained of chest pain. An examination revealed coronary heart disease with atherosclerosis. The administration of orally ultra-low doses of antibodies to the cadherin receptor in the homeopathic potency of C200, 1 tablet 3 times a day, reduced the manifestations of angina pectoris.

 Example 205. Patient A., 46 years old, complained of nausea, pain in the epigastric region. Examination revealed a stomach ulcer. As part of complex therapy, to accelerate healing, a preparation of monoclonal antibodies to the beta-catenin receptor in the homeopathic potency of C50 was prescribed orally 3 times a day, 10 ml each. The purpose of the drug allowed to reduce the symptoms of the disease 5 days after the start of therapy.

Antibodies to ATP-basics
Example 206. Patient R., 57 years old, complained of a heartbeat. After the examination, a diagnosis was made of atrial fibrillation against the background of coronary heart disease. The administration of antibodies to Ca-ATPase in homeopathic dilution of C50 was prescribed, 10 drops 3 times a day. After 3 days, the elimination of arrhythmia was recorded.

Antibodies to amino acid transporters
Example 207. Patient P., 54 years old, complained of pain in the right hypochondrium, nausea. A history of chronic drug hepatitis. The use of polyclonal antibodies to amino acid transporters (glycine, glutamic acid, aspartic acid) in homeopathic dilution of C100 in 5 ml 2 times a day is proposed. After 5 days, an improvement in health was registered.

Antibodies to glucose carriers
Example 208. A patient L., 63 years old, suffering from type 2 diabetes, complained of dry mouth, weakness, dizziness, and the ineffectiveness of sugar-lowering drugs. Assigned oral administration of monoclonal antibodies to the lactose transporter in homeopathic dilution of C50 in 5 ml 3 times a day. After 2 days, the elimination of symptoms of hyperglycemia was noted.

Antibodies to H-cholinergic receptors
Example 209. Patient V., 48 years old, complained of cramps of the lower extremities. Electrolyte abnormalities and diabetes were not detected. A history of sciatic nerve neuralgia. After 3 days of oral administration, 2 times a day, 10 ml of a solution of potentiated natural antibodies to N-cholinergic receptors in homeopathic dilution C100 marked decrease in the intensity of convulsive reactions and pain. Natural antibodies are obtained from the blood serum of patients with myasthenia gravis (myasthenia gravis) according to the method described, for example, in the book: Natural antibodies to low molecular weight compounds. M.A. Myagkova. M .: MGUL, 2001, p. 70-114.

Claims (39)

 1. A method of treating a pathological syndrome by introducing into the body the activated forms of ultra-low doses of antibodies obtained by repeated serial dilution and external exposure to an antigen - a membrane protein or receptor involved in the formation of a pathological syndrome and / or mediating physiological mechanisms, the violation of which leads to the formation pathological syndrome.  2. A drug for the treatment of a pathological syndrome, containing an activated form of ultra-low doses of monoclonal, polyclonal or natural antibodies to a membrane protein or receptor involved in the formation of a pathological syndrome and / or mediating physiological mechanisms, the violation of which leads to the formation of a pathological syndrome, prepared by multiple sequential breeding and external exposure, mainly by homeopathic technology.  3. The drug under item 2, characterized in that the use of antibodies to cholinergic receptors.  4. The drug under item 2, characterized in that the use of antibodies to receptors of hormones - derived amino acids.  5. The drug according to p. 2 or 4, characterized in that use antibodies to adrenergic receptors.  6. The drug according to p. 2 or 4, characterized in that use antibodies to dopamine receptors.  7. The drug according to p. 2 or 4, characterized in that the use of antibodies to serotonin receptors.  8. The drug according to p. 2 or 4, characterized in that the use of antibodies to histamine receptors.  9. The drug according to p. 2 or 4, characterized in that they use antibodies to purine receptors.  10. The drug according to p. 2 or 4, characterized in that the use of antibodies to imidazoline receptors.  11. The drug according to p. 2 or 4, characterized in that the use of antibodies to GABA receptors.  12. The drug according to p. 2 or 4, characterized in that the use of antibodies to amino acid receptors.  13. The drug according to p. 2 or 4, characterized in that they use antibodies to the melatonin receptor.  14. The drug under item 2, characterized in that the use of antibodies to eicosanoid receptors.  15. The drug according to p. 2, characterized in that the use of antibodies to lipoprotein receptors.  16. The drug under item 2, characterized in that the use of antibodies to proteins that bind nitric oxide (NO).  17. The drug according to claim 2, characterized in that the use of antibodies to steroid receptors.  18. The drug according to p. 2, characterized in that the use of antibodies to receptors of protein-peptide hormones.  19. The drug according to p. 2 or 18, characterized in that they use antibodies to kinin receptors.  20. The drug according to p. 2 or 18, characterized in that the use of antibodies to opiate receptors.  21. The drug according to p. 2 or 18, characterized in that they use antibodies to receptors of hypothalamic releasing factors.  22. The drug according to p. 2 or 18, characterized in that the use of antibodies to pituitary hormone receptors.  23. The drug according to p. 2 or 18, characterized in that the use of antibodies to receptors of neuropeptides.  24. The drug according to p. 2 or 18, characterized in that they use antibodies to thyroid hormone receptors.  25. The drug according to p. 2 or 18, characterized in that the use of antibodies to parathyroid hormone receptors.  26. The drug according to p. 2 or 18, characterized in that they use antibodies to receptors of the hormones of the pancreas.  27. The drug according to p. 2 or 18, characterized in that the use of antibodies to receptors of peptide regulators of the vascular wall.  28. The drug according to p. 2 or 18, characterized in that they use antibodies to receptors of growth factors.  29. The drug according to p. 2 or 18, characterized in that the use of antibodies to cytokine receptors.  30. The drug according to p. 2 or 18, characterized in that the use of antibodies to immunoglobulin receptors.  31. The drug according to p. 2 or 18, characterized in that they use antibodies to receptors of differentiation clusters (CD-systems).  32. The drug according to p. 2 or 18, characterized in that use antibodies to the receptors of the components of the complement system.  33. The drug according to p. 2 or 18, characterized in that they use antibodies to T lymphocyte receptors.  34. The drug according to p. 2 or 18, characterized in that the use of antibodies to receptors in lymphocytes.  35. The drug according to p. 2 or 18, characterized in that the use of antibodies to receptors of the hormones of the thymus.  36. The drug according to p. 2 or 18, characterized in that they use antibodies to receptors for adhesion factors and intercellular interactions.  37. The drug according to p. 2, characterized in that for the production of antibodies using associated with the cell membrane, intracellular or soluble receptors, mainly human.  38. The drug according to any one of paragraphs. 2-37, characterized in that the use of antibodies to the polypeptide fragment of a membrane protein or receptor.  39. The drug according to any one of paragraphs. 2-38, characterized in that they use a mixture of various, mainly hundred, homeopathic dilutions.

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